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GB2016271A - Producing gefarnate-containing solid preparations - Google Patents

Producing gefarnate-containing solid preparations

Info

Publication number
GB2016271A
GB2016271A GB7908723A GB7908723A GB2016271A GB 2016271 A GB2016271 A GB 2016271A GB 7908723 A GB7908723 A GB 7908723A GB 7908723 A GB7908723 A GB 7908723A GB 2016271 A GB2016271 A GB 2016271A
Authority
GB
United Kingdom
Prior art keywords
gefarnate
containing solid
producing
pka
solid preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7908723A
Other versions
GB2016271B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of GB2016271A publication Critical patent/GB2016271A/en
Application granted granted Critical
Publication of GB2016271B publication Critical patent/GB2016271B/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A storage stable Gefarnate-containing solid preparation in which Gefarnate is absorbed on a basic solid carrier such as magnesium silicate, metamagnesium aluminosilicate, magnesium oxide, aluminium hydroxide gel or synthetic hydrotalcite, is obtained by treating the surface of the base with a pKa adjusting agent (other than a mono- or di- saccharide or sugar alcohol) such as citric acid, sodium citrate, polyvinyl alcohol or gum arabic, to bring its surface pKa to 9.3 or less (e.g. 3-8), and then absorbing the Gefarnate onto the treated carrier.
GB7908723A 1978-03-14 1979-03-13 Process for producing gefarnate-containing solid preparations Expired GB2016271B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53029746A JPS6026093B2 (en) 1978-03-14 1978-03-14 Method for producing gefalnate-containing solid preparation

Publications (2)

Publication Number Publication Date
GB2016271A true GB2016271A (en) 1979-09-26
GB2016271B GB2016271B (en) 1982-09-02

Family

ID=12284653

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7908723A Expired GB2016271B (en) 1978-03-14 1979-03-13 Process for producing gefarnate-containing solid preparations

Country Status (17)

Country Link
JP (1) JPS6026093B2 (en)
AR (1) AR218711A1 (en)
BE (1) BE874795A (en)
CH (1) CH637827A5 (en)
CS (1) CS207784B2 (en)
ES (1) ES8200632A1 (en)
FR (1) FR2419729B1 (en)
GB (1) GB2016271B (en)
HK (1) HK49283A (en)
IE (1) IE48269B1 (en)
IT (1) IT1162282B (en)
MT (1) MTP843B (en)
MX (1) MX5996E (en)
NL (1) NL7901917A (en)
PH (1) PH16903A (en)
PT (1) PT69341A (en)
ZA (1) ZA791103B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2142235A (en) * 1983-06-08 1985-01-16 Thomae Gmbh Dr K Oral antidiabetic pharmaceutical compositions
US5516529A (en) * 1989-04-07 1996-05-14 Zellweger; Jean-Michel Granulates useful for preparing effervescent pesticide tablets

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025115989A1 (en) * 2023-12-01 2025-06-05 Ｅａファーマ株式会社 Pharmaceutical composition

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3432593A (en) * 1963-09-18 1969-03-11 Key Pharm Inc Delayed and sustained release type pharmaceutical preparation
JPS5635169B2 (en) * 1974-02-14 1981-08-15
SE421042B (en) * 1976-06-29 1981-11-23 Kockums Chem WANT TO REDUCE THE QUANTITY OF BIOLOGICAL ACTIVE SUBSTANCE REQUIRED FOR SOME BIOLOGICAL EFFECT
JPS53148519A (en) * 1977-05-31 1978-12-25 Sumitomo Chem Co Ltd Preparation of solid medicine containing gefarnate

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2142235A (en) * 1983-06-08 1985-01-16 Thomae Gmbh Dr K Oral antidiabetic pharmaceutical compositions
US5516529A (en) * 1989-04-07 1996-05-14 Zellweger; Jean-Michel Granulates useful for preparing effervescent pesticide tablets

Also Published As

Publication number Publication date
PT69341A (en) 1979-04-01
NL7901917A (en) 1979-09-18
FR2419729A1 (en) 1979-10-12
GB2016271B (en) 1982-09-02
MTP843B (en) 1980-02-11
ZA791103B (en) 1980-03-26
ES478539A0 (en) 1981-11-01
PH16903A (en) 1984-04-10
MX5996E (en) 1984-09-18
CH637827A5 (en) 1983-08-31
IE790725L (en) 1979-09-14
IE48269B1 (en) 1984-11-28
CS207784B2 (en) 1981-08-31
IT1162282B (en) 1987-03-25
ES8200632A1 (en) 1981-11-01
FR2419729B1 (en) 1988-07-08
JPS54122718A (en) 1979-09-22
JPS6026093B2 (en) 1985-06-21
HK49283A (en) 1983-11-11
IT7948332A0 (en) 1979-03-13
AR218711A1 (en) 1980-06-30
BE874795A (en) 1979-07-02

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Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19940313