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FR2399251A1 - EXTRACTION PROCESS FOR THE PREPARATION OF PHOSPHOLIPIDS FOR THERAPEUTIC USE FROM ANIMAL ORGANS - Google Patents

EXTRACTION PROCESS FOR THE PREPARATION OF PHOSPHOLIPIDS FOR THERAPEUTIC USE FROM ANIMAL ORGANS

Info

Publication number
FR2399251A1
FR2399251A1 FR7822384A FR7822384A FR2399251A1 FR 2399251 A1 FR2399251 A1 FR 2399251A1 FR 7822384 A FR7822384 A FR 7822384A FR 7822384 A FR7822384 A FR 7822384A FR 2399251 A1 FR2399251 A1 FR 2399251A1
Authority
FR
France
Prior art keywords
phospholipids
acetone
subjected
tissues
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7822384A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AESCULAPIUS LAB CHIM FARMA
Original Assignee
AESCULAPIUS LAB CHIM FARMA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AESCULAPIUS LAB CHIM FARMA filed Critical AESCULAPIUS LAB CHIM FARMA
Publication of FR2399251A1 publication Critical patent/FR2399251A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Ce procédé industriel d'extraction de phospholipides à partir d'organes d'animaux permet d'obtenir un complexe de phospholipides pur, de composition constante et reproductible. Ce procédé comprend 4 phases : a. Les tissus animaux, convenablement broyés et homogénéisés, sont soumis à une macération dans l'acétone à froid; b. Les tissus isolés par filtration sont soumis à une extraction à l'acétone à la température de reflux; c. Les tissus résiduels sont soumis à une extration sous vide dans un courant d'azote avec de l'alcool éthylique, la solution alcoolique est amenée à la siccité et le résidu est repris à l'éther éthylique; d. La solution éthérée est mélangée avec de l'acétone pour précipiter les phospholipides purs.This industrial process for extracting phospholipids from animal organs makes it possible to obtain a complex of pure phospholipids, of constant and reproducible composition. This process comprises 4 phases: a. The animal tissues, suitably ground and homogenized, are subjected to cold maceration in acetone; b. Tissues isolated by filtration are subjected to extraction with acetone at reflux temperature; vs. The residual tissues are subjected to vacuum extraction in a stream of nitrogen with ethyl alcohol, the alcoholic solution is brought to dryness and the residue is taken up in ethyl ether; d. The ethereal solution is mixed with acetone to precipitate the pure phospholipids.

FR7822384A 1977-08-04 1978-07-28 EXTRACTION PROCESS FOR THE PREPARATION OF PHOSPHOLIPIDS FOR THERAPEUTIC USE FROM ANIMAL ORGANS Withdrawn FR2399251A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT26475/77A IT1085693B (en) 1977-08-04 1977-08-04 EXTRACTIVE PROCESS FOR THE PREPARATION OF PHOSPHOLIPIDES FROM ANIMALS, FOR THERAPEUTIC USE

Publications (1)

Publication Number Publication Date
FR2399251A1 true FR2399251A1 (en) 1979-03-02

Family

ID=11219595

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7822384A Withdrawn FR2399251A1 (en) 1977-08-04 1978-07-28 EXTRACTION PROCESS FOR THE PREPARATION OF PHOSPHOLIPIDS FOR THERAPEUTIC USE FROM ANIMAL ORGANS

Country Status (4)

Country Link
ES (1) ES472267A1 (en)
FR (1) FR2399251A1 (en)
GB (1) GB2002631B (en)
IT (1) IT1085693B (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2115422C1 (en) * 1995-06-01 1998-07-20 Нижегородское государственное предприятие по производству бактерийных препаратов - фирма ИМБИО Method of lipid extraction
RU2192265C2 (en) * 2000-04-12 2002-11-10 Ставропольский научно-исследовательский противочумный институт Method for obtaining the complex of phospholipids
RU2275205C2 (en) * 2003-08-18 2006-04-27 Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "МИКРОГЕН" МЗ РФ Biologically active phospholipid-comprising complex for treatment of psoriasis and chronic prostatitis
RU2279885C2 (en) * 2004-06-24 2006-07-20 Общество с ограниченной ответственностью "Биосинтез Мт" Method for simultaneous production of lecithin, cholesterol, kephalin, and biological solvent cake
MD130Z (en) * 2009-10-22 2010-11-30 Институт Микробиологии И Биотехнологии Академии Наук Молдовы Process for obtaining a phospholipid complex from Spirulina platensis biomass
RU2493861C1 (en) * 2012-10-03 2013-09-27 Закрытое акционерное общество "Институт экспериментальной фармакологии" Biologically active complex possessing anti-allergic action

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4888324A (en) * 1985-10-01 1989-12-19 Angio-Medical Corporation Method for enhancing angiogenesis with lipid containing molecules
US5043329A (en) * 1987-02-17 1991-08-27 Board Of Regents, University Of Texas System Methods and compositions employing unique mixtures of polar and neutral lipids for protecting the gastrointestinal tract
US5260284A (en) * 1987-02-17 1993-11-09 Board Of Regents, The University Of Texas System Methods employing unique mixtures of polar and neutral lipids and sterol for lung surfactant replacement therapy
US4950656A (en) * 1987-02-17 1990-08-21 Board Of Regents, The University Of Texas System Methods and compositions employing unique mixtures of polar and neutral lipids for protecting the gastrointestinal tract
US5032585A (en) * 1987-02-17 1991-07-16 Board Of Regents, The University Of Texas System Methods and compositions employing unique mixtures of polar and neutral lipids for surfactant replacement therapy
RU2153881C2 (en) * 1998-10-02 2000-08-10 Нижегородское государственное предприятие по производству бактерийных препаратов Method of preparing lipid complex for therapeutic use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH140867A (en) * 1928-04-11 1930-06-30 Chem Ind Basel Process for the comminution of animal components.
AT333437B (en) * 1974-02-07 1976-11-25 Etapharm Chem Pharm Lab Ges M PROCESS FOR PRODUCING PHOSPHATIDE COMPLEX WITH INCREASED PHOSPHATIDYLATHANOLAMINE CONTENT FROM ANIMAL MATERIAL

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH140867A (en) * 1928-04-11 1930-06-30 Chem Ind Basel Process for the comminution of animal components.
AT333437B (en) * 1974-02-07 1976-11-25 Etapharm Chem Pharm Lab Ges M PROCESS FOR PRODUCING PHOSPHATIDE COMPLEX WITH INCREASED PHOSPHATIDYLATHANOLAMINE CONTENT FROM ANIMAL MATERIAL

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2115422C1 (en) * 1995-06-01 1998-07-20 Нижегородское государственное предприятие по производству бактерийных препаратов - фирма ИМБИО Method of lipid extraction
RU2192265C2 (en) * 2000-04-12 2002-11-10 Ставропольский научно-исследовательский противочумный институт Method for obtaining the complex of phospholipids
RU2275205C2 (en) * 2003-08-18 2006-04-27 Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "МИКРОГЕН" МЗ РФ Biologically active phospholipid-comprising complex for treatment of psoriasis and chronic prostatitis
RU2279885C2 (en) * 2004-06-24 2006-07-20 Общество с ограниченной ответственностью "Биосинтез Мт" Method for simultaneous production of lecithin, cholesterol, kephalin, and biological solvent cake
MD130Z (en) * 2009-10-22 2010-11-30 Институт Микробиологии И Биотехнологии Академии Наук Молдовы Process for obtaining a phospholipid complex from Spirulina platensis biomass
RU2493861C1 (en) * 2012-10-03 2013-09-27 Закрытое акционерное общество "Институт экспериментальной фармакологии" Biologically active complex possessing anti-allergic action

Also Published As

Publication number Publication date
ES472267A1 (en) 1979-10-01
GB2002631B (en) 1982-03-10
IT1085693B (en) 1985-05-28
GB2002631A (en) 1979-02-28

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