HRP960369B1 - Process for the preparation of epoxide - Google Patents
Process for the preparation of epoxideInfo
- Publication number
- HRP960369B1 HRP960369B1 HR960369A HRP960369A HRP960369B1 HR P960369 B1 HRP960369 B1 HR P960369B1 HR 960369 A HR960369 A HR 960369A HR P960369 A HRP960369 A HR P960369A HR P960369 B1 HRP960369 B1 HR P960369B1
- Authority
- HR
- Croatia
- Prior art keywords
- formula
- epoxide
- aqueous sodium
- mixture
- reaction mixture
- Prior art date
Links
- 150000002118 epoxides Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 9
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 6
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 abstract 6
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 abstract 6
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 abstract 6
- -1 allyl acetonide Chemical compound 0.000 abstract 5
- 239000011541 reaction mixture Substances 0.000 abstract 5
- 230000015572 biosynthetic process Effects 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 238000010791 quenching Methods 0.000 abstract 3
- 230000000171 quenching effect Effects 0.000 abstract 3
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 3
- 235000010265 sodium sulphite Nutrition 0.000 abstract 3
- JRNVZBWKYDBUCA-UHFFFAOYSA-N N-chlorosuccinimide Chemical compound ClN1C(=O)CCC1=O JRNVZBWKYDBUCA-UHFFFAOYSA-N 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 238000001816 cooling Methods 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 abstract 2
- 229940011051 isopropyl acetate Drugs 0.000 abstract 2
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 abstract 2
- 235000009518 sodium iodide Nutrition 0.000 abstract 2
- KEQGZUUPPQEDPF-UHFFFAOYSA-N 1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione Chemical compound CC1(C)N(Cl)C(=O)N(Cl)C1=O KEQGZUUPPQEDPF-UHFFFAOYSA-N 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- QWOJMRHUQHTCJG-UHFFFAOYSA-N CC([CH2-])=O Chemical compound CC([CH2-])=O QWOJMRHUQHTCJG-UHFFFAOYSA-N 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/512,602 US5728840A (en) | 1994-03-04 | 1995-08-08 | Process for making an epoxide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP960369A2 HRP960369A2 (en) | 1998-04-30 |
| HRP960369B1 true HRP960369B1 (en) | 2009-05-31 |
Family
ID=24039792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR960369A HRP960369B1 (en) | 1995-08-08 | 1996-08-06 | Process for the preparation of epoxide |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5728840A (xx) |
| AR (1) | AR003195A1 (xx) |
| AU (1) | AU6765296A (xx) |
| BR (1) | BR9609879A (xx) |
| HR (1) | HRP960369B1 (xx) |
| RS (1) | RS49879B (xx) |
| TW (1) | TW327635B (xx) |
| WO (1) | WO1997006164A1 (xx) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981759A (en) * | 1997-06-20 | 1999-11-09 | Merck & Co., Inc. | Process for indinavir intermediate |
| GB2341385A (en) | 1998-09-14 | 2000-03-15 | Merck & Co Inc | Recovery of iodide from chemical process waste water |
| US6482952B2 (en) | 2000-06-20 | 2002-11-19 | Merck & Co., Inc. | Process for preparing acetonides |
| US6835860B2 (en) * | 2002-02-01 | 2004-12-28 | Merck & Co., Inc. | Iodohydroxylation of olefins |
| US7601847B2 (en) | 2004-10-26 | 2009-10-13 | Wyeth | Preparation and purification of 4-(indazol-3-yl)phenols |
| US9948496B1 (en) | 2014-07-30 | 2018-04-17 | Silver Peak Systems, Inc. | Determining a transit appliance for data traffic to a software service |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0541168A1 (en) * | 1991-11-08 | 1993-05-12 | Merck & Co. Inc. | HIV protease inhibitors useful for the treatment of aids |
| WO1995023797A1 (en) * | 1994-03-04 | 1995-09-08 | Merck & Co., Inc. | Process for making an epoxide |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2052907A1 (en) * | 1990-10-11 | 1992-04-12 | Joseph P. Vacca | Hiv protease inhibitors having symmetrical structure |
| CA2057369A1 (en) * | 1990-12-17 | 1992-06-18 | Ann E. Decamp | Stereocontrolled production of hydroxyester, hydroxyamide, and lactone compounds from chiral alpha-amino aldehydes |
| CA2072237A1 (en) * | 1991-07-02 | 1993-01-03 | Merck & Co., Inc. | Stereoselective production of hydroxyamide compounds from chiral -amino epoxides |
| US5169952A (en) * | 1991-07-02 | 1992-12-08 | Merck & Co., Inc. | Stereoselective production of hydroxyamide compounds from chiral α-amino epoxides |
| GB2270914A (en) * | 1992-09-14 | 1994-03-30 | Merck & Co Inc | HIV protease inhibitor compounds |
| US5463067A (en) * | 1993-07-16 | 1995-10-31 | Merck & Co., Inc. | Process for making HIV protease inhibitors |
-
1995
- 1995-08-08 US US08/512,602 patent/US5728840A/en not_active Expired - Lifetime
-
1996
- 1996-07-26 TW TW085109161A patent/TW327635B/zh not_active IP Right Cessation
- 1996-08-05 AR ARP960103887A patent/AR003195A1/es not_active Application Discontinuation
- 1996-08-05 BR BR9609879A patent/BR9609879A/pt not_active Application Discontinuation
- 1996-08-05 AU AU67652/96A patent/AU6765296A/en not_active Abandoned
- 1996-08-05 WO PCT/US1996/012715 patent/WO1997006164A1/en not_active Ceased
- 1996-08-06 HR HR960369A patent/HRP960369B1/xx not_active IP Right Cessation
- 1996-08-07 RS YUP-458/96A patent/RS49879B/sr unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0541168A1 (en) * | 1991-11-08 | 1993-05-12 | Merck & Co. Inc. | HIV protease inhibitors useful for the treatment of aids |
| WO1995023797A1 (en) * | 1994-03-04 | 1995-09-08 | Merck & Co., Inc. | Process for making an epoxide |
Also Published As
| Publication number | Publication date |
|---|---|
| US5728840A (en) | 1998-03-17 |
| BR9609879A (pt) | 1999-03-23 |
| AU6765296A (en) | 1997-03-05 |
| RS49879B (sr) | 2008-08-07 |
| AR003195A1 (es) | 1998-07-08 |
| HRP960369A2 (en) | 1998-04-30 |
| WO1997006164A1 (en) | 1997-02-20 |
| YU45896A (sh) | 1999-06-15 |
| TW327635B (en) | 1998-03-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX9203165A (es) | Derivados de succinimida y composicion farmaceutica que los contiene . | |
| NO178399C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive 3-piperidino-4-hydroksykromanderivater og analoger derav | |
| FI810389L (fi) | Foerfarande foer framstaellning av substituerade imidazolderivat | |
| ES8704965A1 (es) | Un procedimiento para la preparacion de un antibiotico de macrolida | |
| KR890005086A (ko) | 1-[(2- 피리미디닐) 아미노알킬]피페리딘, 그의 제법 및 치료에의 이용 | |
| ES8406467A1 (es) | "procedimiento para preparar nuevos benzo b tiofenos". | |
| ES2066140T3 (es) | Derivados de acidos 7-ceto- y 7-hidroxi-androsta-3,5-dieno-3-carboxilicos. | |
| EA199801000A1 (ru) | Производные алкиламинобензотиазола и -бензоксазола | |
| HRP960369B1 (en) | Process for the preparation of epoxide | |
| NO178396C (no) | Forbedret fremgangsmåte for fremstilling av substituerte indolonderivater og mellomprodukter i fremstillingen derav | |
| YU46045B (sh) | Postupak za proizvodnju n-supstituisanih bis-(2,4-diamino-s-triazin-6-il)-tet rasulfida | |
| ES8705440A1 (es) | Un procedimiento para la produccion de 2h-imidazo-(1',2':1,2)-pirrolo-(3,4-b)-piridinas | |
| ES8205215A1 (es) | Un procedimiento para la preparacion de nuevos derivados del acido acetico. | |
| ES8307236A1 (es) | Un procedimiento para la preparacion de ranitidina. | |
| HUP0002114A1 (hu) | Eljárás 5'-dezoxi-5-fluor-uridin előállítására | |
| ES8506011A1 (es) | Procedimiento para la obtencion de un derivado de tetrahidrobenzotiazol | |
| GB1093113A (en) | 6-substituted penicillanyl alcohols | |
| KR840001957A (ko) | 신규의 이소프로필 아미노 피리미딘 유도체의 제조방법 | |
| JPS5547651A (en) | Production of sulfoxyimine | |
| ES407775A1 (es) | Procedimiento para la preparacion de sulfonilaminopirimidi-nas que disminuyen el azucar en la sangre. | |
| JPS5441831A (en) | Production of p-aninobenzaldehyde | |
| JPS56154475A (en) | Preparation of piperazine derivative | |
| JPS5594374A (en) | Preparation of orotic acid | |
| JPS5535051A (en) | Preparation of naphthostyril | |
| ES462988A1 (es) | Un procedimiento para la obtencion de 2-furil-(4,5-dimetil-2-piridil)-carbinol. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
| B1PR | Patent granted | ||
| PNAN | Change of the applicant name, address/residence |
Owner name: MERCK SHARP & DOHME CORP., US |
|
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20110801 Year of fee payment: 16 |
|
| PBON | Lapse due to non-payment of renewal fee |
Effective date: 20120807 |