GB1269774A - Benzodioxole compounds - Google Patents
Benzodioxole compoundsInfo
- Publication number
- GB1269774A GB1269774A GB3032768A GB3032768A GB1269774A GB 1269774 A GB1269774 A GB 1269774A GB 3032768 A GB3032768 A GB 3032768A GB 3032768 A GB3032768 A GB 3032768A GB 1269774 A GB1269774 A GB 1269774A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- alkoxy
- different
- compositions
- inflammatory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000005528 benzodioxoles Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- -1 morpholino, piperidino, pyrrolidino Chemical group 0.000 abstract 3
- 239000004480 active ingredient Substances 0.000 abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001767 cationic compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
- 150000002892 organic cations Chemical class 0.000 abstract 1
- 239000008188 pellet Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
1,269,774. Anti-inflammatory &c. compositions. LEO A.B. 16 June, 1969 [25 June, 1968], No. 30327/68. Heading A5B. [Also in Division C2] Pharmaceutical compositions, which may be administered orally, parenterally or by pellet implantation contain as active ingredients novel benzodioxole derivatives of the formula wherein R<SP>1</SP> is NH 2 , alkylamino, dialkylamino, morpholino, piperidino, pyrrolidino or dialkylaminoalkylamino, or OR<SP>9</SP> wherein R<SP>9</SP> is H, C 1-4 alkyl or a pharmaceutically acceptable inorganic or organic cation, R<SP>2</SP> and R<SP>3</SP> are the same or different and each is H or C 1-4 alkyl, R<SP>4</SP>, R<SP>5</SP> and R<SP>6</SP> are the same or different and each one is H, F, Cl, CF 3 , NO 2 or OH, C 1-4 alkyl, or C 1-4 alkoxy, R<SP>7</SP> is H or C 1-4 alkyl, R<SP>8</SP> is alkyl, alkenyl or cycloalkyl containing up to eight carbon atoms, optionally substituted with Cl, OH or C 1-4 alkoxy or an aryl group optionally substituted with not more than three equal or different substituents selected from Cl, F, CF 3 , NO 2 , OH, C 1-4 alkyl and C 1-4 alkoxy or R<SP>8</SP> forms together with R<SP>7</SP> and the carbon atom to which they are attached a cycloaliphatic ring containing up to seven carbon atoms, and pharmaceutically acceptable carriers. The above compositions, which may also contain other active ingredients such as analgesics, tranquillizers, steroids or hormones, have anti-inflammatory and/or analgesic and/or anti-pyretic activity.
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3032768A GB1269774A (en) | 1968-06-25 | 1968-06-25 | Benzodioxole compounds |
| SE838969A SE360861B (en) | 1968-06-25 | 1969-06-12 | |
| IE83869A IE33462B1 (en) | 1968-06-25 | 1969-06-18 | Benzodioxole compounds |
| CH949969A CH534149A (en) | 1968-06-25 | 1969-06-20 | Process for the preparation of benzodioxole compounds |
| CA055,038A CA968352A (en) | 1968-06-25 | 1969-06-23 | Pharmaceutically valuable benzodioxole compounds and process for their preparation |
| DE19691931784 DE1931784A1 (en) | 1968-06-25 | 1969-06-23 | New benzodioxole compounds, processes for their manufacture and pharmaceutical preparations containing them |
| DK337369A DK123597B (en) | 1968-06-25 | 1969-06-23 | Analogous process for the preparation of benzodioxole compounds. |
| NO262369A NO128994B (en) | 1968-06-25 | 1969-06-24 | |
| BE735069D BE735069A (en) | 1968-06-25 | 1969-06-24 | |
| ES368730A ES368730A1 (en) | 1968-06-25 | 1969-06-24 | Benzodioxole compounds |
| BR21010269A BR6910102D0 (en) | 1968-06-25 | 1969-06-24 | PROCESS OF PREPARING PHARMACEUTICALLY ACCEPTABLE BENZODIOXOLA COMPOUNDS |
| NL6909723A NL6909723A (en) | 1968-06-25 | 1969-06-25 | |
| AT603069A AT300796B (en) | 1968-06-25 | 1969-06-25 | Process for the preparation of new benzodioxole compounds |
| JP5023269A JPS4913793B1 (en) | 1968-06-25 | 1969-06-25 | |
| FR6921375A FR2014217B1 (en) | 1968-06-25 | 1969-06-25 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3032768A GB1269774A (en) | 1968-06-25 | 1968-06-25 | Benzodioxole compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1269774A true GB1269774A (en) | 1972-04-06 |
Family
ID=10305889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3032768A Expired GB1269774A (en) | 1968-06-25 | 1968-06-25 | Benzodioxole compounds |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS4913793B1 (en) |
| AT (1) | AT300796B (en) |
| BE (1) | BE735069A (en) |
| BR (1) | BR6910102D0 (en) |
| CA (1) | CA968352A (en) |
| CH (1) | CH534149A (en) |
| DE (1) | DE1931784A1 (en) |
| DK (1) | DK123597B (en) |
| ES (1) | ES368730A1 (en) |
| FR (1) | FR2014217B1 (en) |
| GB (1) | GB1269774A (en) |
| IE (1) | IE33462B1 (en) |
| NL (1) | NL6909723A (en) |
| NO (1) | NO128994B (en) |
| SE (1) | SE360861B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115043814A (en) * | 2022-06-30 | 2022-09-13 | 黑龙江中医药大学 | A kind of medicine for treating myocardial ischemia and its application |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3726924A (en) * | 1971-03-26 | 1973-04-10 | Hoffmann La Roche | Method for the preparation of tris (dimethylamino) methane |
-
1968
- 1968-06-25 GB GB3032768A patent/GB1269774A/en not_active Expired
-
1969
- 1969-06-12 SE SE838969A patent/SE360861B/xx unknown
- 1969-06-18 IE IE83869A patent/IE33462B1/en unknown
- 1969-06-20 CH CH949969A patent/CH534149A/en not_active IP Right Cessation
- 1969-06-23 DE DE19691931784 patent/DE1931784A1/en active Pending
- 1969-06-23 DK DK337369A patent/DK123597B/en unknown
- 1969-06-23 CA CA055,038A patent/CA968352A/en not_active Expired
- 1969-06-24 BE BE735069D patent/BE735069A/xx unknown
- 1969-06-24 BR BR21010269A patent/BR6910102D0/en unknown
- 1969-06-24 ES ES368730A patent/ES368730A1/en not_active Expired
- 1969-06-24 NO NO262369A patent/NO128994B/no unknown
- 1969-06-25 JP JP5023269A patent/JPS4913793B1/ja active Pending
- 1969-06-25 NL NL6909723A patent/NL6909723A/xx unknown
- 1969-06-25 FR FR6921375A patent/FR2014217B1/fr not_active Expired
- 1969-06-25 AT AT603069A patent/AT300796B/en not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115043814A (en) * | 2022-06-30 | 2022-09-13 | 黑龙江中医药大学 | A kind of medicine for treating myocardial ischemia and its application |
| CN115043814B (en) * | 2022-06-30 | 2023-02-24 | 黑龙江中医药大学 | Medicine for treating myocardial ischemia and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| AT300796B (en) | 1972-08-10 |
| IE33462L (en) | 1969-12-25 |
| IE33462B1 (en) | 1974-07-10 |
| CA968352A (en) | 1975-05-27 |
| FR2014217B1 (en) | 1973-01-12 |
| BE735069A (en) | 1969-12-01 |
| JPS4913793B1 (en) | 1974-04-03 |
| ES368730A1 (en) | 1971-07-01 |
| DK123597B (en) | 1972-07-10 |
| DE1931784A1 (en) | 1970-01-02 |
| CH534149A (en) | 1973-02-28 |
| NL6909723A (en) | 1969-12-30 |
| FR2014217A1 (en) | 1970-04-17 |
| NO128994B (en) | 1974-02-11 |
| SE360861B (en) | 1973-10-08 |
| BR6910102D0 (en) | 1973-02-08 |
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