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FR2912409B1 - Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine leur procede de preparation,leur utilisation - Google Patents

Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine leur procede de preparation,leur utilisation

Info

Publication number
FR2912409B1
FR2912409B1 FR0701055A FR0701055A FR2912409B1 FR 2912409 B1 FR2912409 B1 FR 2912409B1 FR 0701055 A FR0701055 A FR 0701055A FR 0701055 A FR0701055 A FR 0701055A FR 2912409 B1 FR2912409 B1 FR 2912409B1
Authority
FR
France
Prior art keywords
biotin
binding
preparation
molecular weight
low molecular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0701055A
Other languages
English (en)
Other versions
FR2912409A1 (fr
Inventor
Philippe Hubert
Pierre Mourier
Christian Viskov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR0701055A priority Critical patent/FR2912409B1/fr
Priority to TW097104302A priority patent/TW200846014A/zh
Priority to CA002678168A priority patent/CA2678168A1/fr
Priority to JP2009549440A priority patent/JP5351770B2/ja
Priority to RU2009134188/04A priority patent/RU2009134188A/ru
Priority to KR1020097016908A priority patent/KR20090109104A/ko
Priority to PCT/FR2008/000173 priority patent/WO2008113919A1/fr
Priority to EP08761873A priority patent/EP2121769A1/fr
Priority to CN200880005216A priority patent/CN101636417A/zh
Priority to BRPI0807981-1A2A priority patent/BRPI0807981A2/pt
Priority to AU2008228162A priority patent/AU2008228162A1/en
Priority to MX2009008752A priority patent/MX2009008752A/es
Priority to ARP080100609A priority patent/AR065323A1/es
Publication of FR2912409A1 publication Critical patent/FR2912409A1/fr
Priority to IL200111A priority patent/IL200111A0/en
Priority to US12/539,224 priority patent/US20100081629A1/en
Application granted granted Critical
Publication of FR2912409B1 publication Critical patent/FR2912409B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FR0701055A 2007-02-14 2007-02-14 Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine leur procede de preparation,leur utilisation Expired - Fee Related FR2912409B1 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
FR0701055A FR2912409B1 (fr) 2007-02-14 2007-02-14 Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine leur procede de preparation,leur utilisation
TW097104302A TW200846014A (en) 2007-02-14 2008-02-04 Low molecular weight heparins comprising at least one covalent bond with biotin or a biotin derivative, preparation process therefor and use thereof
MX2009008752A MX2009008752A (es) 2007-02-14 2008-02-12 Heparinas de bajo peso molecular que contienen al menos un enlace covalente con biotina o un derivado de biotina, procedimiento para su preparacion y uso de ellas.
RU2009134188/04A RU2009134188A (ru) 2007-02-14 2008-02-12 Низкомолекулярные гепарины, имеющие по меньшей мере одну ковалентную связь с биотином или производным биотина, способ их получения и их применение
KR1020097016908A KR20090109104A (ko) 2007-02-14 2008-02-12 바이오틴 또는 바이오틴 유도체와의 1개 이상의 공유 결합을 포함하는 저분자량 헤파린, 이의 제조 방법 및 이의 용도
PCT/FR2008/000173 WO2008113919A1 (fr) 2007-02-14 2008-02-12 Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine, leur procede de preparation et leur utilisation
EP08761873A EP2121769A1 (fr) 2007-02-14 2008-02-12 Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine, leur procede de preparation et leur utilisation
CN200880005216A CN101636417A (zh) 2007-02-14 2008-02-12 包括至少一个与生物素或生物素衍生物的共价键的低分子量肝素、其制造和其用途
CA002678168A CA2678168A1 (fr) 2007-02-14 2008-02-12 Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine, leur procede de preparation et leur utilisation
AU2008228162A AU2008228162A1 (en) 2007-02-14 2008-02-12 Low molecular weight heparins including at least one covalent bond with biotin or a biotin derivative, method for making same and use thereof
JP2009549440A JP5351770B2 (ja) 2007-02-14 2008-02-12 ビオチンまたはビオチン誘導体との少なくとも１つの共有結合を含む低分子量ヘパリン、これらの作製方法およびそれらの使用。
BRPI0807981-1A2A BRPI0807981A2 (pt) 2007-02-14 2008-02-12 Heparinas de baixo peso molecular, compreendendo pelo menos uma ligação covalente com a biotina ou um derivado da biotina, o respectivo processo de preparo e o respectivo uso
ARP080100609A AR065323A1 (es) 2007-02-14 2008-02-13 Heparinas de bajo peso molecular que comprenden al menos un enlace covalente con la biotina o un derivado de la biotina , su procedimiento de preparacion y su utilizacion
IL200111A IL200111A0 (en) 2007-02-14 2009-07-28 Low molecular weight heparins including at least one covalent bond with biotin or a biotin derivative, method for making same and use thereof
US12/539,224 US20100081629A1 (en) 2007-02-14 2009-08-11 Low molecular weight heparins including at least one covalent bond with biotin or a biotin derivative, method for making same and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0701055A FR2912409B1 (fr) 2007-02-14 2007-02-14 Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine leur procede de preparation,leur utilisation

Publications (2)

Publication Number Publication Date
FR2912409A1 FR2912409A1 (fr) 2008-08-15
FR2912409B1 true FR2912409B1 (fr) 2012-08-24

Family

ID=38461986

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0701055A Expired - Fee Related FR2912409B1 (fr) 2007-02-14 2007-02-14 Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine leur procede de preparation,leur utilisation

Country Status (15)

Country Link
US (1) US20100081629A1 (fr)
EP (1) EP2121769A1 (fr)
JP (1) JP5351770B2 (fr)
KR (1) KR20090109104A (fr)
CN (1) CN101636417A (fr)
AR (1) AR065323A1 (fr)
AU (1) AU2008228162A1 (fr)
BR (1) BRPI0807981A2 (fr)
CA (1) CA2678168A1 (fr)
FR (1) FR2912409B1 (fr)
IL (1) IL200111A0 (fr)
MX (1) MX2009008752A (fr)
RU (1) RU2009134188A (fr)
TW (1) TW200846014A (fr)
WO (1) WO2008113919A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2584927T7 (es) 2007-10-16 2020-11-05 Progen Pg500 Series Pty Ltd Derivados de oligosacáridos sulfatados novedosos
US8592393B2 (en) 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
WO2009059284A2 (fr) 2007-11-02 2009-05-07 Momenta Pharmaceuticals, Inc. Compositions de polysaccharides non anticoagulants
US8569262B2 (en) 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
CN102985443B (zh) 2010-04-16 2017-05-10 动量制药公司 组织靶向
US10017585B2 (en) 2010-06-17 2018-07-10 Momenta Pharmaceuticals, Inc. Methods and compositions for promoting hair growth
EP3003324A4 (fr) * 2013-05-28 2017-01-25 Momenta Pharmaceuticals, Inc. Compositions pharmaceutiques
CN103421128B (zh) * 2013-07-31 2015-08-12 山东辰中生物制药有限公司 一种高品质低分子帕那肝素的制备方法
EP3388439A1 (fr) * 2017-04-11 2018-10-17 Leadiant Biosciences SA Héparine divisée de n-acétyl glycol conjuguée à la biotine
CN111333664A (zh) * 2020-03-27 2020-06-26 苏州昊帆生物股份有限公司 生物素交联剂、应用及其制备方法
CN117777216A (zh) * 2022-09-21 2024-03-29 中国科学院上海药物研究所 可中和的生物素化肝素五糖的制备方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE38743E1 (en) * 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
FR2663639B1 (fr) * 1990-06-26 1994-03-18 Rhone Poulenc Sante Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.
FR2814463B1 (fr) * 2000-09-22 2002-11-15 Sanofi Synthelabo Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine
US20040229778A1 (en) * 2003-05-13 2004-11-18 Elmaleh David R. Pharmaceutical compositions of antithrombin III for the treatment of retroviral diseases
FR2874924B1 (fr) * 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique

Also Published As

Publication number Publication date
EP2121769A1 (fr) 2009-11-25
US20100081629A1 (en) 2010-04-01
WO2008113919A1 (fr) 2008-09-25
JP5351770B2 (ja) 2013-11-27
JP2010518238A (ja) 2010-05-27
CA2678168A1 (fr) 2008-09-25
AU2008228162A1 (en) 2008-09-25
KR20090109104A (ko) 2009-10-19
MX2009008752A (es) 2009-08-27
RU2009134188A (ru) 2011-03-20
BRPI0807981A2 (pt) 2014-06-24
IL200111A0 (en) 2010-04-15
FR2912409A1 (fr) 2008-08-15
AR065323A1 (es) 2009-05-27
CN101636417A (zh) 2010-01-27
TW200846014A (en) 2008-12-01

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20151030