IL111266A - 2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number: IL111266A
Authority: IL; Israel
Prior art keywords: phenyl; deriv; quinoline; heteroaryl; arylpyridazino
Prior art date: 1993-10-22

Application number

IL11126694A

Other languages

English (en)

Other versions

IL111266A0 (en

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-22

Filing date

1994-10-12

Publication date

2002-03-10

1993-10-22 Priority claimed from GB939321854A external-priority patent/GB9321854D0/en

1994-08-25 Priority claimed from GB9417171A external-priority patent/GB9417171D0/en

1994-10-12 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1994-12-29 Publication of IL111266A0 publication Critical patent/IL111266A0/xx

2002-03-10 Publication of IL111266A publication Critical patent/IL111266A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)

IL11126694A 1993-10-22 1994-10-12 2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM IL111266A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939321854A GB9321854D0 (en)	1993-10-22	1993-10-22	Pyridazino quinoline compounds
GB9417171A GB9417171D0 (en)	1994-08-25	1994-08-25	Pyridazino quinoline compounds

Publications (2)

Publication Number	Publication Date
IL111266A0 IL111266A0 (en)	1994-12-29
IL111266A true IL111266A (en)	2002-03-10

Family

ID=26303731

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11126694A IL111266A (en)	1993-10-22	1994-10-12	2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (29)

Country	Link
US (3)	US5744471A (xx)
EP (2)	EP0724583B1 (xx)
JP (1)	JP3583132B2 (xx)
KR (1)	KR100261209B1 (xx)
CN (1)	CN1053189C (xx)
AT (2)	ATE198072T1 (xx)
AU (2)	AU688393B2 (xx)
CA (1)	CA2171332A1 (xx)
CZ (1)	CZ292311B6 (xx)
DE (2)	DE69434380T2 (xx)
DK (2)	DK1004582T3 (xx)
ES (2)	ES2241513T3 (xx)
FI (2)	FI113865B (xx)
GB (1)	GB9420590D0 (xx)
GR (1)	GR3035080T3 (xx)
HU (1)	HUT74161A (xx)
IL (1)	IL111266A (xx)
MY (2)	MY124316A (xx)
NO (1)	NO306995B1 (xx)
NZ (2)	NZ275472A (xx)
PL (1)	PL180679B1 (xx)
PT (2)	PT1004582E (xx)
RU (1)	RU2168511C2 (xx)
SG (2)	SG92630A1 (xx)
SI (2)	SI1004582T1 (xx)
SK (1)	SK282491B6 (xx)
TW (1)	TW406082B (xx)
UA (1)	UA60291C2 (xx)
WO (1)	WO1995011244A1 (xx)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL111266A (en) *	1993-10-22	2002-03-10	Zeneca Ltd	2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US6214826B1 (en)	1994-11-12	2001-04-10	Zeneca Limited	Pyridazino quinoline compounds
GB9422894D0 (en) *	1994-11-12	1995-01-04	Zeneca Ltd	Pyridazino quinoline compounds
GB9507318D0 (en) *	1995-04-07	1995-05-31	Zeneca Ltd	Alpha substituted pyridazino quinoline compounds
PL355850A1 (en) *	1999-12-23	2004-05-31	Astrazeneca Ab	Method and composition for the treatment of pain
SI1244662T1 (xx) *	1999-12-23	2005-08-31	Astrazeneca Ab
PL356664A1 (en) *	1999-12-23	2004-06-28	Astrazeneca Ab	Compound and method for the treatment of pain
AU2420201A (en) *	1999-12-23	2001-07-09	Astrazeneca Ab	Compounds and methods for the treatment of pain
US6730675B2 (en)	1999-12-23	2004-05-04	Astrazeneca Ab	Compounds and methods for the treatment of pain
WO2001047524A1 (en) *	1999-12-23	2001-07-05	Astrazeneca Ab	Method and composition for the treatment of pain
US6943165B2 (en) *	1999-12-23	2005-09-13	Astrazeneca Ab	Compound and method for the treatment of pain
AU2566101A (en) *	1999-12-23	2001-07-09	Astrazeneca Ab	Compounds and methods for the treatment of pain
WO2001047925A1 (en) *	1999-12-23	2001-07-05	Astrazeneca Ab	Compounds and methods for the treatment of pain
US6787547B2 (en)	1999-12-23	2004-09-07	Astrazeneca Ab	Compound and method for the treatment of pain
AU2420001A (en) *	1999-12-23	2001-07-09	Astrazeneca Ab	Methods and compositions for the treatment of pain
US20030176435A1 (en) *	2002-12-17	2003-09-18	Brown Dean Gordon	Compounds and methods for the treatment of pain
US6403818B1 (en)	2000-02-28	2002-06-11	Eisai Co., Ltd.	Process for producing α-hydroxy-carbonyl compound
EP1325005A1 (en) *	2000-09-29	2003-07-09	AstraZeneca AB	1,2,5,10-tetrahydropyridazino 4,5-b]quinoline-1,10-diones and their use for the treatment of pain
US6933297B2 (en)	2000-09-29	2005-08-23	Astrazeneca Ab	7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione and the use thereof for the treatment of pain
US6946463B2 (en)	2000-09-29	2005-09-20	Astrazeneca Ab	1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-diones and their use for the treatment of pain
EP1325002B1 (en) *	2000-09-29	2006-05-24	AstraZeneca AB	1,2,5,10-tetrahydropyridazino¬4,5-b\|quinoline-1,10-diones and their use for the treatment of pain
EA006854B1 (ru)	2001-05-31	2006-04-28	Санофи-Авентис	Производные аминохинолина и его применение в качестве лигандов аденозина a
WO2005012309A1 (fr) *	2003-08-04	2005-02-10	Valery Khazhmuratovich Zhilov	Bioisosteres cycliques issus d'un systeme purine et composition pharmaceutique a base desdits bioisosteres
PL2489659T3 (pl)	2004-06-24	2018-06-29	Vertex Pharma	Modulatory transporterów posiadających kasetę wiążącą atp
US8354427B2 (en)	2004-06-24	2013-01-15	Vertex Pharmaceutical Incorporated	Modulators of ATP-binding cassette transporters
EP1979367A2 (en) *	2005-12-24	2008-10-15	Vertex Pharmaceuticals Incorporated	Quinolin-4-one derivatives as modulators of abc transporters
PT1993360T (pt)	2005-12-28	2017-05-25	Vertex Pharma	Formas sólidas de n-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-di-hidro-4-oxoquinolina-3-carboxamida
US12458635B2 (en)	2008-08-13	2025-11-04	Vertex Pharmaceuticals Incorporated	Pharmaceutical composition and administrations thereof
US20100074949A1 (en)	2008-08-13	2010-03-25	William Rowe	Pharmaceutical composition and administration thereof
EP3330255B1 (en)	2009-03-20	2020-12-09	Vertex Pharmaceuticals Incorporated	Process for making modulators of cystic fibrosis transmembrane conductance regulator
US8802700B2 (en)	2010-12-10	2014-08-12	Vertex Pharmaceuticals Incorporated	Modulators of ATP-Binding Cassette transporters
IL311180A (en)	2012-02-27	2024-04-01	Vertex Pharma	Pharmaceutical preparations containing a solid dispersion of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide and uses thereof
CN107250113B (zh)	2014-10-07	2019-03-29	弗特克斯药品有限公司	囊性纤维化跨膜传导调节蛋白的调节剂的共晶

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8814458D0 (en) *	1988-06-17	1988-07-20	Wyeth John & Brother Ltd	Heterocyclic compounds
GB9109972D0 (en) *	1991-05-09	1991-07-03	Ici Plc	Therapeutic compounds
GB9208511D0 (en) *	1991-05-09	1992-06-03	Ici Plc	Compounds
IL111266A (en) *	1993-10-22	2002-03-10	Zeneca Ltd	2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
GB9422894D0 (en) *	1994-11-12	1995-01-04	Zeneca Ltd	Pyridazino quinoline compounds
GB9507318D0 (en) *	1995-04-07	1995-05-31	Zeneca Ltd	Alpha substituted pyridazino quinoline compounds

1994
- 1994-10-12 IL IL11126694A patent/IL111266A/xx not_active IP Right Cessation
- 1994-10-12 GB GB9420590A patent/GB9420590D0/en active Pending
- 1994-10-20 DK DK00101917T patent/DK1004582T3/da active
- 1994-10-20 PL PL94314041A patent/PL180679B1/pl not_active IP Right Cessation
- 1994-10-20 PT PT00101917T patent/PT1004582E/pt unknown
- 1994-10-20 SG SG9900943A patent/SG92630A1/en unknown
- 1994-10-20 DE DE69434380T patent/DE69434380T2/de not_active Expired - Fee Related
- 1994-10-20 MY MYPI94002796A patent/MY124316A/en unknown
- 1994-10-20 AU AU79440/94A patent/AU688393B2/en not_active Ceased
- 1994-10-20 NZ NZ275472A patent/NZ275472A/en not_active IP Right Cessation
- 1994-10-20 WO PCT/GB1994/002295 patent/WO1995011244A1/en not_active Ceased
- 1994-10-20 UA UA96041567A patent/UA60291C2/uk unknown
- 1994-10-20 JP JP51152195A patent/JP3583132B2/ja not_active Expired - Fee Related
- 1994-10-20 SG SG1996007261A patent/SG59971A1/en unknown
- 1994-10-20 KR KR1019960702011A patent/KR100261209B1/ko not_active Expired - Fee Related
- 1994-10-20 CA CA002171332A patent/CA2171332A1/en not_active Abandoned
- 1994-10-20 ES ES00101917T patent/ES2241513T3/es not_active Expired - Lifetime
- 1994-10-20 NZ NZ329303A patent/NZ329303A/xx not_active IP Right Cessation
- 1994-10-20 SK SK504-96A patent/SK282491B6/sk not_active IP Right Cessation
- 1994-10-20 CZ CZ19961138A patent/CZ292311B6/cs not_active IP Right Cessation
- 1994-10-20 DK DK94930275T patent/DK0724583T3/da active
- 1994-10-20 AT AT94930275T patent/ATE198072T1/de not_active IP Right Cessation
- 1994-10-20 ES ES94930275T patent/ES2154686T3/es not_active Expired - Lifetime
- 1994-10-20 HU HU9600889A patent/HUT74161A/hu unknown
- 1994-10-20 RU RU96109470/04A patent/RU2168511C2/ru not_active IP Right Cessation
- 1994-10-20 DE DE69426422T patent/DE69426422T2/de not_active Expired - Fee Related
- 1994-10-20 EP EP94930275A patent/EP0724583B1/en not_active Expired - Lifetime
- 1994-10-20 EP EP00101917A patent/EP1004582B1/en not_active Expired - Lifetime
- 1994-10-20 SI SI9430476T patent/SI1004582T1/xx unknown
- 1994-10-20 PT PT94930275T patent/PT724583E/pt unknown
- 1994-10-20 CN CN94194578A patent/CN1053189C/zh not_active Expired - Fee Related
- 1994-10-20 SI SI9430314T patent/SI0724583T1/xx unknown
- 1994-10-20 MY MYPI98002508A patent/MY132875A/en unknown
- 1994-10-20 US US08/637,641 patent/US5744471A/en not_active Expired - Fee Related
- 1994-10-20 AT AT00101917T patent/ATE295846T1/de not_active IP Right Cessation
- 1994-11-18 TW TW083110721A patent/TW406082B/zh not_active IP Right Cessation
1996
- 1996-04-18 FI FI961696A patent/FI113865B/fi active
- 1996-04-19 NO NO961584A patent/NO306995B1/no not_active IP Right Cessation
1997
- 1997-03-03 FI FI970907A patent/FI114916B/fi active IP Right Grant
1998
- 1998-03-19 US US09/044,109 patent/US6232313B1/en not_active Expired - Fee Related
- 1998-05-27 AU AU68999/98A patent/AU721139B2/en not_active Ceased
1999
- 1999-12-06 US US09/455,096 patent/US6103721A/en not_active Expired - Fee Related
2000
- 2000-12-14 GR GR20000402690T patent/GR3035080T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL180679B1 (en)	2001-03-30
DE69434380T2 (de)	2006-05-04
DE69426422T2 (de)	2001-05-10
AU6899998A (en)	1998-07-30
FI113865B (fi)	2004-06-30
CN1053189C (zh)	2000-06-07
ATE295846T1 (de)	2005-06-15
EP0724583A1 (en)	1996-08-07
HK1013997A1 (en)	1999-09-17
ES2241513T3 (es)	2005-11-01
NO961584L (no)	1996-04-19
SI0724583T1 (en)	2001-04-30
AU7944094A (en)	1995-05-08
MY124316A (en)	2006-06-30
HUT74161A (en)	1996-11-28
SG59971A1 (en)	1999-02-22
NO306995B1 (no)	2000-01-24
FI961696L (fi)	1996-04-18
KR100261209B1 (ko)	2000-09-01
GB9420590D0 (en)	1994-11-30
RU2168511C2 (ru)	2001-06-10
EP1004582A2 (en)	2000-05-31
IL111266A0 (en)	1994-12-29
EP0724583B1 (en)	2000-12-13
US5744471A (en)	1998-04-28
ES2154686T3 (es)	2001-04-16
GR3035080T3 (en)	2001-03-30
US6103721A (en)	2000-08-15
NZ275472A (en)	1998-03-25
PT1004582E (pt)	2005-09-30
TW406082B (en)	2000-09-21
SK50496A3 (en)	1997-03-05
FI961696A0 (fi)	1996-04-18
FI114916B (fi)	2005-01-31
SI1004582T1 (xx)	2005-08-31
UA60291C2 (uk)	2003-10-15
JPH09504519A (ja)	1997-05-06
US6232313B1 (en)	2001-05-15
MY132875A (en)	2007-10-31
PT724583E (pt)	2001-03-30
EP1004582B1 (en)	2005-05-18
AU688393B2 (en)	1998-03-12
EP1004582A3 (en)	2000-08-30
CZ292311B6 (cs)	2003-09-17
CN1138332A (zh)	1996-12-18
JP3583132B2 (ja)	2004-10-27
SK282491B6 (sk)	2002-02-05
CA2171332A1 (en)	1995-04-27
DK1004582T3 (da)	2005-08-15
FI970907L (fi)	1997-03-03
AU721139B2 (en)	2000-06-22
HU9600889D0 (en)	1996-06-28
FI970907A0 (fi)	1997-03-03
WO1995011244A1 (en)	1995-04-27
PL314041A1 (en)	1996-08-05
NO961584D0 (no)	1996-04-19
ATE198072T1 (de)	2000-12-15
SG92630A1 (en)	2002-11-19
DE69426422D1 (de)	2001-01-18
NZ329303A (en)	2000-01-28
DE69434380D1 (de)	2005-06-23
DK0724583T3 (da)	2001-03-05
CZ113896A3 (en)	1996-09-11

Publication	Publication Date	Title
IL111266A (en)	2002-03-10	2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PL328310A1 (en)	1999-01-18	Derivatives of quinazoline
MY132405A (en)	2007-10-31	Quinazoline derivatives
NZ330118A (en)	2000-03-27	Thiophenopyrimidines, pharmaceutical compositions thereof and use in treating endocrine, psychiatric and neurologic conditions
DE69428476D1 (de)	2001-11-08	Heterocyclische Verbindungen als Bradykinin Antagonisten
DE60216610D1 (de)	2007-01-18	Verwendung von kondensierten Pyrazolverbindungen für die Herstellung eines Arzneimittels zur Behandlung von Bluthochdruck
GB9107843D0 (en)	1991-05-29	Anti-cancer compounds
HU900728D0 (en)	1990-04-28	Process for preparation of calcium antagonistics
ZA928684B (en)	1994-05-11	Benzimidazole anthelmintic agents
FI954340A7 (fi)	1995-09-15	Menetelmä uusien terapeuttisesti käytt¦kelpoisten 5-substituoitu tia-sykloalka-ÄdÜ-1,2,4-triatsoloÄ1,5-aÜpyrimidiinijohdannaisten valmistamiseksi

Legal Events

Date	Code	Title
2002-08-14	FF	Patent granted
2002-09-12	KB	Patent renewed
2009-05-03	FF	Patent granted
2013-05-30	MM9K	Patent not in force due to non-payment of renewal fees