FR2428034A2 - Derives d'oxadiazole-1,2,4, leur preparation et leur application en therapeutique - Google Patents
Derives d'oxadiazole-1,2,4, leur preparation et leur application en therapeutiqueInfo
- Publication number
- FR2428034A2 FR2428034A2 FR7817114A FR7817114A FR2428034A2 FR 2428034 A2 FR2428034 A2 FR 2428034A2 FR 7817114 A FR7817114 A FR 7817114A FR 7817114 A FR7817114 A FR 7817114A FR 2428034 A2 FR2428034 A2 FR 2428034A2
- Authority
- FR
- France
- Prior art keywords
- alkyl
- negligible
- essential
- treatment
- antihypertensive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000007530 Essential hypertension Diseases 0.000 title abstract 2
- 201000004239 Secondary hypertension Diseases 0.000 title abstract 2
- 230000001624 sedative effect Effects 0.000 title abstract 2
- LZRXFLZXURHVRK-UHFFFAOYSA-N 5-benzyl-1,2,4-oxadiazole Chemical compound C=1C=CC=CC=1CC1=NC=NO1 LZRXFLZXURHVRK-UHFFFAOYSA-N 0.000 title 1
- 230000003276 anti-hypertensive effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 abstract 2
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Dérivés d'oxadiazole de formule :
Priority Applications (20)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7817114A FR2428034A2 (fr) | 1978-06-08 | 1978-06-08 | Derives d'oxadiazole-1,2,4, leur preparation et leur application en therapeutique |
| DE7878400026T DE2860691D1 (en) | 1977-07-12 | 1978-06-20 | 1,2,4-oxadiazol derivatives, their preparation and application in pharmaceutical compositions |
| EP78400026A EP0000452B1 (fr) | 1977-07-12 | 1978-06-20 | Dérivés d'oxadiazole-1,2,4, leur préparation et leur application en thérapeutique. |
| US05/922,527 US4261994A (en) | 1977-07-12 | 1978-07-07 | 1,2,4-Oxadiazole derivatives, their preparation and pharmaceutical use |
| IL55104A IL55104A (en) | 1977-07-12 | 1978-07-07 | 1,2,4-oxadiazole derivatives,their preparation and pharmaceutical compositions containing them |
| DK783073A DK307378A (da) | 1977-07-12 | 1978-07-07 | Fremgangsmaade til fremstilling af 1,2,4-oxadiazoler |
| NO782404A NO782404L (no) | 1977-07-12 | 1978-07-10 | Fremgangsmaate for fremstilling av oksadiazolderivater |
| NZ187825A NZ187825A (en) | 1977-07-12 | 1978-07-10 | 1,2,4-oxadiazole derivatives and pharmaceutical compositions |
| CA307,090A CA1130806A (fr) | 1977-07-12 | 1978-07-10 | Derives du 1,2,4-oxadiazole, avec leur preparation et leurs applications pharmaceutiques |
| GR56739A GR64924B (en) | 1977-07-12 | 1978-07-10 | Method for the preparation of oxadiazole derivatives |
| AU37909/78A AU515506B2 (en) | 1977-07-12 | 1978-07-10 | 1, 2, 4-oxadiazole derivatives |
| PT68267A PT68267A (fr) | 1977-07-12 | 1978-07-10 | Procede de preparation de derives d'oxadiazole-1,2,4 et leur application en therapeutique |
| IT25497/78A IT1096906B (it) | 1977-07-12 | 1978-07-10 | Derivati di 1,2,4-ossadiazolo,loro preparazione e loro applicazione in terapia |
| ES471609A ES471609A1 (es) | 1977-07-12 | 1978-07-11 | Un procedimiento de preparacion de derivados de oxadiazol |
| JP53085017A JPS5834473B2 (ja) | 1977-07-12 | 1978-07-11 | 1,2,4↓−オキサジアゾ−ル誘導体 |
| FI782220A FI782220A7 (fi) | 1977-07-12 | 1978-07-11 | Oxadiazol-1,2,4-derivat deras framstaellning och deras anvaendning i medicinvaord |
| AT505378A AT362367B (de) | 1977-07-12 | 1978-07-12 | Verfahren zur herstellung von neuen 1,2,4-oxa- diazolderivaten sowie von salzen dieser ver- bindungen |
| AR272930A AR222310A1 (es) | 1977-07-12 | 1978-07-12 | Procedimiento para preparar derivados de 5-bencil-(1,2,4)-oxadiazol |
| ES478527A ES478527A1 (es) | 1977-07-12 | 1979-03-12 | Un procedimiento de preparacion de derivados de oxadiazol. |
| US06/034,197 US4242352A (en) | 1977-07-12 | 1979-04-27 | 3-Amino-5-benzyl-1,2,4-oxadiazoles and anti-hypertensive compositions thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7817114A FR2428034A2 (fr) | 1978-06-08 | 1978-06-08 | Derives d'oxadiazole-1,2,4, leur preparation et leur application en therapeutique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2428034A2 true FR2428034A2 (fr) | 1980-01-04 |
| FR2428034B2 FR2428034B2 (fr) | 1980-10-10 |
Family
ID=9209229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7817114A Granted FR2428034A2 (fr) | 1977-07-12 | 1978-06-08 | Derives d'oxadiazole-1,2,4, leur preparation et leur application en therapeutique |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2428034A2 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993009106A1 (fr) * | 1991-10-28 | 1993-05-13 | Tsentr Po Khimii Lekarstvennykh Sredstv | Derives de 5-phenoxymethyle-1,2,4-oxadiazole, leur sels, procede d'obtention et preparation pharmaceutique a base de ceux-ci presentant des proprietes antihypertensives, antiangineuses, antiarrhythmiques et antiglaucomatomeuses |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2461882A1 (de) * | 1973-12-29 | 1975-07-03 | Chinoin Gyogyszer Es Vegyeszet | Verfahren zur herstellung von 3-amino-1,2,4-oxadiazolen |
-
1978
- 1978-06-08 FR FR7817114A patent/FR2428034A2/fr active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2461882A1 (de) * | 1973-12-29 | 1975-07-03 | Chinoin Gyogyszer Es Vegyeszet | Verfahren zur herstellung von 3-amino-1,2,4-oxadiazolen |
Non-Patent Citations (1)
| Title |
|---|
| EXBK/74 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993009106A1 (fr) * | 1991-10-28 | 1993-05-13 | Tsentr Po Khimii Lekarstvennykh Sredstv | Derives de 5-phenoxymethyle-1,2,4-oxadiazole, leur sels, procede d'obtention et preparation pharmaceutique a base de ceux-ci presentant des proprietes antihypertensives, antiangineuses, antiarrhythmiques et antiglaucomatomeuses |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2428034B2 (fr) | 1980-10-10 |
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