FR2812875B1 - Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation - Google Patents
Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparationInfo
- Publication number
- FR2812875B1 FR2812875B1 FR0010427A FR0010427A FR2812875B1 FR 2812875 B1 FR2812875 B1 FR 2812875B1 FR 0010427 A FR0010427 A FR 0010427A FR 0010427 A FR0010427 A FR 0010427A FR 2812875 B1 FR2812875 B1 FR 2812875B1
- Authority
- FR
- France
- Prior art keywords
- casr
- preparation
- modulating activity
- novel diamines
- diamines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000013830 Calcium-Sensing Receptors Human genes 0.000 title 1
- 108010050543 Calcium-Sensing Receptors Proteins 0.000 title 1
- 150000004985 diamines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
- C07C211/36—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/26—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0010427A FR2812875B1 (fr) | 2000-08-08 | 2000-08-08 | Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation |
| US10/344,146 US7157498B2 (en) | 2000-08-08 | 2001-08-07 | Diamines having a CaSR modulating activity |
| AU2001284113A AU2001284113A1 (en) | 2000-08-08 | 2001-08-07 | Novel diamines having a casr modulating activity |
| PCT/FR2001/002562 WO2002012181A1 (fr) | 2000-08-08 | 2001-08-07 | Nouvelles diamines possedant une activite modulatrice des casr |
| EP20010963065 EP1409453A1 (fr) | 2000-08-08 | 2001-08-07 | Diamines possedant une activite modulatrice des casr |
| JP2002518159A JP4896350B2 (ja) | 2000-08-08 | 2001-08-07 | Casr調節活性を有する新規ジアミン |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0010427A FR2812875B1 (fr) | 2000-08-08 | 2000-08-08 | Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2812875A1 FR2812875A1 (fr) | 2002-02-15 |
| FR2812875B1 true FR2812875B1 (fr) | 2003-12-12 |
Family
ID=8853394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR0010427A Expired - Fee Related FR2812875B1 (fr) | 2000-08-08 | 2000-08-08 | Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7157498B2 (fr) |
| EP (1) | EP1409453A1 (fr) |
| JP (1) | JP4896350B2 (fr) |
| AU (1) | AU2001284113A1 (fr) |
| FR (1) | FR2812875B1 (fr) |
| WO (1) | WO2002012181A1 (fr) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE028373T2 (en) | 2004-05-28 | 2017-02-28 | Mitsubishi Tanabe Pharma Corp | Arylalkylamines and processes for their preparation |
| US7361789B1 (en) | 2004-07-28 | 2008-04-22 | Amgen Inc. | Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis |
| FR2885129B1 (fr) * | 2005-04-29 | 2007-06-15 | Proskelia Sas | Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation. |
| AU2006316705B2 (en) * | 2005-11-25 | 2011-09-29 | Galapagos Sas | Urea derivatives useful as calcium receptor modulators |
| BRPI0710814A2 (pt) * | 2006-04-20 | 2011-08-16 | Amgen Inc | formulações de emulsão estável |
| EP2079525A1 (fr) * | 2006-10-26 | 2009-07-22 | Amgen Inc. | Agents modulant le récepteur sensible au calcium |
| WO2008121386A2 (fr) | 2007-03-30 | 2008-10-09 | Amgen Inc. | Procédés de traitement de troubles intestinaux |
| AU2008311974B2 (en) * | 2007-10-15 | 2013-11-21 | Amgen Inc. | Calcium receptor modulating agents |
| WO2010042642A1 (fr) * | 2008-10-08 | 2010-04-15 | Amgen Inc. | Agents modulateurs des récepteurs de calcium |
| WO2010104882A1 (fr) | 2009-03-10 | 2010-09-16 | Amgen Inc. | Procédés de modulation de la motilité des spermatozoïdes |
| JP2012528084A (ja) | 2009-05-27 | 2012-11-12 | レオ ファーマ アクティーゼルスカブ | 新規のカルシウム感知受容体調節化合物およびその医薬用途 |
| EP2435404A1 (fr) | 2009-05-27 | 2012-04-04 | Leo Pharma A/S | Nouveaux composés modulant le récepteur sensible au calcium, et leur utilisation pharmaceutique |
| WO2012000498A1 (fr) | 2010-06-30 | 2012-01-05 | Leo Pharma A/S | Nouvelle forme polymorphe d'un composé calcimimétique |
| CN102958908A (zh) | 2010-06-30 | 2013-03-06 | 利奥制药有限公司 | 钙敏感受体激动化合物的新多晶型 |
| RU2013128973A (ru) | 2010-11-26 | 2015-01-10 | Лео Фарма А/С | Соединения, активные в отношении кальций-чувствительных рецепторов |
| RU2013128968A (ru) | 2010-11-26 | 2015-01-10 | Лео Фарма А/С | Соединения, активные в отношении кальций-чувствительного рецептора |
| WO2012069402A1 (fr) | 2010-11-26 | 2012-05-31 | Leo Pharma A/S | Cyclopentylazines substituées en tant que composés casr-actifs |
| EP2643291A2 (fr) * | 2010-11-26 | 2013-10-02 | Leo Pharma A/S | Composés actifs sur le récepteur sensible au calcium |
| WO2012120476A1 (fr) | 2011-03-10 | 2012-09-13 | Lupin Limited | Morpholines substituées en tant que modulateurs pour le récepteur de calcium |
| EP2686306B1 (fr) | 2011-03-18 | 2017-01-04 | Lupin Atlantis Holdings SA | Dérivés de benzo [b][1, 4]oxazine en tant que modulateurs du récepteur sensible au calcium |
| CA2864332C (fr) | 2012-02-24 | 2020-08-25 | Lupin Limited | Composes substitues de chromane en tant que modulateurs des recepteurs de detection du calcium |
| WO2013136288A1 (fr) | 2012-03-16 | 2013-09-19 | Lupin Limited | Composés de type 3,4-dihydro-2h-benzo[b] [1,4]oxazine substituée utilisés en tant que modulateurs des récepteurs sensibles au calcium |
| IN2015MN00421A (fr) | 2012-08-27 | 2015-09-04 | Lupin Ltd | |
| GB201217330D0 (en) | 2012-09-28 | 2012-11-14 | Univ Cardiff | Therapeutic for treating inflammatory lung disorders |
| TW201602062A (zh) | 2013-08-12 | 2016-01-16 | 魯賓有限公司 | 取代聯苯基化合物作為鈣敏感受體調節劑 |
| AU2014313835A1 (en) | 2013-08-28 | 2016-03-03 | Lupin Atlantis Holdings Sa | Substituted naphthalene compounds as calcium sensing receptor modulators |
| WO2015162538A1 (fr) | 2014-04-21 | 2015-10-29 | Lupin Limited | Composés hétérocycliques en tant que modulateurs des récepteurs de détection du calcium pour le traitement de l'hyperparathyroïdie, de l'insuffisance rénale chronique et de la néphropathie chronique |
| WO2017037616A1 (fr) | 2015-08-31 | 2017-03-09 | Lupin Limited | Composés d'arylalkylamine comme modulateurs des récepteurs sensibles au calcium |
| WO2021130779A1 (fr) | 2019-12-27 | 2021-07-01 | Lupin Limited | Composition pharmaceutique de modulateurs de casr et procédés et utilisations associés |
| PT4090654T (pt) | 2020-01-17 | 2025-10-07 | Lupin Ltd | Métodos, processos e intermediários para a preparação de compostos de cromano |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3262977A (en) * | 1962-03-10 | 1966-07-26 | Chinoin Gyogyszer Es Vegyeszet | N-aralkyl-1, 1-diphenyl-propylamine derivatives |
| JP4555401B2 (ja) * | 1991-08-23 | 2010-09-29 | エヌピーエス ファーマシューティカルズ インコーポレイテッド | カルシウム受容体に活性なアリールアルキルアミン |
| WO1993004373A1 (fr) * | 1991-08-23 | 1993-03-04 | Nps Pharmaceuticals, Inc. | Molecules agissant sur les recepteurs de calcium |
| ATE298739T1 (de) | 1996-04-09 | 2005-07-15 | Nps Pharma Inc | Calcylitische verbindungen |
| JP4117506B2 (ja) * | 1996-05-01 | 2008-07-16 | エヌピーエス ファーマシューティカルズ インコーポレイテッド | 無機イオン活性化合物 |
| WO1998044925A1 (fr) | 1997-04-04 | 1998-10-15 | Smithkline Beecham Corporation | Composes calcilytiques |
| UY24949A1 (es) | 1997-04-08 | 2001-04-30 | Smithkline Beecham Corp | Compuestos calcilíticos |
| AR014975A1 (es) | 1998-04-08 | 2001-04-11 | Nps Pharma Inc | Compuestos calciliticos, una composicion farmaceutica que los comprende, y el uso de los mismos para la fabricacion de un medicamento |
| MY121054A (en) | 1998-04-08 | 2005-12-30 | Smithkline Beecham Corp | Calcilytic compounds as calcium receptor antagonists. |
-
2000
- 2000-08-08 FR FR0010427A patent/FR2812875B1/fr not_active Expired - Fee Related
-
2001
- 2001-08-07 WO PCT/FR2001/002562 patent/WO2002012181A1/fr not_active Ceased
- 2001-08-07 EP EP20010963065 patent/EP1409453A1/fr not_active Withdrawn
- 2001-08-07 AU AU2001284113A patent/AU2001284113A1/en not_active Abandoned
- 2001-08-07 US US10/344,146 patent/US7157498B2/en not_active Expired - Fee Related
- 2001-08-07 JP JP2002518159A patent/JP4896350B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4896350B2 (ja) | 2012-03-14 |
| JP2004505949A (ja) | 2004-02-26 |
| US7157498B2 (en) | 2007-01-02 |
| FR2812875A1 (fr) | 2002-02-15 |
| US20050192317A1 (en) | 2005-09-01 |
| WO2002012181A1 (fr) | 2002-02-14 |
| AU2001284113A1 (en) | 2002-02-18 |
| EP1409453A1 (fr) | 2004-04-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |
Effective date: 20150430 |