GB1224995A - New 5-propargyloxymethyl-2-substituted oxazolidinones and their process of preparation - Google Patents
New 5-propargyloxymethyl-2-substituted oxazolidinones and their process of preparationInfo
- Publication number
- GB1224995A GB1224995A GB4493368A GB4493368A GB1224995A GB 1224995 A GB1224995 A GB 1224995A GB 4493368 A GB4493368 A GB 4493368A GB 4493368 A GB4493368 A GB 4493368A GB 1224995 A GB1224995 A GB 1224995A
- Authority
- GB
- United Kingdom
- Prior art keywords
- propargyloxymethyl
- preparation
- new
- substituted oxazolidinones
- oxazolidinones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000002959 anti-hypotensive effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 230000001670 myorelaxant effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,224,995. Oxazolidinones. DELALANDE S.A. 14 Aug., 1969 [20 Sept., 1968], No. 44933/68. Heading C2C. Novel compounds I in which Z is heterocyclyl are prepared by cyclization of in an alkaline medium. Pharmaceutical compositions comprise a compound I and a suitable carrier, are administered orally, rectally and topically and have sedative, myorelaxant, analgesic, anti-inflammatory and hypotensive properties.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4493368A GB1224995A (en) | 1968-09-20 | 1968-09-20 | New 5-propargyloxymethyl-2-substituted oxazolidinones and their process of preparation |
| FR6928646A FR2018478B1 (en) | 1968-09-20 | 1969-08-21 | |
| NL6913636A NL165165B (en) | 1968-09-20 | 1969-09-08 | PROCESS FOR THE PREPARATION OF A 3- AND 5-PLACE SUBSTITUTED OXAZOLIDINONE-2 WITH PHARMACOLOGICAL EFFECT, AND FORMED PHARMACEUTICAL PREPARATION. |
| ES371343A ES371343A1 (en) | 1968-09-20 | 1969-09-09 | New 5-propargyloxymethyl-2-substituted oxazolidinones and their process of preparation |
| BE738647D BE738647A (en) | 1968-09-20 | 1969-09-10 | |
| DE19691945820 DE1945820A1 (en) | 1968-09-20 | 1969-09-10 | New substituted 5-propargyloxymethyl-2-oxazolidinones, their manufacturing process and their therapeutic application |
| IT5329669A IT1044194B (en) | 1968-09-20 | 1969-09-10 | PROPARGILOSSIMETIL 5 OS SAZOLIDINONI 2 SUBSTITUTED PROCEDURE FOR THEIR PREPARATION AND THEIR APPLICATION IN THERAPY |
| LU59430D LU59430A1 (en) | 1968-09-20 | 1969-09-10 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4493368A GB1224995A (en) | 1968-09-20 | 1968-09-20 | New 5-propargyloxymethyl-2-substituted oxazolidinones and their process of preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1224995A true GB1224995A (en) | 1971-03-10 |
Family
ID=10435285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4493368A Expired GB1224995A (en) | 1968-09-20 | 1968-09-20 | New 5-propargyloxymethyl-2-substituted oxazolidinones and their process of preparation |
Country Status (8)
| Country | Link |
|---|---|
| BE (1) | BE738647A (en) |
| DE (1) | DE1945820A1 (en) |
| ES (1) | ES371343A1 (en) |
| FR (1) | FR2018478B1 (en) |
| GB (1) | GB1224995A (en) |
| IT (1) | IT1044194B (en) |
| LU (1) | LU59430A1 (en) |
| NL (1) | NL165165B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2708236A1 (en) * | 1976-03-01 | 1977-09-08 | Delalande Sa | 3-ARYL-2-OXAZOLIDINONE, METHOD FOR THEIR MANUFACTURE AND MEDICINAL PRODUCTS |
| DE2836305A1 (en) * | 1977-08-26 | 1979-03-01 | Delalande Sa | 5-HYDROXYMETHYL-2-OXAZOLIDINONE, METHOD OF MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING IT |
| US5036093A (en) * | 1987-10-09 | 1991-07-30 | Du Pont Merck Pharmaceutical | Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents |
| US7618990B2 (en) | 2006-08-15 | 2009-11-17 | Wyeth | Oxazolidone derivatives as PR modulators |
| US7618989B2 (en) | 2006-08-15 | 2009-11-17 | Wyeth | Tricyclic oxazolidone derivatives useful as PR modulators |
| EP2244576A4 (en) * | 2008-01-24 | 2011-06-08 | Merck Sharp & Dohme | 1,3-OXAZOLIDIN-2-ONE 3,5-SUBSTITUTED DERIVATIVES |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2538424C2 (en) * | 1975-08-29 | 1983-01-05 | Nordmark-Werke Gmbh, 2000 Hamburg | 4-substituted 5-phenyl-oxazolidone- (2) - compounds and a pharmaceutical preparation containing them |
| DE4406946C2 (en) * | 1994-03-04 | 1998-11-19 | Gesipa Blindniettechnik | Blind rivet nut setting tool |
| EP4371681B1 (en) | 2022-11-17 | 2025-09-24 | Bollhoff Otalu S.A.S. | Setting device for a blind rivet nut |
| EP4653143A1 (en) | 2024-05-21 | 2025-11-26 | Bollhof Otalu SAS | Setting device and method for setting a blind rivet nut |
-
1968
- 1968-09-20 GB GB4493368A patent/GB1224995A/en not_active Expired
-
1969
- 1969-08-21 FR FR6928646A patent/FR2018478B1/fr not_active Expired
- 1969-09-08 NL NL6913636A patent/NL165165B/en not_active IP Right Cessation
- 1969-09-09 ES ES371343A patent/ES371343A1/en not_active Expired
- 1969-09-10 LU LU59430D patent/LU59430A1/xx unknown
- 1969-09-10 BE BE738647D patent/BE738647A/xx unknown
- 1969-09-10 DE DE19691945820 patent/DE1945820A1/en active Pending
- 1969-09-10 IT IT5329669A patent/IT1044194B/en active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2708236A1 (en) * | 1976-03-01 | 1977-09-08 | Delalande Sa | 3-ARYL-2-OXAZOLIDINONE, METHOD FOR THEIR MANUFACTURE AND MEDICINAL PRODUCTS |
| DE2836305A1 (en) * | 1977-08-26 | 1979-03-01 | Delalande Sa | 5-HYDROXYMETHYL-2-OXAZOLIDINONE, METHOD OF MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING IT |
| US5036093A (en) * | 1987-10-09 | 1991-07-30 | Du Pont Merck Pharmaceutical | Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents |
| US7618990B2 (en) | 2006-08-15 | 2009-11-17 | Wyeth | Oxazolidone derivatives as PR modulators |
| US7618989B2 (en) | 2006-08-15 | 2009-11-17 | Wyeth | Tricyclic oxazolidone derivatives useful as PR modulators |
| EP2244576A4 (en) * | 2008-01-24 | 2011-06-08 | Merck Sharp & Dohme | 1,3-OXAZOLIDIN-2-ONE 3,5-SUBSTITUTED DERIVATIVES |
Also Published As
| Publication number | Publication date |
|---|---|
| ES371343A1 (en) | 1971-10-16 |
| LU59430A1 (en) | 1970-03-26 |
| FR2018478A1 (en) | 1970-05-29 |
| FR2018478B1 (en) | 1973-01-12 |
| DE1945820A1 (en) | 1970-04-02 |
| NL6913636A (en) | 1970-03-24 |
| IT1044194B (en) | 1980-03-20 |
| NL165165B (en) | 1980-10-15 |
| BE738647A (en) | 1970-03-10 |
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