GB1469845A - Antiviral polymer - Google Patents
Antiviral polymerInfo
- Publication number
- GB1469845A GB1469845A GB5164674A GB5164674A GB1469845A GB 1469845 A GB1469845 A GB 1469845A GB 5164674 A GB5164674 A GB 5164674A GB 5164674 A GB5164674 A GB 5164674A GB 1469845 A GB1469845 A GB 1469845A
- Authority
- GB
- United Kingdom
- Prior art keywords
- polymerization
- acid
- nov
- ester
- salt form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000000840 anti-viral effect Effects 0.000 title abstract 2
- 229920000642 polymer Polymers 0.000 title abstract 2
- 229920002125 Sokalan® Polymers 0.000 abstract 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- 238000006116 polymerization reaction Methods 0.000 abstract 3
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 239000004584 polyacrylic acid Substances 0.000 abstract 2
- 150000003839 salts Chemical group 0.000 abstract 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- PQLVXDKIJBQVDF-UHFFFAOYSA-N acetic acid;hydrate Chemical compound O.CC(O)=O PQLVXDKIJBQVDF-UHFFFAOYSA-N 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 239000011952 anionic catalyst Substances 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 229920001585 atactic polymer Polymers 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- ANRQGKOBLBYXFM-UHFFFAOYSA-M phenylmagnesium bromide Chemical compound Br[Mg]C1=CC=CC=C1 ANRQGKOBLBYXFM-UHFFFAOYSA-M 0.000 abstract 1
- 229920000058 polyacrylate Polymers 0.000 abstract 1
- 230000000379 polymerizing effect Effects 0.000 abstract 1
- LYBIZMNPXTXVMV-UHFFFAOYSA-N propan-2-yl prop-2-enoate Chemical compound CC(C)OC(=O)C=C LYBIZMNPXTXVMV-UHFFFAOYSA-N 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polymerization Catalysts (AREA)
Abstract
1469845 Anionic acrylate polymerization; polyacrylic acids HOECHST AG 28 Nov 1974 [30 Nov 1973] 51646/74 Heading C3P [Also in Division A5] An isotactic polyacrylic acid is obtained by (a) polymerizing an ester of acrylic acid with an alcohol branched in the alpha position from a solution thereof in an inert solvent using an anionic catalyst at 0‹ to - 80‹ C. (b) if necessary removing any atactic polymer present in excess of 25% and (c) subjecting the polyacrylate to acid hydrolysis. The polymerization is controlled to produce the desired stereoregular product having a molecular weight of 5,000 to 40,000 and a polydispersity of 1À1 to 2. The polymer may be converted into a conventional salt form or ester. Examples refer to the polymerization of isopropyl acrylate in toluene at - 78‹ C. using phenyl magnesium bromide, followed by hydrolysis by refluxing in a water/ trifluoroacetic acid mixture. The polyacrylic acid is then tested in salt form for its antiviral activity in conventional aqueous pharmaceutical preparations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7413939A SE7413939L (en) | 1973-11-07 | 1974-11-06 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19732359621 DE2359621C2 (en) | 1973-11-30 | 1973-11-30 | Antiviral alkali metal or ammonium salts of polyacrylic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1469845A true GB1469845A (en) | 1977-04-06 |
Family
ID=5899471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5164674A Expired GB1469845A (en) | 1973-11-07 | 1974-11-28 | Antiviral polymer |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS5739245B2 (en) |
| BE (1) | BE822845A (en) |
| CA (1) | CA1028446A (en) |
| DE (1) | DE2359621C2 (en) |
| FR (1) | FR2253530B1 (en) |
| GB (1) | GB1469845A (en) |
| NL (1) | NL180480C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2857361A1 (en) * | 2003-07-08 | 2005-01-14 | Genfit S A | PREPARATION OF 1,3-DIPHENYPROP-2-¼n-1-one DERIVATIVES |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2639669C3 (en) * | 1976-09-03 | 1982-05-06 | Hoechst Ag, 6000 Frankfurt | Process for the preparation of a poly (meth) acrylic acid ester with high isotaxy and narrow molecular weight distribution |
| JP7765249B2 (en) * | 2021-11-01 | 2025-11-06 | 積水化学工業株式会社 | Virus infection inhibitors and virus infection inhibitor products |
| JP2023142828A (en) * | 2022-03-25 | 2023-10-05 | 積水化学工業株式会社 | Viral infection inhibitor, viral infection inhibitory particle, and viral infection inhibitory coating |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3222339A (en) * | 1962-08-14 | 1965-12-07 | Rohm & Haas | Polymerization process using an organomagnesium compound as catalyst |
| BE794403A (en) * | 1972-04-05 | 1973-07-23 | Rohm & Haas | NEW POLYMERS OF ALKYL ACRYLATES |
-
1973
- 1973-11-30 DE DE19732359621 patent/DE2359621C2/en not_active Expired
-
1974
- 1974-11-18 CA CA214,192A patent/CA1028446A/en not_active Expired
- 1974-11-25 NL NL7415340A patent/NL180480C/en not_active IP Right Cessation
- 1974-11-28 JP JP13596574A patent/JPS5739245B2/ja not_active Expired
- 1974-11-28 GB GB5164674A patent/GB1469845A/en not_active Expired
- 1974-12-02 BE BE151063A patent/BE822845A/en not_active IP Right Cessation
- 1974-12-02 FR FR7439373A patent/FR2253530B1/fr not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2857361A1 (en) * | 2003-07-08 | 2005-01-14 | Genfit S A | PREPARATION OF 1,3-DIPHENYPROP-2-¼n-1-one DERIVATIVES |
| WO2005005369A1 (en) * | 2003-07-08 | 2005-01-20 | Genfit | Preparation of 1,3-diphenylprop-2-en-1-one derivatives |
| US7385082B2 (en) | 2003-07-08 | 2008-06-10 | Genfit | Preparation of 1,3-diphenylprop-2-en-1-one derivatives |
| EA010410B1 (en) * | 2003-07-08 | 2008-08-29 | Жанфит | Preparation of 1,3-diphenylprop-2-en-1-one derivatives |
| CN1819986B (en) * | 2003-07-08 | 2011-02-02 | 基恩菲特公司 | Preparation of 1,3-Diphenylprop-2-en-1-one Derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5739245B2 (en) | 1982-08-20 |
| NL180480B (en) | 1986-10-01 |
| CA1028446A (en) | 1978-03-21 |
| NL7415340A (en) | 1975-06-03 |
| DE2359621A1 (en) | 1975-06-05 |
| FR2253530A1 (en) | 1975-07-04 |
| JPS5087185A (en) | 1975-07-14 |
| NL180480C (en) | 1987-03-02 |
| DE2359621C2 (en) | 1982-11-18 |
| BE822845A (en) | 1975-06-02 |
| FR2253530B1 (en) | 1978-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |