FR3116435A1 - COSMETIC COMPOSITIONS COMPRISING AN ANTIMICROBIAL AGENT - Google Patents

Abstract

COSMETIC COMPOSITIONS COMPRISING AN ANTIMICROBIAL AGENT SYSTEM WITH IRRITATION REDUCTION OR EYE DISCOMFORT A cosmetic composition includes an antimicrobial system that includes an antimicrobial agent comprising 4-hydroxyacetophenone and one or more additional antimicrobial agents comprising piroctone olamine. The antimicrobial system can be used in a cosmetic composition in which the composition is a makeup-removing composition which is an O/W emulsion, a W/O emulsion, a micellar water, a makeup-removing wipe or a two-phase (or multi-phase) composition ). The antimicrobial system may be free or substantially free of any one or more of parabens, alcohols, formaldehyde and formaldehyde-derived compounds. In certain particular embodiments, the composition is free or substantially free of parabens, formaldehyde, formaldehyde-derived compounds, pentylene glycol, phenoxyethanol, hexylglycerin, ethylhexylglycerin, octylglycerin, benzylglycerin, 3-heptoyl-2,2-propandiol and 1,2 -hexandiol. Figure for abstract: NONE

Description

COSMETIC COMPOSITIONS COMPRISING AN ANTIMICROBIAL AGENT

SYSTEM WITH REDUCTION OF L ' IRRITATION OR
OF THE ' EYE DISCOMFORT

DOMAIN

The present invention relates to make-up removing and cleansing compositions which comprise a novel antimicrobial system which provides effective make-up removal with minimal irritation to eyes and other tissues.

CONTEXT

Typically, makeup removers and cleansers are used all over the face, some of which are necessarily used around the eyes. Indeed, there are cosmetic cleansers designed specifically to remove stubborn makeup, such as regular or waterproof mascara, liner, eye shadow, glitter, and long-wear foundation, in addition to lip products from longer duration. These cleansers may require repeated tugging and rubbing of the skin, especially on and around the delicate eye tissues, which can be inherently irritating to the skin. Additionally, most makeup removers include antimicrobials and preservatives which can also lead to stinging and burning sensations in the eye area due to proximity and in some cases accidental contact with the eyes during the makeup removal process.

Accordingly, there is a need for cosmetic compositions, in particular cleansers and cleansing wipes which will remove makeup and provide the benefits of preservation and protection against microbial growth without causing eye irritation. These compositions and articles would desirably exclude antimicrobial, preservative, and cleansing components that are irritating, such as pentylene glycol, phenoxyethanol, and parabens, without compromising cleansing and antimicrobial efficacy.

According to the present disclosure, a novel antimicrobial system, when used in a makeup remover or cleansing composition, unexpectedly produces significantly reduced or no eye irritation compared to similarly formulated compositions that include conventional antimicrobial systems.

SUMMARY

The disclosure provides, in various embodiments, a cosmetic composition comprising:

1. an antimicrobial system which comprises:a) an antimicrobial agent comprising 4-hydroxyacetophenone; And

b) at least one additional antimicrobial agent comprising piroctone olamine.

According to various embodiments, the cosmetic composition that includes the antimicrobial system is an O/W emulsion, W/O emulsion, micellar water, wipe, or two-phase (or multi-phase) composition. In certain particular embodiments, the cosmetic composition is a makeup-removing composition which is one of an O/W emulsion, a W/O emulsion, a micellar water, a makeup-removing wipe or a two-phase (or multi-phase) composition ).

In some embodiments, the at least one additional antimicrobial agent may also include one or more of the following antimicrobial agents and their salts, including caprylyl glycol, caprylhydroxamic acid, chlorphenesin, benzoic acid, salicylic acid, benzyl alcohol, phenethyl alcohol and benzalkonium chloride.

In some embodiments, the cosmetic composition is free or substantially free of one or more parabens, alcohols, formaldehyde and formaldehyde-derived compounds. In certain particular embodiments, the composition is free or essentially free of parabens, formaldehyde and compounds derived from formaldehyde.

In certain particular embodiments, the composition is free or substantially free of alcohols comprising one or more of ethanol and isopropyl alcohol.

In some embodiments, the composition is free or substantially free of antimicrobials which include one or more of any of pentylene glycol, phenoxyethanol, hexyl glycerin, ethylhexyl glycerin, octyl glycerin, benzyl glycerin, 3-heptoyl-2,2- propandiol and 1,2-hexandiol.

In accordance with various embodiments, the antimicrobial agent comprising 4-hydroxyacetophenone is present at from about 0.2% to about 1% by weight of the composition; the at least one additional antimicrobial agent comprising piroctone olamine (Octopirox), when present, is present at about 0.05% to about 1.5% by weight of the composition. In certain particular embodiments, the composition comprises 4-hydroxyacetophenone present at about 0.25% to about 2% by weight of the composition; the at least one additional antimicrobial agent comprising piroctone olamine, when present, is present at about 0.05% to about 1.5% by weight of the composition.

In accordance with certain embodiments, the disclosure provides a makeup-removing composition, comprising:

1. an antimicrobial system which comprises:a) an antimicrobial agent comprising 4-hydroxyacetophenone; And

b) at least one additional antimicrobial agent comprising piroctone olamine; And

1. a water-based cleaning system.

In accordance with certain embodiments, the disclosure proposes a makeup-removing composition comprising:

1. an antimicrobial system which comprises:a) an antimicrobial agent comprising 4-hydroxyacetophenone; And

b) at least one additional antimicrobial agent comprising piroctone olamine; And

1. a water-based cleaning system that includes:
2. one or more lipophilic emollients;
3. at least one thickener for a water-based system;
4. one or more humectants; And
5. some water.

According to certain embodiments:

1. the at least one lipophilic emollient is chosen from isohexadecane, a C15-19 alkane, isododecane, undecane, tridecane, isopropyl myristate, dicaprylyl ether, ethylhexyl palmitate, isopropyl palmitate, cetearyl ethylhexanoate, isononyl isononanoate , isopropyl isostearate, diisopropyl sebacate, coco caprylate/caprate, diisopropyl adipate and combinations thereof;
2. the at least one thickener is chosen from cross-linked polymer of acrylates/C10-30 alkyl acrylates, copolymers of sodium acrylates, carbomer, xanthan gum, hydroxypropyl guar, gum of ceratonia siliqua (locust bean), polyacryloyldimethyl ammonium taurate, ammonium acryloyldimethyltaurate/steareth-25 methacrylate, and polyacrylate cross-linked polymer-6 and combinations thereof;
3. the at least one humectant comprises glycerin.

In various embodiments, the compositions may include more than one of each of the components, and may further include one or more additives selected from fragrances, beading agents, silica, proteins, protein hydrolysates, vitamins, panthenol, silicones, odor absorbers and coloring matter; essential oils ; fruit extracts, for example Pyrus Malus (apple) fruit extract and powdered Aloe Barbadensis leaf juice; citric acid, sodium chloride; neutralizing or pH-adjusting agents (e.g. triethylamine (TEA) and sodium hydroxide); and their combinations.

In certain embodiments, a cosmetic article comprising the cosmetic composition is provided, the article comprising:

a- a water-insoluble substrate comprising a cosmetic wipe;

b- impregnated in the water-insoluble substrate, a cosmetic composition according to the disclosure,

wherein the cosmetic composition is impregnated onto the water-insoluble substrate at a soak rate of 250% to 400% by weight of the cleansing composition based on the weight of the substrate.

In accordance with various embodiments, the article is formed from synthetic materials or formed from biodegradable and sustainably sourced natural fibers, natural fibers, or regenerated or recycled natural fibers.

In certain particular embodiments, the article comprises nonwoven fibers, the fibers being formed from biodegradable natural fibers of sustainable origin chosen from (1) fibers of natural origin comprising one or a combination of wood pulp, viscose, lyocell, cellulose acetate and cotton, (2) natural fibers including one or a combination of hemp, flax, seaweed, ramie, banana and pineapple, and (3) regenerated or recycled fibers including cotton and combinations of these.

In certain embodiments, the disclosure provides a cosmetic composition comprising: an antimicrobial system which comprises: an antimicrobial agent comprising 4-hydroxyacetophenone; and at least one additional antimicrobial agent comprising piroctone olamine; and a skin care system selected from: a biphasic water-based cleansing system; a multi-phase water-based cleaning system; a monophasic micellar water-based cleansing system; and a topical composition which is one of a serum, essence, cream or mask.

These and other aspects of the invention are set out in the appended claims and described in greater detail in the Detailed Description of the Invention.

This disclosure describes exemplary embodiments in accordance with the general inventive concepts and is not intended to limit the scope of the invention in any way. Indeed, the invention as described in the specification is broader than and not limited to the exemplary embodiments set forth herein, and the terms used herein have their full ordinary meaning.

It should be understood that the foregoing general description and the following detailed description are both exemplary and explanatory and are not restrictive of disclosure.

DETAILED DESCRIPTION

The term "article" is understood herein to mean the combination composed of a water-insoluble carrier and a composition impregnated onto the carrier. This article can in particular be a wipe but it can also have any form, including those described below. The water-insoluble carrier is absorbent and strong enough not to disintegrate during use. The use of the article as defined above is intended to take care of the skin or hair and/or cleanse and/or remove make-up and/or rub the skin.

"Keratinous substrate" and "keratinous tissue" each include, but are not limited to, skin, hair, and nails.

“Cosmetically acceptable” means a support compatible with any keratinous substrate.

In various embodiments, the disclosure provides an antimicrobial system and a makeup remover composition that includes the antimicrobial system. The antimicrobial system includes an antimicrobial agent comprised of 4-hydroxyacetophenone and one or more additional antimicrobial agents comprising piroctone olamine. In some examples, the antimicrobial system can be used in a skin care system selected from: a biphasic water-based cleansing system; a multi-phase water-based cleaning system; a monophasic micellar water-based cleansing system; and a topical composition which is a serum, essence, cream or mask. In certain specific examples, the antimicrobial system can be used in makeup-removing compositions which are an O/W emulsion, a W/O emulsion, a micellar water or a two-phase (or multi-phase) composition. In some embodiments, the composition is used in a makeup remover wipe.

In various embodiments, the antimicrobial system may be free or substantially free of one or more of any of parabens, alcohols, formaldehyde and formaldehyde-derived compounds. In certain particular embodiments, the composition is free or essentially free of parabens, formaldehyde and compounds derived from formaldehyde. In some embodiments, the composition is free or substantially free of one or more of the following compounds: pentylene glycol, phenoxyethanol, hexyl glycerin, ethylhexyl glycerin, octyl glycerin, benzyl glycerin, 1,3-propanediol, 3-heptoyl-2 ,2-propandiol and 1,2-hexandiol. In certain particular embodiments, the composition is free or substantially free of each of the following: pentylene glycol, phenoxyethanol, hexyl glycerin, ethylhexyl glycerin, octyl glycerin, benzyl glycerin, 1,3-propanediol, 3-heptoyl-2,2 -propandiol and 1,2-hexandiol. In some embodiments, the composition is free or substantially free of any alcohol. In certain particular embodiments, the composition is free or substantially free of alcohols including one or more of the following: ethanol and isopropyl alcohol.

In various embodiments, the compositions may include more than one of each of the components, and may further include one or more additives, including humectants, preservatives, fragrances, actives, and pH adjusters, among other cosmetically acceptable.

Through consumer ratings of PD efficacy, compositions according to the disclosure demonstrated makeup removal performance consistent with comparative compositions and significantly improved performance with respect to eye irritation.

In certain embodiments, the disclosure proposes the antimicrobial system and the makeup-removing composition integrated into an article of cosmetic application. The article can be made of synthetic materials, such as PET (polyethylene terephthalate, or polyester) and PP (polypropylene), which can be used alone or in combination with materials of natural origin. And in some embodiments, the article may be formed from durable, biodegradable substrates from sources such as (1) nonwovens made from naturally occurring fibers, such as wood pulp, viscose, Lyocell , cellulose acetate, cotton, (2) nonwovens made from natural fibers, such as hemp, flax, seaweed, ramie, banana, pineapple, and (3) nonwovens - woven from regenerated or recycled fibres, such as cotton.

Many conventional cosmetic items, such as wipes, are made of polymeric materials of fossil origin, such as PET (polyethylene terephthalate, or polyester) and PP (polypropylene), which can be used alone or in combination with materials of natural origin. Such synthetic substrates are desirable because they are relatively less expensive to produce and offer good tensile strength, but since they virtually never degrade, they contribute detrimentally to the environment. As the cosmetics industry increasingly focuses on durability, there is a need for cosmetic articles that employ solid substrates from sources such as (1) naturally occurring fiber-based nonwovens, such as wood pulp, viscose, Lyocell, cellulose acetate, cotton, (2) nonwovens made from natural fibers, such as hemp, flax, seaweed, ramie, banana, l pineapple, and (3) nonwovens made from regenerated or recycled fibers, such as cotton. As used herein, the terms “naturally occurring fiber” refer to fibrous materials formed by chemical treatment which yield derivatives based on natural fibers; “natural fiber” means forms not derived from natural fibers; and "reclaimed/recycled" refers to natural fibers that are recovered from products formed with such fibers.

In some embodiments, the article herein is formed from substrates obtained from sustainable and biodegradable sources. In certain particular embodiments, these materials are selected from fibers of natural origin transformed into nonwovens, using fibers such as wood pulp, viscose, Lyocell, cellulose acetate and cotton . And in some embodiments, the substrates used to form cosmetic articles are Lyocell nonwovens. According to these embodiments which include biodegradable and sustainably sourced natural fibres, an obvious benefit is the possibility of reducing the environmental load. Other benefits can also be obtained by using sustainable and biodegradable substrates. As further described herein, articles that use durable and biodegradable substrates, particularly Lyocell nonwovens, exhibit certain mechanical, textural and absorbent properties.

An item according to the disclosure is clammy to the touch. It has the advantage of being comfortable when applied to the skin and of having a nourishing effect thanks to the presence of an oily phase. When used to cleanse or remove make-up from the skin, an article according to the disclosure is passed over the skin, while optionally leaving it applied for a time sufficient for the make-up products to be dissolved in the impregnating composition of the article, then the skin is wiped clean. The skin can also optionally be rinsed afterwards. The article according to the invention is preferably a cosmetic article suitable for caring for and/or treating the skin of the face, body or hands and for cleaning or removing make-up from the skin of the face and/or body. . It can also be used to care for the hair and to remove make-up from the eyes.

An article according to the disclosure may have any form appropriate to the desired purpose. It may constitute a wipe which has a generally rectangular, square or other shape, which may be single-layered, multi-layered, and which may be folded or unfolded. The article may also be in the form of a glove, a mitt or in any other form suitable for practical use on the face or body, for example in the form of a face with holes for the sites of the eyes, nose and/or mouth, or in the form of a make-up remover finger for application when removing make-up from the eyelashes, or in the form of a disc with one or two faces which may in particular comprise two faces impregnated with different compositions. The article may also have a rough surface which allows the exfoliation (scrub) of the skin.

In an exemplary embodiment, compositions that comprise an inventive antimicrobial system according to the disclosure may be in the form of a makeup remover composition comprising one or more lipophilic emollients, one or more volatile silicone compounds, at least one thickener for a water-based system and one or more humectants and water. It will, of course, be appreciated that in other embodiments, the inventive antimicrobial system according to the disclosure may be provided in a composition which is generally in the form of an O/W emulsion, a W/O emulsion, a micellar water, a make-up remover wipe or a two-phase (or multi-phase) composition. Thus, according to the teachings of the art with regard to the selection of ingredients for various cosmetic compositions, and in particular for makeup-removing compositions, the antimicrobial system can be incorporated to replace the conventional antimicrobial systems of the art. And in particular, these compositions are free or essentially free of one or more of the parabens, surfactants, alcohols, formaldehyde and compounds derived from formaldehyde. And in some embodiments, the compositions are free or substantially free of antimicrobials including one or more of the following: pentylene glycol, phenoxyethanol, hexyl glycerin, ethylhexylglycerin, octylglycerin, benzylglycerin, 3-heptoyl-2,2-propandiol, and 1 ,2-hexandiol.

Lipophilic emollient

In accordance with the disclosure, compositions according to the disclosure may include one or more lipophilic emollients.

The lipophilic emollients can be chosen from liquid, branched or linear alkanes, the length of the carbon chain of which is between C11 and C20. In various embodiments, the liquid alkanes can be selected from those of carbon chain length from C11 to C20. The liquid alkanes can be chosen from those whose carbon chain length is between C11 and C20, or between C15 and C19, or from C11, C12, C13, C14, C15, C16, C17, C18 and C19. In certain particular embodiments, suitable liquid alkanes which can be used according to the disclosure include oils based on hydrocarbons containing from 8 to 16 carbon atoms, and in particular branched C8-C16 alkanes such as isoalkanes in C8-C16. In certain exemplary embodiments, such liquid alkanes may be selected from isoparaffins, for example isododecane (also known as 2,2,4,4,6-pentamethylheptane), isodecane and isohexadecane .

In some embodiments, the at least one lipophilic emollient includes one or more of the following: isohexadecane, C15-19 alkane, isododecane, undecane, tridecane and combinations thereof. In some embodiments, the at least one lipophilic emollient comprises isohexadecane.

The lipophilic emollients can be chosen from polar emollients. Emollients are oil-phase ingredients selected from esters, triglycerides, ethers, carbonates, alcohols, oils, butters, fatty acids, and combinations thereof. In various embodiments, the polar emollients can be chosen from those whose molecular weight is less than or equal to 400 g/mol. More generally, the polar emollient can have a molecular weight of between approximately 50 g/mol and approximately 350 g/mol.

In certain embodiments, suitable polar emollients which may be used according to the disclosure include those derived from C12-C50 fatty acids, preferably C16-C22 saturated fatty acids, and monohydric alcohols. In certain embodiments, these esters can be selected from isopropyl myristate, methyl palmitate, isopropyl laurate, isopropyl palmitate, ethylhexyl palmitate, ethylhexyl laurate, ethylhexyl oleate, ethylhexyl isononanoate , myristyl myristate, 2-ethylhexyl caprate/caprylate (or octyl caprate/caprylate), 2-ethylhexyl palmitate, isostearyl neopentanoate, isononyl isononanoate, hexyl laurate, esters of lactic acid and d fatty alcohols containing 12 or 13 carbon atoms, dicaprylyl carbonate and mixtures thereof.

In certain embodiments, the at least one lipophilic emollient comprises isopropyl myristate, dicaprylyl ether, ethylhexyl palmitate, isopropyl palmitate, cetearyl ethylhexanoate, isononyl isononanoate, isopropyl isostearate, diisopropyl sebacate, coco caprylate/caprate, diisopropyl adipate and combinations thereof. In certain particular embodiments, the at least one lipophilic emollient comprises isopropyl myristate.

In some embodiments, the lipophilic emollient includes dimethicone, cyclopentasiloxane and/or other silicone emollients.

In some particular embodiments, the lipophilic emollient includes isohexadecane, isopropyl myristate, dimethicone, cyclopentasiloxane and/or other silicone emollients.

The amount of each of the at least one or more lipophilic emollients which may be present in the composition is provided in a range of about 1% to about 12% by weight, or about 3% to about 11% by weight , or from about 5% to about 10% or any suitable combination, sub-combination, range or sub-range thereof by weight, based on the weight of the composition. However, one of ordinary skill in this field will appreciate that other ranges fall within the scope of the invention.

Thus, each of the at least one or more lipophilic emollients in the composition may be present by weight, based on the total weight of the composition, in the proportion of approximately 1, 2, 3, 4, 5, 6, 7, 8 , 9, 10, 11 to approximately 12 percent, including increments and ranges in between.

Thickening

In accordance with the disclosure, compositions according to the disclosure may include at least one thickener.

In certain embodiments, the at least one thickener can be chosen from one or more natural gums and synthetic polymers, for example starches (corn, rice, tapioca, potato), gums (xanthan carrageenan, gellan, sclerotium ). In certain particular embodiments, the at least one thickener can be chosen from crosslinked polymer of acrylates/C10-30 alkyl acrylate, copolymer of sodium acrylates, carbomer, xanthan gum, hydroxypropyl guar, ceratonia siliqua (carob), ammonium polyacryloyldimethyl taurate, ammonium acryloyldimethyltaurate/steareth-25 methacrylate cross-linked polymer, and polyacrylate cross-linked polymer-6.

In some embodiments, the composition includes two or more thickeners. In some embodiments, the composition comprises one or both of the following polymeric thickeners: cross-linked polymer of acrylates/10-30 alkyl acrylates and copolymer of sodium acrylates, and optionally one or more additional polymeric thickeners.

The amount of each of the at least one thickener is present in the composition in a range of about 0.01% to about 5%, or about 0.01% to about 3%, or about 0. 05% to about 2.5%, or any suitable combination, sub-combination, range or sub-range thereof by weight, based on the weight of the composition. However, one of ordinary skill in this field will appreciate that other ranges fall within the scope of the invention.

In some embodiments, the total amount of thickener present in the composition ranges from about 0.01% to about 5%, or from about 1.0% to about 3%, or from about 2% to about 2.55%, or any suitable combination, sub-combination, range or sub-range thereof by weight, based on the weight of the composition. However, one of ordinary skill in this field will appreciate that other ranges fall within the scope of the invention.

Thus, one or more thickeners, when present, are present by weight, based on the total weight of the composition, of approximately 0.01, 0.02, 0.03, 0.04, 0.05, 0 .06, 0.07, 0.08, 0.09, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8 , 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0, 3 .5, 4.0, 4.5 to approximately 5.0 percent, including increments and ranges in between.

Solvent / Water

According to the various embodiments, water is present in the compositions in a range from about 40% to about 90%, or from about 55% to about 85%, or from about 60% to about 75%, or from about 65% to about 70%, or any suitable combination, sub-combination, range or sub-range thereof by weight, based on the weight of the composition. However, one of ordinary skill in this field will appreciate that other ranges fall within the scope of the invention. Thus, water is present, by weight, based on the total weight of the composition, from about 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, to about 90 percent by weight, including intermediate increments and ranges.

The water used can be sterile demineralised water and/or floral water such as rose water, cornflower water, chamomile water or lime water, and/or thermal water or natural mineral such as, for example: water from Vittel, water from the Vichy basin, water from Uriage, water from Roche Posay, water from La Bourboule, water from Enghien-les-Bains, water from Saint Gervais-les-Bains , water from Néris-les-Bains, water from Allevar-les-Bains, water from Digne, water from Maizières, water from Neyrac-les-Bains, water from Lons-le-Saunier, water from Eaux Bonnes, water from Rochefort , Saint Christau water, Fumades water, Tercis-les-Bains water or Avène water. The aqueous phase may also include reconstituted thermal water, i.e. water comprising trace elements such as zinc, copper, magnesium, etc. restoring the characteristics of thermal water.

The pH of the composition is not limited but is generally between 2 and 12, and in certain embodiments, between 3 and 11, and between 5 and 9, and between 6 and 8, and in certain embodiments, it is 7. The pH can be adjusted to the desired value by adding a base (organic or inorganic) to the composition, for example ammonia or a primary, secondary or tertiary (poly)amine, such as monoethanolamine, diethanolamine, triethanolamine, isopropanolamine or 1,3-propanediamine, or else by the addition of an inorganic or organic acid, advantageously a carboxylic acid, such as for example citric acid.

In some embodiments, the composition may include one or more additional solvents, for example, monoalcohols such as C1-C8 monohydric alcohols such as ethanol, propanol, butanol, isopropanol, isobutanol and benzyl alcohol, and phenylethyl alcohol.

In some embodiments, the composition is free or substantially free of any alcohol. In certain particular embodiments, the composition is free or substantially free of alcohols including one or more of the following: ethanol and isopropyl alcohol.

Humectant / moisturizing agent

In accordance with the disclosure, an additional humectant may be present in the compositions. In some embodiments, the humectant can include one or more of the polyols, including, for example, glycerin, glycerol, butylene glycol, propylene glycol, isoprene glycol, dipropylene glycol, hexylene glycol and polyethylene glycols, monoethylene glycol, diethylene glycol , triethylene glycol, diethylene glycol, hexylene glycol, glycol ethers such as monopropylene, dipropylene and tripropylene glycol alkyl(C1-C4) ethers, squalane, triacetin, sugars, such as glucose, xylitol, maltitol, sorbitol, sucrose pentaerythritol, inositol, pyrrolidone carboxylic acid, lactic acid, lithium chloride, acetamide MEA, sodium lactate, urea, dicyanamide, hyaluronic acid, aloe vera, honey and seaweed extract.

In some embodiments, the compositions include a humectant comprising glycerin.

According to various embodiments, the amount of humectant present in the compositions can vary from about 1% to about 15%, or from about 2% to about 12%, or from about 3% to about 7% , or from about 4% to about 5%, or any suitable combination, sub-combination, range or sub-range thereof by weight, based on the weight of the composition. However, one of ordinary skill in this field will appreciate that other ranges fall within the scope of the invention.

Thus any one humectant or combination of humectants may be present, by weight, based on the total weight of the composition, is about 1, 2, 3, 4, 5, 6, 7, 8, 9 , 10, 11, 12, 13, 14, to about 15 weight percent, including increments and ranges in between.

Optional Additives

The compositions may also comprise at least one additive used in the cosmetics field which does not affect the properties of the compositions according to the invention, such as additives chosen from perfumes, pearlescent agents, silica, proteins, protein hydrolysates, vitamins, panthenol, silicones, odor absorbers and coloring matter; essential oils ; fruit extracts, for example Pyrus Malus (apple) fruit extract and powdered Aloe Barbadensis leaf juice; citric acid, sodium chloride; neutralizing or pH adjusting agents (e.g., triethylamine (TEA) and sodium hydroxide); and their combinations.

Although the optional active additives are given by way of example, it will be appreciated that other optional components compatible with the cosmetic applications known in the profession can be used. Although the optional additives are given by way of example, it will be appreciated that other optional components compatible with cosmetic applications known in the art can be used.

In accordance with various embodiments, the amount of one or more actives and additives, alone or in combination, present in the composition may range, according to the disclosure, from about 0.001% to about 20%, in weight, or from about 0.005% to about 0.01%, or from about 0.01% to about 0.1%, or from about 0.15% to about 5%, or from about 0.40 % to about 4%, or from about 0.5% to about 2.5% by weight, or from about 1% to about 2%, or any suitable combination, sub-combination, range or sub-range thereof -ci by weight, relative to the total weight of the composition.

Thus, any one or a combination of active ingredients and additives may be present, by weight, based on the total weight of the composition, each or the combination being present from about 0.001, 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 at about 20% by weight, including increments and ranges in between.

Substrate

According to various embodiments, articles are provided comprising a solid substrate impregnated with an inventive antimicrobial system, in some embodiments in the form of a makeup-removing composition. The article may be made of synthetic materials or natural fibers that are biodegradable and of sustainable natural origin, natural fibers or regenerated or recycled natural fibers.

According to some embodiments, the substrate is a nonwoven material. A general description of nonwoven materials is given in Riedel "Nonwoven Bonding Methods and Materials", Nonwoven World (1987). These substrates are obtained according to the normal methods of the technology for the preparation of nonwoven materials. When the substrate is a non-woven material, one can use a non-woven material that does not end up in a ball and that is strong enough not to disintegrate and become fluffy when applied to the skin. It must be absorbent and soft on at least one side for eye make-up removal in particular. Mention may be made, where appropriate, of suitable nonwoven materials, for example those sold under the names Ultraloft 15285-01, Ultraloft 182-008, Ultraloft 182-010 and Ultraloft 182-016 by BBA, Vilmed M1519 Blau, Vilmed M 1550 N and 112-132-3 by Freudenberg, which was sold under the name Norafin 11601-010B by Jacob Holm Industries, the flocked nonwovens sold under the names Univel 109 and Univel 119 by Uni Flockage and the viscose/PLA one supplied by Sandler.

In some embodiments composing an article, a water-insoluble substrate is employed. The water-insoluble substrate may comprise one or more layers and may be selected from the group consisting of woven materials, non-woven materials, foams, sponges, wadding, in the form of sheets, balls or movies. It may in particular be a nonwoven substrate based on fibers of natural origin (linen, wool, cotton, silk, viscose, bamboo fibers) or of synthetic origin (derivatives of cellulose, polyvinyl derivatives, polyesters, such as poly(ethylene terephthalate), polyolefins, such as polyethylene (PET) or polypropylene, polyamides, such as Nylon, or acrylic derivatives) and mixtures thereof, such as viscose/PET, polylactic acid (PLA) or viscose/ polylactic acid (viscose/PLA).

According to one embodiment, the substrate is a nonwoven material, composed of viscose or a nonwoven material composed of a viscose/microviscose blend, by a process of hydroentangling. In certain particular embodiments, the article comprises nonwoven fibers, the fibers being formed from biodegradable natural fibers of sustainable origin chosen from (1) fibers of natural origin comprising one or a combination of wood pulp, viscose, lyocell, cellulose acetate and cotton, (2) natural fibers including one or a combination of hemp, flax, seaweed, ramie, banana and pineapple, and (3) regenerated or recycled fibers including cotton and combinations of these. According to one of these embodiments, the substrate is a nonwoven material formed from a biodegradable material, such as Lyocell.

According to some embodiments, the article may comprise one or more layers having the same or different properties and having properties of elasticity and flexibility and other properties appropriate to the desired use. The substrates may comprise, for example, two parts having different elastic properties, as described in WO-A-99/13861, or may comprise a single layer having different densities, as described in WO-A -99/25318, or may comprise two layers of different textures, as described in document WO-A-98/18441. According to certain embodiments, when the article is used for the body, it may include at least one rough side to allow, at the same time, to massage the skin or to erase the skin.

According to various embodiments, the article can be any size and shape that is appropriate for the desired purpose. Also, it usually has an area between 0.005 m²and 0.1m², or between 0.01 m² and 0.05m². The weight of the substrate can be between 30 g/m²and 200gsm²(gram per square meter), or between 40 g/m²and 60 g/m².

According to various embodiments, the degree of impregnation of the composition on the substrate generally ranges from 100 to 1000%, in certain embodiments from about 150% to about 700%, or from about 250% to about 400% the weight of the substrate. Techniques for impregnating substrates with compositions are well known and can all be applied in the present invention. Generally, the impregnating composition is heated and added to the substrate by one or more techniques including dipping, coating, spraying, and the like.

Examples

EXAMPLE 1 : RAW MATERIALS

Table 1: Raw materials

INCI name Source 4-HYDROXYACETOPHENONE
SYMSAVE H™; Symrise PIROCTONE OLAMINE
OCTOPIROX™; Clariant

EXAMPLE 2 : Inventive Examples :

Various representative embodiments of the inventive compositions are exemplified herein. In some embodiments, the composition is an antimicrobial system. In certain embodiments, the composition is a make-up remover in the form of an O/W emulsion, a W/O emulsion or a micellar water, in make-up removal wipes or in two-phase (or multi-stage). In certain particular exemplified embodiments, the composition is a makeup remover comprising the antimicrobial composition.

Examples of embodiments of the inventive compositions in the form of cleansing and makeup-removing compositions (not impregnated in a substrate) according to the disclosure are provided in Table 2.

Table 2: Inventive Examples

Phase INCI name Ex. Inventive 1 Ex. Inventive 2 A1 WATER (QS) 68.25 68.4 A1 ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER 0.05 0.05 A2 GLYCERIN 5 5 A2 HYDROXYACETOPHENONE 0.5 0.5 A2 PIROCTONE OLAMINE 0.2 0.05 B ISOHEXADECANE 10 10 B ISOPROPYL MYRISTATE 10 10 B DIMETHICONE 3.5 3.5 B SODIUM ACRYLATES COPOLYMER (and) CAPRYLIC/CAPRIC TRIGLYCERIDE 2.5 2.5 Total (% by weight): 100 100 pH 6.09 6.00 Viscosity (M4, 10min) 26.5 UD 26.5 UD Micro Challenge test (T0 & T2M) Succeeded Succeeded Eye irritation and discomfort Goods less than zero Goods less than zero

Inventive Examples 1 and 2 have substantially the same composition as a commercially available product sold under the trademark DERMABLEND MAKEUP DISSOLVER, except that each includes an antimicrobial system which is free (or substantially free) of phenoxyethanol and pentylene glycol, and each includes the antimicrobial 4-hydroxyacetophenone with piroctone olamine. As reported in more detail in the consumer trials, the above table shows that each of the two inventive compositions is associated with little or no irritation, particularly when compared to the comparative composition which was the test and the overall eye irritation potential of the comparison category that includes typical antimicrobial systems.

EXAMPLE 3: Comparative Examples

Exemplary embodiments of the Comparative Examples in the form of cleansing and makeup-removing compositions (not incorporated into a substrate) according to the disclosure are provided in Table 3.

Table 3: Comparative examples

Phase INCI name Ex. Comparative 1 Ex. Comparative 2 Ex. Comparative 3 Ex. Comparative 4 A1 WATER (QS) 68.15 68.15 68.25 66.95 A1 ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER 0.05 0.05 0.05 0.05 A2 GLYCERIN 5 5 5 5 A2 CAPRYLYL GLYCOL 0.3 0.3 0.3 A2 HYDROXYACETOPHENONE 0.5 0.5 A2 PHENOXYETHANOL 0.5 0.3 A2 ETHYLHEXYLGLYCERIN 0.1 A2 PENTYLENE GLYCOL 1.5 B ISOHEXADECANE 10 10 10 10 B ISOPROPYL MYRISTATE 10 10 10 10 B DIMETHICONE 3.5 3.5 3.5 3.5 B SODIUM ACRYLATES COPOLYMER (and) CAPRYLIC/CAPRIC TRIGLYCERIDE 2.5 2.5 2.5 2.5 Total (% by weight): 100 100 100 100 pH 6.02 5.86 5.82 5.82 Viscosity (M4, 10min) 26 to 36 UD 30 to 35 UD 27 to 30 UD 30 to 35 UD Micro Challenge trial Succeeded Succeeded Succeeded Succeeded Eye irritation and discomfort Students Students Students Moderate

Comparative Example 1 is a commercially available product sold under the trademark DERMABLEND MAKEUP DISSOLVER and includes the antimicrobials phenoxyethanol and caprylyl glycol (representative of a typical antimicrobial system used in many cosmetics in the art such as that of the present application ). Comparative Example 2 is identical to Comparative Example 1, except that the phenoxyethanol has been replaced by the antimicrobial 4-hydroxyacetophenone. Comparative Example 3 is identical to Comparative Example 1 except that the composition also includes the antimicrobial agent ethylhexylglycerin. Comparative Example 4 is identical to Comparative Example 2, except that hydroxyacetophenone has been replaced by pentylene glycol. As reported in greater detail in the context of consumer testing, the table above shows that each of the four comparative examples was associated with moderate to severe irritation.

EXAMPLE 4: Antimicrobial Challenge Studies

Studies were conducted with each of the inventive and comparative compositions, as referenced in the tables below, to evaluate their antimicrobial effectiveness against a series of microbes. The results are shown in Tables 4 to 11.

Table 4: Results of microbiological studies*: Inventive example 1 at T0 and room temperature

Inoculum T0 /RT, CFU/g MICROORGANISMS CFU/g 7 days 14 days Escherichia coli 1.7E+06 <200 <200 Enterococcus faecalis 1.1E+06 4.1E+04 <200 Candida albicans 1.3E+06 <200 <200 Aspergillus niger 1.1E+06 <200 <200 * Detection limit: <200 CFU/g

Table 5: Results of microbiological studies*: Inventive Ex. 1, after storage at 45°C for 2 months (accelerated ageing)

Inoculum T2M/45°C, CFU/g MICROORGANISMS CFU/g 7 days 14 days 28 days Escherichia coli 2.3E+06 <200 <200 <200 Pseudomonas aeruginosa 2.8E+06 <200 <200 <200 Staphylococcus aureus 2.5E+06 <200 <200 <200 Enterococcus faecalis 1.6E+06 6.6E+03 <200 <200 Candida albicans 1.4E+06 <200 <200 <200 Aspergillus niger 2.8E+06 <200 <200 <200 * Detection limit: <200 CFU/g

Table 6: Results of microbiological studies*: Inventive Ex. 2 at T0 and room temperature

Inoculum T0 /RT, CFU/g MICROORGANISMS CFU/g 7 days 14 days Escherichia coli 1.7E+06 <200 <200 Enterococcus faecalis 1.8E+06 1.0E+05 <200 Candida albicans 1.3E+06 <200 <200 Aspergillus niger 1.1E+06 <200 <200 * Detection limit: <200 CFU/g

Table 7: Results of the microbiological studies*: Inventive Ex. 2, after storage at 45°C for 2 months (accelerated ageing)

Inoculum T2M/45oC, CFU/g MICROORGANISMS CFU/g 7 days 14 days 28 days Escherichia coli 2.3E+06 <200 <200 <200 Pseudomonas aeruginosa 2.8E+06 <200 <200 <200 Staphylococcus aureus 2.5E+06 <200 <200 <200 Enterococcus faecalis 1.6E+06 8.5E+04 <200 <200 Candida albicans 1.4E+06 <200 <200 <200 Aspergillus niger 2.8E+06 <200 <200 <200 * Detection limit: <200 CFU/g

Table 8: Results of microbiological studies*: Ex. Comparative 1, at T0 and room temperature

Inoculum T0 /RT, CFU/g MICROORGANISMS CFU/g 7 days 14 days Escherichia coli 2.5E+06 <200 <200 Enterococcus faecalis 2.2E+06 <200 <200 Candida albicans 2.6E+06 <200 <200 Aspergillus niger 2.9E+06 <200 <200 * Detection limit: <200 CFU/g

Table 9: Results of microbiological studies*: Comparative Ex. 1, after storage at 45°C for 2 months (accelerated ageing)

Inoculum T2M/45oC, CFU/g MICROORGANISMS CFU/g 7 days 14 days 28 days Escherichia coli 1.8E+06 <200 <200 <200 Pseudomonas aeruginosa 1.9E+06 <200 <200 <200 Staphylococcus aureus 1.6E+06 <200 <200 <200 Enterococcus faecalis 1.6E+06 1.8E+03 <200 <200 Candida albicans 1.9E+06 <200 <200 <200 Aspergillus niger 9.2E+05 <200 <200 <200 * Detection limit: <200 CFU/g

Table 10: Results of microbiological studies*: Ex. Comparative 4 at T0 and room temperature

Inoculum T0 /RT, CFU/g MICROORGANISMS CFU/g 7 days 14 days Escherichia coli 2.4E+06 <200 <200 Pseudomonas aeruginosa 2.5E+06 <200 <200 Staphylococcus aureus 2.5E+06 <200 <200 Enterococcus faecalis 1.1E+06 3.9E+04 <200 Candida albicans 2.4E+06 <200 <200 Aspergillus niger 1.4E+06 <200 <200 * Detection limit: <200 CFU/g

Table 11: Results of microbiological studies: Comparative Ex. 4, after storage at 45oC for 2 months (accelerated ageing)

Inoculum T2M/45oC, CFU/g MICROORGANISMS CFU/g 7 days 14 days 28 days Escherichia coli 2.2E+06 <200 <200 <200 Pseudomonas aeruginosa 2.6E+06 <200 <200 <200 Staphylococcus aureus 1.8E+06 <200 <200 <200 Enterococcus faecalis 1.3E+06 5.9E+04 <200 <200 Candida albicans 1.8E+06 <200 <200 <200 Aspergillus niger 1.8E+06 <200 <200 <200 * Detection limit: <200 CFU/g

EXAMPLE 5: Consumer Study on Eye Irritation and Makeup Removal Efficacy (PD)

A consumer study was conducted to evaluate eye irritation and/or discomfort and PD efficacy of inventive and comparative compositions. Samples of each of the inventive and comparative compositions Ex 1 and Ex 4 were made available to a cohort of 10 consumers. Consumers used the product daily for a period of two weeks and, after two weeks of use, participated in the survey. Eye irritation/discomfort and PD effectiveness were reported on a scale of 1 to 5, as follows:

Eye irritation/discomfort. Scale 1-5: 1 = no tingling, no discomfort; 5 = very pungent and uncomfortable

Efficiency of the PD. Scale 1-5: 1 = no makeup removal or difficult makeup removal; 5 = complete make-up removal with ease

Results showing generally comparable (with respect to PD efficacy) and superior (with respect to eye irritation) performance of the inventive compositions as compared to a comparative composition are shown in Table 12. (NOTE: where indicated, one subject *discontinued use of Comparative Composition 1 after one application due to eye stinging).

Table 12: Consumer test raw scores

Eye irritation or discomfort Effectiveness of PDs Panelist Ex. Inventive 1 Ex. Comparative 1 Ex. Comparative 4 Ex. Inventive 1 Ex. Comparative 1 Ex. Comparative 4 1 1 5 1 4.5 4 4.5 2 1 4 1 3 5 5 3 2 4 3 3 4 5 4 3 4 1 4 3 5 5* 1 4 1 4 1 3 6 2 3 4 4 3 2 7 3 5 4 2 2 2 8 0.5 4 1.5 4.5 4 4.5 9 1 2 1 5 5 5 10 1 5 2 5 5 5 Mean 1.55 4.00 1.95 3.90 3.60 4.10 Standard deviation 0.90 0.94 1.26 0.97 1.35 1.26

EXAMPLE 6: Inventive and Comparative Examples for Cleansing Wipes.

Table 13 shows the PD juice formulas of the inventive and comparative examples, the eye irritation and the PD tests of the corresponding PD wipes. All wipes were prepared by soaking the juice formula at 320% soak rate onto a non-woven Lyocell substrate. The results clearly demonstrated a significant reduction in eye irritation and superior micro challenge results from Ex. Inventive 3 in Comparison to Comparative Examples.

Table 13: Comparison between Inventive Example and Comparative Examples for PD Wipes

Ex. Inventive 3 Comparative example 5 Comparative Example 6 Comparative Example 7 Comparative Example 8 Phase INCI name % in weight % in weight % in weight % in weight % in weight AT WATER 82,265 82.21 82 82.15 81.85 AT CARBOMER 0.1 0.1 0.1 0.1 0.1 AT ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER 0.04 0.04 0.05 0.05 0.05 A1 SODIUM LAUROYL LACTYLATE (and) CERAMIDE NP (and) CERAMIDE AP (and) PHYTOSPHINGOSINE (and) CHOLESTEROL (and) XANTHAN GUM (and) CARBOMER (and) CERAMIDE EOP 0.1 0.1 0.1 0.1 0.1 B GLYCERIN 3 3 3 3 3 B CAPRYLYL GLYCOL 0.3 0.3 0.3 0.3 0.3 B HYDROXYACETOPHENONE 0.5 0.5 0.5 0.5 0.5 B PIROCTONE OLAMINE 0.05 B IODOPROPYNYL BUTYLCARBAMATE (10% active) 0.1 B PHENOXYETHANOL 0.3 0.3 B CHLORPHENESIN 0.15 0.15 B HEXYLENE GLYCOL 1 1 1 1 1 B TRISODIUM ETHYLENEDIAMINE DISUCCINATE 0.1 0.1 0.1 0.1 0.1 VS Sodium hydroxide 0.045 0.05 0.05 0.05 0.05 VS WATER 0.5 0.5 0.5 0.5 0.5 D ISOHEXADECANE 5 5 5 5 5 D ISOPROPYL MYRISTATE 5 5 5 5 5 D DICAPRYLYL ETHER 1 1 1 1 1 D PEG-7 Glyceryl Cocoate 1 1 1 1 1 Total (%) : 100 100 100 100 100 pH 6.90 6.84 6.80 6.77 6.80 Eye irritation and discomfort Minimal Minimal Moderate Moderate Severe Micro Challenge Essay on
Wet wipes SUCCEEDED FAILED
(E.faecalis) SUCCEEDED SUCCEEDED SUCCEEDED

Although the disclosure has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various modifications may be made and equivalents may be substituted for elements thereof without departing from the scope of the disclosure. In addition, many modifications may be made to adapt a particular situation or matter to the teachings of the Disclosure without departing from the essential scope of the Disclosure. Accordingly, it is intended that the disclosure not be limited to the particular embodiment described as the best mode contemplated for carrying out this disclosure, but that the disclosure shall include all embodiments falling within the scope of the appended claims.

"At least one", as used herein, means one or more and therefore includes individual components as well as mixtures/combinations.

The transitional terms "comprising", "consisting essentially of" and "consisting of", when used in the appended claims, in their original and amended form, define the scope of the claims with respect to the additional elements or steps not cited, if any, which are excluded from the scope of the claim(s). The term "comprising" is intended to be inclusive or broad and does not exclude any additional element, method, step or matter not listed. The term "consisting of" excludes any element, step or material other than those specified in the claim and, in the latter case, the impurities usually associated with the specified material(s). The term "consisting essentially of" limits the scope of a claim to the specified elements, steps or matters and to those which do not materially affect the fundamental and novel feature(s) of the claimed disclosure. All materials and methods described herein that incorporate this disclosure may, in other embodiments, be defined more specifically by one of the transitional terms "comprising", "consisting essentially of", and "consisting of".

The terms "free" and "free" indicate that no reliably measurable excluded material is present in the composition, typically 0% by weight, based on the total weight of the composition. The term "essentially free" means that, although it is preferred that no excluded material be present in the composition, it is possible to have very small amounts of the excluded material in the composition of the invention, provided that such amounts do not materially affect the beneficial properties of the composition. In particular, "essentially free" means that the excluded material may be present in the composition in an amount less than about 0.1% by weight, based on the total weight of the composition.

Outside of the working examples, or unless otherwise indicated, all numbers expressing quantities of ingredients and/or reaction conditions should be understood as being modified in all cases by the term "approximately", meaning within the limits of 10 % of the indicated number (for example, "about 10%" means 9% to 11% and "about 2%" means 1.8% to 2.2%).

All percentages and ratios are calculated by weight unless otherwise stated. All percentages are calculated on the basis of the total composition, unless otherwise indicated. As a general rule, unless expressly stated otherwise, "weight" or "quantity", as used herein in relation to the percentage quantity of an ingredient, refers to the quantity of raw material comprising the ingredient, the raw material can be described here as having a lower activity and up to 100% of the ingredient. Therefore, the weight percentage of an active in a composition is represented by the amount of raw material containing the active that is used, and may or may not reflect the final percentage of active, the final percentage of active depending on the percentage by weight of the active ingredient in the raw material.

All ranges and quantities given herein are intended to include subranges and quantities using any point disclosed as a bound. Thus, a range of "1% to 10%, such as 2% to 8%, such as 3% to 5%" is intended to encompass ranges of "1% to 8%", "1% to 5%", "2 % to 10%”, and so on. All numbers, quantities, ranges, etc., are intended to be modified by the term "approximately", whether or not expressly stated. Similarly, a given range of "about 1% to 10%" is meant to have the term "about" modifying both bounds by 1% and 10%. Further, it is understood that where an amount of a component is given, it is intended to mean the amount of active ingredient, unless expressly stated otherwise.

Although the numerical ranges and parameters specifying the general scope of the disclosure are approximations, unless otherwise indicated, the numerical values specified in the specific examples are reported as accurately as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective test measurements. The following example serves to illustrate embodiments of the present disclosure without however being limiting.

Claims (10)

Cosmetic composition, comprising:
To. an antimicrobial system that includes:
i. an antimicrobial agent comprising 4-hydroxyacetophenone; And
ii. at least one additional antimicrobial agent comprising piroctone olamine; Cosmetic composition according to Claim 1, in which the cosmetic composition is a makeup-removing composition which is one of an oil-in-water emulsion, an inverse emulsion (water-in-oil), a micellar water and of a multiphase composition. A cosmetic composition according to claim 1, wherein the at least one additional antimicrobial agent comprises one or more of the antimicrobial agents selected from caprylyl glycol, caprylhydroxamic acid, chlorphenesin, benzoic acid, salicylic acid, benzyl alcohol, phenethyl alcohol, benzalkonium chloride, their salts and their combinations. A cosmetic composition according to claim 1, wherein the composition is free or substantially free of one or more of pentylene glycol, parabens, ethanol, formaldehyde and compounds derived from formaldehyde. Cosmetic composition according to claim 1, wherein the composition is free or essentially free of parabens, formaldehyde and compounds derived from formaldehyde. A cosmetic composition according to claim 1, wherein the composition is free or substantially free of alcohols comprising one or more of ethanol and isopropyl alcohol. A cosmetic composition according to claim 1, wherein the composition is free or substantially free of antimicrobials which include one or more of pentylene glycol, phenoxyethanol, hexylglycerin, ethylhexylglycerin, octylglycerin, benzylglycerin, 3-heptoyl-2,2-propandiol and 1, 2-hexandiol. A cosmetic composition according to claim 1, wherein the antimicrobial agent comprising 4-hydroxyacetophenone is present at about 0.2% to about 1% by weight of the composition; the at least one additional antimicrobial agent comprising piroctone olamine, when present, is present at about 0.05% to about 1.5% by weight of the composition. A cosmetic composition according to claim 1, wherein the composition comprises 4-hydroxyacetophenone present at about 0.25% to about 2% by weight of the composition; the at least one additional antimicrobial agent comprising piroctone olamine, when present, is present at about 0.05% to about 1.5% by weight of the composition. Make-up remover composition, comprising:
To. an antimicrobial system that includes:
i. an antimicrobial agent comprising 4-hydroxyacetophenone; And
ii. at least one additional antimicrobial agent comprising piroctone olamine; And
b. a cleaning system water-based.