IL137475A0 - α-KETOAMIDE INHIBITORS OF 205 PROTEASOME - Google Patents
α-KETOAMIDE INHIBITORS OF 205 PROTEASOMEInfo
- Publication number
- IL137475A0 IL137475A0 IL13747599A IL13747599A IL137475A0 IL 137475 A0 IL137475 A0 IL 137475A0 IL 13747599 A IL13747599 A IL 13747599A IL 13747599 A IL13747599 A IL 13747599A IL 137475 A0 IL137475 A0 IL 137475A0
- Authority
- IL
- Israel
- Prior art keywords
- proteasome
- ketoamide inhibitors
- ketoamide
- inhibitors
- Prior art date
Links
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 title 1
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000004799 α-ketoamides Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/013,365 US6075150A (en) | 1998-01-26 | 1998-01-26 | α-ketoamide inhibitors of 20S proteasome |
| PCT/US1999/001097 WO1999037666A1 (fr) | 1998-01-26 | 1999-01-19 | INHIBITEURS α-CETOAMIDE DE 20S PROTEASOME |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL137475A0 true IL137475A0 (en) | 2001-07-24 |
Family
ID=21759598
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13747599A IL137475A0 (en) | 1998-01-26 | 1999-01-19 | α-KETOAMIDE INHIBITORS OF 205 PROTEASOME |
| IL137475A IL137475A (en) | 1998-01-26 | 2000-07-24 | A-ketoamide grapes of the S20 proteasome |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL137475A IL137475A (en) | 1998-01-26 | 2000-07-24 | A-ketoamide grapes of the S20 proteasome |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6075150A (fr) |
| EP (1) | EP1058689A1 (fr) |
| JP (1) | JP3863370B2 (fr) |
| KR (1) | KR100417888B1 (fr) |
| CN (1) | CN1289340A (fr) |
| AR (1) | AR012781A1 (fr) |
| AU (1) | AU747835B2 (fr) |
| BR (1) | BR9907256A (fr) |
| CA (1) | CA2319150C (fr) |
| GE (1) | GEP20032869B (fr) |
| HU (1) | HUP0100901A3 (fr) |
| IL (2) | IL137475A0 (fr) |
| NO (1) | NO327049B1 (fr) |
| NZ (1) | NZ505892A (fr) |
| PL (1) | PL202504B1 (fr) |
| RU (1) | RU2192429C2 (fr) |
| TW (1) | TW593339B (fr) |
| UA (1) | UA71559C2 (fr) |
| WO (1) | WO1999037666A1 (fr) |
| ZA (1) | ZA99161B (fr) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6921751B1 (en) * | 1998-05-20 | 2005-07-26 | Erasmus Universiteit Rotterdam | Immunoregulator |
| US20040202645A1 (en) * | 2003-04-08 | 2004-10-14 | Khan Nisar Ahmed | Administration of gene-regulatory peptides |
| US8680059B2 (en) * | 1998-05-20 | 2014-03-25 | Biotempt B.V. | Oligopeptide acetate and formulations thereof |
| US20030220258A1 (en) * | 2001-12-21 | 2003-11-27 | Robbert Benner | Treatment of ischemic events |
| US20050227925A1 (en) * | 2004-04-08 | 2005-10-13 | Robbert Benner | Compositions capable of reducing elevated blood urea concentration |
| US6844315B2 (en) | 1998-05-20 | 2005-01-18 | Erasmus Universiteit Rotterdam | Immunoregulator |
| US6902721B1 (en) * | 1998-07-10 | 2005-06-07 | Osteoscreen, Inc. | Inhibitors of proteasomal activity for stimulating bone growth |
| US7358330B2 (en) * | 2001-03-29 | 2008-04-15 | Biotempt B.V. | Immunoregulatory compositions |
| EP1300418A1 (fr) * | 2001-10-04 | 2003-04-09 | Erasmus Universiteit Rotterdam | Régulation génétique par des oligopeptides |
| WO2002070467A1 (fr) * | 2001-02-26 | 2002-09-12 | 4Sc Ag | Derives de diphenyluree, de diamide d'acide diphenyloxalique et de diamide d'acide diphenylsulfurique et leur utilisation comme medicaments |
| US20030220261A1 (en) * | 2001-12-21 | 2003-11-27 | Khan Nisar Ahmed | Treatment of iatrogenic disease |
| US7501391B2 (en) * | 2001-12-21 | 2009-03-10 | Biotempt B.V. | Treatment of transplant survival |
| US20030220257A1 (en) * | 2001-12-21 | 2003-11-27 | Robbert Benner | Treatment of trauma |
| US20080242837A1 (en) * | 2001-12-21 | 2008-10-02 | Khan Nisar A | Peptide compositions |
| US7560433B2 (en) | 2001-12-21 | 2009-07-14 | Biotempt B.V. | Treatment of multiple sclerosis (MS) |
| US20030220260A1 (en) * | 2001-12-21 | 2003-11-27 | Khan Nisar Ahmed | Peptide compositions |
| US20080318871A1 (en) * | 2001-12-21 | 2008-12-25 | Khan Nisar A | Treatment of neurological disorders |
| US7786084B2 (en) * | 2001-12-21 | 2010-08-31 | Biotempt B.V. | Treatment of burns |
| US20040013661A1 (en) * | 2001-12-21 | 2004-01-22 | Gert Wensvoort | Stratification |
| EP1465862A1 (fr) | 2002-01-17 | 2004-10-13 | SmithKline Beecham Corporation | Derives de cetoamides a substitution cycloalkyle, utiles comme inhibiteurs de cathepsine k |
| MXPA04009938A (es) * | 2002-04-11 | 2004-12-13 | Vertex Pharma | Inhibidores de serina proteasas, en particular la proteasa ns3-ns4a del hcv. |
| US7576206B2 (en) | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| US7223745B2 (en) * | 2003-08-14 | 2007-05-29 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| PE20050374A1 (es) | 2003-09-05 | 2005-05-30 | Vertex Pharma | Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc |
| US20090227505A1 (en) * | 2004-01-07 | 2009-09-10 | Biotempt B.V. | Methods and uses for protein breakdown products |
| CA2565407A1 (fr) * | 2004-05-10 | 2005-11-24 | Proteolix, Inc. | Composes d'inhibition enzymatique |
| EP1637529A1 (fr) * | 2004-09-20 | 2006-03-22 | 4Sc Ag | Nouveaux analogues de piperidin-4-yl-thiazole-carboxamide en tant qu'inhibiteurs de proliferation de lymphocytes T er leurs utilisations |
| US7468383B2 (en) * | 2005-02-11 | 2008-12-23 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| US20070027067A1 (en) * | 2005-05-13 | 2007-02-01 | Felicia Etzkorn | Transition-state Inhibitors of Pin1, alpha-Ketoamide-containing peptidomimetics, and synthesis thereof |
| AU2006266609C1 (en) * | 2005-07-05 | 2011-10-27 | Biotempt B.V. | Treatment of tumors |
| BRPI0614696A2 (pt) | 2005-07-29 | 2011-04-12 | Tibotec Pharm Ltd | inibidores macrocìclicos de vìrus da hepatite c |
| AR055361A1 (es) | 2005-07-29 | 2007-08-22 | Medivir Ab | Inhibidores macrociclicos del virus de la hepatitis c |
| KR101434522B1 (ko) * | 2005-11-09 | 2014-08-26 | 오닉스 세라퓨틱스, 인크. | 효소 저해를 위한 화합물 |
| US8594771B2 (en) * | 2005-12-28 | 2013-11-26 | General Electric Company | Devices and methods for self-administered ECG examinations |
| EP1864692A1 (fr) * | 2006-06-07 | 2007-12-12 | Biotempt B.V. | Utilisation de peptides pour la protection contre les radiolésions |
| US7691852B2 (en) | 2006-06-19 | 2010-04-06 | Onyx Therapeutics, Inc. | Compounds for enzyme inhibition |
| NZ578956A (en) * | 2007-02-12 | 2012-02-24 | Biotempt Bv | Treatment of trauma hemorrhage with short oligopeptides |
| US8859021B2 (en) * | 2007-05-14 | 2014-10-14 | Sytheon | Skin appearance through gene manipulation |
| US7442830B1 (en) | 2007-08-06 | 2008-10-28 | Millenium Pharmaceuticals, Inc. | Proteasome inhibitors |
| RS54847B2 (sr) | 2007-10-04 | 2019-09-30 | Onyx Therapeutics Inc | Inhibitori kristalne peptid epoksi keton proteaze i sinteza aminokiselinskih keto-epoksida |
| EP2730580A1 (fr) | 2008-06-17 | 2014-05-14 | Millennium Pharmaceuticals, Inc. | Composés de borates esters et compositions pharmaceutiques contenant des composés |
| JP5675629B2 (ja) | 2008-10-21 | 2015-02-25 | オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | ペプチドエポキシケトンを用いた併用療法 |
| EP3021120A1 (fr) | 2009-02-20 | 2016-05-18 | Michael P. Lisanti | Procédé de diagnostic ou de pronostic d'un néoplasme comprenant la détermination du niveau d'expression d'une protéine dans des cellules stromales adjacentes au néoplasme |
| AR075899A1 (es) | 2009-03-20 | 2011-05-04 | Onyx Therapeutics Inc | Tripeptidos epoxicetonas cristalinos inhibidores de proteasa |
| JP5919196B2 (ja) | 2009-11-13 | 2016-05-18 | オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 転移抑制のためのペプチドエポキシケトンの使用 |
| WO2011087822A1 (fr) | 2009-12-22 | 2011-07-21 | Cephalon, Inc. | Inhibiteurs du protéasome et leurs procédés de préparation, d'épuration et d'utilisation |
| MA34133B1 (fr) | 2010-03-01 | 2013-04-03 | Onyx Therapeutics Inc | Composes pour inhibiteurs de l'immunoproteasome |
| WO2011136905A2 (fr) | 2010-04-07 | 2011-11-03 | Onyx Therapeutics, Inc. | Inhibiteur d'immunoprotéasome de peptide époxycétone cristallin |
| HRP20160851T1 (hr) | 2011-08-11 | 2016-09-23 | Janssen Pharmaceutica N.V. | Prediktori za liječenje karcinoma |
| JP6238900B2 (ja) | 2011-10-28 | 2017-11-29 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｎａｅ阻害物質に対する応答のバイオマーカー |
| JP6286358B2 (ja) | 2011-11-11 | 2018-02-28 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | プロテアソーム阻害剤に応答するバイオマーカー |
| EP2810066B1 (fr) | 2012-01-24 | 2019-07-31 | Millennium Pharmaceuticals, Inc. | Méthodes de traitement du cancer |
| GB2523211B (en) | 2012-01-27 | 2020-03-18 | Univ Jefferson | MCT protein inhibitor-related prognostic and therapeutic methods |
| US20140105921A1 (en) | 2012-07-09 | 2014-04-17 | Onyx Therapeutics, Inc. | Prodrugs of Peptide Epoxy Ketone Protease Inhibitors |
| JP6486826B2 (ja) | 2012-10-01 | 2019-03-20 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 阻害剤に対する応答を予測するためのバイオマーカーおよび方法、ならびにそれらの使用 |
| BR112015008160A2 (pt) * | 2012-10-11 | 2017-07-04 | Hoffmann La Roche | inibidores de imunoproteassoma de cetoamida |
| WO2014172627A1 (fr) | 2013-04-19 | 2014-10-23 | Thomas Jefferson University | Methodes associees a la caveoline-1 pour le traitement d'un glioblastome par temozolomide |
| KR102509950B1 (ko) | 2014-05-20 | 2023-03-14 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 일차 암 치료법 후 사용하기 위한 붕소-함유 프로테아좀 저해제 |
| JP6859559B2 (ja) * | 2017-03-16 | 2021-04-14 | 二村 芳弘 | 抗アレルギー作用を呈するフェニルペプチド誘導体 |
| JP7219473B2 (ja) * | 2017-08-28 | 2023-02-08 | 静岡県公立大学法人 | コリバクチンおよびコリバクチン産生菌の検出方法および検出プローブ |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1206078B (it) * | 1987-06-03 | 1989-04-14 | Polifarma Spa | Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico |
| JPH04211648A (ja) * | 1990-07-27 | 1992-08-03 | Nippon Kayaku Co Ltd | ケト酸アミド誘導体 |
| US5430022A (en) * | 1990-05-14 | 1995-07-04 | Fujisawa Pharmaceutical Co., Ltd. | Peptide compound and its preparation |
| US5693617A (en) * | 1994-03-15 | 1997-12-02 | Proscript, Inc. | Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein |
| US6660268B1 (en) * | 1994-03-18 | 2003-12-09 | The President And Fellows Of Harvard College | Proteasome regulation of NF-KB activity |
| US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| US5834487A (en) * | 1996-09-24 | 1998-11-10 | Cv Therapeutics | Inhibition of 26S and 20S proteasome by indanones |
-
1998
- 1998-01-26 US US09/013,365 patent/US6075150A/en not_active Expired - Fee Related
-
1999
- 1999-01-11 ZA ZA9900161A patent/ZA99161B/xx unknown
- 1999-01-19 GE GEAP19995526A patent/GEP20032869B/en unknown
- 1999-01-19 WO PCT/US1999/001097 patent/WO1999037666A1/fr not_active Ceased
- 1999-01-19 UA UA2000074508A patent/UA71559C2/uk unknown
- 1999-01-19 BR BR9907256-4A patent/BR9907256A/pt not_active Application Discontinuation
- 1999-01-19 AU AU23267/99A patent/AU747835B2/en not_active Ceased
- 1999-01-19 PL PL343269A patent/PL202504B1/pl not_active IP Right Cessation
- 1999-01-19 CN CN99802421A patent/CN1289340A/zh active Pending
- 1999-01-19 CA CA002319150A patent/CA2319150C/fr not_active Expired - Fee Related
- 1999-01-19 NZ NZ505892A patent/NZ505892A/xx unknown
- 1999-01-19 JP JP2000528587A patent/JP3863370B2/ja not_active Expired - Fee Related
- 1999-01-19 IL IL13747599A patent/IL137475A0/xx active IP Right Grant
- 1999-01-19 EP EP99903185A patent/EP1058689A1/fr not_active Ceased
- 1999-01-19 KR KR10-2000-7008135A patent/KR100417888B1/ko not_active Expired - Fee Related
- 1999-01-19 HU HU0100901A patent/HUP0100901A3/hu unknown
- 1999-01-19 RU RU2000122474/04A patent/RU2192429C2/ru not_active IP Right Cessation
- 1999-01-20 AR ARP990100205A patent/AR012781A1/es active IP Right Grant
- 1999-01-22 TW TW088101002A patent/TW593339B/zh not_active IP Right Cessation
- 1999-07-19 US US09/356,842 patent/US6781000B1/en not_active Expired - Fee Related
-
2000
- 2000-07-24 IL IL137475A patent/IL137475A/en not_active IP Right Cessation
- 2000-07-25 NO NO20003807A patent/NO327049B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| UA71559C2 (en) | 2004-12-15 |
| GEP20032869B (en) | 2003-01-27 |
| HUP0100901A2 (hu) | 2001-08-28 |
| AU2326799A (en) | 1999-08-09 |
| JP2002501080A (ja) | 2002-01-15 |
| HUP0100901A3 (en) | 2001-11-28 |
| KR100417888B1 (ko) | 2004-02-11 |
| NO20003807L (no) | 2000-09-25 |
| CA2319150A1 (fr) | 1999-07-29 |
| BR9907256A (pt) | 2001-10-09 |
| TW593339B (en) | 2004-06-21 |
| KR20010034381A (ko) | 2001-04-25 |
| IL137475A (en) | 2006-10-05 |
| US6781000B1 (en) | 2004-08-24 |
| NO327049B1 (no) | 2009-04-14 |
| US6075150A (en) | 2000-06-13 |
| NZ505892A (en) | 2002-10-25 |
| PL343269A1 (en) | 2001-08-13 |
| EP1058689A1 (fr) | 2000-12-13 |
| AU747835B2 (en) | 2002-05-23 |
| CA2319150C (fr) | 2004-08-31 |
| JP3863370B2 (ja) | 2006-12-27 |
| ZA99161B (en) | 1999-07-28 |
| PL202504B1 (pl) | 2009-06-30 |
| AR012781A1 (es) | 2000-11-08 |
| WO1999037666A1 (fr) | 1999-07-29 |
| CN1289340A (zh) | 2001-03-28 |
| RU2192429C2 (ru) | 2002-11-10 |
| NO20003807D0 (no) | 2000-07-25 |
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