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HN2009003357A - Nuevos compuesto ligandos del receptor de la adenosina a3 - Google Patents

Nuevos compuesto ligandos del receptor de la adenosina a3

Info

Publication number
HN2009003357A
HN2009003357A HN2009003357A HN2009003357A HN2009003357A HN 2009003357 A HN2009003357 A HN 2009003357A HN 2009003357 A HN2009003357 A HN 2009003357A HN 2009003357 A HN2009003357 A HN 2009003357A HN 2009003357 A HN2009003357 A HN 2009003357A
Authority
HN
Honduras
Prior art keywords
receiver
ligandos
adenosine
new compound
solvatos
Prior art date
Application number
HN2009003357A
Other languages
English (en)
Inventor
Edit Susan
Kinga Boer
Zoltan Kapui
Geza Timari
Sandor Batori
Zoltan Szlavik
Endre Mikus
Szeredi Judit Vargane
Michel Finet
Szabo Katalin Urban
Tibor Szabo
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of HN2009003357A publication Critical patent/HN2009003357A/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
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    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P27/02Ophthalmic agents
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A LOS LIGANDOS DEL RECEPTOR DE ADENOSIMA A3, DE FORMULA GENERAL I) DENTRO DE ELLOS LOS FAVORABLES A LOS ANTAGONISTAS, SUS SALES, SOLVATOS, N-OXIDOS E ISOMERICOS, A LAS COMPOSICIONES FARMACEUTICAS QUE CONTIENEN GENERAL I) SUS SALES, SOLVATOS, N- OXIDOS E ISOMEROS, A LA PREPARACION DE LOS COMPUESTOS DE FORMULA GENERAL I) SUS SALES, SOLVATOS, N- OXIDOS E ISOMEROS , ASI COMO A LOS NUEVOS INTERMEDIARIOS DE FORMULA GENERAL. (II), (VI), (XI), (XII), Y (XV) Y A LA PREPARACION DE ELLOS.
HN2009003357A 2007-06-07 2009-12-04 Nuevos compuesto ligandos del receptor de la adenosina a3 HN2009003357A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0700395A HUP0700395A2 (en) 2007-06-07 2007-06-07 Substituted [1,2,4] triazolo [1,5-a] quinolines, process for their preparation, pharmaceutical compositions thereof, and intermediates

Publications (1)

Publication Number Publication Date
HN2009003357A true HN2009003357A (es) 2013-08-12

Family

ID=89987565

Family Applications (1)

Application Number Title Priority Date Filing Date
HN2009003357A HN2009003357A (es) 2007-06-07 2009-12-04 Nuevos compuesto ligandos del receptor de la adenosina a3

Country Status (44)

Country Link
US (1) US8338411B2 (es)
EP (1) EP2167470B1 (es)
JP (1) JP5487100B2 (es)
KR (1) KR20100031610A (es)
CN (1) CN101679272B (es)
AR (1) AR066873A1 (es)
AT (1) ATE502016T1 (es)
AU (1) AU2008259534B2 (es)
BR (1) BRPI0812257A2 (es)
CA (1) CA2689612A1 (es)
CL (1) CL2008001648A1 (es)
CO (1) CO6270233A2 (es)
CR (1) CR11171A (es)
CY (1) CY1111644T1 (es)
DE (1) DE602008005589D1 (es)
DK (1) DK2167470T3 (es)
DO (1) DOP2009000276A (es)
EC (1) ECSP099783A (es)
ES (1) ES2363672T3 (es)
GT (1) GT200900301A (es)
HN (1) HN2009003357A (es)
HR (1) HRP20110332T1 (es)
HU (1) HUP0700395A2 (es)
IL (1) IL202471A0 (es)
JO (1) JO2689B1 (es)
MA (1) MA31738B1 (es)
ME (1) ME00958B (es)
MX (1) MX2009013209A (es)
MY (1) MY148654A (es)
NI (1) NI200900210A (es)
NZ (1) NZ581186A (es)
PA (1) PA8782901A1 (es)
PE (1) PE20090325A1 (es)
PL (1) PL2167470T3 (es)
PT (1) PT2167470E (es)
RU (1) RU2489432C2 (es)
SI (1) SI2167470T1 (es)
SV (1) SV2009003420A (es)
TN (1) TN2009000482A1 (es)
TW (1) TWI424998B (es)
UA (1) UA99463C2 (es)
UY (1) UY31130A1 (es)
WO (1) WO2008149168A1 (es)
ZA (1) ZA200908280B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101722289B1 (ko) 2009-07-08 2017-03-31 데르미라 (캐나다), 인코포레이티드 피부과 질환 또는 증상의 치료에 유용한 tofa 유사체
FR3053968A1 (fr) * 2016-07-13 2018-01-19 Biomerieux Reactifs pour la protection reversible de molecules biologiques
CA3037588C (en) * 2016-09-24 2022-07-12 Kbp Biosciences Co., Ltd. Pharmaceutical composition comprising mineralocorticoid receptor antagonist and use thereof
CR20230030A (es) 2018-02-27 2023-03-10 Incyte Corp Imidazopirimidinas y triazolopirimidinas como inhibidores de a2a / a2b (divisional 2020-0441)
MX2020012376A (es) 2018-05-18 2021-03-09 Incyte Corp Derivados de pirimidina fusionados como inhibidores de los receptores de adenosina a2a/a2b.
MX2021000116A (es) 2018-07-05 2021-03-29 Incyte Corp Derivados de pirazina fusionados como inhibidores de a2a/a2b.
PE20211768A1 (es) 2018-11-30 2021-09-07 Merck Sharp & Dohme Derivados de amino triazolo quinazolina 9-sustituidos como antagonistas del receptor de adenosina, composiciones farmaceuticas y su uso
BR112021011948A2 (pt) 2018-12-20 2021-09-08 Incyte Corporation Compostos de imidazopiridazina e imidazopiridina e usos dos mesmos
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1479759A (en) * 1974-11-23 1977-07-13 Lepetit Spa Heterocyclic fused derivatives of indole and quinoline
GR76063B (es) * 1981-04-03 1984-08-03 Roussel Uclaf
ZA836701B (en) * 1982-10-01 1984-10-31 Roussel Uclaf Imidazo(1,2-a)quinolines
GB0108475D0 (en) 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
CN1257160C (zh) * 2001-05-31 2006-05-24 赛诺菲-安万特公司 氨基喹啉衍生物和它们的作为腺苷a3配体的应用
US6514989B1 (en) 2001-07-20 2003-02-04 Hoffmann-La Roche Inc. Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives
AU2002361374A1 (en) 2001-12-21 2003-07-09 JSW-Research Forschungslabor GmbH% Pyrazolyl-substituted triazoloquinoxalines
HUP0105406A3 (en) * 2001-12-21 2003-12-29 Sanofi Aventis Imidazo[1,2-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
HUP0105407A3 (en) * 2001-12-21 2004-04-28 Sanofi Aventis Triazolo[1,5-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
HUP0203976A3 (en) * 2002-11-15 2004-08-30 Sanofi Aventis Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them
WO2005009969A1 (en) * 2003-07-31 2005-02-03 Sanofi-Aventis Aminoquinoline derivatives and their use as adenosine a3 ligands

Also Published As

Publication number Publication date
CN101679272A (zh) 2010-03-24
IL202471A0 (en) 2010-06-30
PL2167470T3 (pl) 2011-08-31
TN2009000482A1 (en) 2011-03-31
MY148654A (en) 2013-05-15
BRPI0812257A2 (pt) 2014-12-23
JP2010529100A (ja) 2010-08-26
HUP0700395A2 (en) 2009-03-02
TWI424998B (zh) 2014-02-01
AR066873A1 (es) 2009-09-16
AU2008259534B2 (en) 2012-07-05
MA31738B1 (fr) 2010-10-01
AU2008259534A1 (en) 2008-12-11
CN101679272B (zh) 2013-02-06
RU2489432C2 (ru) 2013-08-10
NI200900210A (es) 2010-07-15
PA8782901A1 (es) 2009-01-23
CY1111644T1 (el) 2015-10-07
US20100216786A1 (en) 2010-08-26
WO2008149168A1 (en) 2008-12-11
ECSP099783A (es) 2010-01-29
KR20100031610A (ko) 2010-03-23
RU2009149518A (ru) 2011-07-20
DOP2009000276A (es) 2010-01-31
JO2689B1 (en) 2013-03-03
SI2167470T1 (sl) 2011-06-30
UY31130A1 (es) 2009-01-30
NZ581186A (en) 2012-03-30
JP5487100B2 (ja) 2014-05-07
EP2167470B1 (en) 2011-03-16
US8338411B2 (en) 2012-12-25
UA99463C2 (en) 2012-08-27
GT200900301A (es) 2010-04-22
PE20090325A1 (es) 2009-04-17
CR11171A (es) 2010-04-21
TW200914451A (en) 2009-04-01
ATE502016T1 (de) 2011-04-15
PT2167470E (pt) 2011-05-16
EP2167470A1 (en) 2010-03-31
SV2009003420A (es) 2010-04-26
CL2008001648A1 (es) 2008-10-10
ZA200908280B (en) 2010-07-28
HU0700395D0 (en) 2007-07-30
ME00958B (me) 2012-06-20
MX2009013209A (es) 2010-04-09
ES2363672T3 (es) 2011-08-11
CA2689612A1 (en) 2008-12-11
DE602008005589D1 (de) 2011-04-28
CO6270233A2 (es) 2011-04-20
HK1138581A1 (en) 2010-08-27
WO2008149168A8 (en) 2010-01-07
HRP20110332T1 (hr) 2011-06-30
DK2167470T3 (da) 2011-06-27

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