HUE067109T2 - Eljárás egyszeresen védett bifunkciós prodrugok elõállítására, az ezeken alapuló antitest hatóanyag konjugátumok, valamint eljárás az antitest hatóanyag konjugátumok elõállítására - Google Patents
Eljárás egyszeresen védett bifunkciós prodrugok elõállítására, az ezeken alapuló antitest hatóanyag konjugátumok, valamint eljárás az antitest hatóanyag konjugátumok elõállításáraInfo
- Publication number
- HUE067109T2 HUE067109T2 HUE17185977A HUE17185977A HUE067109T2 HU E067109 T2 HUE067109 T2 HU E067109T2 HU E17185977 A HUE17185977 A HU E17185977A HU E17185977 A HUE17185977 A HU E17185977A HU E067109 T2 HUE067109 T2 HU E067109T2
- Authority
- HU
- Hungary
- Prior art keywords
- drug conjugates
- antibody drug
- synthesis
- well
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Saccharide Compounds (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17185977.0A EP3441386B1 (en) | 2017-08-11 | 2017-08-11 | Method for the synthesis of monoprotected bifunctional prodrugs and antibody drug conjugates based thereon as well as a method for preparing antibody drug conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE067109T2 true HUE067109T2 (hu) | 2024-09-28 |
Family
ID=59677027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE17185977A HUE067109T2 (hu) | 2017-08-11 | 2017-08-11 | Eljárás egyszeresen védett bifunkciós prodrugok elõállítására, az ezeken alapuló antitest hatóanyag konjugátumok, valamint eljárás az antitest hatóanyag konjugátumok elõállítására |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US11325888B2 (hu) |
| EP (1) | EP3441386B1 (hu) |
| JP (1) | JP7388717B2 (hu) |
| KR (1) | KR20200039622A (hu) |
| CN (1) | CN110691774A (hu) |
| AU (1) | AU2018315424B2 (hu) |
| DK (1) | DK3441386T3 (hu) |
| ES (1) | ES2983006T3 (hu) |
| FI (1) | FI3441386T3 (hu) |
| HR (1) | HRP20240891T1 (hu) |
| HU (1) | HUE067109T2 (hu) |
| LT (1) | LT3441386T (hu) |
| PL (1) | PL3441386T3 (hu) |
| PT (1) | PT3441386T (hu) |
| RS (1) | RS65726B1 (hu) |
| SI (1) | SI3441386T1 (hu) |
| WO (1) | WO2019030367A1 (hu) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB202306325D0 (en) * | 2023-04-28 | 2023-06-14 | Iksuda Therapeutics Ltd | Antibody-drug conjugate compounds, and methods of use and treatment |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8680293B2 (en) | 2007-08-01 | 2014-03-25 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
| US10442836B2 (en) * | 2013-08-12 | 2019-10-15 | Genentech, Inc. | 1-(chloromethyl)-2,3-dihydro-1H-benzo[E]indole dimer antibody-drug conjugate compounds, and methods of use and treatment |
| JP6980384B2 (ja) * | 2013-12-16 | 2021-12-15 | ジェネンテック， インコーポレイテッド | １−（クロロメチル）−２，３−ジヒドロ−１ｈ−ベンゾ［ｅ］インドール二量体抗体−薬物コンジュゲート化合物、並びに使用及び処置の方法 |
| PE20170935A1 (es) * | 2014-09-12 | 2017-07-13 | Genentech Inc | Anticuerpos anti-her2 e inmunoconjugados |
| DE102016105449A1 (de) | 2015-10-29 | 2017-05-04 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts | Bifunktionale Prodrugs |
-
2017
- 2017-08-11 HU HUE17185977A patent/HUE067109T2/hu unknown
- 2017-08-11 PL PL17185977.0T patent/PL3441386T3/pl unknown
- 2017-08-11 SI SI201731533T patent/SI3441386T1/sl unknown
- 2017-08-11 RS RS20240775A patent/RS65726B1/sr unknown
- 2017-08-11 DK DK17185977.0T patent/DK3441386T3/da active
- 2017-08-11 HR HRP20240891TT patent/HRP20240891T1/hr unknown
- 2017-08-11 ES ES17185977T patent/ES2983006T3/es active Active
- 2017-08-11 FI FIEP17185977.0T patent/FI3441386T3/fi active
- 2017-08-11 EP EP17185977.0A patent/EP3441386B1/en active Active
- 2017-08-11 LT LTEP17185977.0T patent/LT3441386T/lt unknown
- 2017-08-11 PT PT171859770T patent/PT3441386T/pt unknown
-
2018
- 2018-08-10 CN CN201880036652.7A patent/CN110691774A/zh active Pending
- 2018-08-10 US US16/638,289 patent/US11325888B2/en active Active
- 2018-08-10 WO PCT/EP2018/071718 patent/WO2019030367A1/en not_active Ceased
- 2018-08-10 KR KR1020197038198A patent/KR20200039622A/ko not_active Abandoned
- 2018-08-10 JP JP2020506261A patent/JP7388717B2/ja active Active
- 2018-08-10 AU AU2018315424A patent/AU2018315424B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3441386A1 (en) | 2019-02-13 |
| US20200172484A1 (en) | 2020-06-04 |
| HRP20240891T1 (hr) | 2024-10-11 |
| EP3441386B1 (en) | 2024-04-17 |
| SI3441386T1 (sl) | 2024-10-30 |
| PT3441386T (pt) | 2024-07-04 |
| DK3441386T3 (da) | 2024-07-15 |
| KR20200039622A (ko) | 2020-04-16 |
| WO2019030367A8 (en) | 2019-12-19 |
| US11325888B2 (en) | 2022-05-10 |
| JP7388717B2 (ja) | 2023-11-29 |
| WO2019030367A1 (en) | 2019-02-14 |
| PL3441386T3 (pl) | 2024-10-07 |
| LT3441386T (lt) | 2024-08-12 |
| CN110691774A (zh) | 2020-01-14 |
| AU2018315424A1 (en) | 2019-11-28 |
| ES2983006T3 (es) | 2024-10-21 |
| JP2020529446A (ja) | 2020-10-08 |
| FI3441386T3 (fi) | 2024-07-01 |
| RS65726B1 (sr) | 2024-08-30 |
| AU2018315424B2 (en) | 2022-03-17 |
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