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IL113738A - PROCESS AND DIASTEREOMERIC SALTS USEFUL FOR THE OPTICAL RESOLUTION OF RACEMIC 4-[4-[4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINYL]-1- HYDROXYBUTYL]-alpha,alpha-DIMETHYLBENZENE ACETIC ACID - Google Patents

PROCESS AND DIASTEREOMERIC SALTS USEFUL FOR THE OPTICAL RESOLUTION OF RACEMIC 4-[4-[4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINYL]-1- HYDROXYBUTYL]-alpha,alpha-DIMETHYLBENZENE ACETIC ACID

Info

Publication number
IL113738A
IL113738A IL11373895A IL11373895A IL113738A IL 113738 A IL113738 A IL 113738A IL 11373895 A IL11373895 A IL 11373895A IL 11373895 A IL11373895 A IL 11373895A IL 113738 A IL113738 A IL 113738A
Authority
IL
Israel
Prior art keywords
alpha
hydroxydiphenylmethyl
hydroxybutyl
piperidinyl
racemic
Prior art date
Application number
IL11373895A
Other languages
English (en)
Other versions
IL113738A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL113738A0 publication Critical patent/IL113738A0/xx
Publication of IL113738A publication Critical patent/IL113738A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL11373895A 1994-05-16 1995-05-15 PROCESS AND DIASTEREOMERIC SALTS USEFUL FOR THE OPTICAL RESOLUTION OF RACEMIC 4-[4-[4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINYL]-1- HYDROXYBUTYL]-alpha,alpha-DIMETHYLBENZENE ACETIC ACID IL113738A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24291994A 1994-05-16 1994-05-16

Publications (2)

Publication Number Publication Date
IL113738A0 IL113738A0 (en) 1995-08-31
IL113738A true IL113738A (en) 2003-10-31

Family

ID=22916643

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11373895A IL113738A (en) 1994-05-16 1995-05-15 PROCESS AND DIASTEREOMERIC SALTS USEFUL FOR THE OPTICAL RESOLUTION OF RACEMIC 4-[4-[4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINYL]-1- HYDROXYBUTYL]-alpha,alpha-DIMETHYLBENZENE ACETIC ACID

Country Status (21)

Country Link
US (3) US20030078429A1 (xx)
EP (1) EP0759904B1 (xx)
JP (1) JPH10503752A (xx)
KR (1) KR100387459B1 (xx)
CN (3) CN1119330C (xx)
AT (1) ATE194328T1 (xx)
AU (1) AU689578B2 (xx)
CA (1) CA2189000C (xx)
DE (1) DE69517810T2 (xx)
DK (1) DK0759904T3 (xx)
ES (1) ES2149357T3 (xx)
FI (1) FI114095B (xx)
GR (1) GR3034444T3 (xx)
IL (1) IL113738A (xx)
MX (1) MX9605611A (xx)
NO (1) NO308031B1 (xx)
NZ (1) NZ284277A (xx)
PT (1) PT759904E (xx)
TW (1) TW424085B (xx)
WO (1) WO1995031436A1 (xx)
ZA (1) ZA953793B (xx)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9805870A (xx) * 1996-01-22 1999-01-31
US6242464B1 (en) 1996-01-22 2001-06-05 Chiroscience Limited Single isomer methylphenidate and resolution process
US5925761A (en) * 1997-02-04 1999-07-20 Sepracor Inc. Synthesis of terfenadine and derivatives
DE10145223A1 (de) * 2001-09-13 2003-04-03 Basf Ag Verfahren zur Herstellung von meso-Zeaxanthin
ITMI20041568A1 (it) * 2004-07-30 2004-10-30 Dipharma Spa "polimorfi di fexofenadina base"
DE602007012417D1 (de) 2006-03-14 2011-03-24 Univ Southern California Mems-Vorrichtung zur Wirkstofffreisetzung
WO2009086112A2 (en) 2007-12-20 2009-07-09 University Of Southern California Apparatus and methods for delivering therapeutic agents
US9849238B2 (en) 2008-05-08 2017-12-26 Minipumps, Llc Drug-delivery pump with intelligent control
EP2891501B1 (en) 2008-05-08 2016-09-21 MiniPumps, LLC Methods of manufacture of drug-delivery pumps
ES2534864T3 (es) 2008-05-08 2015-04-29 Minipumps, Llc Bombas implantables y cánulas para las mismas
DK2387556T3 (da) * 2009-01-16 2014-11-03 Basf Se Separation af en enantiomerblanding af (r)- og (s)-3-amino-1-butanol
KR101697388B1 (ko) 2009-08-18 2017-01-17 미니펌프스, 엘엘씨 적응 제어기를 갖춘 전해 약품 운반 펌프
CN103497145B (zh) * 2013-10-10 2016-01-27 南昌大学 一种光学纯多奈哌齐的制备工艺
KR102768447B1 (ko) * 2018-09-28 2025-02-17 (주)셀트리온 (-)-시벤졸린 숙신산염의 신규한 제조 공정
CR20220159A (es) * 2019-10-17 2022-06-02 Bayer Ag Procedimiento para la preparación de (4s)–4–(4–ciano–2–metoxi–fenil)–5–hidroxi–2,8–dimetil–1,4–dihidro–1,6–naftiridin–3–carboxilato de 2–cianoetilo por separación de racematos por medio de éster de ácido tartárico diastereoisómero
BR112022005511A2 (pt) * 2019-10-17 2022-06-21 Bayer Ag Processo para a preparação de 2-cianoetil (4s)-4-(4-ciano-2-metoxifenil)-5-etóxi-2,8-dimetil-1,4-di-hidro-1,6-naftiridina-3-carboxilato por resolução ótica por meio de ésteres tartáricos diastereoméricos

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3452086A (en) * 1966-04-29 1969-06-24 Bristol Myers Co Substituted tartranilic acid resolving agents
IT951631B (it) * 1971-03-18 1973-07-10 Richardson Merrell Spa Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi
US3878217A (en) * 1972-01-28 1975-04-15 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
FR2201108B1 (xx) * 1972-09-25 1977-12-23 Copier Henri
US4128663A (en) * 1977-03-15 1978-12-05 The Upjohn Company Anilide derivatives as antidepressants
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4285957A (en) * 1979-04-10 1981-08-25 Richardson-Merrell Inc. 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof
EP0108817A1 (en) * 1982-11-06 1984-05-23 Kanegafuchi Chemical Industry Co., Ltd. Stable composition of S-adenosyl-L-methionine and process for preparation thereof
JPS59210086A (ja) * 1983-05-13 1984-11-28 Kyowa Hakko Kogyo Co Ltd Ｄｘ―５２―１類及びその塩類
US5011989A (en) * 1987-10-09 1991-04-30 Sumitomo Chemical Company, Limited Optically active hydroxybenzylamine
US4931557A (en) * 1988-10-17 1990-06-05 Eli Lilly And Company Method of resolving cis 3-amino-4-(2-furyl)vinyl)-1-methoxycarbonylmethyl-azetidin-2-one and di-p-toluoyl-tartaric acid salts thereof
US4968837A (en) * 1989-07-28 1990-11-06 Ethyl Corporation Resolution of racemic mixtures

Also Published As

Publication number Publication date
JPH10503752A (ja) 1998-04-07
GR3034444T3 (en) 2000-12-29
ATE194328T1 (de) 2000-07-15
CN100369897C (zh) 2008-02-20
IL113738A0 (en) 1995-08-31
ZA953793B (en) 1996-01-19
DE69517810D1 (de) 2000-08-10
US20060014793A1 (en) 2006-01-19
FI964566L (fi) 1996-11-14
EP0759904B1 (en) 2000-07-05
HK1039485A1 (en) 2002-04-26
CN1740156A (zh) 2006-03-01
AU2284095A (en) 1995-12-05
US20040186137A1 (en) 2004-09-23
HK1088603A1 (zh) 2006-11-10
CA2189000C (en) 2002-08-13
ES2149357T3 (es) 2000-11-01
NO964858L (no) 1997-01-15
DK0759904T3 (da) 2000-10-02
CN1309121A (zh) 2001-08-22
EP0759904A1 (en) 1997-03-05
NO308031B1 (no) 2000-07-10
DE69517810T2 (de) 2000-12-14
CN1229346C (zh) 2005-11-30
KR100387459B1 (ko) 2003-11-20
CA2189000A1 (en) 1995-11-23
CN1119330C (zh) 2003-08-27
FI114095B (fi) 2004-08-13
CN1148382A (zh) 1997-04-23
FI964566A0 (fi) 1996-11-14
AU689578B2 (en) 1998-04-02
PT759904E (pt) 2000-10-31
NO964858D0 (no) 1996-11-15
WO1995031436A1 (en) 1995-11-23
NZ284277A (en) 1998-01-26
US20030078429A1 (en) 2003-04-24
MX9605611A (es) 1998-05-31
TW424085B (en) 2001-03-01

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