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GT200000158A - Piridinas y piridacinas sustituidas con actividad de inhibicion de angiogenesis. - Google Patents

Piridinas y piridacinas sustituidas con actividad de inhibicion de angiogenesis.

Info

Publication number
GT200000158A
GT200000158A GT200000158A GT200000158A GT200000158A GT 200000158 A GT200000158 A GT 200000158A GT 200000158 A GT200000158 A GT 200000158A GT 200000158 A GT200000158 A GT 200000158A GT 200000158 A GT200000158 A GT 200000158A
Authority
GT
Guatemala
Prior art keywords
piridines
replaced
inhibition activity
pyridacines
angiogenesis inhibition
Prior art date
Application number
GT200000158A
Other languages
English (en)
Inventor
Jaques P Dumas
Stephen James Boyer
Julie A Dixon
Teddy Kite Joe
Harold C E Kluender
Wendy Lee
Dhanapalan Nagarathnam
Robert N Sibley
Ning Su
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200000158A publication Critical patent/GT200000158A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A PRODUCTOS FARMACEUTICOS HETEROCICLICOS DE MOLECULAS PEQUEÑAS, Y MAS PARTICULARMENTE, A PIRIDINAS Y PIRIDACINAS SUSTITUIDAS QUE TIENEN ACTIVIDAD DE INHIBICION DE ANGIOGENESIS.
GT200000158A 1999-09-28 2000-09-22 Piridinas y piridacinas sustituidas con actividad de inhibicion de angiogenesis. GT200000158A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40760099A 1999-09-28 1999-09-28

Publications (1)

Publication Number Publication Date
GT200000158A true GT200000158A (es) 2002-03-16

Family

ID=23612752

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200000158A GT200000158A (es) 1999-09-28 2000-09-22 Piridinas y piridacinas sustituidas con actividad de inhibicion de angiogenesis.

Country Status (35)

Country Link
EP (1) EP1228063B1 (es)
JP (1) JP4919567B2 (es)
KR (3) KR100890473B1 (es)
CN (3) CN100374435C (es)
AR (3) AR025752A1 (es)
AT (1) ATE422494T1 (es)
AU (1) AU782820B2 (es)
BG (1) BG65860B1 (es)
BR (1) BRPI0014382B8 (es)
CA (1) CA2385817C (es)
CO (1) CO5200835A1 (es)
CZ (1) CZ304767B6 (es)
DE (1) DE60041548D1 (es)
DO (1) DOP2000000070A (es)
EE (1) EE05258B1 (es)
ES (1) ES2320525T3 (es)
GT (1) GT200000158A (es)
HR (1) HRP20020308A2 (es)
HU (1) HU230223B1 (es)
IL (3) IL148880A0 (es)
MA (1) MA25563A1 (es)
MX (1) MXPA02003156A (es)
MY (3) MY143580A (es)
NO (1) NO20021520L (es)
NZ (1) NZ518589A (es)
PA (1) PA8503201A1 (es)
PE (1) PE20010607A1 (es)
PL (1) PL205957B1 (es)
RS (1) RS50369B (es)
RU (1) RU2260008C2 (es)
SK (1) SK287417B6 (es)
TW (1) TW593315B (es)
UA (1) UA75053C2 (es)
WO (1) WO2001023375A2 (es)
ZA (1) ZA200202760B (es)

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JP2006503796A (ja) * 2001-12-21 2006-02-02 バイエル・フアーマシユーチカルズ・コーポレーシヨン ピリダジンまたはピリジン誘導体を含んでなる抗−脈管形成組み合わせ療法
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KR100553398B1 (ko) * 2004-03-12 2006-02-16 한미약품 주식회사 티에노[3,2-c]피리딘 유도체의 제조 방법 및 이에사용되는 중간체
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EP2281901B1 (en) 2005-08-02 2013-11-27 Eisai R&D Management Co., Ltd. Anti-tumour pharmaceutical composition with angiogenesis inhibitors
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EP2036557B1 (en) 2006-05-18 2015-10-21 Eisai R&D Management Co., Ltd. Antitumor agent for thyroid cancer
CN101511793B (zh) 2006-08-28 2011-08-03 卫材R&D管理有限公司 针对未分化型胃癌的抗肿瘤剂
AU2008211952B2 (en) 2007-01-29 2012-07-19 Eisai R & D Management Co., Ltd. Composition for treatment of undifferentiated-type of gastric cancer
JP5638244B2 (ja) 2007-11-09 2014-12-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害物質と抗腫瘍性白金錯体との併用
CN101481380B (zh) * 2008-01-08 2012-10-17 浙江医药股份有限公司新昌制药厂 噻吩并哒嗪类化合物及其制备方法、药物组合物及其用途
MX2012014776A (es) 2010-06-25 2013-01-29 Eisai R&D Man Co Ltd Agente antitumoral que emplea compuestos con efecto inhibidor de cinasas combinados.
MX2013009931A (es) 2011-04-18 2013-10-01 Eisai R&D Man Co Ltd Agentes terapeuticos contra tumores.
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US9334239B2 (en) 2012-12-21 2016-05-10 Eisai R&D Management Co., Ltd. Amorphous form of quinoline derivative, and method for producing same
US10517861B2 (en) 2013-05-14 2019-12-31 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
CN103396361B (zh) * 2013-07-24 2016-05-04 中国人民解放军第二军医大学 3,4-二氢异喹啉类抗肿瘤化合物及其制备方法与应用
CN106660964B (zh) 2014-08-28 2021-09-03 卫材R&D管理有限公司 高纯度喹啉衍生物及其生产方法
PL3263106T3 (pl) 2015-02-25 2024-04-02 Eisai R&D Management Co., Ltd. Sposób tłumienia goryczy pochodnej chinoliny
KR102662228B1 (ko) 2015-03-04 2024-05-02 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
CN104804008B (zh) * 2015-03-27 2016-03-23 亿腾药业(泰州)有限公司 一种工业化生产甲磺酸特拉替尼的方法
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Also Published As

Publication number Publication date
CA2385817A1 (en) 2001-04-05
MY143377A (en) 2011-05-13
SK5912002A3 (en) 2003-01-09
CN1769282A (zh) 2006-05-10
MY143580A (en) 2011-05-31
EE200200161A (et) 2003-08-15
EP1228063B1 (en) 2009-02-11
BG65860B1 (bg) 2010-03-31
AU1569601A (en) 2001-04-30
HUP0202704A3 (en) 2003-12-29
ZA200202760B (en) 2003-10-29
CN1769283A (zh) 2006-05-10
CO5200835A1 (es) 2002-09-27
ATE422494T1 (de) 2009-02-15
TW593315B (en) 2004-06-21
BR0014382B1 (pt) 2014-04-01
KR20080091505A (ko) 2008-10-13
AR082231A2 (es) 2012-11-21
NZ518589A (en) 2005-03-24
NO20021520D0 (no) 2002-03-26
KR100890473B1 (ko) 2009-03-26
KR100895571B1 (ko) 2009-04-29
CN100422173C (zh) 2008-10-01
IL148880A0 (en) 2002-09-12
MXPA02003156A (es) 2002-09-30
HK1091819A1 (zh) 2007-01-26
PL205957B1 (pl) 2010-06-30
AU782820B2 (en) 2005-09-01
AR082232A2 (es) 2012-11-21
NO20021520L (no) 2002-05-23
UA75053C2 (en) 2006-03-15
MY135058A (en) 2008-01-31
IL193367A (en) 2011-03-31
KR100895572B1 (ko) 2009-04-29
AR025752A1 (es) 2002-12-11
RS50369B (sr) 2009-11-10
CN100422172C (zh) 2008-10-01
DE60041548D1 (de) 2009-03-26
KR20020038775A (ko) 2002-05-23
PL366342A1 (en) 2005-01-24
PA8503201A1 (es) 2002-08-26
CN100374435C (zh) 2008-03-12
WO2001023375A3 (en) 2002-05-02
DOP2000000070A (es) 2002-02-28
IL193368A (en) 2011-05-31
CZ304767B6 (cs) 2014-10-08
HUP0202704A2 (hu) 2002-12-28
JP2003526632A (ja) 2003-09-09
CN1420879A (zh) 2003-05-28
BR0014382A (pt) 2003-06-24
WO2001023375A2 (en) 2001-04-05
CA2385817C (en) 2010-05-04
ES2320525T3 (es) 2009-05-25
RU2260008C2 (ru) 2005-09-10
IL193367A0 (en) 2009-02-11
SK287417B6 (sk) 2010-09-07
HRP20020308A2 (en) 2004-06-30
YU22902A (sh) 2004-12-31
PE20010607A1 (es) 2001-07-12
MA25563A1 (fr) 2002-10-01
EE05258B1 (et) 2010-02-15
HU230223B1 (en) 2015-10-28
BRPI0014382B8 (pt) 2021-05-25
CZ20021444A3 (cs) 2002-08-14
IL193368A0 (en) 2009-02-11
HRP20020308B1 (es) 2013-01-31
EP1228063A2 (en) 2002-08-07
JP4919567B2 (ja) 2012-04-18
HK1091818A1 (zh) 2007-01-26
KR20080086547A (ko) 2008-09-25
BG106637A (bg) 2003-02-28

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