GB1109964A - Complex of theophylline and soluble saccharin, process for its preparation and therapeutic composition comprising same - Google Patents
Complex of theophylline and soluble saccharin, process for its preparation and therapeutic composition comprising sameInfo
- Publication number
- GB1109964A GB1109964A GB2373566A GB2373566A GB1109964A GB 1109964 A GB1109964 A GB 1109964A GB 2373566 A GB2373566 A GB 2373566A GB 2373566 A GB2373566 A GB 2373566A GB 1109964 A GB1109964 A GB 1109964A
- Authority
- GB
- United Kingdom
- Prior art keywords
- theophylline
- complex
- saccharin
- soluble saccharin
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 title abstract 8
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 title abstract 4
- 229960000278 theophylline Drugs 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 2
- XTPLQANXHDDXIH-UHFFFAOYSA-N azanium;1,1-dioxo-1,2-benzothiazol-3-olate Chemical compound N.C1=CC=C2C(=O)NS(=O)(=O)C2=C1 XTPLQANXHDDXIH-UHFFFAOYSA-N 0.000 abstract 2
- 229910052700 potassium Inorganic materials 0.000 abstract 2
- 239000011591 potassium Substances 0.000 abstract 2
- 229910052708 sodium Inorganic materials 0.000 abstract 2
- 239000011734 sodium Substances 0.000 abstract 2
- XNVYXHPPYWIPKX-UHFFFAOYSA-N 2,2,5,7-tetramethyl-1-oxo-3h-indene-4-carbonyl chloride Chemical compound CC1=CC(C)=C(C(Cl)=O)C2=C1C(=O)C(C)(C)C2 XNVYXHPPYWIPKX-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 229960001490 methapyrilene hydrochloride Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960003447 pseudoephedrine hydrochloride Drugs 0.000 abstract 1
- BALXUFOVQVENIU-KXNXZCPBSA-N pseudoephedrine hydrochloride Chemical compound [H+].[Cl-].CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-KXNXZCPBSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Novel complexes of theophylline and soluble saccharin are prepared by reaction of theophylline and a soluble saccharin, such as sodium, potassium or ammonium saccharin.ALSO:Pharmaceutical compositions, useful as bronchial dilators, comprise a complex of theophylline and a soluble saccharin, such as sodium, potassium or ammonium saccharin, and a carrier, alone or with other therapeutically useful agents, such as pseudoephedrine hydrochloride and methapyrilene hydrochloride. The compositions are particularly suitable for oral and intravenous administration.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46274765A | 1965-06-09 | 1965-06-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1109964A true GB1109964A (en) | 1968-04-18 |
Family
ID=23837621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2373566A Expired GB1109964A (en) | 1965-06-09 | 1966-05-26 | Complex of theophylline and soluble saccharin, process for its preparation and therapeutic composition comprising same |
Country Status (4)
| Country | Link |
|---|---|
| DE (1) | DE1620205A1 (en) |
| ES (1) | ES327680A1 (en) |
| FR (1) | FR5823M (en) |
| GB (1) | GB1109964A (en) |
-
1966
- 1966-05-26 GB GB2373566A patent/GB1109964A/en not_active Expired
- 1966-06-06 FR FR64248A patent/FR5823M/fr not_active Expired
- 1966-06-08 ES ES0327680A patent/ES327680A1/en not_active Expired
- 1966-06-10 DE DE19661620205 patent/DE1620205A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE1620205A1 (en) | 1970-02-12 |
| FR5823M (en) | 1968-02-26 |
| ES327680A1 (en) | 1967-08-16 |
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