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FR2974373B1 - Signature moleculaire des taches pigmentaires cutanees, associee a la matrice extracellulaire - Google Patents

Signature moleculaire des taches pigmentaires cutanees, associee a la matrice extracellulaire

Info

Publication number
FR2974373B1
FR2974373B1 FR1153537A FR1153537A FR2974373B1 FR 2974373 B1 FR2974373 B1 FR 2974373B1 FR 1153537 A FR1153537 A FR 1153537A FR 1153537 A FR1153537 A FR 1153537A FR 2974373 B1 FR2974373 B1 FR 2974373B1
Authority
FR
France
Prior art keywords
genes
extracellular matrix
relates
skin
pigment spots
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1153537A
Other languages
English (en)
Other versions
FR2974373A1 (fr
Inventor
Francoise Bernerd
Christine Duval
Lacharriere Olivier De
Stephanie Nouveau
Xavier Marat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LOreal SA
Original Assignee
LOreal SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1153537A priority Critical patent/FR2974373B1/fr
Application filed by LOreal SA filed Critical LOreal SA
Priority to CN201280030372.8A priority patent/CN103619318B/zh
Priority to EP12722443.4A priority patent/EP2699221B1/fr
Priority to ES12722443.4T priority patent/ES2624671T3/es
Priority to PCT/FR2012/050860 priority patent/WO2012172220A1/fr
Priority to JP2014505704A priority patent/JP6181042B2/ja
Priority to KR1020137031099A priority patent/KR102072783B1/ko
Priority to US14/111,802 priority patent/US20150307940A1/en
Publication of FR2974373A1 publication Critical patent/FR2974373A1/fr
Application granted granted Critical
Publication of FR2974373B1 publication Critical patent/FR2974373B1/fr
Priority to JP2017079650A priority patent/JP6836950B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
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    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
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    • A61Q19/04—Preparations for care of the skin for chemically tanning the skin
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6881—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from skin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
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Abstract

La présente invention concerne une signature moléculaire des taches pigmentaires cutanées, comprenant les gènes FRAS1, LEPREL1, MATN2, DST, PLOD2, ITGA2, COL6A3, CRTAP, LAMC1, LAMB3, LAMAS, ITGAV, ITGB1 et ACTN1, et diverses applications de cette signature. L'invention concerne notamment une méthode de caractérisation d'une tache pigmentaire apparente ou soupçonnée chez un être humain, comprenant la comparaison des niveaux d'expression, dans des échantillons de peau issue de ladite tache et de peau adjacente non lésée, d'au moins un gène dermique lié à la matrice extracellulaire choisi parmi la liste constituée des gènes FRAS1, LEPREL1, MATN2, DST, PLOD2, ITGA2, COL6A3, CRTAP, LAMC1, LAMB3, LAMA3, ITGAV, ITGB1 et ACTN1. L'invention concerne également des méthodes d'évaluation de l'efficacité d'un traitement des taches pigmentaires, des méthodes cosmétiques et thérapeutiques de traitement des taches pigmentaires, ainsi que divers modulateurs desdits gènes et leur utilisation.
FR1153537A 2011-04-22 2011-04-22 Signature moleculaire des taches pigmentaires cutanees, associee a la matrice extracellulaire Expired - Fee Related FR2974373B1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
FR1153537A FR2974373B1 (fr) 2011-04-22 2011-04-22 Signature moleculaire des taches pigmentaires cutanees, associee a la matrice extracellulaire
EP12722443.4A EP2699221B1 (fr) 2011-04-22 2012-04-20 Signature moléculaire des taches pigmentaires cutanées, associée à la matrice extracellulaire
ES12722443.4T ES2624671T3 (es) 2011-04-22 2012-04-20 Firma molecular de manchas pigmentarias cutáneas, asociada a la matriz extracelular
PCT/FR2012/050860 WO2012172220A1 (fr) 2011-04-22 2012-04-20 Signature moléculaire des taches pigmentaires cutanées, associée à la matrice extracellulaire
CN201280030372.8A CN103619318B (zh) 2011-04-22 2012-04-20 和细胞外基质相关的皮肤色斑分子标签
JP2014505704A JP6181042B2 (ja) 2011-04-22 2012-04-20 細胞外マトリックスに関連した皮膚色素斑の分子シグネチャー
KR1020137031099A KR102072783B1 (ko) 2011-04-22 2012-04-20 세포외 매트릭스와 연관되는, 피부 색소 반점의 분자 지표
US14/111,802 US20150307940A1 (en) 2011-04-22 2012-04-20 Molecular signature of cutaneous pigmentary spots, associated with the extracellular matrix
JP2017079650A JP6836950B2 (ja) 2011-04-22 2017-04-13 細胞外マトリックスに関連した皮膚色素斑の分子シグネチャー

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1153537A FR2974373B1 (fr) 2011-04-22 2011-04-22 Signature moleculaire des taches pigmentaires cutanees, associee a la matrice extracellulaire

Publications (2)

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FR2974373A1 FR2974373A1 (fr) 2012-10-26
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