IL163970A0 - Dedifferentiated, programmable stemcells of monocytic origin, and their production and use - Google Patents
Dedifferentiated, programmable stemcells of monocytic origin, and their production and useInfo
- Publication number
- IL163970A0 IL163970A0 IL16397003A IL16397003A IL163970A0 IL 163970 A0 IL163970 A0 IL 163970A0 IL 16397003 A IL16397003 A IL 16397003A IL 16397003 A IL16397003 A IL 16397003A IL 163970 A0 IL163970 A0 IL 163970A0
- Authority
- IL
- Israel
- Prior art keywords
- production
- dedifferentiated
- programmable
- stemcells
- monocytic origin
- Prior art date
Links
- 210000000130 stem cell Anatomy 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 210000001616 monocyte Anatomy 0.000 abstract 2
- 108010002386 Interleukin-3 Proteins 0.000 abstract 1
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 abstract 1
- 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
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- C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
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| DE10214095A DE10214095C1 (de) | 2002-03-28 | 2002-03-28 | Dedifferenzierte, programmierbare Stammzellen monozytären Ursprungs, sowie deren Herstellung und Verwendung |
| US10/372,657 US20040101962A1 (en) | 2002-03-28 | 2003-02-25 | Dedifferentiated, programmable stem cells of monocytic origin, and their production and use |
| PCT/EP2003/002121 WO2003083091A1 (fr) | 2002-03-28 | 2003-02-25 | Cellules souches dedifferenciees programmables, d'origine monocytique, ainsi que leur production et leur utilisation |
| PCT/EP2003/003279 WO2003083092A1 (fr) | 2002-03-28 | 2003-03-28 | Cellules souches dedifferenciees programmables d'origine monocytique, production et utilisation de ces dernieres |
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| JP (2) | JP4146802B2 (fr) |
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| TW (1) | TWI288779B (fr) |
| WO (1) | WO2003083092A1 (fr) |
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| GB9502022D0 (en) * | 1995-02-02 | 1995-03-22 | Abuljadayel Ilham M S | A method for preparing lymphohaematopoietic progenitor cells |
| TWI288779B (en) * | 2002-03-28 | 2007-10-21 | Blasticon Biotech Forschung | Dedifferentiated, programmable stem cells of monocytic origin, and their production and use |
| DE10231655A1 (de) * | 2002-07-12 | 2004-02-26 | Blasticon Biotechnologische Forschung Gmbh | Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung |
| WO2004043990A2 (fr) * | 2002-11-07 | 2004-05-27 | University Of Chicago | Materiels a base de cellules souches humaines et procedes correspondant |
| US20040136973A1 (en) * | 2002-11-07 | 2004-07-15 | Eliezer Huberman | Human stem cell materials and methods |
| US20060188485A1 (en) * | 2003-07-11 | 2006-08-24 | Bernd Karl Friedrich Kremer | Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical preparations |
| ITRM20030376A1 (it) | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
| WO2005071065A1 (fr) * | 2004-01-26 | 2005-08-04 | Cognis France S.A.S | Procede permettant d'etudier les interactions fonctionnelles entre les neurones sensoriels et les keratinocytes ou les melanocytes |
| EP1600500A1 (fr) * | 2004-05-27 | 2005-11-30 | Georg-August-Universität Göttingen | Méthode de production de cellules pluripotentes a partir de monocytes |
| CN101087563A (zh) * | 2004-11-08 | 2007-12-12 | 约翰霍普金斯大学 | 活检钳 |
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| WO2006096931A1 (fr) * | 2005-03-18 | 2006-09-21 | The University Of Queensland | Reparation et regeneration renale |
| WO2008048671A1 (fr) | 2006-10-18 | 2008-04-24 | University Of Illinois | Cellules souches de type embryonnaire dérivées du sang périphérique d'un être humain adulte et procédés d'utilisation associés |
| US9388382B2 (en) | 2005-10-05 | 2016-07-12 | The Board Of Trustees Of The University Of Illinois | Isolation of CD14 negative, CD45 positive and CD117 positive embryonic-like stem cells free of monocytes from human umbilical cord blood mononuclear cells |
| ITTO20050819A1 (it) | 2005-11-18 | 2007-05-19 | Univ Degli Studi Torino | Linea cellulare staminale pluripotente, linee cellulari derivate, procedimenti per la loro produzione e relativi usi |
| WO2007131200A2 (fr) * | 2006-05-05 | 2007-11-15 | Opexa Therapeutics | Cellules souches dérivées de monocytes |
| EP2019862A4 (fr) * | 2006-05-05 | 2009-08-05 | Opexa Therapeutics | Cellules du type ilots pancreatiques |
| US20080050814A1 (en) * | 2006-06-05 | 2008-02-28 | Cryo-Cell International, Inc. | Procurement, isolation and cryopreservation of fetal placental cells |
| US20080064098A1 (en) * | 2006-06-05 | 2008-03-13 | Cryo-Cell International, Inc. | Procurement, isolation and cryopreservation of maternal placental cells |
| ITRM20060498A1 (it) * | 2006-09-20 | 2008-03-21 | Alessandra Gambacurta | Metodo di espansione di cellule staminali adulte da sangue periferico e relativi usi in campo medico |
| US20100093089A1 (en) * | 2006-11-09 | 2010-04-15 | Eduardo Marban | Dedifferentiation of adult mammalian cardiomyocytes into cardiac stem cells |
| ITTO20060937A1 (it) * | 2006-12-29 | 2008-06-30 | Medestea Biotech S R L | Linee cellulari immortali differenziate atte a produrre albumina e fattori di crescita, procedimenti per la loro preparazione da una linea cellulare leucemica e loro usi. |
| EP2039758B1 (fr) * | 2007-09-21 | 2010-09-01 | Universität Leipzig | Support de culture de cellule et procédé de culture de cellules souches et cellules de progéniteur |
| ITUD20080058A1 (it) | 2008-03-18 | 2009-09-19 | Thankstem S R L | Kit per la raccolta di sangue, preferibilmente periferico, per la produzione di cellule staminali |
| WO2009157610A1 (fr) * | 2008-06-26 | 2009-12-30 | Pusan National University Industry-University Cooperation Foundation | Cellule dédifférenciée par le sélénium, procédé de préparation et utilisation de celle-ci |
| CA2977823A1 (fr) * | 2008-11-25 | 2010-06-03 | Otsuka Pharmaceutical Co., Ltd. | Cellule souche d'utilisation therapeutique qui est issue de monocyte humain et son procede d'induction |
| KR100950195B1 (ko) * | 2009-03-20 | 2010-03-29 | 서울대학교산학협력단 | Znf281을 발현하는 제대혈 유래 만능 줄기세포의 분리방법 |
| RU2635317C2 (ru) * | 2009-10-19 | 2017-11-10 | Тристем Трейдинг (Сайпрес) Лимитед | Лечение с применением перепрограммированных зрелых и дифференцированных клеток |
| US20110091433A1 (en) * | 2009-10-19 | 2011-04-21 | Ilham Mohamed Saleh Saeed Abuljadayel | Treatment using reprogrammed mature adult cells |
| CN101760446B (zh) * | 2009-12-31 | 2012-09-12 | 浙江中赢控股集团有限公司 | 制备单核细胞型干细胞的方法及应用 |
| US9249392B2 (en) | 2010-04-30 | 2016-02-02 | Cedars-Sinai Medical Center | Methods and compositions for maintaining genomic stability in cultured stem cells |
| US9845457B2 (en) | 2010-04-30 | 2017-12-19 | Cedars-Sinai Medical Center | Maintenance of genomic stability in cultured stem cells |
| EP2603579B1 (fr) * | 2010-08-12 | 2015-07-01 | ABAG Verwaltungs GmbH | Procédés de production de cellules présentant des caractéristiques des hépatocytes |
| SG10201601853XA (en) | 2011-03-11 | 2016-04-28 | Univ Singapore | Pericyte progenitors from peripheral blood |
| JP5577472B2 (ja) * | 2012-02-10 | 2014-08-20 | 医療法人社団博心厚生会 | 単球増殖剤、単球増殖用培地、単球の製造方法、樹状細胞の製造方法、及び樹状細胞ワクチンの製造方法 |
| WO2013180395A1 (fr) * | 2012-05-29 | 2013-12-05 | 한국생명공학연구원 | Métabolite pour favoriser la génération, la conservation et la prolifération de cellules souches pluripotentes, et composition et procédé de culture le comprenant |
| US9884076B2 (en) | 2012-06-05 | 2018-02-06 | Capricor, Inc. | Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy |
| EP2882445B1 (fr) | 2012-08-13 | 2019-04-24 | Cedars-Sinai Medical Center | Exosomes et acides micro-ribonucléiques pour la régénération de tissus |
| AU2013354909A1 (en) * | 2012-12-06 | 2015-07-02 | Fuwan Pty Ltd | A method of generating multilineage potential cells |
| EP2862926B1 (fr) | 2013-10-17 | 2018-12-05 | Centre National de la Recherche Scientifique (CNRS) | Procédé de différentiation in vitro de cellules issues de la circulation sanguine en cellules de type neuronal et ses applications |
| KR20160093654A (ko) * | 2013-12-06 | 2016-08-08 | 푸완 피티와이 리미티드 | 종양을 치료하는 방법 |
| HUE040661T2 (hu) * | 2014-05-09 | 2019-03-28 | Thankstem S R L | Eljárás felnõtt õssejtek szaporítására teljes vérbõl |
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| BR112017014195B1 (pt) | 2014-12-31 | 2023-04-11 | Poet Research, Inc | Processos para produzir uma corrente (slip stream) de açúcar e sistemas para produzir uma corrente (slip stream) de açúcar |
| WO2017040548A1 (fr) * | 2015-08-31 | 2017-03-09 | I Peace, Inc. | Système de production de cellules souches pluripotentes, et procédé de production de cellules souches pluripotentes induites |
| WO2017123662A1 (fr) | 2016-01-11 | 2017-07-20 | Cedars-Sinai Medical Center | Cellules dérivées de cardiosphères et exosomes sécrétés par ces cellules dans le traitement d'une insuffisance cardiaque à fraction d'éjection préservée |
| US11351200B2 (en) | 2016-06-03 | 2022-06-07 | Cedars-Sinai Medical Center | CDC-derived exosomes for treatment of ventricular tachyarrythmias |
| EP3515459A4 (fr) | 2016-09-20 | 2020-08-05 | Cedars-Sinai Medical Center | Cellules dérivées de cardiosphères et leurs vésicules extracellulaires pour retarder ou inverser le vieillissement et des troubles liés à l'âge |
| US11759482B2 (en) | 2017-04-19 | 2023-09-19 | Cedars-Sinai Medical Center | Methods and compositions for treating skeletal muscular dystrophy |
| CN107904202B (zh) * | 2017-11-22 | 2018-11-20 | 北京恩诺生物科技有限公司 | 一种制备多能干细胞样细胞的方法、组合物和应用 |
| AU2018375151B2 (en) | 2017-11-29 | 2025-06-26 | Spinalcyte Llc | Interaction of fibroblasts and immune cells for activation and uses thereof |
| US11660355B2 (en) | 2017-12-20 | 2023-05-30 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
| EP3749344A4 (fr) | 2018-02-05 | 2022-01-26 | Cedars-Sinai Medical Center | Procédés d'utilisation thérapeutique d'exosomes et d'arn y |
| CA3175071A1 (fr) | 2020-03-11 | 2021-09-16 | Bit Bio Limited | Procede de generation de cellules hepatiques |
| JP6826744B1 (ja) * | 2020-07-17 | 2021-02-10 | 医療法人Yanaga CLinic | 成熟脂肪細胞含有組成物の製造方法 |
| AU2022241371A1 (en) * | 2021-03-18 | 2023-09-21 | South Eastern Sydney Local Health District | Bioengineered endothelial constructs |
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| JPH10506530A (ja) * | 1994-09-23 | 1998-06-30 | ザ ジェネラル ホスピタル コーポレーション | 哺乳類細胞において外来遺伝子を発現する非哺乳類dnaウイルスの使用 |
| US5871986A (en) * | 1994-09-23 | 1999-02-16 | The General Hospital Corporation | Use of a baculovirus to express and exogenous gene in a mammalian cell |
| US7112440B2 (en) | 1995-02-02 | 2006-09-26 | Ghazi Jaswinder Dhoot | Method of increasing the relative number of CD45 low cells in a cell population |
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| GB9502022D0 (en) | 1995-02-02 | 1995-03-22 | Abuljadayel Ilham M S | A method for preparing lymphohaematopoietic progenitor cells |
| US5650309A (en) * | 1995-05-16 | 1997-07-22 | The Regents Of The University Of California | Viral vectors |
| US6043092A (en) * | 1996-03-18 | 2000-03-28 | University Of Pittsburgh | Cell culture media for mammalian cells |
| US5827740A (en) * | 1996-07-30 | 1998-10-27 | Osiris Therapeutics, Inc. | Adipogenic differentiation of human mesenchymal stem cells |
| WO1998014561A1 (fr) | 1996-10-04 | 1998-04-09 | Becton Dickinson And Company | Identification d'un precurseur de moelle osseuse cd34+ destine a des cellules dendritiques dans le sang et les tissus lymphoides |
| EP0983345A1 (fr) * | 1997-05-21 | 2000-03-08 | THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services | Procedes et compositions permettant d'obtenir des cellules dendritiques a partir de populations amplifiees de monocytes, et d'activer les cellules t |
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| WO2000070022A2 (fr) | 1999-05-14 | 2000-11-23 | City Of Hope | Expansion ex vivo de cellules souches hematopoietiques multipotentes mammaliennes |
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| TWI288779B (en) * | 2002-03-28 | 2007-10-21 | Blasticon Biotech Forschung | Dedifferentiated, programmable stem cells of monocytic origin, and their production and use |
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| US20040136973A1 (en) | 2002-11-07 | 2004-07-15 | Eliezer Huberman | Human stem cell materials and methods |
| WO2004043990A2 (fr) | 2002-11-07 | 2004-05-27 | University Of Chicago | Materiels a base de cellules souches humaines et procedes correspondant |
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| US20050260158A1 (en) * | 2003-11-07 | 2005-11-24 | Eliezer Huberman | Human stem cell materials and methods |
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- 2003-03-28 EP EP04026289A patent/EP1506999A1/fr not_active Withdrawn
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