GB904797A - Ophthalmic medicaments comprising phenanthridinium salts - Google Patents
Ophthalmic medicaments comprising phenanthridinium saltsInfo
- Publication number
- GB904797A GB904797A GB4372159A GB4372159A GB904797A GB 904797 A GB904797 A GB 904797A GB 4372159 A GB4372159 A GB 4372159A GB 4372159 A GB4372159 A GB 4372159A GB 904797 A GB904797 A GB 904797A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- alkyl
- amidinophenyldiazoimino
- pyrimid
- acylamido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- -1 2-amino-6-methyl-pyrimid-4-ylamino group Chemical group 0.000 abstract 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000000022 bacteriostatic agent Substances 0.000 abstract 1
- 229960002798 cetrimide Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000010410 dusting Methods 0.000 abstract 1
- 239000003889 eye drop Substances 0.000 abstract 1
- 229940012356 eye drops Drugs 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 239000008188 pellet Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compositions for treating infections of the human and animal eye comprise a carrier and, as essential active ingredient, a compound of general formula <FORM:0904797/VI/1> wherein R1 represents hydrogen, amino, acylamido, lower (C1-) alkoxycarbonylamino, amidinophenyldiazoimino or the 2-amino-6-methyl-pyrimid-4-ylamino group quaternized in the 1-position, R2 represents amino, acylamido, lower (C1-) alkoxycarbonylamino, amidinophenyldiazoimino or the 2-amino-6-methyl-pyrimid-4 ylamino group quaternized in the 1-position, R3 represents alkyl, aralkyl, alkenyl, aralkenyl or aryl all of which may carry as further substituents one or more amino, alkylamino, nitro, halo, alkyl or alkoxy groups, R4 represents alkyl, alkenyl, hydroxyalkyl, alkoxyalkyl or amino-alkyl and X represents a pharmaceutically acceptable anion. The compositions may be in conventional forms, e.g. eye-drops, pellets, ointments and dusting powders. Bacteriostatic agents, e.g. "cetrimide" may also be present.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4372159A GB904797A (en) | 1959-12-23 | 1959-12-23 | Ophthalmic medicaments comprising phenanthridinium salts |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4372159A GB904797A (en) | 1959-12-23 | 1959-12-23 | Ophthalmic medicaments comprising phenanthridinium salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB904797A true GB904797A (en) | 1962-08-29 |
Family
ID=10430041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4372159A Expired GB904797A (en) | 1959-12-23 | 1959-12-23 | Ophthalmic medicaments comprising phenanthridinium salts |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB904797A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2196255A (en) * | 1986-10-14 | 1988-04-27 | Res & Dev Co Ltd | Eyedrops |
| WO2002053132A1 (en) * | 2001-01-08 | 2002-07-11 | Virbac S.A. | Water-soluble powdery or granular compositions based on phenanthridines and their uses |
-
1959
- 1959-12-23 GB GB4372159A patent/GB904797A/en not_active Expired
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2196255A (en) * | 1986-10-14 | 1988-04-27 | Res & Dev Co Ltd | Eyedrops |
| DE3734835A1 (en) * | 1986-10-14 | 1988-06-01 | Res & Dev Co Ltd | MEDICINES FOR OPHTHALMOLOGICAL USE |
| GB2196255B (en) * | 1986-10-14 | 1991-05-15 | Res & Dev Co Ltd | Eyedrops |
| WO2002053132A1 (en) * | 2001-01-08 | 2002-07-11 | Virbac S.A. | Water-soluble powdery or granular compositions based on phenanthridines and their uses |
| FR2819188A1 (en) * | 2001-01-08 | 2002-07-12 | Virbac Sa | WATER-SOLUBLE PULVERULENT OR GRANULATED COMPOSITIONS BASED ON PHENANTHRIDINES AND USES THEREOF |
| AP1704A (en) * | 2001-01-08 | 2007-01-02 | Virbac Sa | Water-soluble powdery or granular compositions based on phenanthridines and their uses. |
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