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FR2839513A1 - Nouveaux composes derives d'alcaloides, leur procede de preparation, et leur utilisation pour la preparation de medicaments - Google Patents

Nouveaux composes derives d'alcaloides, leur procede de preparation, et leur utilisation pour la preparation de medicaments

Info

Publication number
FR2839513A1
FR2839513A1 FR0205740A FR0205740A FR2839513A1 FR 2839513 A1 FR2839513 A1 FR 2839513A1 FR 0205740 A FR0205740 A FR 0205740A FR 0205740 A FR0205740 A FR 0205740A FR 2839513 A1 FR2839513 A1 FR 2839513A1
Authority
FR
France
Prior art keywords
preparation
alkaloids
drugs
novel compounds
compounds derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR0205740A
Other languages
English (en)
Inventor
Alfred Francois Trigalo
Francois Frappier
Philippe Rasoanaivo
Suzanne Ratsimamanga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR0205740A priority Critical patent/FR2839513A1/fr
Priority to AU2003246880A priority patent/AU2003246880A1/en
Priority to PCT/FR2003/001358 priority patent/WO2003095459A2/fr
Publication of FR2839513A1 publication Critical patent/FR2839513A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention concerne des composés répondant à la formule générale suivante (I) :dans laquelle :- la liaison en pointillés dans le cycle représente une liaison simple ou double, et- R, R' et R " représentent un atome d'hydrogène, un groupe alkyle de 1 à 7 atomes de carbone, substitué ou non, linéaire ou cyclique, un groupe benzyle, un groupe alkylène de 1 à 3 atomes de carbone, un groupe acyle de 1 à 5 atomes de carbone.
FR0205740A 2002-05-07 2002-05-07 Nouveaux composes derives d'alcaloides, leur procede de preparation, et leur utilisation pour la preparation de medicaments Withdrawn FR2839513A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR0205740A FR2839513A1 (fr) 2002-05-07 2002-05-07 Nouveaux composes derives d'alcaloides, leur procede de preparation, et leur utilisation pour la preparation de medicaments
AU2003246880A AU2003246880A1 (en) 2002-05-07 2003-04-30 Alkaloid-derived compounds and use thereof in cancer and malaria treatment
PCT/FR2003/001358 WO2003095459A2 (fr) 2002-05-07 2003-04-30 Composes derives d'alcaloides et leur utilisation dans le traitement de malaria et cancer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0205740A FR2839513A1 (fr) 2002-05-07 2002-05-07 Nouveaux composes derives d'alcaloides, leur procede de preparation, et leur utilisation pour la preparation de medicaments

Publications (1)

Publication Number Publication Date
FR2839513A1 true FR2839513A1 (fr) 2003-11-14

Family

ID=29286369

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0205740A Withdrawn FR2839513A1 (fr) 2002-05-07 2002-05-07 Nouveaux composes derives d'alcaloides, leur procede de preparation, et leur utilisation pour la preparation de medicaments

Country Status (3)

Country Link
AU (1) AU2003246880A1 (fr)
FR (1) FR2839513A1 (fr)
WO (1) WO2003095459A2 (fr)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
RAFATRO H ET AL: "ISOLATION FROM RAT URINE AND HUMAN LIVER MICROSOMES AND IDENTIFICATION BY ELECTROSPRAY AND NANOSPRAY TANDEM MASS SPECTROMETRY OF NEW MALAGASHANINE METABOLITES", JOURNAL OF MASS SPECTROMETRY, WILEY, CHICHESTER, GB, vol. 35, no. 9, 2000, pages 1112 - 1120, XP008013040, ISSN: 1076-5174 *
RAFATRO H ET AL: "REVERSAL ACTIVITY OF THE NATURALLY OCCURRING CHEMOSENSITIZER MALAGASHANINE IN PLASMODIUM MALARIA", BIOCHEMICAL PHARMACOLOGY, PERGAMON, OXFORD, GB, vol. 59, no. 9, 2000, pages 1053 - 1061, XP001133775, ISSN: 0006-2952 *
RAMANITRAHASIMBOLA D ET AL: "EFFECTS OF THE NATURALLY-OCCURRING CHEMOSENSITIZER MALAGASHANINE AND ITS COMBINATION WITH CHLOROQUINE ON KB AND P388 CELL LINES AND ISOLATED AURICLE", PHYTOMEDICINE, GUSTAV FISCHER VERLAG, STUTTGART, DE, vol. 6, no. 5, 1999, pages 331 - 334, XP008013030, ISSN: 0944-7113 *

Also Published As

Publication number Publication date
WO2003095459A3 (fr) 2004-04-08
WO2003095459A2 (fr) 2003-11-20
AU2003246880A1 (en) 2003-11-11
AU2003246880A8 (en) 2003-11-11

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20060131