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HK1201061A1 - Cbp/catenin antagonists for enhancing asymmetric division of somatic stem cells - Google Patents

Cbp/catenin antagonists for enhancing asymmetric division of somatic stem cells Download PDF

Info

Publication number
HK1201061A1
HK1201061A1 HK15101516.6A HK15101516A HK1201061A1 HK 1201061 A1 HK1201061 A1 HK 1201061A1 HK 15101516 A HK15101516 A HK 15101516A HK 1201061 A1 HK1201061 A1 HK 1201061A1
Authority
HK
Hong Kong
Prior art keywords
cbp
catenin
loss
somatic stem
symptom
Prior art date
Application number
HK15101516.6A
Other languages
English (en)
Chinese (zh)
Inventor
Michael Kahn
Jia-Ling Teo
Michael Mcmillan
Yi Zhao
Yongfeng Wu
Original Assignee
University Of Southern California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2011/061062 external-priority patent/WO2012068299A2/fr
Application filed by University Of Southern California filed Critical University Of Southern California
Publication of HK1201061A1 publication Critical patent/HK1201061A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
HK15101516.6A 2011-10-07 2012-05-15 Cbp/catenin antagonists for enhancing asymmetric division of somatic stem cells HK1201061A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161545033P 2011-10-07 2011-10-07
US61/545,033 2011-10-07
USPCT/US2011/061062 2011-11-16
PCT/US2011/061062 WO2012068299A2 (fr) 2010-11-16 2011-11-16 Antagonistes du système cbp/caténine destinés à promouvoir la division asymétrique des cellules souches somatiques
PCT/US2012/038003 WO2013052162A1 (fr) 2011-10-07 2012-05-15 Antagonistes du système cbp/caténine favorisant la division asymétrique de cellules souches somatiques

Publications (1)

Publication Number Publication Date
HK1201061A1 true HK1201061A1 (en) 2015-08-21

Family

ID=48044063

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15101516.6A HK1201061A1 (en) 2011-10-07 2012-05-15 Cbp/catenin antagonists for enhancing asymmetric division of somatic stem cells

Country Status (10)

Country Link
US (1) US9371330B2 (fr)
EP (1) EP2763995A4 (fr)
JP (1) JP2014528445A (fr)
KR (1) KR20140094528A (fr)
CN (1) CN103958517B (fr)
AU (1) AU2012319069A1 (fr)
BR (1) BR112014008360A2 (fr)
CA (1) CA2851187A1 (fr)
HK (1) HK1201061A1 (fr)
WO (1) WO2013052162A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160074400A1 (en) * 2012-08-06 2016-03-17 University Of Southern California Wnt modulators for the protection, mitigation and treatment of radiation injury
AU2013332733A1 (en) * 2012-10-19 2015-06-04 Prism Pharma Co., Ltd. Treatment of hyperproliferative and pre-cancerous skin diseases using an inhibitor of CBP/catenin
WO2017156350A1 (fr) 2016-03-09 2017-09-14 K-Gen, Inc. Méthodes de traitement du cancer
WO2021183791A1 (fr) 2020-03-12 2021-09-16 City Of Hope Inhibiteurs de la voie de signalisation de wnt/cbp/caténine et leurs utilisations
EP4117663A4 (fr) 2020-03-12 2024-07-03 3+2 Pharma LLC Inhibiteurs de la voie de signalisation cbp/caténine et leurs utilisations
KR20230129222A (ko) * 2020-10-05 2023-09-07 제네시스 몰레큘러 테크놀로지스, 인코포레이티드 피부과 응용을 위한 국부 제제
US20230390296A1 (en) * 2020-10-30 2023-12-07 Keio University Novel treatment and prevention of sarcopenia-related diseases
US20240352020A1 (en) * 2021-08-26 2024-10-24 3+2 Pharma, Llc Pyrazole-containing cbp/catenin antagonists and uses thereof
CN115251009B (zh) * 2022-06-23 2023-06-20 宁夏医科大学总医院 一种大鼠斑秃模型的构建方法
WO2024091572A1 (fr) 2022-10-25 2024-05-02 Veradermics Incorporated Compositions et procédés d'utilisation de minoxidil à libération modifiée

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262321A (en) 1991-05-31 1993-11-16 Dana-Farber Cancer Institute DNA encoding p107 tumor suppressor
US5750336A (en) 1994-02-10 1998-05-12 The Salk Institute For Biological Studies Assays for the identification of compounds which inhibit activation of cAMP and mitogen responsive genes
US5658784A (en) 1994-04-14 1997-08-19 Dana-Farber Cancer Institute, Inc. Nucleic acid encoding transcription factor p300 and uses of p300
US6184223B1 (en) 1995-10-27 2001-02-06 Molecumetics Ltd. Reverse-turn mimetics and methods relating thereto
US7671054B1 (en) 2001-10-12 2010-03-02 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US20040072831A1 (en) * 2001-10-12 2004-04-15 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US7566711B2 (en) 2001-10-12 2009-07-28 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US7576084B2 (en) 2001-10-12 2009-08-18 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US7232822B2 (en) 2001-10-12 2007-06-19 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US6762185B1 (en) 2002-03-01 2004-07-13 Choongwae Pharma Corporation Compounds useful for treatment of cancer, compositions containing the same, and methods of their use
NZ545568A (en) * 2003-08-28 2009-06-26 Choongwae Pharma Corp Use of compounds that modulate beta-catenin/TCF activated transcription for manufacture of a medicamnet to treat cancer
JP3722146B1 (ja) 2004-06-16 2005-11-30 セイコーエプソン株式会社 プロジェクタおよび画像補正方法
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
JP2008533155A (ja) 2005-03-18 2008-08-21 インスティテュート フォー ケミカル ジェノミックス アルファへリックス模倣剤および線維症の治療に関する方法
US7563825B1 (en) 2005-03-18 2009-07-21 Choongwae Pharma Corporation Modulation of beta-catenin coactivator interactions to effect stem cell growth or differentiation
US20080009500A1 (en) 2005-11-08 2008-01-10 Michael Kahn Alpha-helix mimetics and methods relating to the treatment of fibrotic disorders
US20090215783A1 (en) 2006-05-30 2009-08-27 Choongwae Pharma Corporation Composition for induction or inhibition of stem cell differentiation
JP5545573B2 (ja) 2008-10-14 2014-07-09 株式会社 ＰＲＩＳＭ ＢｉｏＬａｂ アルファへリックスミメティック及び関連の方法
CN102459576B (zh) 2009-04-27 2015-04-01 渥太华医院研究所 用于调节干细胞的组合物和方法及其应用
CN102482258B (zh) 2009-05-07 2014-06-25 株式会社棱镜制药 α-螺旋模拟物和与其相关的方法
JP6163105B2 (ja) 2010-11-16 2017-07-12 ユニバーシティー オブ サザン カリフォルニア 体性幹細胞の非対称分裂を促進するためのｃｂｐ／カテニン拮抗剤
CN103517904A (zh) 2011-02-25 2014-01-15 株式会社棱镜制药 α-螺旋模拟物和与其相关的方法

Also Published As

Publication number Publication date
US20150232468A1 (en) 2015-08-20
EP2763995A1 (fr) 2014-08-13
EP2763995A4 (fr) 2015-05-27
JP2014528445A (ja) 2014-10-27
US9371330B2 (en) 2016-06-21
WO2013052162A1 (fr) 2013-04-11
CN103958517B (zh) 2016-10-19
KR20140094528A (ko) 2014-07-30
CA2851187A1 (fr) 2013-04-11
CN103958517A (zh) 2014-07-30
BR112014008360A2 (pt) 2017-04-25
AU2012319069A1 (en) 2014-05-29

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