DK1004582T3 - Pyradazinoquinolinforbindelser - Google Patents

Pyradazinoquinolinforbindelser

Info

Publication number: DK1004582T3
Authority: DK; Denmark
Prior art keywords: phenyl; deriv; substd; opt; furyl
Prior art date: 1993-10-22

Application number

DK00101917T

Other languages

English (en)

Inventor

Thomas Michael Bare

Timothy Wayne Davenport

James Roy Empfield

Richard Bruce Sparks

Kinney Jeffrey Alan Mc

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-22

Filing date

1994-10-20

Publication date

2005-08-15

1993-10-22 Priority claimed from GB939321854A external-priority patent/GB9321854D0/en

1994-08-25 Priority claimed from GB9417171A external-priority patent/GB9417171D0/en

1994-10-20 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2005-08-15 Application granted granted Critical

2005-08-15 Publication of DK1004582T3 publication Critical patent/DK1004582T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Quinoline Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK00101917T 1993-10-22 1994-10-20 Pyradazinoquinolinforbindelser DK1004582T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939321854A GB9321854D0 (en)	1993-10-22	1993-10-22	Pyridazino quinoline compounds
GB9417171A GB9417171D0 (en)	1994-08-25	1994-08-25	Pyridazino quinoline compounds

Publications (1)

Publication Number	Publication Date
DK1004582T3 true DK1004582T3 (da)	2005-08-15

Family

ID=26303731

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK94930275T DK0724583T3 (da)	1993-10-22	1994-10-20	Pyridazino-quinolin-forbindelser
DK00101917T DK1004582T3 (da)	1993-10-22	1994-10-20	Pyradazinoquinolinforbindelser

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK94930275T DK0724583T3 (da)	1993-10-22	1994-10-20	Pyridazino-quinolin-forbindelser

Country Status (29)

Country	Link
US (3)	US5744471A (da)
EP (2)	EP1004582B1 (da)
JP (1)	JP3583132B2 (da)
KR (1)	KR100261209B1 (da)
CN (1)	CN1053189C (da)
AT (2)	ATE295846T1 (da)
AU (2)	AU688393B2 (da)
CA (1)	CA2171332A1 (da)
CZ (1)	CZ292311B6 (da)
DE (2)	DE69434380T2 (da)
DK (2)	DK0724583T3 (da)
ES (2)	ES2154686T3 (da)
FI (2)	FI113865B (da)
GB (1)	GB9420590D0 (da)
GR (1)	GR3035080T3 (da)
HU (1)	HUT74161A (da)
IL (1)	IL111266A (da)
MY (2)	MY132875A (da)
NO (1)	NO306995B1 (da)
NZ (2)	NZ275472A (da)
PL (1)	PL180679B1 (da)
PT (2)	PT1004582E (da)
RU (1)	RU2168511C2 (da)
SG (2)	SG59971A1 (da)
SI (2)	SI0724583T1 (da)
SK (1)	SK282491B6 (da)
TW (1)	TW406082B (da)
UA (1)	UA60291C2 (da)
WO (1)	WO1995011244A1 (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9420590D0 (en) *	1993-10-22	1994-11-30	Zeneca Ltd	Pyridazino quinoline compounds
GB9422894D0 (en) *	1994-11-12	1995-01-04	Zeneca Ltd	Pyridazino quinoline compounds
US6214826B1 (en)	1994-11-12	2001-04-10	Zeneca Limited	Pyridazino quinoline compounds
GB9507318D0 (en) *	1995-04-07	1995-05-31	Zeneca Ltd	Alpha substituted pyridazino quinoline compounds
WO2001047524A1 (en) *	1999-12-23	2001-07-05	Astrazeneca Ab	Method and composition for the treatment of pain
PL355850A1 (en) *	1999-12-23	2004-05-31	Astrazeneca Ab	Method and composition for the treatment of pain
SK8792002A3 (en) *	1999-12-23	2003-05-02	Astrazeneca Ab	Quinoline-based compound, pharmaceutical composition containing same and use thereof
US6943165B2 (en) *	1999-12-23	2005-09-13	Astrazeneca Ab	Compound and method for the treatment of pain
JP2003519147A (ja) *	1999-12-23	2003-06-17	アストラゼネカ・アクチエボラーグ	痛みの処置のための化合物および方法
US20030176435A1 (en) *	2002-12-17	2003-09-18	Brown Dean Gordon	Compounds and methods for the treatment of pain
US20050124622A1 (en) *	1999-12-23	2005-06-09	Brown Dean G.	Compounds and methods for the treatment of pain
US6787547B2 (en)	1999-12-23	2004-09-07	Astrazeneca Ab	Compound and method for the treatment of pain
AU2566101A (en) *	1999-12-23	2001-07-09	Astrazeneca Ab	Compounds and methods for the treatment of pain
US6730675B2 (en)	1999-12-23	2004-05-04	Astrazeneca Ab	Compounds and methods for the treatment of pain
AU2420001A (en) *	1999-12-23	2001-07-09	Astrazeneca Ab	Methods and compositions for the treatment of pain
EP1577311A1 (en) *	1999-12-23	2005-09-21	AstraZeneca AB	Salts of a pyridazino aquinoline derivative and use for the treatment of pain
US6403818B1 (en)	2000-02-28	2002-06-11	Eisai Co., Ltd.	Process for producing α-hydroxy-carbonyl compound
EP1325004A1 (en)	2000-09-29	2003-07-09	AstraZeneca AB	1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-diones and their use for the treatment of pain
US6933297B2 (en)	2000-09-29	2005-08-23	Astrazeneca Ab	7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione and the use thereof for the treatment of pain
JP2004509963A (ja) *	2000-09-29	2004-04-02	アストラゼネカ・アクチエボラーグ	１，２，５，１０−テトラヒドロピリダジノ［４，５−ｂ］キノリン−１，１０−ジオン及び疼痛治療のためのその使用
WO2002026738A1 (en) *	2000-09-29	2002-04-04	Astrazeneca Ab	1,2,5,10-TETRAHYDROPYRIDAZINO[4,5-b]QUINOLINE-1,10-DIONES AND THEIR USE FOR THE TREATMENT OF PAIN
SK14142003A3 (sk) *	2001-05-31	2005-03-04	Sanofi-Aventis	Aminochinolínové a aminopyridínové deriváty a ich použitie ako adenozínových A3 ligandov
AU2003301513A1 (en)	2003-08-04	2005-02-15	Valery Khazhmuratovich Zhilov	Cyclic bioisosters of purine system derivatives and a pharmaceutical composition based thereon
NZ587549A (en) *	2004-06-24	2012-10-26	Vertex Pharma	6-Amino-indole derivatives and processes for their preparation
US8354427B2 (en)	2004-06-24	2013-01-15	Vertex Pharmaceutical Incorporated	Modulators of ATP-binding cassette transporters
JP2009521468A (ja) *	2005-12-24	2009-06-04	バーテックスファーマシューティカルズインコーポレイテッド	Ａｂｃ輸送体の調節因子としてのキノリン−４−オン誘導体
CA2635581C (en)	2005-12-28	2017-02-28	Vertex Pharmaceuticals Incorporated	Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US12458635B2 (en)	2008-08-13	2025-11-04	Vertex Pharmaceuticals Incorporated	Pharmaceutical composition and administrations thereof
US20100074949A1 (en)	2008-08-13	2010-03-25	William Rowe	Pharmaceutical composition and administration thereof
PL2408750T3 (pl)	2009-03-20	2016-02-29	Vertex Pharma	Sposób otrzymywania modulatorów błonowego regulatora przewodnictwa swoistego dla mukowiscydozy
US8802700B2 (en)	2010-12-10	2014-08-12	Vertex Pharmaceuticals Incorporated	Modulators of ATP-Binding Cassette transporters
AU2013226076B2 (en)	2012-02-27	2017-11-16	Vertex Pharmaceuticals Incorporated	Pharmaceutical composition and administration thereof
KR20170063954A (ko)	2014-10-07	2017-06-08	버텍스 파마슈티칼스 인코포레이티드	낭성 섬유증 막횡단 전도도 조절자의 조정제의 공-결정

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8814458D0 (en) *	1988-06-17	1988-07-20	Wyeth John & Brother Ltd	Heterocyclic compounds
GB9109972D0 (en) *	1991-05-09	1991-07-03	Ici Plc	Therapeutic compounds
GB9208511D0 (en) *	1991-05-09	1992-06-03	Ici Plc	Compounds
GB9420590D0 (en) *	1993-10-22	1994-11-30	Zeneca Ltd	Pyridazino quinoline compounds
GB9422894D0 (en) *	1994-11-12	1995-01-04	Zeneca Ltd	Pyridazino quinoline compounds
GB9507318D0 (en) *	1995-04-07	1995-05-31	Zeneca Ltd	Alpha substituted pyridazino quinoline compounds

1994
- 1994-10-12 GB GB9420590A patent/GB9420590D0/en active Pending
- 1994-10-12 IL IL11126694A patent/IL111266A/xx not_active IP Right Cessation
- 1994-10-20 UA UA96041567A patent/UA60291C2/uk unknown
- 1994-10-20 CA CA002171332A patent/CA2171332A1/en not_active Abandoned
- 1994-10-20 SI SI9430314T patent/SI0724583T1/xx unknown
- 1994-10-20 MY MYPI98002508A patent/MY132875A/en unknown
- 1994-10-20 PT PT00101917T patent/PT1004582E/pt unknown
- 1994-10-20 AT AT00101917T patent/ATE295846T1/de not_active IP Right Cessation
- 1994-10-20 EP EP00101917A patent/EP1004582B1/en not_active Expired - Lifetime
- 1994-10-20 JP JP51152195A patent/JP3583132B2/ja not_active Expired - Fee Related
- 1994-10-20 SG SG1996007261A patent/SG59971A1/en unknown
- 1994-10-20 PT PT94930275T patent/PT724583E/pt unknown
- 1994-10-20 KR KR1019960702011A patent/KR100261209B1/ko not_active Expired - Fee Related
- 1994-10-20 NZ NZ275472A patent/NZ275472A/en not_active IP Right Cessation
- 1994-10-20 ES ES94930275T patent/ES2154686T3/es not_active Expired - Lifetime
- 1994-10-20 CN CN94194578A patent/CN1053189C/zh not_active Expired - Fee Related
- 1994-10-20 DE DE69434380T patent/DE69434380T2/de not_active Expired - Fee Related
- 1994-10-20 US US08/637,641 patent/US5744471A/en not_active Expired - Fee Related
- 1994-10-20 DE DE69426422T patent/DE69426422T2/de not_active Expired - Fee Related
- 1994-10-20 DK DK94930275T patent/DK0724583T3/da active
- 1994-10-20 ES ES00101917T patent/ES2241513T3/es not_active Expired - Lifetime
- 1994-10-20 SG SG9900943A patent/SG92630A1/en unknown
- 1994-10-20 HU HU9600889A patent/HUT74161A/hu unknown
- 1994-10-20 AU AU79440/94A patent/AU688393B2/en not_active Ceased
- 1994-10-20 AT AT94930275T patent/ATE198072T1/de not_active IP Right Cessation
- 1994-10-20 WO PCT/GB1994/002295 patent/WO1995011244A1/en not_active Ceased
- 1994-10-20 SK SK504-96A patent/SK282491B6/sk not_active IP Right Cessation
- 1994-10-20 MY MYPI94002796A patent/MY124316A/en unknown
- 1994-10-20 SI SI9430476T patent/SI1004582T1/xx unknown
- 1994-10-20 PL PL94314041A patent/PL180679B1/pl not_active IP Right Cessation
- 1994-10-20 RU RU96109470/04A patent/RU2168511C2/ru not_active IP Right Cessation
- 1994-10-20 EP EP94930275A patent/EP0724583B1/en not_active Expired - Lifetime
- 1994-10-20 CZ CZ19961138A patent/CZ292311B6/cs not_active IP Right Cessation
- 1994-10-20 NZ NZ329303A patent/NZ329303A/xx not_active IP Right Cessation
- 1994-10-20 DK DK00101917T patent/DK1004582T3/da active
- 1994-11-18 TW TW083110721A patent/TW406082B/zh not_active IP Right Cessation
1996
- 1996-04-18 FI FI961696A patent/FI113865B/fi active
- 1996-04-19 NO NO961584A patent/NO306995B1/no not_active IP Right Cessation
1997
- 1997-03-03 FI FI970907A patent/FI114916B/fi active IP Right Grant
1998
- 1998-03-19 US US09/044,109 patent/US6232313B1/en not_active Expired - Fee Related
- 1998-05-27 AU AU68999/98A patent/AU721139B2/en not_active Ceased
1999
- 1999-12-06 US US09/455,096 patent/US6103721A/en not_active Expired - Fee Related
2000
- 2000-12-14 GR GR20000402690T patent/GR3035080T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL180679B1 (en)	2001-03-30
US6232313B1 (en)	2001-05-15
JPH09504519A (ja)	1997-05-06
DK0724583T3 (da)	2001-03-05
RU2168511C2 (ru)	2001-06-10
MY132875A (en)	2007-10-31
JP3583132B2 (ja)	2004-10-27
UA60291C2 (uk)	2003-10-15
ATE198072T1 (de)	2000-12-15
ES2241513T3 (es)	2005-11-01
HK1013997A1 (en)	1999-09-17
WO1995011244A1 (en)	1995-04-27
ES2154686T3 (es)	2001-04-16
GR3035080T3 (en)	2001-03-30
ATE295846T1 (de)	2005-06-15
EP1004582B1 (en)	2005-05-18
PT724583E (pt)	2001-03-30
PT1004582E (pt)	2005-09-30
TW406082B (en)	2000-09-21
SK50496A3 (en)	1997-03-05
FI113865B (fi)	2004-06-30
CN1138332A (zh)	1996-12-18
CZ292311B6 (cs)	2003-09-17
NZ329303A (en)	2000-01-28
SI1004582T1 (da)	2005-08-31
EP1004582A2 (en)	2000-05-31
NO961584D0 (no)	1996-04-19
AU688393B2 (en)	1998-03-12
FI114916B (fi)	2005-01-31
HU9600889D0 (en)	1996-06-28
AU721139B2 (en)	2000-06-22
AU7944094A (en)	1995-05-08
IL111266A (en)	2002-03-10
MY124316A (en)	2006-06-30
FI961696L (fi)	1996-04-18
GB9420590D0 (en)	1994-11-30
EP0724583B1 (en)	2000-12-13
NO306995B1 (no)	2000-01-24
US5744471A (en)	1998-04-28
DE69426422T2 (de)	2001-05-10
SG59971A1 (en)	1999-02-22
DE69434380D1 (de)	2005-06-23
CZ113896A3 (en)	1996-09-11
NZ275472A (en)	1998-03-25
CN1053189C (zh)	2000-06-07
DE69434380T2 (de)	2006-05-04
SK282491B6 (sk)	2002-02-05
SG92630A1 (en)	2002-11-19
IL111266A0 (en)	1994-12-29
HUT74161A (en)	1996-11-28
KR100261209B1 (ko)	2000-09-01
AU6899998A (en)	1998-07-30
NO961584L (no)	1996-04-19
SI0724583T1 (en)	2001-04-30
EP1004582A3 (en)	2000-08-30
FI961696A0 (fi)	1996-04-18
US6103721A (en)	2000-08-15
FI970907A0 (fi)	1997-03-03
FI970907L (fi)	1997-03-03
PL314041A1 (en)	1996-08-05
CA2171332A1 (en)	1995-04-27
EP0724583A1 (en)	1996-08-07
DE69426422D1 (de)	2001-01-18

Publication	Publication Date	Title
DK1004582T3 (da)	2005-08-15	Pyradazinoquinolinforbindelser
PT846686E (pt)	2002-05-31	Derivados de 1-fenil-pirazole e suas utilizacoes como agentes parasiticidas
DE69720965D1 (de)	2003-05-22	Chinazolinderivate und deren verwendung als vegf hemmer
ATE393150T1 (de)	2008-05-15	2-imino-1,3-thiazin-derivate
ATE182891T1 (de)	1999-08-15	Indazolderivate
DE60216610D1 (de)	2007-01-18	Verwendung von kondensierten Pyrazolverbindungen für die Herstellung eines Arzneimittels zur Behandlung von Bluthochdruck
ATE132136T1 (de)	1996-01-15	Antitumor anthracenderivate
DE69316392D1 (de)	1998-02-19	Azanoradamantane
DE69011714D1 (de)	1994-09-29	Kalziumantagonisten.
ATE404558T1 (de)	2008-08-15	Antimikrobielle 4-oxochinolizinverbindungen, die als teilstruktur ein 2-pyridonskelett aufweisen
ES2090701T3 (es)	1996-10-16	Agentes antihelminticos de bencimidazol.