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ATE388958T1 - 4'-c-substituierte 2-haloadenosinderivate - Google Patents

4'-c-substituierte 2-haloadenosinderivate

Info

Publication number
ATE388958T1
ATE388958T1 AT05006326T AT05006326T ATE388958T1 AT E388958 T1 ATE388958 T1 AT E388958T1 AT 05006326 T AT05006326 T AT 05006326T AT 05006326 T AT05006326 T AT 05006326T AT E388958 T1 ATE388958 T1 AT E388958T1
Authority
AT
Austria
Prior art keywords
substituted
haloadenosine
derivative
derivatives
provides
Prior art date
Application number
AT05006326T
Other languages
English (en)
Inventor
Satoru Kohgo
Hiroshi Ohrui
Eiichi Kodama
Masao Matsuoka
Hiroaki Mitsuya
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Application granted granted Critical
Publication of ATE388958T1 publication Critical patent/ATE388958T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT05006326T 2004-03-24 2005-03-23 4'-c-substituierte 2-haloadenosinderivate ATE388958T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004087198 2004-03-24
JP2004263409 2004-09-10

Publications (1)

Publication Number Publication Date
ATE388958T1 true ATE388958T1 (de) 2008-03-15

Family

ID=34934441

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05006326T ATE388958T1 (de) 2004-03-24 2005-03-23 4'-c-substituierte 2-haloadenosinderivate

Country Status (8)

Country Link
US (3) US7339053B2 (de)
EP (1) EP1589026B1 (de)
JP (2) JP4253342B2 (de)
AT (1) ATE388958T1 (de)
CA (1) CA2502109C (de)
DE (1) DE602005005240T2 (de)
ES (1) ES2300892T3 (de)
WO (1) WO2005090349A1 (de)

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DE60336441D1 (de) 2002-09-02 2011-05-05 Samsung Electronics Co Ltd Kontaktstruktur für eine Halbleitervorrichtung, dünnschichtige Transistoranordnung mit einer solchen Kontaktstruktur und dessen Herstellungsmethode
CA2502109C (en) * 2004-03-24 2010-02-23 Yamasa Corporation 4'-c-substituted-2-haloadenosine derivative
AU2008211081A1 (en) 2007-01-31 2008-08-07 Biosuccess Biotech Company Compositions and methods of use of phorbol esters
US11696908B2 (en) 2007-01-31 2023-07-11 Biosuccess Biotech Co. Ltd. Compositions and methods of use of phorbol esters
US10369222B2 (en) 2012-01-18 2019-08-06 Biosuccess Biotech Co., Ltd. Compositions and methods of use of phorbol esters for the treatment of stroke
US11564901B2 (en) 2007-01-31 2023-01-31 Biosuccess Biotech Co., Ltd. Compositions and methods of use of phorbol esters
US9533938B2 (en) 2007-01-31 2017-01-03 Biosuccess Biotech Co., Ltd. Compositions and methods of use of phorbol esters for the treatment of stroke
US9636317B2 (en) 2007-01-31 2017-05-02 Biosuccess Biotech Co. Ltd. Compositions and methods of use of phorbol esters
US9974764B2 (en) 2007-01-31 2018-05-22 Biosuccess Biotech Co. Ltd. Compositions and methods of use of phorbol esters in the treatment of neoplasms
KR101156330B1 (ko) 2007-02-13 2012-06-13 미쓰비시덴키 가부시키가이샤 표시 장치 및 그 제조 방법
US10099996B2 (en) 2012-01-18 2018-10-16 Biosuccess Biotech Co. Ltd. Compositions and methods of use of phorbol esters in the treatment of neoplasms
US9550722B2 (en) 2012-01-18 2017-01-24 Biosuccess Biotech Co. Ltd. Compositions and methods of use of phorbal esters for the treatment of stroke
JP6191989B2 (ja) * 2014-02-12 2017-09-06 学校法人東京理科大学 アデニン誘導体又はその薬理学的に許容しうる塩、その製造方法、及びその用途
WO2015143712A1 (en) 2014-03-28 2015-10-01 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors
MA41213A (fr) * 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
WO2017053216A2 (en) * 2015-09-23 2017-03-30 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors and preparations thereof
JOP20170038B1 (ar) 2016-02-12 2021-08-17 Merck Sharp & Dohme مركبات للاستخدام لعلاج عدوى بفيروس hiv والوقاية منه
EP3454868A4 (de) 2016-05-12 2019-12-18 Merck Sharp & Dohme Corp. Wirkstofffreisetzungssystem zur freisetzung von viruziden
US20190388336A1 (en) * 2016-06-20 2019-12-26 Merck Sharp & Dohme Corp. Drug Delivery System for the Delivery of Antiviral Agents
EP3543238B1 (de) 2016-11-16 2021-05-19 National Center for Global Health and Medicine Nukleosidderivate mit antiviraler aktivität
WO2018191093A1 (en) * 2017-04-10 2018-10-18 Merck Sharp & Dohme Corp. Drug delivery system for the delivery of antiviral agents
WO2019016679A1 (en) * 2017-07-18 2019-01-24 Viiv Healthcare Company Combination drug therapy
US11040975B2 (en) 2017-12-08 2021-06-22 Merck Sharp & Dohme Corp. Carbocyclic nucleoside reverse transcriptase inhibitors
US20200407393A1 (en) * 2018-03-07 2020-12-31 Glaxosmithkline Intellectual Property (No. 2) Limited Medical Use
JP7402225B2 (ja) 2018-05-11 2023-12-20 ロード アイランド ホスピタル ヌクレオシド系逆転写酵素阻害剤を用いて関節障害を処置するための組成物および方法
WO2020007070A1 (zh) * 2018-07-02 2020-01-09 河南真实生物科技有限公司 4'-取代核苷的晶型、制备和应用
CA3105823C (en) 2018-07-09 2023-07-25 Merck Sharp & Dohme Corp. Enzymatic synthesis of 4'-ethynyl nucleoside analogs
US20220117993A1 (en) * 2018-08-09 2022-04-21 Glaxosmithkline Intellectual Property (No. 2) Limited Compounds Useful in HIV Therapy
US20210323993A1 (en) * 2018-08-30 2021-10-21 Glaxosmithkline Intellectual Property (No. 2) Limited Compounds Useful in HIV Therapy
BR112021012133A8 (pt) * 2018-12-20 2023-04-11 Merck Sharp & Dohme Forma 1 anidra cristalina de 4'-etinil-2-fluoro-2'-desoxiadenosina, forma 4 anidra cristalina de 4'-etinil-2-fluoro-2'-desoxiadenosina, e, composição farmacêutica
AU2020211600A1 (en) 2019-01-25 2021-07-22 Brown University Compositions and methods for treating, preventing or reversing age-associated inflammation and disorders
MA55200A (fr) 2019-03-06 2022-01-12 Glaxosmithkline Ip No 2 Ltd Composés utiles dans la thérapie du vih
US12391694B2 (en) 2019-06-24 2025-08-19 Merck Sharp & Dohme Llc Process for the preparation of 2-fluoroadenine
CN114502175B (zh) * 2019-07-27 2025-02-25 腾盛博药生物科技有限公司 腺苷衍生物和包含其的药物组合物
WO2021024114A1 (en) * 2019-08-08 2021-02-11 Glaxosmithkline Intellectual Property (No.2) Limited 4'-ethynyl-2'-deoxyadenosine derivatives and their use in hiv therapy
CR20220053A (es) * 2019-08-13 2022-04-20 Merck Sharp & Dohme Sistema de administración de medicamentos para la administración de agentes antivíricos
WO2021038509A1 (en) * 2019-08-28 2021-03-04 Glaxosmithkline Intellectual Property (No.2) Limited 4'-ethynyl-2'-deoxyadenosine derivatives and their use in hiv therapy
MX2022002899A (es) * 2019-09-11 2022-05-16 Scripps Research Inst Profarmacos antivirales y composiciones farmaceuticas de los mismos.
TWI845826B (zh) 2020-03-20 2024-06-21 美商基利科學股份有限公司 4'-c-經取代-2-鹵基-2'-去氧腺苷核苷之前藥及其製造與使用方法
EP4146302A4 (de) * 2020-05-05 2024-05-22 Merck Sharp & Dohme LLC Arzneimittelabgabesystem zur abgabe von antiviralen mitteln und kontrazeptiva
WO2022159872A1 (en) 2021-01-25 2022-07-28 Brii Biosciences, Inc. Adenosine derivative and pharmaceutical composition comprising the same
AU2022211056A1 (en) 2021-01-25 2023-07-20 Brii Biosciences, Inc. Combination therapy for hiv with adenosine derivative and capsid inhibitors
EP4298105A1 (de) * 2021-02-23 2024-01-03 VIIV Healthcare Company Verbindungen zur hiv-behandlung
EP4358968A4 (de) * 2021-06-22 2025-05-07 Rome Therapeutics, Inc. 4-ethinyl-3-hydroxy-tetrahydrofuranyl-adeninphosphoramidate und verwandte verbindungen und ihre verwendung bei der behandlung von medizinischen erkrankungen
PE20250684A1 (es) 2022-03-15 2025-03-04 Rome Therapeutics Inc Compuestos y metodos para el tratamiento de enfermedades

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192749A (en) * 1990-05-21 1993-03-09 Syntex (U.S.A.) Inc. 4'-substituted nucleosides
JP4076114B2 (ja) * 1999-05-12 2008-04-16 ヤマサ醤油株式会社 ４’−ｃ−エチニルプリンヌクレオシド化合物
ES2207504T3 (es) * 1999-05-12 2004-06-01 Yamasa Corporation Nucleosidos 4'-c-etinilpurina.
WO2003068796A1 (en) 2002-02-15 2003-08-21 Yamasa Corporation 4’-c-cyano-2’-deoxypurine nucleosides
CA2514466C (en) * 2003-02-19 2015-05-26 Yale University Anti-viral nucleoside analogs and methods for treating viral infections, especially hiv infections
CA2502109C (en) * 2004-03-24 2010-02-23 Yamasa Corporation 4'-c-substituted-2-haloadenosine derivative

Also Published As

Publication number Publication date
JP5213194B2 (ja) 2013-06-19
US20090234110A1 (en) 2009-09-17
WO2005090349A1 (ja) 2005-09-29
JPWO2005090349A1 (ja) 2008-01-31
JP2011256173A (ja) 2011-12-22
DE602005005240T2 (de) 2009-03-12
CA2502109C (en) 2010-02-23
ES2300892T3 (es) 2008-06-16
DE602005005240D1 (de) 2008-04-24
CA2502109A1 (en) 2005-09-24
US7339053B2 (en) 2008-03-04
US8039614B2 (en) 2011-10-18
US20080153774A1 (en) 2008-06-26
US7625877B2 (en) 2009-12-01
JP4253342B2 (ja) 2009-04-08
EP1589026B1 (de) 2008-03-12
US20050215512A1 (en) 2005-09-29
EP1589026A1 (de) 2005-10-26

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