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GT200200043A - Nuevos compuestos antiinflamatorios de bencimidazol - Google Patents

Nuevos compuestos antiinflamatorios de bencimidazol

Info

Publication number
GT200200043A
GT200200043A GT200200043A GT200200043A GT200200043A GT 200200043 A GT200200043 A GT 200200043A GT 200200043 A GT200200043 A GT 200200043A GT 200200043 A GT200200043 A GT 200200043A GT 200200043 A GT200200043 A GT 200200043A
Authority
GT
Guatemala
Prior art keywords
bencimidazol
new
inflammatory compounds
compounds
quinasas
Prior art date
Application number
GT200200043A
Other languages
English (en)
Inventor
Mark Anthony Dombrosky
Michael Anthony Letavic
Kim Francis Mcclure
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200200043A publication Critical patent/GT200200043A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVOS COMPUESTOS ANTIINFLAMATORIOS DE BENCIMIDAZOL DE FORMULA GENERAL (I) EN DONDE R1,R2,R3,HET, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS SON POTENTES INHIBIDORES DE LAS MAP QUINASAS, PREFERIBLEMENTE DE LA QUINASA P38 POR LO QUE SON UTILES EN OSTEOARTRITIS, ARTRITIS REUMATOIDE, CANCER, REPERFUSION O ISQUEMIA EN APOPLEJIA O EN UN ATAQUE CARDIACO.
GT200200043A 2001-03-09 2002-03-05 Nuevos compuestos antiinflamatorios de bencimidazol GT200200043A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27479101P 2001-03-09 2001-03-09

Publications (1)

Publication Number Publication Date
GT200200043A true GT200200043A (es) 2003-02-11

Family

ID=23049627

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200200043A GT200200043A (es) 2001-03-09 2002-03-05 Nuevos compuestos antiinflamatorios de bencimidazol

Country Status (17)

Country Link
US (1) US7056918B2 (es)
EP (1) EP1370557B1 (es)
JP (1) JP2004526727A (es)
AP (1) AP2002002460A0 (es)
AT (1) ATE309997T1 (es)
BR (1) BR0207957A (es)
CA (1) CA2440211A1 (es)
DE (1) DE60207390T2 (es)
DO (1) DOP2002000349A (es)
ES (1) ES2251582T3 (es)
GT (1) GT200200043A (es)
MX (1) MXPA03008142A (es)
PA (1) PA8540901A1 (es)
PE (1) PE20030200A1 (es)
TN (1) TNSN02021A1 (es)
UY (1) UY27198A1 (es)
WO (1) WO2002072576A1 (es)

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US20030092749A1 (en) 2003-05-15
PA8540901A1 (es) 2002-10-28
CA2440211A1 (en) 2002-09-19
EP1370557B1 (en) 2005-11-16
DE60207390T2 (de) 2006-07-20
ES2251582T3 (es) 2006-05-01
DE60207390D1 (de) 2005-12-22
EP1370557A1 (en) 2003-12-17
ATE309997T1 (de) 2005-12-15
MXPA03008142A (es) 2003-12-12
UY27198A1 (es) 2002-11-29
WO2002072576A1 (en) 2002-09-19
PE20030200A1 (es) 2003-03-12
BR0207957A (pt) 2004-02-25
AP2002002460A0 (en) 2002-06-30
US7056918B2 (en) 2006-06-06
JP2004526727A (ja) 2004-09-02
TNSN02021A1 (fr) 2005-12-23
DOP2002000349A (es) 2002-10-15

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