[go: up one dir, main page]

HK1054571A1 - Novel proteases - Google Patents

Novel proteases Download PDF

Info

Publication number
HK1054571A1
HK1054571A1 HK03106801.3A HK03106801A HK1054571A1 HK 1054571 A1 HK1054571 A1 HK 1054571A1 HK 03106801 A HK03106801 A HK 03106801A HK 1054571 A1 HK1054571 A1 HK 1054571A1
Authority
HK
Hong Kong
Prior art keywords
protease
novel proteases
various
protease polypeptides
stk
Prior art date
Application number
HK03106801.3A
Other languages
Chinese (zh)
Inventor
D. Plowman Gregory
Whyte David
Sudarsanam Sucha
Manning Gerard
Caenepeel Sean
Payne Villa
Original Assignee
Sugen, Inc.
Pharmacia & Upjohn Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen, Inc., Pharmacia & Upjohn Company filed Critical Sugen, Inc.
Publication of HK1054571A1 publication Critical patent/HK1054571A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Rheumatology (AREA)
  • Analytical Chemistry (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)

Abstract

The present invention relates to protease polypeptides, nucleotide sequences encoding the protease polypeptides, as well as various products and methods useful for the diagnosis and treatment of various protease-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the of PTK's and STK's have been identified and their protein structure predicted.
HK03106801.3A 2000-05-04 2001-05-04 Novel proteases HK1054571A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20187900P 2000-05-04 2000-05-04
US201879P 2000-05-04
PCT/US2001/014431 WO2001083782A2 (en) 2000-05-04 2001-05-04 Novel proteases

Publications (1)

Publication Number Publication Date
HK1054571A1 true HK1054571A1 (en) 2003-12-05

Family

ID=22747660

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03106801.3A HK1054571A1 (en) 2000-05-04 2001-05-04 Novel proteases

Country Status (6)

Country Link
EP (1) EP1294901A2 (en)
JP (1) JP2004504812A (en)
AU (1) AU2001259473A1 (en)
CA (1) CA2408105A1 (en)
HK (1) HK1054571A1 (en)
WO (1) WO2001083782A2 (en)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030096391A1 (en) * 2000-12-22 2003-05-22 Millennium Pharmaceuticals, Inc. 17903, a novel human aminopeptidase and uses therefor
US6683165B1 (en) 1999-04-13 2004-01-27 Genome Therapeutics Corporation Human gene relating to respiratory diseases and obesity
US7034132B2 (en) 2001-06-04 2006-04-25 Anderson David W Therapeutic polypeptides, nucleic acids encoding same, and methods of use
IL149416A0 (en) 1999-11-19 2002-11-10 Solvay Pharm Bv Human enzymes of the metalloprotease family
EP1134286A3 (en) * 2000-03-14 2003-05-02 Pfizer Products Inc. Adamts polypeptides, nucleic acids encoding them, and uses thereof
WO2001078894A2 (en) * 2000-04-13 2001-10-25 Schering Corporation Novel human gene relating to respiratory diseases, obesity, and inflammatory bowel disease
DE10031932A1 (en) * 2000-06-30 2002-01-10 Basf Ag Calpain protease 12
EP1307568A2 (en) * 2000-07-28 2003-05-07 Immunex Corporation Metalloproteinase-disintegrin polypeptides and methods of making and use thereof
GB0020345D0 (en) * 2000-08-17 2000-10-04 Glaxo Group Ltd Protein
EP1311690B1 (en) * 2000-08-22 2006-07-26 Lexicon Genetics Incorporated Human proteases and polynucleotides encoding the same
WO2002020805A2 (en) * 2000-09-11 2002-03-14 Bayer Aktiengesellschaft Regulation of human carboxypeptidase-like enzyme
WO2002024927A2 (en) * 2000-09-20 2002-03-28 Bayer Aktiengesellschaft Regulation of human adam-ts 1 precursor-like protein
AU2001296307A1 (en) * 2000-09-25 2002-04-08 Millennium Pharmaceuticals, Inc. 55054, a human metalloprotease and uses therefor
AU2002215312A1 (en) * 2000-09-29 2002-04-08 Lexicon Genetics Incorporated Human proteases and polynucleotides encoding the same
WO2002026955A2 (en) * 2000-09-29 2002-04-04 Lexicon Genetics Incorporated Human proteases and polynucleotides encoding the same
JP2004524818A (en) * 2000-10-04 2004-08-19 レキシコン・ジェネティクス・インコーポレーテッド Novel protease and polynucleotide encoding it
WO2002033087A2 (en) * 2000-10-17 2002-04-25 Curagen Corporation Proteins and nucleic acids encoding same
US6689599B1 (en) * 2000-10-20 2004-02-10 Genetics Institute, Llc Aggrecanase molecules
US20040024181A1 (en) * 2000-10-26 2004-02-05 Gangolli Esha A. Novel human proteins, polynucleotides encoding them and methods of using the same
WO2002051995A1 (en) * 2000-12-22 2002-07-04 Millennium Pharmaceuticals, Inc. A human metallo protease member of the adamts family, and uses thereof
ATE353961T1 (en) * 2000-12-25 2007-03-15 Astellas Pharma Inc NEW PROTEASES
US6903201B2 (en) 2001-01-05 2005-06-07 Curagen Corporation Proteins and nucleic acids encoding same
WO2002057461A2 (en) * 2001-01-18 2002-07-25 Bayer Aktiengesellschaft Regulation of human adam-ts-like zinc metalloprotease
EP1567642A4 (en) * 2001-04-03 2006-02-08 Bristol Myers Squibb Co Polynucleotide encoding a novel cysteine protease of the calpain superfamily, can-12, and variants thereof
US7034134B2 (en) * 2001-04-26 2006-04-25 Bristol-Myers Squibb Company Polynucleotide encoding a novel metalloprotease highly expressed in the testis, MMP-29
JP2005506833A (en) * 2001-06-04 2005-03-10 キュラジェン コーポレイション Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding antigens, and methods of use
US7129077B2 (en) 2001-07-10 2006-10-31 Bayer Healthcare Ag Regulation of human aminopeptidase N
AU2002319703A1 (en) 2001-07-27 2003-02-17 Wyeth Aggrecanase molecules
EP1436388A4 (en) * 2001-08-22 2005-08-03 Lexicon Genetics Inc NEW HUMAN PROTEASES AND POLYNUCLEOTIDES ENCODING SAME
WO2003027282A1 (en) * 2001-09-24 2003-04-03 Daiichi Fine Chemical Co., Ltd. Adamts-15, -16, -17, -18 and -19
AU2002351945A1 (en) * 2001-11-13 2003-05-26 Universite De Liege A new disintegrin and metalloproteinase with thrombospondin type i repeats polynucleotide and its encoded polypeptide
US20030228676A1 (en) * 2001-12-31 2003-12-11 Agostino Michael J. Aggrecanase molecules
KR20040077928A (en) * 2002-01-31 2004-09-07 와이어쓰 Aggrecanase molecules
AU2003227428A1 (en) * 2002-04-19 2003-11-03 K. K. Dnaform Novel proteins and dnas encoding the same
JP3689103B2 (en) * 2002-06-20 2005-08-31 アステラス製薬株式会社 New promoter
NL1022371C2 (en) * 2003-01-13 2003-11-18 Hoffmann La Roche Novel metalloprotease containing a thrombospondin domain (MPTS protein) is useful to treat aggrecan associated disease including rheumatoid arthritis and osteoarthritis
WO2004073657A2 (en) * 2003-02-19 2004-09-02 Protein Design Labs, Inc. Methods of diagnosis of cancer and other diseases, composition and methods of screening for modulators of cancer and other diseases
WO2005031359A2 (en) * 2003-09-27 2005-04-07 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with arginyl aminopeptidase rnpep (rnpep)
WO2005040792A2 (en) * 2003-10-21 2005-05-06 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with arginyl aminopeptidase (aminopeptidase b)-like 1 (rnpepl1)
US7892750B1 (en) * 2004-12-23 2011-02-22 University Of Notre Dame Du Lac Cathepsin E as a marker of colon cancer
JP5532216B2 (en) * 2009-12-28 2014-06-25 国立大学法人埼玉大学 Breast cancer detection method
CN114075544A (en) * 2020-08-21 2022-02-22 复旦大学附属华山医院 Method for preparing de-ubiquitin erythrocyte product based on ultrafiltration centrifugation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO841276L (en) * 1983-03-31 1984-10-01 Codon Genetic Eng Lab RECOMBINANT DNA CODING FOR A POLYPEPTIDE THAT EXPRESSES MILK CONTINUOUS ACTIVITY
US6046031A (en) * 1997-01-21 2000-04-04 Human Genome Sciences, Inc. Metalloproteinases
WO2000053774A2 (en) * 1999-03-08 2000-09-14 Neurocrine Biosciences, Inc. Metalloproteinases and methods of use therefor
US6383780B1 (en) * 1999-11-19 2002-05-07 Millennium Pharmaceuticals, Inc. 2786, a novel human aminopeptidase
WO2001098468A2 (en) * 2000-06-16 2001-12-27 Incyte Genomics, Inc. Proteases

Also Published As

Publication number Publication date
WO2001083782A2 (en) 2001-11-08
WO2001083782A3 (en) 2003-01-23
JP2004504812A (en) 2004-02-19
CA2408105A1 (en) 2001-11-08
AU2001259473A1 (en) 2001-11-12
EP1294901A2 (en) 2003-03-26

Similar Documents

Publication Publication Date Title
WO2001083782A3 (en) Novel proteases
WO2002000860A3 (en) Novel proteases
WO2004006838A3 (en) Novel kinases
WO2001038503A3 (en) Novel human protein kinases and protein kinase-like enzymes
WO2000073469A3 (en) Protein kinases
MXPA03001984A (en) Human coagulation factor vii variants.
GB0100551D0 (en) Protein
WO2001066594A3 (en) Human protein kinases and protein kinase-like enzymes
WO2003048205A3 (en) Novel proteins with il-6 inhibiting activity
WO2001046394A3 (en) Mammalian protein phosphatases
WO2000068247A3 (en) Serine proteases
WO2001055356A3 (en) Human protein kinases and protein kinase-like enzymes
HK1052726A1 (en) Human protein kinases and protein kinase-like enzymes
WO1999066051A3 (en) Nek-related and bub1-related protein kinases
WO2004053117A3 (en) Serine protease
MX9805158A (en) Dna encoding a plasminogen activating protein.
WO2004056983A3 (en) Metalloprotease proteins
DE69730967D1 (en) Human dnase ii
WO2002086067A3 (en) Mycobacterial sulfation pathway proteins and methods of use thereof
WO2002033058A3 (en) Novel cysteine proteases and uses thereof
WO2001092491A3 (en) Mammalian protein phosphatases identified by in-silico analysis
WO2005049818A3 (en) Genes encoding human deubiquitinating enzymes
WO2002062976A3 (en) Serine proteases
WO2003054178A3 (en) Metalloprotease proteins
WO2002029023A8 (en) Nicastrin protein