HUE058263T2 - Mutációk detektálása rákszûrési és magzatelemzési célból - Google Patents
Mutációk detektálása rákszûrési és magzatelemzési célbólInfo
- Publication number
- HUE058263T2 HUE058263T2 HUE16748745A HUE16748745A HUE058263T2 HU E058263 T2 HUE058263 T2 HU E058263T2 HU E16748745 A HUE16748745 A HU E16748745A HU E16748745 A HUE16748745 A HU E16748745A HU E058263 T2 HUE058263 T2 HU E058263T2
- Authority
- HU
- Hungary
- Prior art keywords
- cancer screening
- detecting mutations
- fetal analysis
- fetal
- analysis
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/50—Mutagenesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medical Informatics (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562114471P | 2015-02-10 | 2015-02-10 | |
| US201562271196P | 2015-12-22 | 2015-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE058263T2 true HUE058263T2 (hu) | 2022-07-28 |
Family
ID=56615337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE16748745A HUE058263T2 (hu) | 2015-02-10 | 2016-02-14 | Mutációk detektálása rákszûrési és magzatelemzési célból |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10240209B2 (hu) |
| EP (2) | EP4012715B1 (hu) |
| JP (3) | JP6829211B2 (hu) |
| KR (1) | KR20170125044A (hu) |
| CN (2) | CN107771221B (hu) |
| AU (2) | AU2016218631B2 (hu) |
| CA (1) | CA2976303A1 (hu) |
| DK (1) | DK3256605T3 (hu) |
| ES (1) | ES2908347T3 (hu) |
| HU (1) | HUE058263T2 (hu) |
| PT (1) | PT3256605T (hu) |
| SG (1) | SG11201706529TA (hu) |
| TW (3) | TWI740817B (hu) |
| WO (1) | WO2016127944A1 (hu) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI335354B (en) | 2006-09-27 | 2011-01-01 | Univ Hong Kong Chinese | Methods for the detection of the degree of the methylation of a target dna and kits |
| WO2012129363A2 (en) | 2011-03-24 | 2012-09-27 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| EP4424826A3 (en) | 2012-09-04 | 2024-11-27 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| WO2014093330A1 (en) | 2012-12-10 | 2014-06-19 | Clearfork Bioscience, Inc. | Methods for targeted genomic analysis |
| SG11201604923XA (en) | 2013-12-28 | 2016-07-28 | Guardant Health Inc | Methods and systems for detecting genetic variants |
| WO2016008451A1 (en) | 2014-07-18 | 2016-01-21 | The Chinese University Of Hong Kong | Methylation pattern analysis of tissues in dna mixture |
| KR102696857B1 (ko) | 2014-07-25 | 2024-08-19 | 유니버시티 오브 워싱톤 | 무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법 |
| US20160053301A1 (en) | 2014-08-22 | 2016-02-25 | Clearfork Bioscience, Inc. | Methods for quantitative genetic analysis of cell free dna |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| ES2908347T3 (es) | 2015-02-10 | 2022-04-28 | Univ Hong Kong Chinese | Detección de mutaciones para cribado de cáncer y análisis fetal |
| PT3967775T (pt) | 2015-07-23 | 2023-10-10 | Univ Hong Kong Chinese | Análise de padrões de fragmentação de adn sem células |
| IL285202B2 (en) | 2015-11-11 | 2025-03-01 | Resolution Bioscience Inc | High-efficiency construction of DNA libraries |
| JP2019507585A (ja) | 2015-12-17 | 2019-03-22 | ガーダント ヘルス， インコーポレイテッド | 無細胞ｄｎａの分析による腫瘍遺伝子コピー数を決定するための方法 |
| US11514289B1 (en) | 2016-03-09 | 2022-11-29 | Freenome Holdings, Inc. | Generating machine learning models using genetic data |
| EP3427183A1 (en) * | 2016-03-10 | 2019-01-16 | Genomic Vision | Method of curvilinear signal detection and analysis and associated platform |
| EP3497220A4 (en) | 2016-08-10 | 2020-04-01 | Grail, Inc. | METHODS OF PREPARING DOUBLE-INDEXING DNA LIBRARIES FOR BISULPHITE CONVERSION SEQUENCING |
| MX2019002093A (es) | 2016-08-25 | 2019-06-20 | Resolution Bioscience Inc | Métodos para la detección de cambios de copia genómica en muestras de adn. |
| KR20240155386A (ko) | 2016-09-30 | 2024-10-28 | 가던트 헬쓰, 인크. | 무세포 핵산의 다중-해상도 분석 방법 |
| US9850523B1 (en) | 2016-09-30 | 2017-12-26 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
| EP3535415A4 (en) | 2016-10-24 | 2020-07-01 | The Chinese University of Hong Kong | TUMOR DETECTION METHODS AND SYSTEMS |
| AU2017369018B2 (en) | 2016-11-30 | 2021-02-25 | The Chinese University Of Hong Kong | Analysis of cell-free DNA in urine and other samples |
| WO2018119216A1 (en) * | 2016-12-21 | 2018-06-28 | The Regents Of The University Of California | Deconvolution and detection of rare dna in plasma |
| WO2018137685A1 (en) | 2017-01-25 | 2018-08-02 | The Chinese University Of Hong Kong | Diagnostic applications using nucleic acid fragments |
| EP3366780B1 (en) | 2017-02-23 | 2020-05-06 | Siemens Healthcare GmbH | Single-molecule sequence and high sensitivity methylation analysis for tissue-specific analysis |
| IT201700045353A1 (it) * | 2017-04-26 | 2018-10-26 | Bioscience Services S R L | Metodo per la ricerca e l'individuazione di una condizione genetica prodromica all'insorgenza di tumori solidi |
| WO2018213498A1 (en) * | 2017-05-16 | 2018-11-22 | Guardant Health, Inc. | Identification of somatic or germline origin for cell-free dna |
| US10081829B1 (en) | 2017-06-13 | 2018-09-25 | Genetics Research, Llc | Detection of targeted sequence regions |
| US10636512B2 (en) | 2017-07-14 | 2020-04-28 | Cofactor Genomics, Inc. | Immuno-oncology applications using next generation sequencing |
| EP3431610A1 (en) * | 2017-07-19 | 2019-01-23 | Noscendo GmbH | Methods and devices for nucleic acid-based real-time determination of disease states |
| CN111051536A (zh) | 2017-07-26 | 2020-04-21 | 香港中文大学 | 利用不含细胞的病毒核酸改善癌症筛选 |
| US20190108311A1 (en) * | 2017-10-06 | 2019-04-11 | Grail, Inc. | Site-specific noise model for targeted sequencing |
| JP7421474B2 (ja) | 2017-11-03 | 2024-01-24 | ガーダント ヘルス， インコーポレイテッド | 腫瘍遺伝子変異量の正規化 |
| US12367978B2 (en) | 2017-12-01 | 2025-07-22 | Illumina, Inc. | Methods and systems for determining somatic mutation clonality |
| SG11202006542XA (en) * | 2018-01-12 | 2020-08-28 | Grail Inc | Methods for analyzing viral nucleic acid |
| CN119753091A (zh) | 2018-04-02 | 2025-04-04 | 格里尔公司 | 用于扩增与癌症相关联的cfDNA分子的化验板 |
| US20210158895A1 (en) * | 2018-04-13 | 2021-05-27 | Dana-Farber Cancer Institute, Inc. | Ultra-sensitive detection of cancer by algorithmic analysis |
| US20210104297A1 (en) * | 2018-04-16 | 2021-04-08 | Grail, Inc. | Systems and methods for determining tumor fraction in cell-free nucleic acid |
| EP3784806A4 (en) * | 2018-04-24 | 2022-01-19 | Grail, LLC | SYSTEMS AND METHODS OF USING A PATHOGENIC NUCLEIC ACID LOAD TO DETERMINE IF A SUBJECT HAS A CANCER CONDITION |
| CN108900319B (zh) * | 2018-05-30 | 2021-05-25 | 北京百度网讯科技有限公司 | 故障检测方法和装置 |
| CN112752854B (zh) * | 2018-07-23 | 2025-03-18 | 夸登特健康公司 | 用于通过肿瘤分数和覆盖率调整肿瘤突变负荷的方法和系统 |
| WO2020023671A1 (en) * | 2018-07-24 | 2020-01-30 | Protocol Intelligence, Inc. | Methods and systems for treating cancer and predicting and optimizing treatment outcomes in individual cancer patients |
| CA3106820A1 (en) * | 2018-07-26 | 2020-01-30 | Lexent Bio, Inc. | Multiple sequencing using a single flow cell |
| CN109022619A (zh) * | 2018-08-27 | 2018-12-18 | 郑州安图生物工程股份有限公司 | 一种用于检测人类疱疹病毒4型的试剂盒 |
| EP3856903A4 (en) | 2018-09-27 | 2022-07-27 | Grail, LLC | METHYLATION MARKER AND TARGETED METHYLATION PROBE PANEL |
| CN113168885B (zh) * | 2018-11-13 | 2024-07-16 | 麦利亚德基因公司 | 用于体细胞突变的方法和系统及其用途 |
| CA3123474A1 (en) * | 2018-12-19 | 2020-06-25 | The Chinese University Of Hong Kong | Cell-free dna end characteristics |
| ES3013495T3 (en) | 2019-01-31 | 2025-04-14 | Guardant Health Inc | Method for isolating and sequencing cell-free dna |
| CN109841265B (zh) * | 2019-02-22 | 2021-09-21 | 清华大学 | 使用片段化模式确定血浆游离核酸分子组织来源的方法和系统及应用 |
| US12497662B2 (en) | 2019-04-16 | 2025-12-16 | Grail, Inc. | Systems and methods for tumor fraction estimation from small variants |
| WO2020236941A1 (en) * | 2019-05-20 | 2020-11-26 | Foundation Medicine, Inc. | Systems and methods for evaluating tumor fraction |
| KR20220013349A (ko) * | 2019-06-03 | 2022-02-04 | 일루미나, 인코포레이티드 | 검출 한계 기반 품질 제어 메트릭 |
| AU2020297585A1 (en) * | 2019-06-21 | 2022-01-20 | Coopersurgical, Inc. | Systems and methods for using density of single nucleotide variations for the verification of copy number variations in human embryos |
| US20210065842A1 (en) * | 2019-07-23 | 2021-03-04 | Grail, Inc. | Systems and methods for determining tumor fraction |
| JP2022544626A (ja) * | 2019-08-19 | 2022-10-19 | グリーン クロス ゲノム コーポレーション | 核酸断片間距離情報を用いた染色体異常検出方法 |
| KR102835853B1 (ko) * | 2019-10-08 | 2025-07-17 | 일루미나, 인코포레이티드 | 클론성 조혈증으로부터의 세포 유리 dna 돌연변이의 단편 크기 특성화 |
| WO2021137770A1 (en) * | 2019-12-30 | 2021-07-08 | Geneton S.R.O. | Method for fetal fraction estimation based on detection and interpretation of single nucleotide variants |
| JP2023510318A (ja) * | 2020-01-08 | 2023-03-13 | ザ チャイニーズ ユニバーシティ オブ ホンコン | 無細胞試料の二末端ｄｎａ断片タイプおよびその用途 |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US20220177971A1 (en) * | 2020-12-08 | 2022-06-09 | The Chinese University Of Hong Kong | Methods using characteristics of urinary and other dna |
| CN113628683B (zh) * | 2021-08-24 | 2024-04-09 | 慧算医疗科技（上海）有限公司 | 一种高通量测序突变检测方法、设备、装置及可读存储介质 |
| US20230207128A1 (en) * | 2021-12-29 | 2023-06-29 | AiOnco, Inc. | Processing encrypted data for artificial intelligence-based analysis |
| CN114582429B (zh) * | 2022-03-03 | 2023-06-13 | 四川大学 | 基于层次注意力神经网络的结核分枝杆菌耐药性预测方法及装置 |
| KR102491322B1 (ko) * | 2022-03-29 | 2023-01-27 | 주식회사 아이엠비디엑스 | 암 진단을 위한 다중 분석 예측 모델의 제조 방법 |
| EP4526481A2 (en) * | 2022-05-19 | 2025-03-26 | Personalis, Inc. | Methods and system for using methylation data for disease detection and quantification |
| CN115394358B (zh) * | 2022-08-31 | 2023-05-12 | 西安理工大学 | 基于深度学习的单细胞测序基因表达数据插补方法和系统 |
| EP4567818A4 (en) * | 2022-09-09 | 2025-12-17 | Nanjing Genscript Biotech Co Ltd | METHOD FOR DESIGNING A SEQUENCE OF HUMANIZED ANTIBODY |
| CN115424666B (zh) * | 2022-09-13 | 2023-07-11 | 江苏先声医学诊断有限公司 | 一种基于全基因组重亚硫酸盐测序数据筛选泛癌早筛分子标志物的方法及系统 |
| JP7736309B2 (ja) * | 2022-11-18 | 2025-09-09 | 株式会社ニューギン | 遊技機 |
| JP7736308B2 (ja) * | 2022-11-18 | 2025-09-09 | 株式会社ニューギン | 遊技機 |
| JP7736307B2 (ja) * | 2022-11-18 | 2025-09-09 | 株式会社ニューギン | 遊技機 |
| JP7736310B2 (ja) * | 2022-11-18 | 2025-09-09 | 株式会社ニューギン | 遊技機 |
| US20240229149A1 (en) * | 2023-01-09 | 2024-07-11 | Clearnote Health, Inc. | 5-HYDROXYMETHYLATION ANALYSIS OF BUFFY COAT gDNA IN CANCER DETECTION |
| WO2025054456A1 (en) * | 2023-09-08 | 2025-03-13 | Ellison Institute, Llc | Methods of determining variability in molecular alterations |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1169347B1 (en) | 1999-04-02 | 2008-07-02 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
| US20030219765A1 (en) | 2000-03-23 | 2003-11-27 | Jose Costa | Methods for evaluating cancer risk |
| WO2003062441A1 (en) | 2002-01-18 | 2003-07-31 | Genzyme Corporation | Methods for fetal dna detection and allele quantitation |
| US7704687B2 (en) | 2002-11-15 | 2010-04-27 | The Johns Hopkins University | Digital karyotyping |
| AU2004217872B2 (en) | 2003-03-05 | 2010-03-25 | Genetic Technologies Limited | Identification of fetal DNA and fetal cell markers in maternal plasma or serum |
| PL201608B1 (pl) | 2003-06-13 | 2009-04-30 | Cezary Cybulski | Sposób i zestaw do wykrywania wysokiej genetycznie uwarunkowanej predyspozycji do raka prostaty oraz zastosowanie zmiany germinalnej w obrębie genu NBS1 |
| DE60328193D1 (de) | 2003-10-16 | 2009-08-13 | Sequenom Inc | Nicht invasiver Nachweis fötaler genetischer Merkmale |
| CA2562310A1 (en) | 2004-04-30 | 2005-11-17 | Yale University | Methods and compositions for cancer diagnosis |
| US20070122823A1 (en) | 2005-09-01 | 2007-05-31 | Bianchi Diana W | Amniotic fluid cell-free fetal DNA fragment size pattern for prenatal diagnosis |
| EP2385143B1 (en) | 2006-02-02 | 2016-07-13 | The Board of Trustees of the Leland Stanford Junior University | Non-invasive fetal genetic screening by digital analysis |
| SI2351858T1 (sl) | 2006-02-28 | 2015-06-30 | University Of Louisville Research Foundation Med Center Three, | Zaznavanje fetalnih kromosomskih nenormalnosti z uporabo tandema polimorfizmov posameznih nukleotidov |
| EA010571B1 (ru) | 2006-08-15 | 2008-10-30 | Институт Молекулярной Генетики Российской Академии Наук (Имг Ран) | Способ диагностики немелкоклеточного рака легких и набор для его осуществления |
| US8580501B2 (en) | 2007-05-25 | 2013-11-12 | Decode Genetics Ehf. | Genetic variants on chr 5p12 and 10q26 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment |
| CN106834481A (zh) | 2007-07-23 | 2017-06-13 | 香港中文大学 | 用于分析遗传变异的方法 |
| US20090053719A1 (en) | 2007-08-03 | 2009-02-26 | The Chinese University Of Hong Kong | Analysis of nucleic acids by digital pcr |
| US20100041048A1 (en) | 2008-07-31 | 2010-02-18 | The Johns Hopkins University | Circulating Mutant DNA to Assess Tumor Dynamics |
| ES2620294T3 (es) | 2008-09-20 | 2017-06-28 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnóstico no invasivo de la aneuploidia fetal por secuenciación |
| US20100136560A1 (en) | 2008-12-02 | 2010-06-03 | The Johns Hopkins University | Integrated Analyses of Breast and Colorectal Cancers |
| US20120021428A1 (en) | 2009-03-31 | 2012-01-26 | Marcus Otte | Method for diagnosis of cancer and monitoring of cancer treatments |
| WO2011038507A1 (en) | 2009-10-02 | 2011-04-07 | Centre For Addiction And Mental Health | Method for analysis of dna methylation profiles of cell-free circulating dna in bodily fluids |
| WO2011053790A2 (en) | 2009-10-30 | 2011-05-05 | Fluidigm Corporation | Assay of closely linked targets in fetal diagnosis and coincidence detection assay for genetic analysis |
| EP2496717B1 (en) | 2009-11-05 | 2017-06-07 | The Chinese University of Hong Kong | Fetal genomic analysis from a maternal biological sample |
| ES3026544T3 (en) | 2009-11-06 | 2025-06-11 | Univ Hong Kong Chinese | Size-based genomic analysis for prenatal diagnosis |
| GB0922006D0 (en) | 2009-12-17 | 2010-02-03 | Genome Res Ltd | Diagnostic |
| AU2010343276B2 (en) | 2010-01-19 | 2015-05-28 | Verinata Health, Inc. | Methods for determining fraction of fetal nucleic acid in maternal samples |
| EP2513341B1 (en) | 2010-01-19 | 2017-04-12 | Verinata Health, Inc | Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing |
| EP2536854B1 (en) | 2010-02-18 | 2017-07-19 | The Johns Hopkins University | Personalized tumor biomarkers |
| EP2426217A1 (en) | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
| KR102040307B1 (ko) | 2010-11-30 | 2019-11-27 | 더 차이니즈 유니버시티 오브 홍콩 | 암과 연관된 유전적 또는 분자적 이상들의 검출 |
| KR101974492B1 (ko) | 2011-07-26 | 2019-05-02 | 베리나타 헬스, 인코포레이티드 | 샘플 중 상이한 이수성의 존재 또는 부재를 결정하는 방법 |
| WO2013052913A2 (en) | 2011-10-06 | 2013-04-11 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| WO2013086352A1 (en) | 2011-12-07 | 2013-06-13 | Chronix Biomedical | Prostate cancer associated circulating nucleic acid biomarkers |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| US9862995B2 (en) | 2012-03-13 | 2018-01-09 | Abhijit Ajit Patel | Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing |
| KR20150028256A (ko) | 2012-05-31 | 2015-03-13 | 스미토모 덴키 고교 가부시키가이샤 | 산화물 초전도 박막과 그의 제조 방법 |
| US11261494B2 (en) | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
| EP4424826A3 (en) * | 2012-09-04 | 2024-11-27 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| CA2884066C (en) | 2012-09-20 | 2021-08-10 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| CN105339507A (zh) * | 2013-02-21 | 2016-02-17 | 托马生物科学公司 | 用于核酸分析的方法、组合物和试剂盒 |
| CA2906818C (en) | 2013-03-15 | 2022-08-16 | Verinata Health, Inc. | Generating cell-free dna libraries directly from blood |
| US10174375B2 (en) * | 2013-09-20 | 2019-01-08 | The Chinese University Of Hong Kong | Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases |
| US10262755B2 (en) * | 2014-04-21 | 2019-04-16 | Natera, Inc. | Detecting cancer mutations and aneuploidy in chromosomal segments |
| US20160002717A1 (en) | 2014-07-02 | 2016-01-07 | Boreal Genomics, Inc. | Determining mutation burden in circulating cell-free nucleic acid and associated risk of disease |
| KR102696857B1 (ko) | 2014-07-25 | 2024-08-19 | 유니버시티 오브 워싱톤 | 무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법 |
| EP3224380A1 (en) | 2014-11-25 | 2017-10-04 | The Broad Institute Inc. | Clonal haematopoiesis |
| ES2989276T3 (es) | 2014-12-05 | 2024-11-25 | Found Medicine Inc | Análisis multigénico de muestras tumorales |
| EP4574996B1 (en) | 2014-12-31 | 2025-11-05 | Guardant Health, Inc. | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results |
| ES2908347T3 (es) | 2015-02-10 | 2022-04-28 | Univ Hong Kong Chinese | Detección de mutaciones para cribado de cáncer y análisis fetal |
| WO2016149261A1 (en) | 2015-03-16 | 2016-09-22 | Personal Genome Diagnostics, Inc. | Systems and methods for analyzing nucleic acid |
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