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FR2905949B1 - Derives fluores de catharanthine, leur preparation et leur utilisation comme precurseurs d'alcaloides dimeres de vinca - Google Patents

Derives fluores de catharanthine, leur preparation et leur utilisation comme precurseurs d'alcaloides dimeres de vinca

Info

Publication number
FR2905949B1
FR2905949B1 FR0608226A FR0608226A FR2905949B1 FR 2905949 B1 FR2905949 B1 FR 2905949B1 FR 0608226 A FR0608226 A FR 0608226A FR 0608226 A FR0608226 A FR 0608226A FR 2905949 B1 FR2905949 B1 FR 2905949B1
Authority
FR
France
Prior art keywords
catharanthin
dimeres
vinca
alkaloids
precursors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0608226A
Other languages
English (en)
Other versions
FR2905949A1 (fr
Inventor
Lionel Moisan
Sebastien Comesse
Emerson Giovanelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0608226A priority Critical patent/FR2905949B1/fr
Application filed by Commissariat a lEnergie Atomique CEA, Pierre Fabre Medicament SA filed Critical Commissariat a lEnergie Atomique CEA
Priority to PCT/EP2007/059991 priority patent/WO2008034882A1/fr
Priority to DE602007008748T priority patent/DE602007008748D1/de
Priority to RU2009113535/04A priority patent/RU2448957C2/ru
Priority to AU2007298920A priority patent/AU2007298920B2/en
Priority to PT07820424T priority patent/PT2078017E/pt
Priority to PL07820424T priority patent/PL2078017T3/pl
Priority to MX2009003121A priority patent/MX2009003121A/es
Priority to CA002664040A priority patent/CA2664040A1/fr
Priority to JP2009528728A priority patent/JP5280364B2/ja
Priority to EP07820424A priority patent/EP2078017B9/fr
Priority to CN2007800384442A priority patent/CN101522679B/zh
Priority to NZ575884A priority patent/NZ575884A/en
Priority to US12/442,193 priority patent/US8101748B2/en
Priority to AT07820424T priority patent/ATE478871T1/de
Priority to BRPI0717063-7A priority patent/BRPI0717063A2/pt
Priority to KR1020097007521A priority patent/KR20090063256A/ko
Priority to ES07820424T priority patent/ES2349387T3/es
Publication of FR2905949A1 publication Critical patent/FR2905949A1/fr
Application granted granted Critical
Publication of FR2905949B1 publication Critical patent/FR2905949B1/fr
Priority to IL197640A priority patent/IL197640A/en
Priority to TN2009000097A priority patent/TN2009000097A1/fr
Priority to MA31759A priority patent/MA31134B1/fr
Priority to NO20091491A priority patent/NO20091491L/no
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
FR0608226A 2006-09-20 2006-09-20 Derives fluores de catharanthine, leur preparation et leur utilisation comme precurseurs d'alcaloides dimeres de vinca Expired - Fee Related FR2905949B1 (fr)

Priority Applications (22)

Application Number Priority Date Filing Date Title
FR0608226A FR2905949B1 (fr) 2006-09-20 2006-09-20 Derives fluores de catharanthine, leur preparation et leur utilisation comme precurseurs d'alcaloides dimeres de vinca
US12/442,193 US8101748B2 (en) 2006-09-20 2007-09-20 Fluorinated catharanthine derivatives, their preparation and their utilisation as Vinca dimeric alkaloid precursors
RU2009113535/04A RU2448957C2 (ru) 2006-09-20 2007-09-20 Фторированные производные катарантина, их получение и применение в качестве прекурсоров димерных алкалоидов vinca
AU2007298920A AU2007298920B2 (en) 2006-09-20 2007-09-20 Fluorinated catharanthine derivatives, their preparation and their utilisation as Vinca dimeric alkaloid precursors
PT07820424T PT2078017E (pt) 2006-09-20 2007-09-20 Derivados fluorados de catarantina, sua preparação e sua ultilização com precursores dos álcaloides diméricos da vinca
PL07820424T PL2078017T3 (pl) 2006-09-20 2007-09-20 Fluorowane pochodne katarantyny, ich wytwarzanie i ich zastosowanie jako prekursorów dimerycznych alkaloidów Vinca
MX2009003121A MX2009003121A (es) 2006-09-20 2007-09-20 Derivados fluorados de catarantina, su preparacion y su utilizacion como precursores de alcaloides dimericos vinca.
CA002664040A CA2664040A1 (fr) 2006-09-20 2007-09-20 Derives fluores de catharanthine, leur preparation et leur utilisation en tant que precurseurs des alcaloides dimeres du vinca
JP2009528728A JP5280364B2 (ja) 2006-09-20 2007-09-20 フッ素化カタランチン誘導体、それらの製造、およびビンカ二量体アルカロイド前駆体としてそれらの利用
DE602007008748T DE602007008748D1 (de) 2006-09-20 2007-09-20 Fluorierte catharanthinderivate, ihre herstellung und ihre verwendung als dimere vorstufen für vincaalkaloide
CN2007800384442A CN101522679B (zh) 2006-09-20 2007-09-20 氟化长春碱衍生物、其制备和其作为长春花二聚生物碱前体的用途
NZ575884A NZ575884A (en) 2006-09-20 2007-09-20 Fluorinated catharanthine derivatives, their preparation and their utilisation as vinca dimeric alkaloid precursors
PCT/EP2007/059991 WO2008034882A1 (fr) 2006-09-20 2007-09-20 Dérivés fluorés de catharanthine, leur préparation et leur utilisation en tant que précurseurs des alcaloïdes dimères du vinca
AT07820424T ATE478871T1 (de) 2006-09-20 2007-09-20 Fluorierte catharanthinderivate, ihre herstellung und ihre verwendung als dimere vorstufen für vincaalkaloide
BRPI0717063-7A BRPI0717063A2 (pt) 2006-09-20 2007-09-20 Derivados de catarantina fluorada, sua preparação e sua utilização como precursores alcalóides diméricos de vinca
KR1020097007521A KR20090063256A (ko) 2006-09-20 2007-09-20 함불소 카타란틴 유도체, 이의 제조방법 및 빈카 이합체성 알카로이드 전구체로서의 용도
ES07820424T ES2349387T3 (es) 2006-09-20 2007-09-20 Derivados fluorados de catarantina, su preparación y su utilización como precursores de alcaloides diméricos de la vinca.
EP07820424A EP2078017B9 (fr) 2006-09-20 2007-09-20 Dérivés fluorés de catharanthine, leur préparation et leur utilisation en tant que précurseurs des alcaloïdes dimères du vinca
IL197640A IL197640A (en) 2006-09-20 2009-03-17 History of cataractin converted by fluorine, their preparation and use as precursors to Vinca alkaloid dimeric
TN2009000097A TN2009000097A1 (en) 2006-09-20 2009-03-19 Fluorinated catharanthine derivatives, their preparation and their utilisation as vinca dimeric alkaloid precursors
MA31759A MA31134B1 (fr) 2006-09-20 2009-04-03 Dérivés fluorés de catharanthine, leur préparation et leur utilisation comme précurseurs des alcaloïdes dimères du vinca.
NO20091491A NO20091491L (no) 2006-09-20 2009-04-16 Fluorerte catharantinderivater, deres fremstilling og deres anvendelse som vincadimore alkaloidforlopere

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0608226A FR2905949B1 (fr) 2006-09-20 2006-09-20 Derives fluores de catharanthine, leur preparation et leur utilisation comme precurseurs d'alcaloides dimeres de vinca

Publications (2)

Publication Number Publication Date
FR2905949A1 FR2905949A1 (fr) 2008-03-21
FR2905949B1 true FR2905949B1 (fr) 2008-11-21

Family

ID=37982436

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0608226A Expired - Fee Related FR2905949B1 (fr) 2006-09-20 2006-09-20 Derives fluores de catharanthine, leur preparation et leur utilisation comme precurseurs d'alcaloides dimeres de vinca

Country Status (22)

Country Link
US (1) US8101748B2 (fr)
EP (1) EP2078017B9 (fr)
JP (1) JP5280364B2 (fr)
KR (1) KR20090063256A (fr)
CN (1) CN101522679B (fr)
AT (1) ATE478871T1 (fr)
AU (1) AU2007298920B2 (fr)
BR (1) BRPI0717063A2 (fr)
CA (1) CA2664040A1 (fr)
DE (1) DE602007008748D1 (fr)
ES (1) ES2349387T3 (fr)
FR (1) FR2905949B1 (fr)
IL (1) IL197640A (fr)
MA (1) MA31134B1 (fr)
MX (1) MX2009003121A (fr)
NO (1) NO20091491L (fr)
NZ (1) NZ575884A (fr)
PL (1) PL2078017T3 (fr)
PT (1) PT2078017E (fr)
RU (1) RU2448957C2 (fr)
TN (1) TN2009000097A1 (fr)
WO (1) WO2008034882A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8940754B2 (en) 2010-02-22 2015-01-27 The Scripps Research Institute 10′-fluorinated Vinca alkaloids provide enhanced biological activity against MDR cancer cells
CN105121447B (zh) * 2013-04-19 2018-02-02 暨南大学 长春碱类衍生物及其制备方法和应用
CN105503907B (zh) * 2016-01-18 2018-01-09 北京大学 对映选择性合成Vinca类生物碱的方法
WO2025117491A1 (fr) * 2023-12-01 2025-06-05 Kuleon Llc Analogues d'azépino et leurs procédés de fabrication et d'utilisation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU180924B (en) * 1977-05-20 1983-05-30 Richter Gedeon Vegyeszet Process for producing leurosine-type alkaloides
FR2632643B1 (fr) * 1988-06-10 1990-09-07 Adir Nouveau procede de preparation de derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique
JPH0341081A (ja) * 1989-07-10 1991-02-21 Mitsui Petrochem Ind Ltd 二量体アルカロイド類の製造方法
FR2707988B1 (fr) * 1993-07-21 1995-10-13 Pf Medicament Nouveaux dérivés antimitotiques des alcaloïdes binaires du catharantus rosesus, leur procédé de préparation et les compositions pharmaceutiques les comprenant.
FR2761990B1 (fr) * 1997-04-10 1999-06-25 Pf Medicament Derives halogenes antimitotiques d'alcaloides de vinca
FR2779146B1 (fr) * 1998-06-02 2002-01-18 Roowin Nouveaux derives de vinca-alcaloides et procedes de preparation
CN1218950C (zh) * 2004-02-18 2005-09-14 东北林业大学 一种长春碱的生产方法

Also Published As

Publication number Publication date
ATE478871T1 (de) 2010-09-15
JP2010504303A (ja) 2010-02-12
IL197640A0 (en) 2009-12-24
EP2078017B9 (fr) 2011-09-07
MX2009003121A (es) 2009-07-31
FR2905949A1 (fr) 2008-03-21
DE602007008748D1 (de) 2010-10-07
AU2007298920B2 (en) 2012-03-08
KR20090063256A (ko) 2009-06-17
CN101522679B (zh) 2013-12-18
AU2007298920A1 (en) 2008-03-27
IL197640A (en) 2013-03-24
NZ575884A (en) 2011-09-30
TN2009000097A1 (en) 2010-08-19
MA31134B1 (fr) 2010-02-01
RU2448957C2 (ru) 2012-04-27
US20100093997A1 (en) 2010-04-15
EP2078017A1 (fr) 2009-07-15
PT2078017E (pt) 2010-11-09
PL2078017T3 (pl) 2011-02-28
US8101748B2 (en) 2012-01-24
NO20091491L (no) 2009-05-13
BRPI0717063A2 (pt) 2013-10-15
CA2664040A1 (fr) 2008-03-27
CN101522679A (zh) 2009-09-02
EP2078017B1 (fr) 2010-08-25
ES2349387T3 (es) 2010-12-30
JP5280364B2 (ja) 2013-09-04
WO2008034882A1 (fr) 2008-03-27
RU2009113535A (ru) 2010-10-27

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Year of fee payment: 11

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Effective date: 20180531