[go: up one dir, main page]

HK1211867A1 - Ophthalmic formulation of polyoxyl lipid or polyoxyl fatty acid and treatment of ocular conditions - Google Patents

Ophthalmic formulation of polyoxyl lipid or polyoxyl fatty acid and treatment of ocular conditions Download PDF

Info

Publication number
HK1211867A1
HK1211867A1 HK15112910.5A HK15112910A HK1211867A1 HK 1211867 A1 HK1211867 A1 HK 1211867A1 HK 15112910 A HK15112910 A HK 15112910A HK 1211867 A1 HK1211867 A1 HK 1211867A1
Authority
HK
Hong Kong
Prior art keywords
polyoxyl
fatty acid
treatment
ophthalmic formulation
ocular conditions
Prior art date
Application number
HK15112910.5A
Other languages
English (en)
Chinese (zh)
Inventor
Ashim K. Mitra
Sidney L. WEISS
Eugene J. Mcnally
Original Assignee
Sun Pharma Global Fze
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50148510&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1211867(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sun Pharma Global Fze filed Critical Sun Pharma Global Fze
Publication of HK1211867A1 publication Critical patent/HK1211867A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK15112910.5A 2012-08-24 2013-08-23 Ophthalmic formulation of polyoxyl lipid or polyoxyl fatty acid and treatment of ocular conditions HK1211867A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261693189P 2012-08-24 2012-08-24
US201261693189P 2012-08-24
PCT/US2013/056513 WO2014032026A1 (en) 2012-08-24 2013-08-23 Ophthalmic formulation of polyoxyl lipid or polyoxyl fatty acid and treatment of ocular conditions

Publications (1)

Publication Number Publication Date
HK1211867A1 true HK1211867A1 (en) 2016-06-03

Family

ID=50148510

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15112910.5A HK1211867A1 (en) 2012-08-24 2013-08-23 Ophthalmic formulation of polyoxyl lipid or polyoxyl fatty acid and treatment of ocular conditions

Country Status (16)

Country Link
US (5) US8980839B2 (xx)
EP (2) EP2887923B1 (xx)
AU (1) AU2013305539B2 (xx)
CA (2) CA2914472C (xx)
DK (1) DK2887923T3 (xx)
ES (1) ES2948387T3 (xx)
FI (1) FI2887923T3 (xx)
HK (1) HK1211867A1 (xx)
HR (1) HRP20230559T1 (xx)
HU (1) HUE062145T2 (xx)
LT (1) LT2887923T (xx)
MX (1) MX361858B (xx)
PL (1) PL2887923T3 (xx)
PT (1) PT2887923T (xx)
SI (1) SI2887923T1 (xx)
WO (1) WO2014032026A1 (xx)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8980839B2 (en) 2012-08-24 2015-03-17 Ocular Technologies Sarl Topical aqueous nanomicellar, ophthalmic solutions and uses thereof
AU2015264181A1 (en) * 2014-05-23 2016-12-01 Ocular Technologies Sarl Topical formulations and uses thereof
WO2016172712A2 (en) 2015-04-23 2016-10-27 Sydnexis, Inc. Ophthalmic composition
US9421199B2 (en) 2014-06-24 2016-08-23 Sydnexis, Inc. Ophthalmic composition
WO2016028800A1 (en) * 2014-08-20 2016-02-25 A.T. Resolve Sarl Treatment of corneal haze
KR101587412B1 (ko) * 2014-10-17 2016-01-21 주식회사 휴온스 사이클로스포린 및 트레할로스를 포함하는 안과용 조성물
US20180133217A1 (en) * 2015-05-04 2018-05-17 Ocular Technologies Sarl Topical formulations and uses thereof
HK1248570A1 (zh) * 2015-05-29 2018-10-19 西德奈克西斯公司 D2o稳定化的药物制剂
PL3373976T3 (pl) 2015-11-10 2024-06-24 Sun Pharmaceutical Industries Limited Preparaty do stosowania miejscowego i ich zastosowanie
WO2017083410A1 (en) * 2015-11-12 2017-05-18 Ocular Technologies Sarl Topical formulations and uses thereof
US10918694B2 (en) * 2016-02-29 2021-02-16 Sun Pharma Global Fze Topical cyclosporine-containing formulations and uses thereof
EP3448361A4 (en) 2016-04-29 2019-11-20 I-Novion, Inc. LIQUID PENTABLOCK COPOLYMER FORMULATIONS FOR CONTINUOUS RELEASE OF THERAPEUTICS
IL310360A (en) * 2016-11-29 2024-03-01 Oculis Operations Sarl Preparation of solid cyclodextrin complexes for ophthalmic active pharmaceutical ingredient delivery
CN107334734B (zh) * 2017-07-10 2020-03-17 浙江大学 一种西罗莫司或其衍生物的眼用制剂
KR102704402B1 (ko) 2018-10-24 2024-09-06 (주)아모레퍼시픽 피부장벽 강화용 조성물
AU2020298754B2 (en) 2019-07-01 2025-06-26 Oculis Operations Sàrl Method for stabilizing the pH of an aqueous composition comprising a drug
US20230172946A1 (en) * 2019-08-18 2023-06-08 Iview Therapeutics, Inc. In-situ Gel Forming Ophthalmic Formulations Containing Difluprednate
AU2020402031A1 (en) * 2019-12-09 2022-06-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Biomolecule for treatment of corneal pathologies
US11918275B2 (en) 2021-04-30 2024-03-05 Cilag Gmbh International Electrosurgical adaptation techniques of energy modality for combination electrosurgical instruments based on shorting or tissue impedance irregularity
KR20220159751A (ko) 2021-05-26 2022-12-05 (주)아모레퍼시픽 미백용 조성물 및 이를 이용한 피부 미백방법
EP4355301A1 (en) 2021-06-14 2024-04-24 Sun Pharmaceutical Industries Limited Cyclosporine formulations for use in patients undergoing cataract surgery
EP4387589A4 (en) * 2021-08-20 2025-09-03 Sun Pharmaceutical Ind Ltd STABLE OPHTHALMIC FORMULATION OF CYCLOSPORINE AND PROCESS FOR ITS MANUFACTURE

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2406A (en) * 1841-12-30 Construction of railroad-scbapers fob cleaning te-ie tracks from sl
FR520E (fr) 1901-11-13 1903-01-26 Bermont Victor Etienne Procédé industriel d'extraction directe du zinc contenu dans les minerais oxydés, et plus spécialement dans la smithsonite (znco3) et la calamine (h2zn2sio5)
HK1004520A1 (en) 1992-05-13 1998-11-27 Novartis Ag Ophthalmic compositions containing a cyclosporin
NZ247516A (en) * 1993-04-28 1995-02-24 Bernard Charles Sherman Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant
US5484597A (en) 1993-07-30 1996-01-16 Chesebrough-Pond's Usa Co. Clear hydroalcholic cosmetic microemulsions
NZ280689A (en) * 1995-12-15 1997-08-22 Bernard Charles Sherma Sherman Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol
MX9701946A (es) 1997-03-14 1998-04-30 Arturo Jimenez Bayardo Solucion oftalmica transportadora.
US6816968B1 (en) * 1998-07-10 2004-11-09 Silverbrook Research Pty Ltd Consumable authentication protocol and system
US7678836B2 (en) * 1999-11-04 2010-03-16 Fxs Ventures, Llc Method for rendering a contact lens wettable
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
AU3846801A (en) 2000-02-16 2001-08-27 Brigham & Womens Hospital Aspirin-triggered lipid mediators
US20030176356A1 (en) 2001-04-24 2003-09-18 University Of North Texas Health Science Center Endothelin antagonists and endothelin-converting enzyme inhibitors for the treatment of glaucoma
PT1435910E (pt) 2001-10-19 2009-09-07 Isotechnika Inc Novos pré-concentrados de microemulsão de análogos da ciclosporina
AU2002365167A1 (en) 2001-12-18 2003-07-09 The Brigham And Women's Hospital Inhibition or prevention of infection by bacteria with epa, dha or analogs
ES2527753T3 (es) 2002-04-01 2015-01-29 University Of Southern California Eicosanoides trihidroxi poliinsaturados
US7582785B2 (en) 2002-04-01 2009-09-01 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
SI2216318T1 (sl) 2002-08-12 2019-01-31 Brigham And Women's Hospital Resolvini: biološke matrice za terapevtske intervencije
US7759395B2 (en) 2002-08-12 2010-07-20 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
WO2004069181A2 (en) 2003-02-03 2004-08-19 Pharmacia Corporation Composition for the treatment of intraocular pressure
JP2004238346A (ja) 2003-02-07 2004-08-26 Shiono Chemical Co Ltd トラニラストの安定な水溶液製剤
WO2004078143A2 (en) 2003-03-05 2004-09-16 The Brigham And Women's Hospital Inc. Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs
WO2004096261A1 (es) 2003-05-02 2004-11-11 Arturo Jimenez Bayardo Metodo para preparar una solucion acuosa de ciclosporina-a y solucion acuosa resultante
US7087237B2 (en) * 2003-09-19 2006-08-08 Advanced Ocular Systems Limited Ocular solutions
EP1755537A4 (en) 2004-04-14 2009-12-09 Univ Boston METHOD AND COMPOSITIONS FOR PREVENTING OR TREATING PERIODONTOPATHIA
US20060020563A1 (en) * 2004-07-26 2006-01-26 Coleman Christopher R Supervised neural network for encoding continuous curves
EP1655021B1 (en) * 2004-11-09 2008-10-29 Novagali Pharma SA Oil-in-water type emulsion with low concentration of cationic agent and positive zeta potential
EA010802B1 (ru) 2004-11-19 2008-12-30 Мартек Байосайенсиз Корпорейшн Оксилипины из полиненасыщенных жирных кислот с длинной цепью и способы их получения и применения
RU2007149249A (ru) * 2005-06-09 2009-07-20 Сантен Фармасьютикал Ко., Лтд (Jp) Глазные капли, содержащие рофлумиласт
JP5235662B2 (ja) 2005-06-16 2013-07-10 ミリアド ジェネティクス， インコーポレイテッド 薬学的組成物およびその使用
US20070015691A1 (en) 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
EP1904056B1 (en) 2005-07-18 2009-04-29 Minu, L.L.C. Use of a macrolide to restore corneal sensation
WO2007090162A2 (en) 2006-01-31 2007-08-09 Martek Biosciences Corporation OXYLIPINS FROM STEARIDONIC ACID AND γ-LINOLENIC ACID AND METHODS OF MAKING AND USING THE SAME
US10137083B2 (en) * 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
FR2904568B1 (fr) * 2006-08-03 2008-09-05 Dynastar Skis Sa Procede de fabrication d'une planche de glisse
US20110190389A1 (en) 2007-02-20 2011-08-04 Linda Arterburn Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same
US20100310462A1 (en) 2007-04-18 2010-12-09 Biochromix Ab Binding of pathological forms of proteins using conjugated polyelectrolytes
US8512687B2 (en) * 2007-07-09 2013-08-20 Novagali Pharma Sa Oil in water emulsion comprising NSAIDs and quaternary ammonium halides
US20090048929A1 (en) * 2007-08-15 2009-02-19 Paul Im Authenticated travel record
WO2009028674A1 (ja) 2007-08-29 2009-03-05 Wakamoto Pharmaceutical Co., Ltd. ラタノプロスト含有水性医薬組成物
MX2007011165A (es) 2007-09-12 2009-03-11 Arturo Jimenez Bayardo Composición farmacéutica estable de timolol, dorzolamida y brimonidina.
ES2667945T3 (es) * 2007-10-08 2018-05-16 Aurinia Pharmaceuticals Inc. Composiciones oftálmicas que comprenden inhibidores de calcineurina o Inhibidores de mTOR
CA2710843A1 (en) * 2008-01-04 2009-07-16 Alcon Pharmaceuticals Ltd. Stable aqueous cyclosporin compositions
TWI544927B (zh) * 2008-03-17 2016-08-11 愛爾康研究有限公司 具有低濃度的表面活性劑以促進治療劑之生物可利用性的藥學組成物
CA2725523C (en) 2008-05-28 2017-01-10 Alcon Research, Ltd. Self-preserved emulsions
EP2127638A1 (en) * 2008-05-30 2009-12-02 Santen Pharmaceutical Co., Ltd Method and composition for treating ocular hypertension and glaucoma
AU2010257181A1 (en) * 2009-06-02 2012-01-12 Brian Charles Keller Pure PEG-lipid conjugates
MX338355B (es) * 2009-06-09 2016-04-13 Aurinia Pharmaceuticals Inc Sistemas de suministro de farmaco topico para uso oftalmico.
CN102481301A (zh) * 2009-09-17 2012-05-30 千寿制药株式会社 含有拉坦前列素的水性滴眼剂以及抑制拉坦前列素对树脂的吸附的方法
US8637569B2 (en) 2009-10-22 2014-01-28 Api Genesis, Llc Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds
US9011861B2 (en) 2010-02-25 2015-04-21 Schepens Eye Research Institute Therapeutic compositions for the treatment of dry eye disease
KR20130139748A (ko) 2010-05-07 2013-12-23 썬 파마 어드밴스트 리서치 컴패니 리미티드 신규 안과용 조성물
WO2013025696A1 (en) 2011-08-15 2013-02-21 Teva Pharmaceutical Industries Ltd. Ophthalmic formulations and processes for their preparation
KR101211902B1 (ko) 2012-04-30 2012-12-13 주식회사 휴온스 사이클로스포린 함유 무자극성 나노에멀젼 안약 조성물
AU2013257830A1 (en) 2012-05-11 2014-11-20 Cipla Limited Pharmaceutical composition
US8980839B2 (en) 2012-08-24 2015-03-17 Ocular Technologies Sarl Topical aqueous nanomicellar, ophthalmic solutions and uses thereof
US10946076B2 (en) 2013-02-13 2021-03-16 The Research Foundation For The State University Of New York Glaucoma treatment
AU2015264181A1 (en) 2014-05-23 2016-12-01 Ocular Technologies Sarl Topical formulations and uses thereof
US9421199B2 (en) 2014-06-24 2016-08-23 Sydnexis, Inc. Ophthalmic composition
US20180133217A1 (en) 2015-05-04 2018-05-17 Ocular Technologies Sarl Topical formulations and uses thereof
PL3373976T3 (pl) 2015-11-10 2024-06-24 Sun Pharmaceutical Industries Limited Preparaty do stosowania miejscowego i ich zastosowanie
WO2017083410A1 (en) 2015-11-12 2017-05-18 Ocular Technologies Sarl Topical formulations and uses thereof
US10918694B2 (en) 2016-02-29 2021-02-16 Sun Pharma Global Fze Topical cyclosporine-containing formulations and uses thereof
WO2017152129A2 (en) 2016-03-03 2017-09-08 Ocular Technologies Sarl Treatment of glaucoma and/or retinal diseases and formulations useful therefore

Also Published As

Publication number Publication date
HRP20230559T1 (hr) 2023-09-15
EP2887923B1 (en) 2023-04-05
US10441630B2 (en) 2019-10-15
HUE062145T2 (hu) 2023-10-28
CA2914472A1 (en) 2014-02-27
LT2887923T (lt) 2023-07-10
US20160256520A1 (en) 2016-09-08
CA2914472C (en) 2019-09-03
WO2014032026A1 (en) 2014-02-27
SI2887923T1 (sl) 2023-09-29
ES2948387T3 (es) 2023-09-11
MX2015002239A (es) 2016-01-08
US20160256521A1 (en) 2016-09-08
DK2887923T3 (da) 2023-07-03
US8980839B2 (en) 2015-03-17
EP4218729A1 (en) 2023-08-02
AU2013305539B2 (en) 2018-08-02
EP2887923A1 (en) 2015-07-01
US20150165048A1 (en) 2015-06-18
US20140057854A1 (en) 2014-02-27
US9937225B2 (en) 2018-04-10
AU2013305539A1 (en) 2015-03-12
FI2887923T3 (fi) 2023-06-30
US20150148299A1 (en) 2015-05-28
PT2887923T (pt) 2023-06-28
MX361858B (es) 2018-12-18
EP2887923A4 (en) 2016-03-30
PL2887923T3 (pl) 2023-08-14
CA3050298A1 (en) 2014-02-27

Similar Documents

Publication Publication Date Title
HK1211867A1 (en) Ophthalmic formulation of polyoxyl lipid or polyoxyl fatty acid and treatment of ocular conditions
HK1231376A1 (zh) 局部制剂及其应用
WO2013170068A3 (en) Nuclear transport modulators and uses thereof
EP4410312A3 (en) Topical cyclosporine-containing formulations and uses thereof
WO2013171764A3 (en) Ophthalmic formulations
WO2014152029A3 (en) Oxazolo[5,4-c]quinolin-2-one compounds as bromodomain inhibitors
BR112015007778A2 (pt) profármacos neutralizantes de vegf para o tratamento de condições oculares
NZ704247A (en) Compositions and treatment for eye diseases and disorders
HK1202448A1 (en) Topical formulation for administering a compound
PH12014501693A1 (en) Antimicrobial compositions comprising dgla, 15-ohepa and/or 15-hetre and methods of use thereof
EP4360621A3 (en) Formulations of bendamustine
WO2014107730A3 (en) Use of fatty acid niacin conjugates for treating diseases
HK1216839A1 (zh) 调整释放制剂
IN2015DN04151A (xx)
WO2012162439A3 (en) Compositions comprising fusidic acid and packages therefor
WO2012158405A3 (en) Compositions and methods for the treatment of skin diseases
WO2015048188A8 (en) Modified fibroblast growth factors for the treatment of ocular disorders
WO2017152129A3 (en) Treatment of glaucoma and/or retinal diseases and formulations useful therefore
WO2012099899A3 (en) Topical dermatological compositions for the treatment of acne
EP4364810A3 (en) Topical formulations and uses thereof
WO2013046059A3 (en) Methods and compositions for tamarind-based ocular disease treatment in combination with trehalose
PH12015501538A1 (en) Topical ocular analgesic agents
HK1219654A1 (zh) 用於治疗眼科疾病和病症的方法
WO2013127539A3 (de) Pharmazeutische formulierung enthaltend flupirtin
WO2013109202A3 (en) Pharmaceutical compounds comprising cefetamet