GB995398A - Novel hypotensive composition - Google Patents
Novel hypotensive compositionInfo
- Publication number
- GB995398A GB995398A GB40698/63A GB4069863A GB995398A GB 995398 A GB995398 A GB 995398A GB 40698/63 A GB40698/63 A GB 40698/63A GB 4069863 A GB4069863 A GB 4069863A GB 995398 A GB995398 A GB 995398A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- specifications
- carbon atoms
- alkyl group
- referred
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 208000001953 Hypotension Diseases 0.000 title 1
- 208000021822 hypotensive Diseases 0.000 title 1
- 230000001077 hypotensive effect Effects 0.000 title 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 206010020772 Hypertension Diseases 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- QWJNFFYFEKXZBF-UHFFFAOYSA-N cyanocyanamide Chemical compound N#CNC#N QWJNFFYFEKXZBF-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 229960004592 isopropanol Drugs 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 235000011007 phosphoric acid Nutrition 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds of the formula <FORM:0995398/C2/1> wherein R is an hydrogen atom or an alkyl group having from 1 to 3 carbon atoms, and non-toxic acid-addition salts thereof, are prepared by the interaction of an appropriate amine with sodium dicyanimide in a lower alkanol solvent in the presence of mineral acid. Suitable solvents are iso-propanol, and n-butanol. Suitable acids are H2SO4, H3PO4. Specifications 599,713, 599,722 and 631,878 are referred to.ALSO:Pharmaceutical compositions for the control of hypertension comprise <FORM:0995398/A5-A6/1> wherein R is hydrogen or a lower alkyl group, having 1 to 3 carbon atoms, and their acid-addition salts. The medicament is administered orally. Specifications 599,713 and 631,878 are referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23613362A | 1962-11-07 | 1962-11-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB995398A true GB995398A (en) | 1965-06-16 |
Family
ID=22888258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB40698/63A Expired GB995398A (en) | 1962-11-07 | 1963-10-15 | Novel hypotensive composition |
Country Status (7)
| Country | Link |
|---|---|
| BR (1) | BR6354400D0 (en) |
| CH (1) | CH433247A (en) |
| DE (1) | DE1443386C3 (en) |
| ES (1) | ES293287A1 (en) |
| FR (1) | FR2977M (en) |
| GB (1) | GB995398A (en) |
| MY (1) | MY6900093A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3729530A1 (en) * | 1987-09-04 | 1989-03-16 | Degussa | PROCESS FOR PREPARING 1,6-DI (N (ARROW HIGH) 3 (ARROW HIGH) -CYANO-N (ARROW HIGH) 1 (ARROW HIGH) GUANIDINO) HEXANE |
-
1963
- 1963-10-15 GB GB40698/63A patent/GB995398A/en not_active Expired
- 1963-10-17 FR FR950857A patent/FR2977M/en active Active
- 1963-11-06 BR BR154400/63A patent/BR6354400D0/en unknown
- 1963-11-06 CH CH1359663A patent/CH433247A/en unknown
- 1963-11-07 DE DE1443386A patent/DE1443386C3/en not_active Expired
- 1963-11-07 ES ES293287A patent/ES293287A1/en not_active Expired
-
1969
- 1969-12-31 MY MY196993A patent/MY6900093A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE1443386B2 (en) | 1973-06-20 |
| BR6354400D0 (en) | 1973-07-19 |
| DE1443386C3 (en) | 1974-01-24 |
| ES293287A1 (en) | 1964-04-01 |
| CH433247A (en) | 1967-04-15 |
| MY6900093A (en) | 1969-12-31 |
| DE1443386A1 (en) | 1969-01-30 |
| FR2977M (en) | 1964-11-30 |
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