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FR2777291B1 - Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie - Google Patents

Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie

Info

Publication number
FR2777291B1
FR2777291B1 FR9804389A FR9804389A FR2777291B1 FR 2777291 B1 FR2777291 B1 FR 2777291B1 FR 9804389 A FR9804389 A FR 9804389A FR 9804389 A FR9804389 A FR 9804389A FR 2777291 B1 FR2777291 B1 FR 2777291B1
Authority
FR
France
Prior art keywords
nep
therapy
screening
inhibitors useful
novel membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9804389A
Other languages
English (en)
Other versions
FR2777291A1 (fr
Inventor
Tanja Ouimet
Claude Gros
Christiane Haret Rose
Marie Chantal Bonhomme
Patricia Facchinetti
Jean Charles Schwartz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Priority to FR9804389A priority Critical patent/FR2777291B1/fr
Priority to CA002325599A priority patent/CA2325599A1/fr
Priority to EP99911898A priority patent/EP1068336A2/fr
Priority to PCT/FR1999/000807 priority patent/WO1999053077A1/fr
Priority to JP2000543624A priority patent/JP2002511271A/ja
Publication of FR2777291A1 publication Critical patent/FR2777291A1/fr
Application granted granted Critical
Publication of FR2777291B1 publication Critical patent/FR2777291B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FR9804389A 1998-04-08 1998-04-08 Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie Expired - Fee Related FR2777291B1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
FR9804389A FR2777291B1 (fr) 1998-04-08 1998-04-08 Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie
CA002325599A CA2325599A1 (fr) 1998-04-08 1999-04-07 Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie
EP99911898A EP1068336A2 (fr) 1998-04-08 1999-04-07 Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie
PCT/FR1999/000807 WO1999053077A1 (fr) 1998-04-08 1999-04-07 Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie
JP2000543624A JP2002511271A (ja) 1998-04-08 1999-04-07 新規膜メタロプロテアーゼｎｅｐｉｉ及び治療において有用な阻害因子のスクリーニングのためのその使用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9804389A FR2777291B1 (fr) 1998-04-08 1998-04-08 Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie

Publications (2)

Publication Number Publication Date
FR2777291A1 FR2777291A1 (fr) 1999-10-15
FR2777291B1 true FR2777291B1 (fr) 2000-07-07

Family

ID=9525008

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9804389A Expired - Fee Related FR2777291B1 (fr) 1998-04-08 1998-04-08 Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie

Country Status (5)

Country Link
EP (1) EP1068336A2 (fr)
JP (1) JP2002511271A (fr)
CA (1) CA2325599A1 (fr)
FR (1) FR2777291B1 (fr)
WO (1) WO1999053077A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020086405A1 (en) * 2000-09-25 2002-07-04 Inmaculada Silos-Santiago 56638, a novel human neprilysin protease and uses thereof
CA2260376A1 (fr) 1999-02-11 2000-08-11 Universite De Montreal Nouvelles metalloproteases de la famille de la neprilysine
EP1069188A1 (fr) * 1999-07-15 2001-01-17 Sanofi-Synthelabo Métallopeptidases membranaires de type neprolysin
CN1250717C (zh) 1999-11-19 2006-04-12 索尔瓦药物有限公司 金属蛋白酶家族中的人酶
JP2001275687A (ja) * 2000-04-04 2001-10-09 Masafumi Matsuo 膜結合型メタロプロテアーゼ及びその可溶性分泌型
US6991916B2 (en) 2000-07-14 2006-01-31 Pfizer Inc. Compounds for the treatment of sexual dysfunction
GB0017387D0 (en) 2000-07-14 2000-08-30 Pfizer Ltd Novel enzyme

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960700A (en) * 1986-12-24 1990-10-02 Genentech, Inc. Compositions and methods for the synthesis and assay of a mammalian enkephalinase

Also Published As

Publication number Publication date
CA2325599A1 (fr) 1999-10-21
JP2002511271A (ja) 2002-04-16
EP1068336A2 (fr) 2001-01-17
FR2777291A1 (fr) 1999-10-15
WO1999053077A1 (fr) 1999-10-21

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20051230