IL110687A - Dihydrobenzopyran derivatives their preparation and pharmaceutical compositions containing them - Google Patents

Dihydrobenzopyran derivatives their preparation and pharmaceutical compositions containing them

Info

Publication number: IL110687A
Authority: IL; Israel
Prior art keywords: formula; hydrogen; 6alkyl; alkyl; radical
Prior art date: 1993-08-19

Application number

IL11068794A

Other languages

English (en)

Other versions

IL110687A0 (en

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-08-19

Filing date

1994-08-17

Publication date

2001-03-19

1994-08-17 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1994-11-11 Publication of IL110687A0 publication Critical patent/IL110687A0/xx

2001-03-19 Publication of IL110687A publication Critical patent/IL110687A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Polymerisation Methods In General (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Cephalosporin Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Dental Preparations (AREA)

IL11068794A 1993-08-19 1994-08-17 Dihydrobenzopyran derivatives their preparation and pharmaceutical compositions containing them IL110687A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP93202441		1993-08-19
EP93202442		1993-08-19
EP93202443		1993-08-19

Publications (2)

Publication Number	Publication Date
IL110687A0 IL110687A0 (en)	1994-11-11
IL110687A true IL110687A (en)	2001-03-19

Family

ID=27235325

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11068794A IL110687A (en)	1993-08-19	1994-08-17	Dihydrobenzopyran derivatives their preparation and pharmaceutical compositions containing them

Country Status (25)

Country	Link
US (2)	US5824682A (zh)
EP (1)	EP0714396B1 (zh)
JP (1)	JP3044065B2 (zh)
KR (1)	KR100330696B1 (zh)
CN (1)	CN1052006C (zh)
AT (1)	ATE256130T1 (zh)
AU (1)	AU677428B2 (zh)
BR (1)	BR9407317A (zh)
CA (1)	CA2168021C (zh)
CZ (1)	CZ287771B6 (zh)
DE (1)	DE69433401T2 (zh)
ES (1)	ES2212797T3 (zh)
FI (1)	FI120791B (zh)
HU (1)	HU226525B1 (zh)
IL (1)	IL110687A (zh)
MY (1)	MY134487A (zh)
NO (1)	NO315235B1 (zh)
NZ (1)	NZ271995A (zh)
PL (1)	PL181385B1 (zh)
RO (1)	RO116900B1 (zh)
RU (1)	RU2129556C1 (zh)
SK (1)	SK282402B6 (zh)
TW (1)	TW269684B (zh)
WO (1)	WO1995005383A1 (zh)
ZA (1)	ZA946269B (zh)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
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BR9407317A (pt) *	1993-08-19	1996-04-16	Janssen Pharmaceutica Nv	Derivados vasoconstritores da diidrobenzopirana
DE69524528T2 (de) *	1994-10-14	2002-08-01	Merck Patent Gmbh	ZNS wirksames (R)-(-)-2-[5-(4-Fluorophenyl)-3-pyridylmethylaminomethyl]chroman
US5541199A (en) *	1995-06-02	1996-07-30	American Home Products Corporation	Chroman-2-ylmethylamino derivatives
US5670667A (en) *	1995-07-25	1997-09-23	American Home Products Corporation	Chroman-2-ylmethylamino derivatives
US5663194A (en) *	1995-07-25	1997-09-02	Mewshaw; Richard E.	Chroman-2-ylmethylamino derivatives
US5684039A (en) *	1995-07-25	1997-11-04	American Home Products Corporation	Chroman-2-ylmethylamino derivatives
US7189753B1 (en)	1997-11-06	2007-03-13	Cady Roger K	Preemptive prophylaxis of migraine
US6133277A (en) *	1997-12-05	2000-10-17	Janssen Pharmaceutica N.V.	(Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
ATE256125T1 (de) *	1999-06-02	2003-12-15	Janssen Pharmaceutica Nv	Aminoalkyl substituierte (benzodioxane, benzofurane oder benzopyrane) derivate
IL146824A0 (en)	1999-06-02	2002-07-25	Janssen Pharmaceutica Nv	Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
DE19948480A1 (de)	1999-10-08	2001-04-12	Bsh Bosch Siemens Hausgeraete	Wärmetauscher, wie Verdampfer, Verflüssiger oder dergleichen
JO2178B1 (en) *	1999-10-19	2003-04-23	اف . هوفمان لاروش ايه جي	Treatment of invasive diseases, using selected anti-PAR materials
JO2654B1 (en)	2000-09-04	2012-06-17	شركة جانسين فارماسوتيكا ان. في	Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en)	2000-11-21	2007-06-17	شركة جانسين فارماسوتيكا ان. في	Second-phenyl carboxy amides are useful as lipid-lowering agents
DK1381613T3 (da)	2001-04-26	2005-01-24	Wyeth Corp	Antidepressive azaheterocyclylmethylderivater af oxaheterocyclokondenserede 1,4-benzodioxaner
US6706736B2 (en)	2001-04-26	2004-03-16	Wyeth	Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-[1,4]-benzodioxans
DE10120619A1 (de) *	2001-04-26	2002-10-31	Merck Patent Gmbh	2-(5-(4-Fluorphenyl)-3-pyridylmethylaminomethyl-chroman
US6555560B2 (en)	2001-04-30	2003-04-29	Wyeth	Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene
US6906206B2 (en) *	2001-04-30	2005-06-14	Wyeth	Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene
DE60211186T2 (de) *	2001-09-19	2007-01-18	Merck Patent Gmbh	Neue verwendung substituierter aminomethylchromane
CN1561338A (zh) *	2001-10-04	2005-01-05	惠氏公司	作为5－羟基色胺－6配体的苯并二氢吡喃衍生物
WO2003029239A1 (en)	2001-10-04	2003-04-10	Wyeth	Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands
RS50905B (sr) *	2002-04-10	2010-08-31	Dongbu Hannong Chemical Co.Ltd.	Derivati benzopirana supstituisani sa sekundarnim aminima uključujući tetrazol, postupak za njihovo dobijanje i farmaceutske kompozicije koje ih sadrže
WO2006034473A2 (en) *	2004-09-23	2006-03-30	Reddy Us Therapeutics, Inc.	Novel pyrimidine compounds, process for their preparation and compositions containing them
GT200600166A (es) *	2005-04-22	2007-03-14		Derivados de cromano y cromeno y usos de los mismos
AR059898A1 (es)	2006-03-15	2008-05-07	Janssen Pharmaceutica Nv	Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200815388A (en) *	2006-04-18	2008-04-01	Wyeth Corp	Chromane and chromene derivatives and uses thereof
CL2007003043A1 (es) *	2006-10-24	2008-05-30	Wyeth Corp	Compuestos derivados de cromano; composicion farmaceutica que los comprende; y uso para el tratamiento de un trastorno psicotico, bipolar, depresivo y ansiedad entre otros.
TW200845978A (en) *	2007-03-07	2008-12-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en)	2007-03-07	2009-01-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
SI2203439T1 (sl)	2007-09-14	2011-05-31	Ortho Mcneil Janssen Pharm	1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni
US8722894B2 (en) *	2007-09-14	2014-05-13	Janssen Pharmaceuticals, Inc.	1,3-disubstituted-4-phenyl-1H-pyridin-2-ones
NZ584152A (en)	2007-09-14	2011-11-25	Ortho Mcneil Janssen Pharm	1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
RU2492170C9 (ru) *	2007-11-14	2013-12-27	Орто-Макнейл-Янссен Фармасьютикалз, Инк.	Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2
AU2009289784B2 (en)	2008-09-02	2012-03-22	Addex Pharma S.A.	3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
US8697689B2 (en)	2008-10-16	2014-04-15	Janssen Pharmaceuticals, Inc.	Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
WO2010060589A1 (en)	2008-11-28	2010-06-03	Ortho-Mcneil-Janssen Pharmaceuticals, Inc.	Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
CN102439008B (zh)	2009-05-12	2015-04-29	杨森制药有限公司	1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
MY153913A (en)	2009-05-12	2015-04-15	Janssen Pharmaceuticals Inc	7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
BRPI1010831A2 (pt)	2009-05-12	2016-04-05	Addex Pharmaceuticals Sa	derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2
PT2649069E (pt)	2010-11-08	2015-11-20	Janssen Pharmaceuticals Inc	Derivados de 1,2,4-triazolo[4,3-a]piridina e sua utilização como moduladores alostéricos positivos de recetores mglur2
JP5852665B2 (ja)	2010-11-08	2016-02-03	ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド	１，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
WO2012062759A1 (en)	2010-11-08	2012-05-18	Janssen Pharmaceuticals, Inc.	1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JO3368B1 (ar)	2013-06-04	2019-03-13	Janssen Pharmaceutica Nv	مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar)	2013-09-06	2019-03-13	Janssen Pharmaceutica Nv	مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
ES2860298T3 (es)	2014-01-21	2021-10-04	Janssen Pharmaceutica Nv	Combinaciones que comprenden moduladores alostéricos positivos del receptor glutamatérgico metabotrópico de subtipo 2 y su uso
AU2015208233B2 (en)	2014-01-21	2019-08-29	Janssen Pharmaceutica Nv	Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use

Family Cites Families (6)

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Publication number	Priority date	Publication date	Assignee	Title
US4405622A (en) *	1980-10-16	1983-09-20	Syntex (U.S.A.) Inc.	[1-(1,4-Benzodioxan-2-yl)-4-(4-aminopyrimidin-2-yl]piperazines useful as anti-depressants
CA1337429C (en) *	1983-12-05	1995-10-24	Guy Rosalia Eugene Van Lommen	Derivatives of 2,2'-iminobisethanol
FR2593504B1 (fr) *	1986-01-30	1988-12-09	Ile De France	Nouveaux derives de dihydrobenzofuranne - et de chromane - carboxamides, leurs procedes de preparation et leur utilisation comme neuroleptiques
DE3901814A1 (de) *	1988-07-28	1990-02-01	Bayer Ag	Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
SI9300097B (en) *	1992-02-27	2001-12-31	Janssen Pharmaceutica Nv	(benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines
BR9407317A (pt) *	1993-08-19	1996-04-16	Janssen Pharmaceutica Nv	Derivados vasoconstritores da diidrobenzopirana

1994
- 1994-08-12 BR BR9407317A patent/BR9407317A/pt not_active Application Discontinuation
- 1994-08-12 CZ CZ1996374A patent/CZ287771B6/cs not_active IP Right Cessation
- 1994-08-12 RO RO96-00284A patent/RO116900B1/ro unknown
- 1994-08-12 DE DE69433401T patent/DE69433401T2/de not_active Expired - Lifetime
- 1994-08-12 AT AT94926191T patent/ATE256130T1/de not_active IP Right Cessation
- 1994-08-12 ES ES94926191T patent/ES2212797T3/es not_active Expired - Lifetime
- 1994-08-12 US US08/586,760 patent/US5824682A/en not_active Expired - Lifetime
- 1994-08-12 NZ NZ271995A patent/NZ271995A/en not_active IP Right Cessation
- 1994-08-12 EP EP94926191A patent/EP0714396B1/en not_active Expired - Lifetime
- 1994-08-12 KR KR1019960700632A patent/KR100330696B1/ko not_active Expired - Lifetime
- 1994-08-12 SK SK195-96A patent/SK282402B6/sk not_active IP Right Cessation
- 1994-08-12 CA CA002168021A patent/CA2168021C/en not_active Expired - Lifetime
- 1994-08-12 WO PCT/EP1994/002703 patent/WO1995005383A1/en not_active Ceased
- 1994-08-12 AU AU76131/94A patent/AU677428B2/en not_active Expired
- 1994-08-12 PL PL94313082A patent/PL181385B1/pl unknown
- 1994-08-12 HU HU9600373A patent/HU226525B1/hu unknown
- 1994-08-12 CN CN94193152A patent/CN1052006C/zh not_active Expired - Lifetime
- 1994-08-12 RU RU96105980A patent/RU2129556C1/ru active
- 1994-08-16 TW TW083107469A patent/TW269684B/zh not_active IP Right Cessation
- 1994-08-17 MY MYPI94002161A patent/MY134487A/en unknown
- 1994-08-17 IL IL11068794A patent/IL110687A/en not_active IP Right Cessation
- 1994-08-18 ZA ZA946269A patent/ZA946269B/xx unknown
1995
- 1995-08-02 JP JP8506755A patent/JP3044065B2/ja not_active Expired - Lifetime
1996
- 1996-02-16 FI FI960723A patent/FI120791B/fi not_active IP Right Cessation
- 1996-02-19 NO NO19960649A patent/NO315235B1/no not_active IP Right Cessation
1998
- 1998-07-28 US US09/123,893 patent/US6100268A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
RO116900B1 (ro)	2001-07-30
AU677428B2 (en)	1997-04-24
JP3044065B2 (ja)	2000-05-22
NO315235B1 (no)	2003-08-04
HU9600373D0 (en)	1996-04-29
TW269684B (zh)	1996-02-01
MY134487A (en)	2007-12-31
RU2129556C1 (ru)	1999-04-27
WO1995005383A1 (en)	1995-02-23
EP0714396B1 (en)	2003-12-10
ES2212797T3 (es)	2004-08-01
KR100330696B1 (ko)	2002-10-04
CN1052006C (zh)	2000-05-03
CA2168021C (en)	2007-07-03
CN1129451A (zh)	1996-08-21
US6100268A (en)	2000-08-08
ZA946269B (en)	1996-02-19
CZ37496A3 (en)	1996-05-15
PL313082A1 (en)	1996-05-27
SK282402B6 (sk)	2002-01-07
DE69433401T2 (de)	2004-09-16
EP0714396A1 (en)	1996-06-05
US5824682A (en)	1998-10-20
ATE256130T1 (de)	2003-12-15
DE69433401D1 (de)	2004-01-22
HUT74677A (en)	1997-01-28
BR9407317A (pt)	1996-04-16
CA2168021A1 (en)	1995-02-23
JPH09501916A (ja)	1997-02-25
AU7613194A (en)	1995-03-14
NO960649L (no)	1996-02-19
FI960723A0 (fi)	1996-02-16
IL110687A0 (en)	1994-11-11
SK19596A3 (en)	1997-02-05
FI960723A7 (fi)	1996-02-16
NO960649D0 (no)	1996-02-19
CZ287771B6 (en)	2001-01-17
FI120791B (fi)	2010-03-15
PL181385B1 (pl)	2001-07-31
HU226525B1 (en)	2009-03-30
NZ271995A (en)	1996-11-26

Publication	Publication Date	Title
IL110687A (en)	2001-03-19	Dihydrobenzopyran derivatives their preparation and pharmaceutical compositions containing them
JP3819933B2 (ja)	2006-09-13	血管収縮性ジヒドロベンゾピラン誘導体
EP0639192B1 (en)	1996-05-15	(benzodioxan, benzofuran or benzopyran)-alkylamino] alkyl substituted guanidines as selective vascoconstrictors
AU682396B2 (en)	1997-10-02	Vasoconstrictive substituted aryloxyalkyl diamines
CA2168022C (en)	2006-11-21	Vasoconstrictive substituted dihydropyranopyridines
AU692361B2 (en)	1998-06-04	Vasoconstrictive substituted 2,3-dihydro-1,4-dioxinopyridines

Legal Events

Date	Code	Title
2001-07-24	FF	Patent granted
2001-10-31	KB	Patent renewed
2004-09-27	KB	Patent renewed
2008-11-27	KB	Patent renewed
2012-07-31	KB	Patent renewed
2015-03-31	EXP	Patent expired