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HUE039900T2 - Gyógyszerek humán fejlõdésre gyakorolt toxicitásának elõrejelzése humán õssejtszerû sejtek és metabolomika alkalmazásával - Google Patents

Gyógyszerek humán fejlõdésre gyakorolt toxicitásának elõrejelzése humán õssejtszerû sejtek és metabolomika alkalmazásával

Info

Publication number
HUE039900T2
HUE039900T2 HUE11760090A HUE11760090A HUE039900T2 HU E039900 T2 HUE039900 T2 HU E039900T2 HU E11760090 A HUE11760090 A HU E11760090A HU E11760090 A HUE11760090 A HU E11760090A HU E039900 T2 HUE039900 T2 HU E039900T2
Authority
HU
Hungary
Prior art keywords
human
metabolomics
pharmaceuticals
cells
predicting
Prior art date
Application number
HUE11760090A
Other languages
English (en)
Inventor
Paul West
April Weir
Alan Smith
Elizabeth Donley
Gabriela Cezar
Original Assignee
Stemina Biomarker Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stemina Biomarker Discovery Inc filed Critical Stemina Biomarker Discovery Inc
Publication of HUE039900T2 publication Critical patent/HUE039900T2/hu

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
HUE11760090A 2010-03-22 2011-03-22 Gyógyszerek humán fejlõdésre gyakorolt toxicitásának elõrejelzése humán õssejtszerû sejtek és metabolomika alkalmazásával HUE039900T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31616510P 2010-03-22 2010-03-22
US39442610P 2010-10-19 2010-10-19

Publications (1)

Publication Number Publication Date
HUE039900T2 true HUE039900T2 (hu) 2019-02-28

Family

ID=44673582

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE11760090A HUE039900T2 (hu) 2010-03-22 2011-03-22 Gyógyszerek humán fejlõdésre gyakorolt toxicitásának elõrejelzése humán õssejtszerû sejtek és metabolomika alkalmazásával

Country Status (8)

Country Link
US (2) US8703424B2 (hu)
EP (1) EP2550365B1 (hu)
JP (2) JP5814337B2 (hu)
AU (1) AU2011232577C1 (hu)
CA (1) CA2793216C (hu)
DK (1) DK2550365T3 (hu)
HU (1) HUE039900T2 (hu)
WO (1) WO2011119637A1 (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011232577C1 (en) * 2010-03-22 2016-07-14 Stemina Biomarker Discovery, Inc. Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomics
US20150133340A1 (en) * 2012-03-07 2015-05-14 Hoffmann-La Roche Inc. Method of determining teratogenic risk
JP6339581B2 (ja) * 2012-11-02 2018-06-06 ステミナ バイオマーカー ディスカバリー， インコーポレイテッド ヒト幹様細胞およびメタボロミック比率を使用した医薬品のヒト発達毒性の予測
US20160103949A1 (en) * 2013-05-28 2016-04-14 Five3 Genomics, Llc Paradigm drug response networks
EP3019624B1 (en) * 2013-07-09 2020-09-16 Stemina Biomarker Discovery, Inc. Biomarkers of autism spectrum disorder
CN107923888A (zh) * 2015-05-29 2018-04-17 沃特世科技公司 代谢途径和代谢物鉴定
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
CN109839498A (zh) * 2017-11-27 2019-06-04 中国科学院大连化学物理研究所 一种pm2.5颗粒对人肺细胞内自由基代谢通路影响的评估方法
CN108254467B (zh) * 2018-01-22 2020-11-03 岛津企业管理（中国）有限公司 一种肺炎多糖疫苗水解液中戊糖、己糖、氨基糖和糖醛酸的含量测定方法
US20210072230A1 (en) * 2018-03-09 2021-03-11 Stemina Biomarker Discovery, Inc. In vitro assay to predict cardiotoxicity
WO2020083486A1 (en) * 2018-10-24 2020-04-30 Universität Heidelberg Phenotypic profiling by mass spectrometry and machine learning
WO2020142035A1 (en) * 2018-12-31 2020-07-09 Istanbul Sehir University Disease diagnosis system
US20220246231A1 (en) * 2019-07-09 2022-08-04 Shimadzu Corporation Method for constructing model for predicting differentiation efficiency of ips cell and method for predicting differentiation efficiency of ips cell
US20220146527A1 (en) * 2019-09-17 2022-05-12 Chang Gung University Method of creating characteristic profiles of mass spectra and identification model for analyzing and identifying features of microorganisms
CN113136411A (zh) * 2020-01-17 2021-07-20 奥维嘉生物科技（北京）有限公司 使用人体干细胞的评估方法、药物评估方法及检测试剂盒
WO2024248145A1 (ja) 2023-06-01 2024-12-05 富士フイルム株式会社 情報処理装置、情報処理方法、及びプログラム

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
DE19525285C2 (de) 1995-06-28 1999-04-15 Inst Pflanzengenetik & Kultur In vitro Testverfahren zum Nachweis Chemikalien-induzierter embryotoxischer/teratogener Effekte
DE69903800T2 (de) 1998-03-18 2003-10-02 Massachusetts Institute Of Technology, Cambridge Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
IL151170A0 (en) * 2000-03-14 2003-04-10 Es Cell Int Pte Ltd Embryonic stem cells and neural progenitor cells derived therefrom
EP1299398A1 (en) * 2000-07-06 2003-04-09 Fal Diagnostics Methods and kits for the detection of arginine compounds
US6680203B2 (en) 2000-07-10 2004-01-20 Esperion Therapeutics, Inc. Fourier transform mass spectrometry of complex biological samples
EP1176189A1 (en) 2000-07-21 2002-01-30 Fornix Biosciences N.V. Stem cell-like cells
EE200300343A (et) 2001-01-19 2003-10-15 Omnigene Bioproducts Inc. Pantoteenhappe võimendatud produktsiooni meetod
EP1362911A4 (en) 2001-02-23 2005-01-05 Mitsubishi Chem Corp ENZYMGEN OF THE MEDICAMENT METABOLISM TRANSGENIC ANIMAL AND USE THEREOF
AU2002320316A1 (en) 2001-07-06 2003-01-21 Lipomics Technologies, Inc. Generating, viewing, interpreting, and utilizing a quantitative database of metabolites
WO2003018760A2 (en) 2001-08-24 2003-03-06 Advanced Cell Technology, Inc. Screening assays for identifying differentiation-inducing agents and production of differentiated cells for cell therapy
US20040121305A1 (en) 2002-12-18 2004-06-24 Wiegand Roger Charles Generation of efficacy, toxicity and disease signatures and methods of use thereof
CA2511501A1 (en) 2002-12-24 2004-07-15 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US8843356B2 (en) * 2002-12-27 2014-09-23 Merck Sharp & Dohme Corp. Computer systems and methods for associating genes with traits using cross species data
EP1589814B1 (en) 2003-01-16 2009-08-12 The General Hospital Corporation Use of three-dimensional microfabricated tissue engineered systems for pharmacologic applications
WO2005005662A2 (en) 2003-07-08 2005-01-20 Axiogenesis Ag Secreted proteins as markers for cell differentiation
AU2004256209B2 (en) 2003-07-08 2010-04-08 Axiogenesis Ag Novel method for the preparation of embryoid bodies (EBs) and uses thereof
US7590837B2 (en) 2003-08-23 2009-09-15 Softex Incorporated Electronic device security and tracking system and method
WO2005080551A2 (en) 2004-02-12 2005-09-01 University Of Newcastle Upon Tyne Stem cells
GB0504096D0 (en) 2005-02-28 2005-04-06 Tipogen As Method
WO2006112841A1 (en) 2005-04-19 2006-10-26 The Scripps Research Institute Methods for metabolite profiling
US7604948B2 (en) 2005-05-05 2009-10-20 The Regents Of The University Of California Biomarkers for diagnosing an autism spectrum disorder
AU2007224240B2 (en) * 2006-03-02 2013-07-25 Revvity Health Sciences, Inc. Methods for distinguishing isomers using mass spectrometry
BRPI0710054B8 (pt) 2006-04-10 2021-07-27 Wisconsin Alumni Res Found métodos para identificar um ou uma pluralidade de metabólitos celulares, para triar um composto de teste, e, para testar um composto de teste
WO2008140463A2 (en) 2006-06-12 2008-11-20 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Biomarker panels for assessing radiation injury and exposure
EP2052255A2 (en) 2006-08-18 2009-04-29 Huntington Medical Research Institutes Methods of determining levels of free amino acids and dipeptides and diagnosing alzheimer's diseases
US20120132313A1 (en) 2006-08-25 2012-05-31 Anubha Bhatla Systems and methods for cutting materials
CA2675997A1 (en) 2007-02-05 2008-08-14 Wisconsin Alumni Research Foundation Biomarkers of ionizing radiation response
US20090220996A1 (en) 2007-03-06 2009-09-03 Reliance Life Sciences Pvt Ltd. In vitro Assay Methods for Classifying Embryotoxicity of Compounds
JP2009136181A (ja) * 2007-12-05 2009-06-25 Dainippon Sumitomo Pharma Co Ltd 物質が有する催奇形性誘発活性の検定方法
EP2279417B1 (en) 2008-05-28 2016-07-20 Georgia Tech Research Corporation Metabolic biomarkers for ovarian cancer and methods of use thereof
AU2009254181A1 (en) * 2008-06-04 2009-12-10 Proteosys Ag Protein biomarkers for in vitro testing of developmental toxicity and embryotoxicity of chemical substances
JP5204600B2 (ja) * 2008-09-24 2013-06-05 住友化学株式会社 催奇形性の予測方法
AU2011232577C1 (en) * 2010-03-22 2016-07-14 Stemina Biomarker Discovery, Inc. Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomics

Also Published As

Publication number Publication date
JP2013522649A (ja) 2013-06-13
CA2793216C (en) 2020-01-07
WO2011119637A1 (en) 2011-09-29
US20140273069A1 (en) 2014-09-18
US8703424B2 (en) 2014-04-22
AU2011232577A1 (en) 2012-10-18
DK2550365T3 (en) 2018-09-10
US10473641B2 (en) 2019-11-12
JP2016032470A (ja) 2016-03-10
WO2011119637A9 (en) 2015-12-10
JP6254561B2 (ja) 2017-12-27
EP2550365B1 (en) 2018-07-04
AU2011232577B2 (en) 2016-01-14
US20110312019A1 (en) 2011-12-22
JP5814337B2 (ja) 2015-11-17
EP2550365A4 (en) 2013-09-04
CA2793216A1 (en) 2011-09-29
EP2550365A1 (en) 2013-01-30
AU2011232577C1 (en) 2016-07-14

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