FR2233049A1 - Phenylacetic acid derivs. - having analgesic and antiinflammatory props. - Google Patents
Phenylacetic acid derivs. - having analgesic and antiinflammatory props.Info
- Publication number
- FR2233049A1 FR2233049A1 FR7322101A FR7322101A FR2233049A1 FR 2233049 A1 FR2233049 A1 FR 2233049A1 FR 7322101 A FR7322101 A FR 7322101A FR 7322101 A FR7322101 A FR 7322101A FR 2233049 A1 FR2233049 A1 FR 2233049A1
- Authority
- FR
- France
- Prior art keywords
- analgesic
- phenylacetic acid
- antiinflammatory
- props
- acid derivs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 title abstract 4
- 230000000202 analgesic effect Effects 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- 229960003424 phenylacetic acid Drugs 0.000 title abstract 2
- 239000003279 phenylacetic acid Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- VRVRGVPWCUEOGV-UHFFFAOYSA-N 2-aminothiophenol Chemical compound NC1=CC=CC=C1S VRVRGVPWCUEOGV-UHFFFAOYSA-N 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000025747 Rheumatic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000036407 pain Effects 0.000 abstract 1
- 230000000552 rheumatic effect Effects 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Phenylacetic acid derivs of formula (I) and their salts with bases are new (where R is H or Me) they are prepd. by reacting, in an organic solvent, a salt of o-aminothiophenol and and oxidising the intermediate. (I) have analgesic and antiinflammatory properties, used in the treatment of allergies, esp. rheumatic pains. Dosages are 200 mg - 4 g per 24 hrs. in the form of e.g. 100-500 mg tablets, 100 mg-1g suppositories or 100-500 mg injections. LF50 is ca. 300 mg/kg IP and >300 mg/kg p.o. on two examples tested.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7322101A FR2233049A1 (en) | 1973-06-18 | 1973-06-18 | Phenylacetic acid derivs. - having analgesic and antiinflammatory props. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7322101A FR2233049A1 (en) | 1973-06-18 | 1973-06-18 | Phenylacetic acid derivs. - having analgesic and antiinflammatory props. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2233049A1 true FR2233049A1 (en) | 1975-01-10 |
Family
ID=9121100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7322101A Withdrawn FR2233049A1 (en) | 1973-06-18 | 1973-06-18 | Phenylacetic acid derivs. - having analgesic and antiinflammatory props. |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2233049A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0169688A1 (en) * | 1984-07-10 | 1986-01-29 | Sankyo Company Limited | Process for preparing anti-inflammatory cycloalkylidenemethylphenylacetic acid derivatives |
| US5336500A (en) * | 1991-06-04 | 1994-08-09 | Ecolab Inc. | Sanitizing composition comprising a blend of aromatic and polyunsaturated carboxylic acid |
-
1973
- 1973-06-18 FR FR7322101A patent/FR2233049A1/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0169688A1 (en) * | 1984-07-10 | 1986-01-29 | Sankyo Company Limited | Process for preparing anti-inflammatory cycloalkylidenemethylphenylacetic acid derivatives |
| US5336500A (en) * | 1991-06-04 | 1994-08-09 | Ecolab Inc. | Sanitizing composition comprising a blend of aromatic and polyunsaturated carboxylic acid |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |