|
AU8816298A
(en)
|
1997-08-22 |
1999-03-16 |
Zeneca Limited |
Oxindolylquinazoline derivatives as angiogenesis inhibitors
|
|
EP1006113A1
(en)
|
1998-12-02 |
2000-06-07 |
Pfizer Products Inc. |
Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth
|
|
UA71945C2
(en)
*
|
1999-01-27 |
2005-01-17 |
Pfizer Prod Inc |
Substituted bicyclic derivatives being used as anticancer agents
|
|
GB9918057D0
(en)
*
|
1999-07-30 |
1999-10-06 |
Univ Bristol |
Therapeutic agents
|
|
UA74803C2
(uk)
|
1999-11-11 |
2006-02-15 |
Осі Фармасьютікалз, Інк. |
Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
|
|
GB0010757D0
(en)
*
|
2000-05-05 |
2000-06-28 |
Astrazeneca Ab |
Chemical compounds
|
|
EP1287001B1
(en)
*
|
2000-06-06 |
2004-09-29 |
Pfizer Products Inc. |
Thiophene derivatives useful as anticancer agents
|
|
EP1311500A2
(en)
*
|
2000-08-09 |
2003-05-21 |
AstraZeneca AB |
Indole, azaindole and indazole derivatives having vegf inhibiting activity
|
|
AU2001293817A1
(en)
|
2000-09-20 |
2002-04-02 |
Merck Patent Gmbh |
4-amino-quinazolines
|
|
US6503914B1
(en)
|
2000-10-23 |
2003-01-07 |
Board Of Regents, The University Of Texas System |
Thienopyrimidine-based inhibitors of the Src family
|
|
AUPR213700A0
(en)
|
2000-12-18 |
2001-01-25 |
Biota Scientific Management Pty Ltd |
Antiviral agents
|
|
KR20020051675A
(ko)
*
|
2000-12-23 |
2002-06-29 |
이상남 |
4-페닐아미노티에노 [3,2-디] 피리미딘 유도체 및 이의제조방법
|
|
GEP20084484B
(en)
|
2001-01-05 |
2008-09-25 |
Pfizer |
Antibodies to insulin-like growth factor i receptor
|
|
DE60212487T2
(de)
*
|
2001-04-13 |
2006-12-21 |
Pfizer Products Inc., Groton |
Bizyklisch substituierte 4-Aminopyridopyrimidinderivate
|
|
US6995171B2
(en)
|
2001-06-21 |
2006-02-07 |
Agouron Pharmaceuticals, Inc. |
Bicyclic pyrimidine and pyrimidine derivatives useful as anticancer agents
|
|
US7829566B2
(en)
|
2001-09-17 |
2010-11-09 |
Werner Mederski |
4-amino-quinazolines
|
|
AR039067A1
(es)
|
2001-11-09 |
2005-02-09 |
Pfizer Prod Inc |
Anticuerpos para cd40
|
|
AU2002357193A1
(en)
*
|
2001-12-19 |
2003-07-09 |
Smithkline Beecham Corporation |
Thienopyrimidine compounds as protein tyrosine kinase inhibitors
|
|
WO2003055890A1
(en)
*
|
2001-12-21 |
2003-07-10 |
Bayer Pharmaceuticals Corporation |
Thienopyrimidine derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
|
|
JP4505228B2
(ja)
*
|
2002-01-10 |
2010-07-21 |
バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト |
Rho−キナーゼ阻害剤
|
|
JP4423043B2
(ja)
|
2002-01-23 |
2010-03-03 |
バイエル ファーマセチカル コーポレーション |
Rho−キナーゼ阻害剤
|
|
EP1470121B1
(en)
|
2002-01-23 |
2012-07-11 |
Bayer HealthCare LLC |
Pyrimidine derivatives as rho-kinase inhibitors
|
|
WO2003064428A1
(en)
*
|
2002-01-29 |
2003-08-07 |
H. Lundbeck A/S |
Furano- and thienopyrimidines as neurokinase inhibitors
|
|
AU2003216322A1
(en)
|
2002-02-15 |
2003-09-09 |
Rigel Pharmaceuticals, Inc. |
Inhibitors of tubulin polymerization
|
|
US20030225273A1
(en)
*
|
2002-03-21 |
2003-12-04 |
Michaelides Michael R. |
Thiopyrimidine and isothiazolopyrimidine kinase inhibitors
|
|
UA77303C2
(en)
*
|
2002-06-14 |
2006-11-15 |
Pfizer |
Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
|
|
AU2003246972A1
(en)
|
2002-08-06 |
2004-02-23 |
Astrazeneca Ab |
Condensed pyridines and pyrimidines with tie2 (tek) activity
|
|
TWI335913B
(en)
*
|
2002-11-15 |
2011-01-11 |
Vertex Pharma |
Diaminotriazoles useful as inhibitors of protein kinases
|
|
CL2003002287A1
(es)
|
2002-11-25 |
2005-01-14 |
Wyeth Corp |
COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS
|
|
US7276519B2
(en)
|
2002-11-25 |
2007-10-02 |
Wyeth |
Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors
|
|
MXPA05006676A
(es)
|
2002-12-19 |
2005-08-16 |
Pfizer |
Compuestos de indazol y composiciones farmaceuticas para inhibir proteinquinasas, y procedimientos para su uso.
|
|
DK1625121T3
(da)
|
2002-12-20 |
2010-05-10 |
Pfizer Prod Inc |
Pyrimidinderivater til behandling af abnorm cellevækst
|
|
ES2401330T3
(es)
|
2003-02-26 |
2013-04-18 |
Sugen, Inc. |
Compuesto de heteroarilamino inhibidores de proteín quinasas
|
|
ES2280040T3
(es)
*
|
2003-07-24 |
2007-09-01 |
Bayer Pharmaceuticals Corporation |
Compuestos de tetrahidrobenzotienopirimidinamina sustituidos utiles para tratar trastornos hiperproliferativos.
|
|
HN2004000285A
(es)
|
2003-08-04 |
2006-04-27 |
Pfizer Prod Inc |
ANTICUERPOS DIRIGIDOS A c-MET
|
|
PE20050338A1
(es)
*
|
2003-08-06 |
2005-05-16 |
Vertex Pharma |
Compuestos de aminotriazoles como inhibidores de proteina quinasas
|
|
CA2535614C
(en)
|
2003-08-14 |
2009-12-22 |
Array Biopharma Inc. |
Quinazoline analogs as receptor tyrosine kinase inhibitors
|
|
US7501427B2
(en)
|
2003-08-14 |
2009-03-10 |
Array Biopharma, Inc. |
Quinazoline analogs as receptor tyrosine kinase inhibitors
|
|
ATE412655T1
(de)
|
2003-08-29 |
2008-11-15 |
Pfizer |
Als neue antiangiogene mittel geeignete thienopyridinphenylacetamide und derivate davon
|
|
AR045563A1
(es)
|
2003-09-10 |
2005-11-02 |
Warner Lambert Co |
Anticuerpos dirigidos a m-csf
|
|
US7332521B2
(en)
*
|
2003-09-25 |
2008-02-19 |
Wyeth |
Substituted indoles
|
|
US7419978B2
(en)
|
2003-10-22 |
2008-09-02 |
Bristol-Myers Squibb Company |
Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
|
|
AP2006003619A0
(en)
|
2003-12-23 |
2006-06-30 |
Pfizer |
Novel quinoline derivatives
|
|
US7470712B2
(en)
*
|
2004-01-21 |
2008-12-30 |
Bristol-Myers Squibb Company |
Amino-benzazoles as P2Y1 receptor inhibitors
|
|
CA2553513A1
(en)
*
|
2004-01-22 |
2005-08-04 |
Altana Pharma Ag |
N-4-(6- (heteo) aryl-pyrimidin-4-ylaminophenyl) -bezenesulfonamides as kinase inhibitors
|
|
WO2005116035A1
(en)
*
|
2004-05-27 |
2005-12-08 |
Pfizer Products Inc. |
Pyrrolopyrimidine derivatives useful in cancer treatment
|
|
GB0412467D0
(en)
*
|
2004-06-04 |
2004-07-07 |
Astrazeneca Ab |
Chemical compounds
|
|
US20050288290A1
(en)
*
|
2004-06-28 |
2005-12-29 |
Borzilleri Robert M |
Fused heterocyclic kinase inhibitors
|
|
JP5065017B2
(ja)
|
2004-06-28 |
2012-10-31 |
バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト |
4,6位で二置換されたピリミジン及びプロテインキナーゼインヒビターとしてのそれらの使用
|
|
EP1802341A1
(en)
|
2004-07-16 |
2007-07-04 |
Pfizer Products Inc. |
Combination treatment for non-hematologic malignancies using an anti-igf-1r antibody
|
|
EP1781664B1
(en)
*
|
2004-07-30 |
2013-09-04 |
MethylGene Inc. |
Inhibitors of vegf receptor and hgf receptor signaling
|
|
HRP20100298T1
(hr)
|
2004-08-26 |
2010-06-30 |
Pfizer Inc. |
Enantiomerno čisti aminoheteroarilni spojevi kao inhibitori proteinskih kinaza
|
|
GB0423653D0
(en)
*
|
2004-10-25 |
2004-11-24 |
Piramed Ltd |
Pharmaceutical compounds
|
|
CN101083996A
(zh)
*
|
2004-10-28 |
2007-12-05 |
Irm责任有限公司 |
作为hedgehog途径调节剂的化合物和组合物
|
|
US7576080B2
(en)
*
|
2004-12-23 |
2009-08-18 |
Memory Pharmaceuticals Corporation |
Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors
|
|
WO2006077024A2
(en)
*
|
2005-01-19 |
2006-07-27 |
F. Hoffmann-La Roche Ag |
5-aminoindole derivatives
|
|
CA2601157A1
(en)
|
2005-03-16 |
2006-09-28 |
Osi Pharmaceuticals, Inc. |
Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors
|
|
NZ562453A
(en)
|
2005-03-31 |
2010-04-30 |
Agensys Inc |
Antibodies and related molecules that bind to 161P2F10B proteins
|
|
UA95775C2
(uk)
|
2005-04-26 |
2011-09-12 |
Пфайзер Инк. |
Антитіло, яке специфічно зв'язується з р-кадгерином
|
|
BRPI0610322B8
(pt)
*
|
2005-05-20 |
2021-05-25 |
Methylgene Inc |
inibidores de sinalização de receptor de vegf e de receptor de hgf e composição farmacêutica
|
|
BRPI0610382A2
(pt)
*
|
2005-05-20 |
2010-06-15 |
Methylgene Inc |
inibidores de sinalização de receptor de vegf e receptor de hgf
|
|
US20060281768A1
(en)
*
|
2005-06-10 |
2006-12-14 |
Gaul Michael D |
Thienopyrimidine and thienopyridine kinase modulators
|
|
US20100143341A1
(en)
*
|
2005-06-22 |
2010-06-10 |
Develogen Aktiengesellschaft |
Thienopyrimidines for pharmaceutical compositions
|
|
US7608592B2
(en)
|
2005-06-30 |
2009-10-27 |
Virobay, Inc. |
HCV inhibitors
|
|
AR055625A1
(es)
*
|
2005-09-02 |
2007-08-29 |
Pfizer |
Procedimientos mejorados para preparar derivados de tienopiridinas heteroaril amida benzocondensados
|
|
AP2013006963A0
(en)
|
2005-09-07 |
2013-07-31 |
Amgen Fremont Inc |
Human monoclonal antibodies to activin receptor-like Kinase-1
|
|
DK1926996T3
(da)
|
2005-09-20 |
2012-01-23 |
Osi Pharmaceuticals Llc |
Biologiske markører, som er prædiktive for anti-cancer-reaktion på insulinlignende vækstfaktor-1-receptorkinasehæmmere
|
|
AR056200A1
(es)
*
|
2005-09-27 |
2007-09-26 |
Wyeth Corp |
Tieno [2,3-b]piridin-5-carbonitrilos como inhibidores de proteina quinasa
|
|
US20070213305A1
(en)
*
|
2005-11-02 |
2007-09-13 |
Cytovia, Inc. |
N-alkyl-N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
|
|
WO2007056208A2
(en)
*
|
2005-11-02 |
2007-05-18 |
Cytovia, Inc. |
N-arylalkyl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
|
|
US20070099877A1
(en)
*
|
2005-11-02 |
2007-05-03 |
Cytovia, Inc. |
N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
|
|
KR101086967B1
(ko)
|
2005-11-15 |
2011-11-29 |
어레이 바이오파마 인크. |
과다증식성 질환의 치료를 위한 erbb 유형 i 수용체티로신 키나제 억제제로서의 n4-페닐-퀴나졸린-4-아민유도체 및 관련 화합물
|
|
EP1989211A2
(en)
*
|
2006-01-30 |
2008-11-12 |
Array Biopharma, Inc. |
Heterobicyclic thiophene compounds for the treatment of cancer
|
|
WO2007107005A1
(en)
*
|
2006-03-22 |
2007-09-27 |
Methylgene, Inc. |
Inhibitors of protein tyrosine kinase activity
|
|
CA2644910C
(en)
|
2006-03-31 |
2014-01-28 |
Abbott Laboratories |
Indazole compounds
|
|
EA200802118A1
(ru)
|
2006-04-07 |
2009-04-28 |
Девелоджен Ациенгезельшафт |
Обладающие ингибирующей активностью в отношении mnk1/mnk2 тиенопиримидины, предназначенные для применения в фармацевтических композициях
|
|
MEP43308A
(en)
|
2006-05-09 |
2011-02-10 |
Pfizer Prod Inc |
Cycloalkylamino acid derivatives and pharmaceutical compositions thereof
|
|
EP1889847A1
(en)
|
2006-07-10 |
2008-02-20 |
DeveloGen Aktiengesellschaft |
Pyrrolopyrimidines for pharmaceutical compositions
|
|
AU2007316417B2
(en)
|
2006-11-06 |
2013-08-22 |
Tolero Pharmaceuticals, Inc. |
Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
|
|
US7888352B2
(en)
|
2006-12-07 |
2011-02-15 |
Piramed Limited |
Phosphoinositide 3-kinase inhibitor compounds and methods of use
|
|
WO2008082839A2
(en)
*
|
2006-12-29 |
2008-07-10 |
Abbott Laboratories |
Pim kinase inhibitors as cancer chemotherapeutics
|
|
AU2007342007A1
(en)
*
|
2006-12-29 |
2008-07-10 |
Rigel Pharmaceuticals, Inc. |
Substituted triazoles useful as Axl inhibitors
|
|
US20080161254A1
(en)
*
|
2007-01-03 |
2008-07-03 |
Virobay, Inc. |
Hcv inhibitors
|
|
CN101679456B
(zh)
*
|
2007-06-12 |
2012-09-05 |
霍夫曼-拉罗奇有限公司 |
噻唑并嘧啶类和它们作为磷脂酰肌醇3-激酶的抑制剂的应用
|
|
EP2014662A1
(de)
*
|
2007-07-12 |
2009-01-14 |
Bayer Schering Pharma Aktiengesellschaft |
Indolylalkylthienopyrimidylamine als Modulatoren des EP2-Rezeptors
|
|
EP2014663A1
(de)
*
|
2007-07-12 |
2009-01-14 |
Bayer Schering Pharma AG |
Thienopyrimidylamine als Modulatoren des EP2-Rezeptors
|
|
ES2399774T3
(es)
*
|
2007-09-24 |
2013-04-03 |
Genentech, Inc. |
Compuestos de tiazolopirimidina inhibidores de PI3K y métodos de uso
|
|
PL2205608T3
(pl)
*
|
2007-10-18 |
2013-09-30 |
Boehringer Ingelheim Int |
Sposób otrzymywania dihydrotieno[3,2-d]pirymidyn i związków pośrednich stosowanych w tym sposobie
|
|
CN101909631B
(zh)
|
2007-10-25 |
2012-09-12 |
健泰科生物技术公司 |
制备噻吩并嘧啶化合物的方法
|
|
WO2009062288A1
(en)
*
|
2007-11-15 |
2009-05-22 |
Boehringer Ingelheim International Gmbh |
Inhibitors of human immunodeficiency virus replication
|
|
EA019869B1
(ru)
*
|
2007-11-28 |
2014-06-30 |
Дана Фарбер Кансер Инститьют, Инк. |
Низкомолекулярные миристатные ингибиторы тирозинкиназы bcr-abl и способы их применения
|
|
JP5419894B2
(ja)
*
|
2008-01-11 |
2014-02-19 |
グレンマーク ファーマシューティカルズ, エセ.アー. |
Trpv3モジュレーターとしての縮合ピリミジン誘導体
|
|
CN101969973B
(zh)
|
2008-02-07 |
2015-07-22 |
维罗贝股份有限公司 |
组织蛋白酶b抑制剂
|
|
CN102015723B
(zh)
|
2008-03-05 |
2014-07-30 |
梅特希尔基因公司 |
蛋白酪氨酸激酶活性的抑制剂
|
|
US8119647B2
(en)
*
|
2008-04-23 |
2012-02-21 |
Glenmark Pharmaceuticals S.A. |
Fused pyrimidineone compounds as TRPV3 modulators
|
|
RU2011110908A
(ru)
|
2008-08-26 |
2012-10-10 |
Бёрингер Ингельхайм Интернациональ Гмбх (De) |
Тиенопиримидины для фармацевтических композиций
|
|
US8476410B2
(en)
|
2008-10-16 |
2013-07-02 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Fully human antibodies to high molecular weight-melanoma associated antigen and uses thereof
|
|
KR101126736B1
(ko)
*
|
2008-11-27 |
2012-04-12 |
주식회사 레고켐 바이오사이언스 |
티로신 키나아제 저해 화합물, 이의 이성질체 또는 이의 약학적으로 허용가능한 염 및 이를 포함하는 약학적 조성물
|
|
AU2010210986A1
(en)
|
2009-02-09 |
2011-08-25 |
Supergen, Inc. |
Pyrrolopyrimidinyl Axl kinase inhibitors
|
|
JP2012518657A
(ja)
|
2009-02-25 |
2012-08-16 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
併用抗癌治療
|
|
US20110171124A1
(en)
|
2009-02-26 |
2011-07-14 |
Osi Pharmaceuticals, Inc. |
In situ methods for monitoring the EMT status of tumor cells in vivo
|
|
TW201035088A
(en)
|
2009-02-27 |
2010-10-01 |
Supergen Inc |
Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors
|
|
WO2010099363A1
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
|
WO2010099138A2
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
|
US8465912B2
(en)
|
2009-02-27 |
2013-06-18 |
OSI Pharmaceuticals, LLC |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
|
JP5709766B2
(ja)
|
2009-03-12 |
2015-04-30 |
ジェネンテック, インコーポレイテッド |
造血器腫瘍の治療のためのホスホイノシチド3キナーゼ阻害剤化合物と化学療法剤の併用
|
|
US8158625B2
(en)
*
|
2009-05-27 |
2012-04-17 |
Genentech, Inc. |
Bicyclic indole-pyrimidine PI3K inhibitor compounds selective for P110 delta, and methods of use
|
|
CA2761445A1
(en)
|
2009-05-27 |
2010-12-02 |
Genentech, Inc. |
Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use
|
|
BR112012000735A2
(pt)
|
2009-07-13 |
2016-11-16 |
Genentech Inc |
"métodos, kits e conjuntos de compostos"
|
|
WO2011014726A1
(en)
|
2009-07-31 |
2011-02-03 |
Osi Pharmaceuticals, Inc. |
Mtor inhibitor and angiogenesis inhibitor combination therapy
|
|
JP2013503846A
(ja)
|
2009-09-01 |
2013-02-04 |
ファイザー・インク |
ベンズイミダゾール誘導体
|
|
KR20120105423A
(ko)
|
2009-09-11 |
2012-09-25 |
제넨테크, 인크. |
항암제에 반응할 증가된 가능성을 갖는 환자를 확인하는 방법
|
|
WO2011033006A1
(en)
|
2009-09-17 |
2011-03-24 |
F. Hoffmann-La Roche Ag |
Methods and compositions for diagnostics use in cancer patients
|
|
WO2011073521A1
(en)
|
2009-12-15 |
2011-06-23 |
Petri Salven |
Methods for enriching adult-derived endothelial progenitor cells and uses thereof
|
|
PT2534153T
(pt)
|
2010-02-12 |
2016-12-27 |
Pfizer |
Sais e polimorfos de 8-fluoro-2-{4-[(metilamino}metil]fenil}-1,3,4,5-tetrahidro-6h-azepino[5,4,3-cd]indol-6-ona
|
|
UY33241A
(es)
|
2010-02-26 |
2011-09-30 |
Boehringer Ingelheim Int |
?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?.
|
|
JP5575275B2
(ja)
|
2010-02-26 |
2014-08-20 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
医薬組成物のための置換アルキル基含有チエノピリミジン
|
|
AR080326A1
(es)
|
2010-02-26 |
2012-03-28 |
Boehringer Ingelheim Int |
Tienipirimidinas que contienen cicloalquilo para composiciones farmaceuticas
|
|
US20110275644A1
(en)
|
2010-03-03 |
2011-11-10 |
Buck Elizabeth A |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
|
AU2011223655A1
(en)
|
2010-03-03 |
2012-06-28 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
|
BR112012026470A2
(pt)
|
2010-04-16 |
2016-08-09 |
Genentech Inc |
método para prever a sensibilidade de crescimento de células tumorais e para tratar um tumor em um paciente
|
|
CN102250112A
(zh)
*
|
2010-05-18 |
2011-11-23 |
上海再启生物技术有限公司 |
7-溴-4-氨基噻吩并嘧啶的制备方法
|
|
WO2011149126A1
(ko)
*
|
2010-05-26 |
2011-12-01 |
한국과학기술연구원 |
타이로신 카이네이즈 저해능을 가지는 항염증 화합물을 포함하는 약학적 조성물
|
|
DK2578590T3
(da)
*
|
2010-05-26 |
2017-11-20 |
Korea Inst Sci & Tech |
Anti-inflammatorisk forbindelse med inhibitorisk aktivitet mod flere tyrosinkinaser og farmaceutisk sammensætning indeholdende samme
|
|
WO2011153224A2
(en)
|
2010-06-02 |
2011-12-08 |
Genentech, Inc. |
Diagnostic methods and compositions for treatment of cancer
|
|
AU2011268356B2
(en)
|
2010-06-16 |
2013-09-19 |
University Of Pittsburgh-Of The Commonwealth System Of Higher Education |
Antibodies to endoplasmin and their use
|
|
EP2594566A4
(en)
|
2010-07-16 |
2014-10-01 |
Kyowa Hakko Kirin Co Ltd |
AROMATIC HETEROCYCLIC NITROGEN CYCLE DERIVATIVE
|
|
MX2013000676A
(es)
|
2010-07-19 |
2013-02-27 |
Hoffmann La Roche |
Metodo para identificar pacientes con probabilidad incrementada de responder a una terapia anti-cancer.
|
|
MX2013000667A
(es)
|
2010-07-19 |
2013-02-27 |
Hoffmann La Roche |
Metodo para identificar pacientes con probabilidad incrementada de responder a una terapia anticancer.
|
|
EP2596026B1
(en)
|
2010-07-23 |
2020-04-08 |
Trustees of Boston University |
Anti-despr inhibitors as therapeutics for inhibition of pathological angiogenesis and tumor cell invasiveness and for molecular imaging and targeted delivery
|
|
MX2013003101A
(es)
|
2010-09-17 |
2013-09-26 |
Purdue Pharma Lp |
Compuestos de piridina y sus usos.
|
|
WO2012042421A1
(en)
|
2010-09-29 |
2012-04-05 |
Pfizer Inc. |
Method of treating abnormal cell growth
|
|
CA2813162C
(en)
|
2010-10-20 |
2015-06-16 |
Pfizer Inc. |
Pyridine-2- derivatives as smoothened receptor modulators
|
|
US20140004209A1
(en)
|
2010-12-22 |
2014-01-02 |
Genentech, Inc. |
Autophagy inducer and inhibitor combination therapy for the treatment of neoplasms
|
|
CA2826295C
(en)
|
2011-02-04 |
2020-10-20 |
Duquesne University Of The Holy Spirit |
Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient
|
|
US20120214830A1
(en)
|
2011-02-22 |
2012-08-23 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma
|
|
WO2012142164A1
(en)
|
2011-04-12 |
2012-10-18 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Human monoclonal antibodies that bind insulin-like growth factor (igf) i and ii
|
|
TR201905909T4
(tr)
|
2011-04-19 |
2019-05-21 |
Pfizer |
Kanser tedavisi için anti-4-1bb antikorlarının ve adcc indükleyici antikorların kombinasyonları.
|
|
EP2702173A1
(en)
|
2011-04-25 |
2014-03-05 |
OSI Pharmaceuticals, LLC |
Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
|
|
WO2013012918A1
(en)
|
2011-07-19 |
2013-01-24 |
Infinity Pharmaceuticals Inc. |
Heterocyclic compounds and uses thereof
|
|
EP3409278B8
(en)
|
2011-07-21 |
2020-11-04 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Heterocyclic protein kinase inhibitors
|
|
BR112014006840A2
(pt)
|
2011-09-22 |
2017-04-04 |
Pfizer |
derivados de pirrolopirimidina e purina
|
|
EP3275902A1
(en)
|
2011-10-04 |
2018-01-31 |
IGEM Therapeutics Limited |
Ige anti-hmw-maa antibody
|
|
CN103087077B
(zh)
*
|
2011-11-03 |
2016-05-18 |
上海希迈医药科技有限公司 |
噻吩并嘧啶和呋喃并嘧啶类衍生物、其制备方法及其在医药上的应用
|
|
AU2012335247A1
(en)
|
2011-11-08 |
2014-05-29 |
Pfizer Inc. |
Methods of treating inflammatory disorders using anti-M-CSF antibodies
|
|
JP6109193B2
(ja)
*
|
2012-01-10 |
2017-04-05 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
チエノピリミジン化合物
|
|
FR2988722B1
(fr)
*
|
2012-04-03 |
2014-05-09 |
Sanofi Sa |
Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques
|
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
|
CN103360407B
(zh)
*
|
2012-04-10 |
2016-06-22 |
上海希迈医药科技有限公司 |
一种噻吩并嘧啶类衍生物、其制备方法及其在医药上的应用
|
|
CN103664991B
(zh)
*
|
2012-09-19 |
2016-12-28 |
中国科学院福建物质结构研究所 |
噻吩[2,3‑d]嘧啶衍生物、其制备方法及其用途
|
|
JP6243918B2
(ja)
|
2012-10-16 |
2017-12-06 |
トレロ ファーマシューティカルズ, インコーポレイテッド |
Pkm2調節因子およびそれらの使用方法
|
|
US9260426B2
(en)
|
2012-12-14 |
2016-02-16 |
Arrien Pharmaceuticals Llc |
Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
|
|
MX369175B
(es)
|
2013-02-25 |
2019-10-30 |
Genentech Inc |
Métodos para detectar mutantes de akt resistentes a fármacos.
|
|
HUE044558T2
(hu)
|
2013-03-14 |
2019-11-28 |
Tolero Pharmaceuticals Inc |
JAK és ALK2 inhibitorok és eljárások alkalmazásukra
|
|
US9206188B2
(en)
|
2013-04-18 |
2015-12-08 |
Arrien Pharmaceuticals Llc |
Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors
|
|
AR096654A1
(es)
*
|
2013-06-20 |
2016-01-27 |
Ab Science |
Derivados de benzimidazol como inhibidores selectivos de proteína quinasa
|
|
WO2015051304A1
(en)
|
2013-10-04 |
2015-04-09 |
Aptose Biosciences Inc. |
Compositions, biomarkers and their use in treatment of cancer
|
|
UA115388C2
(uk)
|
2013-11-21 |
2017-10-25 |
Пфайзер Інк. |
2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань
|
|
EP4012049A3
(en)
|
2014-04-04 |
2022-08-24 |
Crown Bioscience, Inc. (Taicang) |
Methods for determining responsiveness to mek/erk inhibitors
|
|
WO2015155624A1
(en)
|
2014-04-10 |
2015-10-15 |
Pfizer Inc. |
Dihydropyrrolopyrimidine derivatives
|
|
PE20161436A1
(es)
|
2014-04-30 |
2017-01-08 |
Pfizer |
Derivados de diheterociclo enlazado a cicloalquilo
|
|
WO2016001789A1
(en)
|
2014-06-30 |
2016-01-07 |
Pfizer Inc. |
Pyrimidine derivatives as pi3k inhibitors for use in the treatment of cancer
|
|
WO2016008011A1
(en)
*
|
2014-07-16 |
2016-01-21 |
Novogen ltd |
Functionalised and substituted indoles as anti-cancer agents
|
|
EP3473271B1
(en)
|
2014-07-31 |
2022-07-20 |
The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services |
Human monoclonal antibodies against epha4 and their use
|
|
ES2746839T3
(es)
|
2014-12-18 |
2020-03-09 |
Pfizer |
Derivados de pirimidina y triazina y su uso como inhibidores de AXL
|
|
BR112017022666A8
(pt)
|
2015-04-20 |
2022-10-18 |
Tolero Pharmaceuticals Inc |
Preparando resposta à alvocidib por perfilamento mitocondrial
|
|
MX382566B
(es)
|
2015-05-01 |
2025-03-13 |
Univ Emory |
Analogos de nucleosidos para el tratamiento de la familia de virus flaviviridae y cancer
|
|
TR201911032T4
(tr)
|
2015-05-18 |
2019-08-21 |
Tolero Pharmaceuticals Inc |
Artırılmış biyoyararlanıma sahip alvocıdıb ön ilaçları.
|
|
WO2017009751A1
(en)
|
2015-07-15 |
2017-01-19 |
Pfizer Inc. |
Pyrimidine derivatives
|
|
JP7083497B2
(ja)
|
2015-08-03 |
2022-06-13 |
スミトモ ファーマ オンコロジー, インコーポレイテッド |
がんの処置のための併用療法
|
|
KR20180100125A
(ko)
|
2015-12-03 |
2018-09-07 |
아지오스 파마슈티컬스 아이엔씨. |
Mtap 널 암을 치료하기 위한 mat2a 억제제
|
|
BR112018012914B1
(pt)
|
2015-12-22 |
2023-04-18 |
SHY Therapeutics LLC |
Composto, uso de um composto e composição farmacêutica
|
|
AU2017231781C1
(en)
*
|
2016-03-11 |
2021-12-16 |
Ac Immune Sa |
Bicyclic compounds for diagnosis and therapy
|
|
CN107652273B
(zh)
*
|
2016-07-26 |
2020-05-01 |
沈阳药科大学 |
嘧啶类衍生物及其制备方法和应用
|
|
US11279694B2
(en)
|
2016-11-18 |
2022-03-22 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Alvocidib prodrugs and their use as protein kinase inhibitors
|
|
CN110234659A
(zh)
|
2016-12-19 |
2019-09-13 |
特雷罗药物股份有限公司 |
用于敏感性分析的分析肽和方法
|
|
AU2018288841B2
(en)
|
2017-06-21 |
2022-09-29 |
SHY Therapeutics LLC |
Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, Rasopathies, and fibrotic disease
|
|
US11497756B2
(en)
|
2017-09-12 |
2022-11-15 |
Sumitomo Pharma Oncology, Inc. |
Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib
|
|
WO2019075367A1
(en)
|
2017-10-13 |
2019-04-18 |
Tolero Pharmaceuticals, Inc. |
PKM2 ACTIVATORS IN COMBINATION WITH OXYGEN REACTIVE SPECIES FOR THE TREATMENT OF CANCER
|
|
MX2021000977A
(es)
|
2018-07-26 |
2021-04-12 |
Sumitomo Pharma Oncology Inc |
Metodos para tratar enfermedades asociadas con expresion anormal de receptor de activina a tipo 1 (acvr1) e inhibidores de acvr1 para uso en los mismos.
|
|
WO2020106825A1
(en)
*
|
2018-11-20 |
2020-05-28 |
Georgetown University |
Compositions and methods for treating neurodegenerative, myodegenerative, and lysosomal storage disorders
|
|
KR20210099066A
(ko)
|
2018-12-04 |
2021-08-11 |
스미토모 다이니폰 파마 온콜로지, 인크. |
암의 치료를 위한 작용제로서 사용하기 위한 cdk9 억제제 및 그의 다형체
|
|
WO2020132071A1
(en)
|
2018-12-19 |
2020-06-25 |
Shy Therapeutics. Llc |
Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and f1brotic disease
|
|
ES2974634T3
(es)
|
2018-12-21 |
2024-06-28 |
Celgene Corp |
Inhibidores de tienopiridinas de RIPK2
|
|
JP7662528B2
(ja)
|
2019-02-12 |
2025-04-15 |
スミトモ ファーマ アメリカ, インコーポレイテッド |
複素環式タンパク質キナーゼ阻害剤を含む製剤
|
|
US12398140B2
(en)
|
2019-02-13 |
2025-08-26 |
Ptc Therapeutics, Inc. |
Substituted pyrrolo [2,3-d]pyrimidines for treating familial dysautonomia
|
|
EP3924049A1
(en)
|
2019-02-13 |
2021-12-22 |
PTC Therapeutics, Inc. |
Thioeno[3,2-b] pyridin-7-amine compounds for treating familial dysautonomia
|
|
CN113195469B
(zh)
*
|
2019-02-19 |
2024-05-24 |
四川科伦博泰生物医药股份有限公司 |
含氮并环化合物、其制备方法及用途
|
|
WO2020180768A1
(en)
*
|
2019-03-01 |
2020-09-10 |
Revolution Medicines, Inc. |
Bicyclic heteroaryl compounds and uses thereof
|
|
US11793802B2
(en)
|
2019-03-20 |
2023-10-24 |
Sumitomo Pharma Oncology, Inc. |
Treatment of acute myeloid leukemia (AML) with venetoclax failure
|
|
JP7547360B2
(ja)
|
2019-03-22 |
2024-09-09 |
スミトモ ファーマ オンコロジー, インコーポレイテッド |
Pkm2モジュレーターを含む組成物およびそれを使用する処置の方法
|
|
CN114269753B
(zh)
*
|
2019-09-29 |
2024-03-05 |
四川科伦博泰生物医药股份有限公司 |
一种含氮并环类化合物,包含其的药物组合物,其制备方法及其用途
|
|
JP2023506488A
(ja)
*
|
2019-12-12 |
2023-02-16 |
ピーティーシー セラピューティクス, インコーポレイテッド |
家族性自律神経失調症を処置するための化合物
|
|
WO2021155006A1
(en)
|
2020-01-31 |
2021-08-05 |
Les Laboratoires Servier Sas |
Inhibitors of cyclin-dependent kinases and uses thereof
|
|
CN115746017B
(zh)
*
|
2022-11-30 |
2024-06-07 |
英维沃化工科技(广州)有限公司 |
一种噻吩并嘧啶类化合物及其制备方法和应用
|