GB2286395B - Diketopiperazine derivatives and pharmaceutical uses thereof - Google Patents
Diketopiperazine derivatives and pharmaceutical uses thereofInfo
- Publication number
- GB2286395B GB2286395B GB9502874A GB9502874A GB2286395B GB 2286395 B GB2286395 B GB 2286395B GB 9502874 A GB9502874 A GB 9502874A GB 9502874 A GB9502874 A GB 9502874A GB 2286395 B GB2286395 B GB 2286395B
- Authority
- GB
- United Kingdom
- Prior art keywords
- pharmaceutical uses
- diketopiperazine derivatives
- diketopiperazine
- derivatives
- pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9402807A GB9402807D0 (en) | 1994-02-14 | 1994-02-14 | Pharmaceutical compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB9502874D0 GB9502874D0 (en) | 1995-04-05 |
| GB2286395A GB2286395A (en) | 1995-08-16 |
| GB2286395B true GB2286395B (en) | 1998-08-26 |
Family
ID=10750355
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9402807A Pending GB9402807D0 (en) | 1994-02-14 | 1994-02-14 | Pharmaceutical compounds |
| GB9502874A Expired - Fee Related GB2286395B (en) | 1994-02-14 | 1995-02-14 | Diketopiperazine derivatives and pharmaceutical uses thereof |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9402807A Pending GB9402807D0 (en) | 1994-02-14 | 1994-02-14 | Pharmaceutical compounds |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0745070A1 (en) |
| JP (1) | JPH09509157A (en) |
| AU (1) | AU693159B2 (en) |
| CA (1) | CA2182877A1 (en) |
| GB (2) | GB9402807D0 (en) |
| IL (1) | IL112624A0 (en) |
| WO (1) | WO1995021832A1 (en) |
| ZA (1) | ZA951180B (en) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL112627A0 (en) * | 1994-02-14 | 1995-05-26 | Xenova Ltd | Diketopiperazines, their preparation and pharmaceutical or veterinary compositions containing them |
| GB9426090D0 (en) * | 1994-12-23 | 1995-02-22 | Xenova Ltd | Pharmaceutical compounds |
| GB9708805D0 (en) | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| BR9809591A (en) | 1997-05-03 | 2001-09-11 | Smithkline Beecham Plc | Tetraidoisoquinoline derivatives as modulators of dopamine d3 receptors |
| EP1237377B1 (en) | 1997-06-09 | 2013-02-27 | Hitachi, Ltd. | Image decoding |
| GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
| AU761018B2 (en) | 1998-10-08 | 2003-05-29 | Smithkline Beecham Plc | Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents) |
| BR0017067A (en) * | 2000-01-18 | 2002-10-22 | Nereus Pharmaceuticals Inc | Cell division inhibitor, dehydrogenase, method for producing a cell division and compound inhibitor |
| AU2001294505B2 (en) * | 2000-05-09 | 2006-07-27 | Angiorx Corporation | Piperazinedione compounds |
| US7288545B2 (en) | 2000-05-09 | 2007-10-30 | Angiorx Corporation | Piperazinedione compounds |
| ATE417614T1 (en) * | 2000-05-09 | 2009-01-15 | Angiorx Corp | PIPERAZINDIONE COMPOUNDS |
| CA2453050A1 (en) | 2000-09-06 | 2002-03-14 | A.P. Pharma, Inc. | Degradable polyacetal polymers |
| GB2372740A (en) * | 2001-01-17 | 2002-09-04 | Xenova Ltd | Diketopiperazines |
| TW591020B (en) * | 2001-06-20 | 2004-06-11 | Wyeth Corp | 6-(aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| ES2295695T3 (en) * | 2002-08-02 | 2008-04-16 | Nereus Pharmaceuticals, Inc. | DEHYDROPHENYLHYSINAS AND ITS ANALOGS AND THE SYNTHESIS OF DEHYDROPHENYLHYTHINES AND THEIR ANALOGS. |
| US7935704B2 (en) | 2003-08-01 | 2011-05-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| JP2007520565A (en) * | 2004-02-04 | 2007-07-26 | ネレアス ファーマシューティカルズ インコーポレイテッド | Synthesis of dehydrophenylahistine and their analogs, and dehydrophenylahistine and their analogs |
| KR100966749B1 (en) * | 2004-05-26 | 2010-06-30 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | Cinnamid compounds |
| AU2005297966B2 (en) | 2004-10-26 | 2010-12-23 | Eisai R & D Management Co., Ltd. | Amorphous object of cinnamide compound |
| TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
| TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| US7884234B2 (en) | 2006-10-12 | 2011-02-08 | Institute Of Medicinal Molecular Design, Inc. | N-phenyloxamide derivatives |
| JP5207972B2 (en) | 2006-10-12 | 2013-06-12 | 株式会社医薬分子設計研究所 | Carboxylic acid derivatives |
| US8129527B2 (en) | 2006-11-03 | 2012-03-06 | Nereus Pharmacuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| TW200848054A (en) | 2007-02-28 | 2008-12-16 | Eisai R&D Man Co Ltd | Two cyclic oxomorpholine derivatives |
| EP2181992B8 (en) | 2007-08-31 | 2013-06-26 | Eisai R&D Management Co., Ltd. | Polycyclic compound |
| US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| BRPI0816560A2 (en) | 2007-10-23 | 2015-09-01 | Inst Med Molecular Design Inc | Parent-1 production inhibition method method for prevention or amelioration of a disease caused by over-production of parent-1 " |
| JPWO2009125606A1 (en) | 2008-04-11 | 2011-08-04 | 株式会社医薬分子設計研究所 | PAI-1 inhibitor |
| JP2011530559A (en) * | 2008-08-13 | 2011-12-22 | ビーエーエスエフ ソシエタス・ヨーロピア | Process for preparing piperazinedione derivatives |
| US9604930B2 (en) * | 2012-12-21 | 2017-03-28 | Epizyme, Inc. | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof |
| CN105272968B (en) * | 2014-06-10 | 2018-03-13 | 首都医科大学 | The diketone of (3S, 6R) 3,6 disubstituted piperazine 2,5, it is prepared and application |
| WO2016034673A1 (en) | 2014-09-03 | 2016-03-10 | Ctxt Pty Ltd | Tetrahydroisoquinoline derived prmt5-inhibitors |
| US10005792B2 (en) | 2014-09-03 | 2018-06-26 | Ctxt Pty. Ltd. | Aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived PRMT5-inhibitors |
| GB201415573D0 (en) | 2014-09-03 | 2014-10-15 | Cancer Therapeutics Crc Pty Ltd | Compounds |
| KR102623404B1 (en) | 2015-03-06 | 2024-01-11 | 비욘드스프링 파마수티컬스, 인코포레이티드. | How to Treat Brain Tumors |
| JP6769982B2 (en) | 2015-03-06 | 2020-10-14 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | How to treat cancer associated with RAS mutations |
| ES2910035T3 (en) | 2015-07-13 | 2022-05-11 | Beyondspring Pharmaceuticals Inc | Plinabulin Compositions |
| CA3013467A1 (en) | 2016-02-08 | 2017-08-17 | Beyondspring Pharmaceuticals, Inc. | Compositions containing tucaresol or its analogs |
| GB201604031D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
| GB201604027D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
| GB201604029D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
| GB201604020D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
| GB201604030D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
| GB201604022D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
| EP3463337A4 (en) | 2016-06-06 | 2020-02-12 | Beyondspring Pharmaceuticals, Inc. | COMPOSITION AND METHOD FOR REDUCING NEUTROPENIA |
| CN106565686B (en) * | 2016-10-11 | 2019-03-01 | 深圳海王医药科技研究院有限公司 | Antitubulin |
| CN110431135A (en) | 2017-01-06 | 2019-11-08 | 大连万春布林医药有限公司 | Tubulin binding compounds and therapeutic uses thereof |
| KR20190109479A (en) | 2017-02-01 | 2019-09-25 | 비욘드스프링 파마수티컬스, 인코포레이티드. | How to reduce neutropenia |
| IL273428B2 (en) | 2017-09-22 | 2023-09-01 | Jubilant Epipad LLC | Heterocyclic compounds as pad inhibitors |
| CN111225915B (en) | 2017-10-18 | 2023-03-07 | 朱比兰特埃皮帕德有限公司 | Imidazopyridine compounds as PAD inhibitors |
| BR112020008851A2 (en) | 2017-11-06 | 2020-10-20 | Jubilant Prodel LLC | compound of formula i, process for preparing compounds of formula i, pharmaceutical composition, method for treating and / or preventing various diseases, use, method for treating cancer, method of treating cancer and method for treating and / or prevention of cancer and infectious diseases |
| JP7368369B2 (en) | 2017-11-24 | 2023-10-24 | ジュビラント・エピスクライブ・エルエルシー | Heterocyclic compounds as PRMT5 inhibitors |
| SG11202006985TA (en) | 2018-01-24 | 2020-08-28 | Beyondspring Pharmaceuticals Inc | Composition and method for reducing thrombocytopenia via the administration of plinabulin |
| JP7279063B6 (en) | 2018-03-13 | 2024-02-15 | ジュビラント プローデル エルエルシー | Bicyclic compounds as inhibitors of PD1/PD-L1 interaction/activation |
| WO2022216908A1 (en) | 2021-04-09 | 2022-10-13 | Beyondspring Pharmaceuticals, Inc. | Therapeutic compositions and methods for treating tumors |
| CN116239578B (en) * | 2022-12-08 | 2024-09-13 | 中国海洋大学 | Piperazine dione ring compound, synthesis method thereof and application thereof in preparation of antitumor drugs |
| CN116400068B (en) * | 2023-02-13 | 2023-09-22 | 泉州圣源警用侦察设备有限公司 | Reagent for revealing potential biological trace containing DNA and revealing method |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE621862C (en) * | 1932-07-01 | 1935-11-14 | Guenther Schiemann Dr | Process for the preparation of condensation products of nucleus fluorinated aryl aldehydes |
| GB9217331D0 (en) * | 1992-08-14 | 1992-09-30 | Xenova Ltd | Pharmaceutical compounds |
| JPH08247357A (en) * | 1995-03-13 | 1996-09-27 | Zexel Corp | Flange joint and forming method thereof |
-
1994
- 1994-02-14 GB GB9402807A patent/GB9402807D0/en active Pending
-
1995
- 1995-02-13 IL IL11262495A patent/IL112624A0/en unknown
- 1995-02-14 CA CA002182877A patent/CA2182877A1/en not_active Abandoned
- 1995-02-14 JP JP7521082A patent/JPH09509157A/en not_active Ceased
- 1995-02-14 WO PCT/GB1995/000302 patent/WO1995021832A1/en not_active Ceased
- 1995-02-14 GB GB9502874A patent/GB2286395B/en not_active Expired - Fee Related
- 1995-02-14 EP EP95908314A patent/EP0745070A1/en not_active Withdrawn
- 1995-02-14 ZA ZA951180A patent/ZA951180B/en unknown
- 1995-02-14 AU AU16677/95A patent/AU693159B2/en not_active Ceased
Non-Patent Citations (1)
| Title |
|---|
| Chemical Abstracts 65:16969e * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0745070A1 (en) | 1996-12-04 |
| AU1667795A (en) | 1995-08-29 |
| WO1995021832A1 (en) | 1995-08-17 |
| CA2182877A1 (en) | 1995-08-17 |
| GB9402807D0 (en) | 1994-04-06 |
| GB9502874D0 (en) | 1995-04-05 |
| AU693159B2 (en) | 1998-06-25 |
| ZA951180B (en) | 1996-08-14 |
| GB2286395A (en) | 1995-08-16 |
| IL112624A0 (en) | 1995-05-26 |
| JPH09509157A (en) | 1997-09-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB2286395B (en) | Diketopiperazine derivatives and pharmaceutical uses thereof | |
| AU2505795A (en) | 1-arylpyrimidine derivatives and pharmaceutical use thereof | |
| NZ321576A (en) | 6-imidazol-1-ylmethyl-2-oxo-quinoline derivatives and medicaments | |
| NZ329176A (en) | 2,5-dioxo-imidazolidine derivatives and medicaments | |
| HUP0000474A3 (en) | Arylethenesulfonamide derivatives and drug composition containing the same | |
| GB2286393B (en) | Piperazinedione derivatives and pharmaceutical uses thereof | |
| HUP9904335A3 (en) | Arylpiperidinol and arylpiperidine derivatives and drugs containing the same | |
| GB2303851B (en) | Pharmaceutical diketopiperazine compounds | |
| HUP9900424A2 (en) | Thiazolylbenzofuran derivatives and pharmaceutical compositions containing them | |
| IL121298A (en) | N-(4-aryl-thiazol-2-yl)-sulphonamide derivatives and their uses | |
| NZ332309A (en) | Alkylamino-benzothiazole and -benzoxazole derivatives and medicaments | |
| IL116525A0 (en) | Piperazinedione derivatives their preparation and use | |
| AU4204697A (en) | Tetrahydroisoquinoline derivatives and their pharmaceutical use | |
| ZA967800B (en) | Heteroaryllsubstituted acryloylguanidine derivatives and pharmaceutical compositions comprising them | |
| HUP0000719A3 (en) | Arylpiperidinopropanol and arylpiperazinopropanol derivatives and pharmaceuticals containing the same | |
| HUP9602196A2 (en) | Sulfonyl- and sulfinyl-benzoyl-guanidine derivatives and pharmaceutical compositions thereof | |
| HUP0002331A3 (en) | 20-aralkyl-5alpha-pregnane derivatives and pharmaceutical compositions thereof | |
| NZ305898A (en) | Taxoid derivatives and medicaments | |
| HUP9602977A3 (en) | Arylpiperidine and arylpiperazine derivatives and drugs containing the same | |
| IL115982A (en) | Cyclolignan derivatives and pharmaceutical compositions containing them | |
| IL116893A0 (en) | Piperazine derivatives and pharmaceutical compositions containing them | |
| AU3107497A (en) | Asialotrisaccharide moranoline derivatives and drugs | |
| HUP0000275A3 (en) | Phenanethridinium derivatives and pharmaceutical compositions containing them | |
| GB2286392B (en) | Piperazine derivatives and pharmaceutical uses thereof | |
| IL117618A0 (en) | Diphenylmethyl-azetidinone derivatives and pharmaceutical compositions containing the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20050214 |