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FR2866649A1 - Bras espaceur moleculaire, procede de fabrication, et utilisations sur une puce d'analyse a molecules ou biomolecules - Google Patents

Bras espaceur moleculaire, procede de fabrication, et utilisations sur une puce d'analyse a molecules ou biomolecules

Info

Publication number
FR2866649A1
FR2866649A1 FR0450346A FR0450346A FR2866649A1 FR 2866649 A1 FR2866649 A1 FR 2866649A1 FR 0450346 A FR0450346 A FR 0450346A FR 0450346 A FR0450346 A FR 0450346A FR 2866649 A1 FR2866649 A1 FR 2866649A1
Authority
FR
France
Prior art keywords
spacer arm
useful
double bond
includes double
new molecular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR0450346A
Other languages
English (en)
Inventor
Veronique Peretti
Francoise Vinet
David Bonnaffe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique CEA filed Critical Commissariat a lEnergie Atomique CEA
Priority to FR0450346A priority Critical patent/FR2866649A1/fr
Priority to CNA2005800055588A priority patent/CN1922195A/zh
Priority to EP05728104A priority patent/EP1718657A1/fr
Priority to US10/590,137 priority patent/US20080044838A2/en
Priority to PCT/FR2005/050117 priority patent/WO2005085263A1/fr
Priority to JP2007500273A priority patent/JP2007523945A/ja
Publication of FR2866649A1 publication Critical patent/FR2866649A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention se rapporte à un bras espaceur moléculaire, à un procédé de fixation d'une unité moléculaire à un support solide, ainsi qu'à l'utilisation de ce bras espaceur sur des puces d'analyse à molécules ou biomolécules. Le bras espaceur est de formule (I) :dans laquelle X0, X4 = C, O, S, Se, N, P, As ; X1-3 = C, O, N, S, Se, P, As, ou aryle, hétéroaryle en C1-6 ; Z1-2 = C-R, Si-R, N, P et As, où R = alkyle en C1-6 ; R1-3 = H, ou alkyle, aryle, hétéroaryle en C1-6 ; [Gp] = groupement protecteur de >N ; n, m et n = nombres entiers ≥ 1 ; [Sup] = H ou un support solide silanisé ; et [mo] = H ou une unité moléculaire destinée à être fixée de manière covalente par l'intermédiaire dudit bras espaceur sur ledit support solide silanisé.
FR0450346A 2004-02-25 2004-02-25 Bras espaceur moleculaire, procede de fabrication, et utilisations sur une puce d'analyse a molecules ou biomolecules Withdrawn FR2866649A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR0450346A FR2866649A1 (fr) 2004-02-25 2004-02-25 Bras espaceur moleculaire, procede de fabrication, et utilisations sur une puce d'analyse a molecules ou biomolecules
CNA2005800055588A CN1922195A (zh) 2004-02-25 2005-02-22 分子间隔臂、其制备方法、以及在包含分子或生物分子的分析芯片上的应用
EP05728104A EP1718657A1 (fr) 2004-02-25 2005-02-22 Bras espaceur moleculaire, procede de fabrication, et utilisations sur une puce d analyse a molecules ou biomolecules
US10/590,137 US20080044838A2 (en) 2004-02-25 2005-02-22 Molecular Spacer Arm, Process for the Production Thereof and Uses on an Analytical Chip Comprising Molecules or Biomolecules
PCT/FR2005/050117 WO2005085263A1 (fr) 2004-02-25 2005-02-22 Bras espaceur moleculaire, procede de fabrication, et utilisations sur une puce d'analyse a molecules ou biomolecules
JP2007500273A JP2007523945A (ja) 2004-02-25 2005-02-22 分子スペーサーアーム、製造方法、ならびに分子もしくは生体分子を有する分析チップ上での利用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0450346A FR2866649A1 (fr) 2004-02-25 2004-02-25 Bras espaceur moleculaire, procede de fabrication, et utilisations sur une puce d'analyse a molecules ou biomolecules

Publications (1)

Publication Number Publication Date
FR2866649A1 true FR2866649A1 (fr) 2005-08-26

Family

ID=34834238

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0450346A Withdrawn FR2866649A1 (fr) 2004-02-25 2004-02-25 Bras espaceur moleculaire, procede de fabrication, et utilisations sur une puce d'analyse a molecules ou biomolecules

Country Status (6)

Country Link
US (1) US20080044838A2 (fr)
EP (1) EP1718657A1 (fr)
JP (1) JP2007523945A (fr)
CN (1) CN1922195A (fr)
FR (1) FR2866649A1 (fr)
WO (1) WO2005085263A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0906324A1 (fr) * 1996-05-24 1999-04-07 Basf Aktiengesellschaft Derives glucidiques et leur synthese en phase solide
US6579725B1 (en) * 1999-03-05 2003-06-17 Massachusetts Institute Of Technology Linkers for synthesis of oligosaccharides on solid supports

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0906324A1 (fr) * 1996-05-24 1999-04-07 Basf Aktiengesellschaft Derives glucidiques et leur synthese en phase solide
US6579725B1 (en) * 1999-03-05 2003-06-17 Massachusetts Institute Of Technology Linkers for synthesis of oligosaccharides on solid supports

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ANDRADE R B ET AL: "SOLID-PHASE OLIGOSACCHARIDE SYNTHESIS: PREPARATION OF COMPLEX STRUCTURES USING A NOVEL LINKER AND DIFFERENT GLYCOSYLATING AGENTS", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 1, no. 11, 1999, pages 1811 - 1814, XP000914375, ISSN: 1523-7060 *
BARTA, NANCY S. ET AL: "Studies of the regiospecific 3-aza-Cope rearrangement promoted by electrophilic reagents", JOURNAL OF ORGANIC CHEMISTRY, vol. 57, no. 26, 1992, pages 7188 - 7194, XP002302571, ISSN: 0022-3263 *
BOUET, G. ET AL: "The addition of saturated aliphatic organomagnesium compounds to disubstituted, non-conjugated triple bonds. IV. The effect of a functional thioether group .alpha. to the triple bond. Catalytic action of copper", JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol. 135, no. 2, 1977, pages 151 - 159, XP002302569, ISSN: 0022-328X *
BRYCE, MARTIN R. ET AL: "Metal-assisted fragmentation of N-aryl- and -alkyl-N- trimethylsilylaminosulfur chlorides and N-aryl- and -alkyl-aminosulfur chlorides in the presence of conjugated dienes: synthesis and reactivity of 2-substituted-3,6-dihydro-1,2-thiazines", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC AND BIO-ORGANIC CHEMISTRY, vol. 15, 1996, pages 1825 - 1831, XP009038623, ISSN: 0300-922X *
GERMON C ET AL: "ALKENYL-COPPER DERIVATIVES. 28 (1) : STEREOSPECIFIC SYNTHESIS OF TERTIARY ALLYLIC AMINES OF E OR Z CONFIGURATION", BULLETIN DE LA SOCIETY CHIMIQUE DE FRANCE, MASSON, PARIS, FR, vol. 9/10, no. 2, 1984, pages 377 - 389, XP008011272, ISSN: 0037-8968 *
LAROCK, RICHARD C. ET AL: "Synthesis of Aryl-Substituted Allylic Amines via Palladium-Catalyzed Coupling of Aryl Iodides, Nonconjugated Dienes, and Amines", JOURNAL OF ORGANIC CHEMISTRY, vol. 59, no. 26, 1994, pages 8107 - 8114, XP002302570, ISSN: 0022-3263 *
MORNET, R. ET AL: "Addition of saturated gliphatic organomagnesiums to nonconjugated disubstituted triple bonds", JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol. 86, no. 1, 1975, pages 57 - 67, XP002302568, ISSN: 0022-328X *

Also Published As

Publication number Publication date
US20070190570A1 (en) 2007-08-16
WO2005085263A1 (fr) 2005-09-15
US20080044838A2 (en) 2008-02-21
EP1718657A1 (fr) 2006-11-08
CN1922195A (zh) 2007-02-28
JP2007523945A (ja) 2007-08-23

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Effective date: 20091030