IL157815A0 - Fused pyridine derivatives for use as vanilloid receptor antagonists for treating pain - Google Patents

Fused pyridine derivatives for use as vanilloid receptor antagonists for treating pain

Info

Publication number: IL157815A0
Authority: IL; Israel
Prior art keywords: receptor antagonists; treating pain; pyridine derivatives; vanilloid receptor; fused pyridine
Prior art date: 2001-03-26

Application number

IL15781502A

Other languages

English (en)

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-26

Filing date

2002-03-25

Publication date

2004-03-28

2001-03-26 Priority claimed from GB0107505A external-priority patent/GB0107505D0/en

2002-03-25 Application filed by Novartis Ag filed Critical Novartis Ag

2004-03-28 Publication of IL157815A0 publication Critical patent/IL157815A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Vascular Medicine (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

IL15781502A 2001-03-26 2002-03-25 Fused pyridine derivatives for use as vanilloid receptor antagonists for treating pain IL157815A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0107505A GB0107505D0 (en)	2001-03-26	2001-03-26	Organic compounds
US33828101P	2001-12-06	2001-12-06
PCT/EP2002/003332 WO2002076946A2 (en)	2001-03-26	2002-03-25	Fused pyridine derivatives for use as vanilloid receptor antagonists for treating pain.

Publications (1)

Publication Number	Publication Date
IL157815A0 true IL157815A0 (en)	2004-03-28

Family

ID=26245894

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL15781502A IL157815A0 (en)	2001-03-26	2002-03-25	Fused pyridine derivatives for use as vanilloid receptor antagonists for treating pain

Country Status (17)

Country	Link
US (1)	US7915264B2 (es)
EP (1)	EP1377576A2 (es)
JP (1)	JP4205430B2 (es)
KR (1)	KR20030083755A (es)
CN (1)	CN1500089A (es)
BR (1)	BR0208338A (es)
CA (1)	CA2441599A1 (es)
CZ (1)	CZ20032561A3 (es)
HU (1)	HUP0303623A2 (es)
IL (1)	IL157815A0 (es)
MX (1)	MXPA03008754A (es)
NO (1)	NO326546B1 (es)
PE (1)	PE20021161A1 (es)
PL (1)	PL363907A1 (es)
RU (1)	RU2003130221A (es)
SK (1)	SK11952003A3 (es)
WO (1)	WO2002076946A2 (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU8022901A (en)	2000-08-21	2002-03-04	Pacific Corp	Novel thiourea derivatives and the pharmaceutical compositions containing the same
JP2004506714A (ja)	2000-08-21	2004-03-04	パシフィック　コーポレーション	新規チオ尿素化合物及びこれを含有する薬学的組成物
PL371587A1 (en)	2002-01-17	2005-06-27	Neurogen Corporation	Substituted quinazolin-4-ylamine analogues as modulators of capsaicin receptors
DK1472225T3 (da)	2002-02-01	2010-08-09	Euro Celtique Sa	2-Piperazinpyridiner, som er anvendelige til behandling af smerte
US6864261B2 (en)	2002-05-02	2005-03-08	Euro-Celtique S.A.	Therapeutic agents useful for treating pain
GB0229808D0 (en) *	2002-12-20	2003-01-29	Glaxo Group Ltd	Novel compositions
ES2337254T3 (es)	2003-02-14	2010-04-22	Glaxo Group Limited	Derivados de carboxamida.
WO2004103954A1 (ja)	2003-05-20	2004-12-02	Ajinomoto Co., Inc.	アミド誘導体
GB0319150D0 (en)	2003-08-14	2003-09-17	Glaxo Group Ltd	Novel compounds
AU2004290626A1 (en)	2003-11-14	2005-06-02	Merck Sharp & Dohme Limited	Bicyclic pyrimidin-4-(3H)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (VR1)
GB0412769D0 (en)	2004-06-08	2004-07-07	Novartis Ag	Organic compounds
WO2006019965A2 (en) *	2004-07-16	2006-02-23	Takeda San Diego, Inc.	Dipeptidyl peptidase inhibitors
WO2006007851A2 (en)	2004-07-19	2006-01-26	Novo Nordisk A/S	Capsaicin inhibitors for treating obesity and-related disorders
DE102004039373A1 (de)	2004-08-12	2006-02-23	Grünenthal GmbH	Para-Alkyl-substituierte N-(4-Hydroxy-3-methoxy-benzyl)-zimtsäureamide und deren Verwendung zur Herstellung von Arzneimitteln
KR20060087386A (ko)	2005-01-28	2006-08-02	주식회사 대웅제약	신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물
WO2006098554A1 (en) *	2005-03-16	2006-09-21	Amorepacific Corporation	Novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and a pharmaceutical composition containing the same
GB0506147D0 (en) *	2005-03-24	2005-05-04	Merck Sharp & Dohme	Therapeutic agents
GB0509573D0 (en) *	2005-05-11	2005-06-15	Merck Sharp & Dohme	Therapeutic compounds
WO2006122200A1 (en) *	2005-05-11	2006-11-16	Merck Sharp & Dohme Limited	2,3-substituted fused bicyclic pyrimidin-4(3h)-ones modulating the function of the vanilloid-1 receptor (vr1)
CN103382176A (zh) *	2005-10-19	2013-11-06	格吕伦塔尔有限公司	新颖的辣椒素受体配体和它们用于生产药物的用途
GB0525068D0 (en)	2005-12-08	2006-01-18	Novartis Ag	Organic compounds
KR100761222B1 (ko) *	2006-03-08	2007-10-04	성균관대학교산학협력단	약물의존중독을 예방 및 치료하기 위한 바닐로이드 수용체길항제
GB0614471D0 (en)	2006-07-20	2006-08-30	Syngenta Ltd	Herbicidal Compounds
AU2007288203B2 (en)	2006-08-23	2013-01-17	Neurogen Corporation	2-phenoxy pyrimidinone analogues
US20080207659A1 (en)	2007-02-15	2008-08-28	Asit Kumar Chakraborti	Inhibitors of phosphodiesterase type 4
TW200902014A (en) *	2007-04-20	2009-01-16	Novartis Ag	Uses of vanilloid receptor antagonists
BRPI0813825A2 (pt) *	2007-07-18	2015-01-06	Novartis Ag	Combinações sinergísticas de antagonistas de vr-1 e inibidores da cox-2
EP2229388A4 (en) *	2008-01-11	2012-03-07	Glenmark Pharmaceuticals Sa	CONDENSED PYRIMIDINE DERIVATIVES AS TRPV3 MODULATORS
WO2009121036A2 (en) *	2008-03-27	2009-10-01	Neurogen Corporation	Substituted aryl pyrimidinone derivatives
NZ587771A (en)	2008-04-18	2011-05-27	Dae Woong Pharma	Novel benzoxazine benzimidazole derivatives, pharmaceutical composition comprising same, and a use thereof
US8349852B2 (en)	2009-01-13	2013-01-08	Novartis Ag	Quinazolinone derivatives useful as vanilloid antagonists
WO2011092293A2 (en)	2010-02-01	2011-08-04	Novartis Ag	Cyclohexyl amide derivatives as crf receptor antagonists
CN102762572A (zh)	2010-02-01	2012-10-31	诺瓦提斯公司	作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物
US8835444B2 (en)	2010-02-02	2014-09-16	Novartis Ag	Cyclohexyl amide derivatives as CRF receptor antagonists
KR101293384B1 (ko)	2010-10-13	2013-08-05	주식회사 대웅제약	신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도
UY34094A (es)	2011-05-27	2013-01-03	Novartis Ag	Derivados de la piperidina 3-espirocíclica como agonistas de receptores de la ghrelina
EA201491990A1 (ru)	2012-05-03	2015-02-27	Новартис Аг	L-малатная соль 2,7-диазаспиро[4.5]дец-7-иловых производных и их кристаллические формы в качестве агонистов грелиновых рецепторов
ES2991706T3 (es)	2015-12-23	2024-12-04	Commw Scient Ind Res Org	Compuestos de enamina para protección contra radiación UV
CN108863949B (zh) *	2018-07-09	2021-01-15	湖南博隽生物医药有限公司	一种用于治疗慢性炎性痛的辣椒素受体拮抗剂及合成方法
DE102022104759A1 (de)	2022-02-28	2023-08-31	SCi Kontor GmbH	Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen
CN114605408B (zh) *	2022-03-30	2023-06-16	沈阳药科大学	5-羟基-1,3-二取代苯基吡啶并[2,3-d]嘧啶类化合物及其制法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2749344A (en)	1953-01-02	1956-06-05	Burroughs Wellcome Co	Pyrimidine compounds
US5958930A (en) *	1991-04-08	1999-09-28	Duquesne University Of The Holy Ghost	Pyrrolo pyrimidine and furo pyrimidine derivatives
EP0743855A1 (en)	1994-01-03	1996-11-27	Acea Pharmaceuticals, Inc.	8-aza, 6-aza and 6,8-diaza-1,4-dihydroquinoxaline-2,3-diones and the use thereof as antagonists for the glycine/nmda receptor
FR2750862B1 (fr)	1996-07-12	1998-10-16	Dupin Jean Pierre	Utilisation d'heterocycles diazotes fusionnes avec un systeme aromatique ou heteroaromatique pour le traitement des maladies thrombo-emboliques

2002
- 2002-03-25 IL IL15781502A patent/IL157815A0/xx unknown
- 2002-03-25 KR KR10-2003-7012460A patent/KR20030083755A/ko not_active Ceased
- 2002-03-25 WO PCT/EP2002/003332 patent/WO2002076946A2/en not_active Ceased
- 2002-03-25 JP JP2002576207A patent/JP4205430B2/ja not_active Expired - Fee Related
- 2002-03-25 HU HU0303623A patent/HUP0303623A2/hu unknown
- 2002-03-25 US US10/469,756 patent/US7915264B2/en not_active Expired - Fee Related
- 2002-03-25 RU RU2003130221/04A patent/RU2003130221A/ru not_active Application Discontinuation
- 2002-03-25 EP EP02730062A patent/EP1377576A2/en not_active Withdrawn
- 2002-03-25 CA CA002441599A patent/CA2441599A1/en not_active Abandoned
- 2002-03-25 BR BR0208338-8A patent/BR0208338A/pt not_active IP Right Cessation
- 2002-03-25 CZ CZ20032561A patent/CZ20032561A3/cs unknown
- 2002-03-25 CN CNA028073495A patent/CN1500089A/zh active Pending
- 2002-03-25 SK SK1195-2003A patent/SK11952003A3/sk unknown
- 2002-03-25 PL PL02363907A patent/PL363907A1/xx not_active Application Discontinuation
- 2002-03-25 MX MXPA03008754A patent/MXPA03008754A/es not_active Application Discontinuation
- 2002-03-26 PE PE2002000241A patent/PE20021161A1/es not_active Application Discontinuation
2003
- 2003-09-16 NO NO20034122A patent/NO326546B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO2002076946A3 (en)	2002-12-27
US20040138454A1 (en)	2004-07-15
US7915264B2 (en)	2011-03-29
BR0208338A (pt)	2004-03-09
HUP0303623A2 (hu)	2004-03-01
JP2004528312A (ja)	2004-09-16
EP1377576A2 (en)	2004-01-07
WO2002076946A2 (en)	2002-10-03
MXPA03008754A (es)	2004-02-18
CN1500089A (zh)	2004-05-26
CA2441599A1 (en)	2002-10-03
NO326546B1 (no)	2009-01-05
SK11952003A3 (sk)	2004-03-02
NO20034122D0 (no)	2003-09-16
NO20034122L (no)	2003-09-16
CZ20032561A3 (cs)	2003-12-17
PE20021161A1 (es)	2003-02-21
JP4205430B2 (ja)	2009-01-07
KR20030083755A (ko)	2003-10-30
PL363907A1 (en)	2004-11-29
RU2003130221A (ru)	2005-04-10

Publication	Publication Date	Title
IL157815A0 (en)	2004-03-28	Fused pyridine derivatives for use as vanilloid receptor antagonists for treating pain
PL369026A1 (en)	2005-04-18	Urea-compounds active as vanilloid receptor antagonists for the treatment of pain
HUP0301671A3 (en)	2010-03-29	4-phenyl-pyridine derivatives as neurokinin-1 receptor antagonists, process for their preparation and their use
HUP0302719A3 (en)	2007-08-28	Substituted amine derivatives and their use for the treatment of angiogenesis
IL159350A0 (en)	2004-06-01	Use of nk-1 receptor antagonists with pyridinic structure, for the treatment of brain, spinal or nerve injury
IL144851A0 (en)	2002-06-30	3-phenylpyridine derivatives and their use as nk-1 receptor antagonists
MXPA03009644A (es)	2004-01-29	Grupos azabiciclicos sustituidos para el tratamiento de enfermedades.
IL152700A0 (en)	2003-06-24	Substituted 1-aminoalkyl-lactams and their use as muscarinc receptor antagonists
PL353854A1 (en)	2003-12-01	Substituted 1,5-dihydropyrrol-2-on derivatives as nmda receptor antagonists for the treatment of pain
HUP0202253A3 (en)	2003-12-29	Selective iglur5 receptor antagonists for the treatment of migraine
AU2002352476A8 (en)	2003-07-09	Urea derivatives and their use as vanilloid receptor antagonists
PL366173A1 (en)	2005-01-24	4-phenyl-pyridine derivatives as neurokinin-1 receptor antagonists
PL356990A1 (en)	2004-07-12	Isoxazolecarboxamide derivatives as alpha1-adrenergic receptor antagonists
AU2003290059A8 (en)	2004-07-09	Use of cd137 antagonists for the treatment of tumors
EP1248607A4 (en)	2004-10-06	UROTENSIN II RECEPTOR ANTAGONISTS
EP1359915A4 (en)	2004-07-21	UROTENSIN-II RECEPTOR ANTAGONISTS
HUP0100934A3 (en)	2002-09-30	Use of fused pyridine derivatives for production pharmaceutical compositions for the treatment of depression, anxiety or psychopathy
IL145166A0 (en)	2002-06-30	Biphenyl derivatives as antagonists of the neurokinine-1 receptor
IL156087A0 (en)	2003-12-23	Histamine receptor antagonists
AU2003264297A1 (en)	2004-04-30	Use of vanilloid receptor antagonists for the treatment of pain
HUP0201709A2 (en)	2002-09-28	Ureidopiperidine derivatives as selective human nk3 receptor antagonists, pharmaceutical compositions containing them and use of them for producing pharmaceutical compositions
EP1377289A4 (en)	2008-09-10	HETEROCYCLIC COMPOUNDS WITH THERAPEUTIC USE
AU2003245995A8 (en)	2004-01-19	Use of gaba-c receptor antagonists for the treatment of myopia
SI1200402T1 (sl)	2006-02-28	Substituirani 1,5-dihidropirol-2-on-derivati, ucinkoviti kot antagonisti NMDA-receptorja za tretiranje bolecinskih stanj
AU2002354104A1 (en)	2003-06-23	Fused bicyclic pyridine derivatives as tachykinin receptor antagonists