GB1377674A - Tetracycline complex - Google Patents
Tetracycline complexInfo
- Publication number
- GB1377674A GB1377674A GB3236772A GB3236772A GB1377674A GB 1377674 A GB1377674 A GB 1377674A GB 3236772 A GB3236772 A GB 3236772A GB 3236772 A GB3236772 A GB 3236772A GB 1377674 A GB1377674 A GB 1377674A
- Authority
- GB
- United Kingdom
- Prior art keywords
- piperazine
- biguanide
- tetracycline
- formaldehyde
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000004098 Tetracycline Substances 0.000 title abstract 6
- 229960002180 tetracycline Drugs 0.000 title abstract 6
- 229930101283 tetracycline Natural products 0.000 title abstract 4
- 235000019364 tetracycline Nutrition 0.000 title abstract 4
- 150000003522 tetracyclines Chemical class 0.000 title abstract 4
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 14
- WSFSSNUMVMOOMR-UHFFFAOYSA-N formaldehyde Substances O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 abstract 2
- 229940123208 Biguanide Drugs 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000007795 chemical reaction product Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1377674 Tetracycline complex; piperazine biguanide-formaldehyde compound SPA-SOC PRODOTTI ANTIBIOTICI SpA 22 June 1973 [11 July 1972] 32367/72 Heading C2C A novel complex of equimolar amounts of tetracycline, formaldehyde and piperazine biguanide is prepared by reacting the component substances with each other, or by reacting (i) a piperazine biguanide-formaldehyde reaction product with tetracycline or (ii) a piperazine biguanide-tetracycline reaction product with formaldehyde. The reaction may be performed in a solvent (e.g. methanol or ethanol) at about 5-30‹ C. The said complex may be salified with one or two equivalents of an organic or inorganic acid to give a mono- or di-acid addition salt. Preparation of the intermediates referred to in (i) and (ii) above viz. a 1: 1 piperazine biguanide-formaldehyde compound, and a 1 - 1 piperazine biguanide-tetracycline compound) is described. Also the preparation of piperazine biguanide free base by treatment of the bihydrochloride salt with methanolic NaOH is described. The novel complexes and their salts may be admixed with a pharmaceutical carrier to provide antibiotic pharmaceutical compositions.
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3236772A GB1377674A (en) | 1972-07-11 | 1972-07-11 | Tetracycline complex |
| BE787620A BE787620A (en) | 1972-07-11 | 1972-08-16 | NEW THERAPEUTICALLY ACTIVE COMPLEX CONTAINING TETRACYCLINE |
| DE2241076A DE2241076C3 (en) | 1972-07-11 | 1972-08-21 | Tetracycline complex and its salts, process for its preparation and pharmaceutical compositions containing this complex |
| FR7230613A FR2191880B1 (en) | 1972-07-11 | 1972-08-29 | |
| JP627273A JPS531807B2 (en) | 1972-07-11 | 1973-01-10 | |
| CH978273A CH585190A5 (en) | 1972-07-11 | 1973-07-05 | |
| CA176,037A CA994335A (en) | 1972-07-11 | 1973-07-10 | Tetracycline complex |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3236772A GB1377674A (en) | 1972-07-11 | 1972-07-11 | Tetracycline complex |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1377674A true GB1377674A (en) | 1974-12-18 |
Family
ID=10337520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3236772A Expired GB1377674A (en) | 1972-07-11 | 1972-07-11 | Tetracycline complex |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS531807B2 (en) |
| BE (1) | BE787620A (en) |
| CA (1) | CA994335A (en) |
| CH (1) | CH585190A5 (en) |
| DE (1) | DE2241076C3 (en) |
| FR (1) | FR2191880B1 (en) |
| GB (1) | GB1377674A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4923414U (en) * | 1972-06-02 | 1974-02-27 | ||
| JPS5311724Y2 (en) * | 1975-01-09 | 1978-03-30 | ||
| JPS5424032Y2 (en) * | 1975-04-03 | 1979-08-15 | ||
| JP2534143B2 (en) * | 1989-11-28 | 1996-09-11 | 三菱農機株式会社 | Planting rod stop device for transplanter |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1042207A (en) * | 1963-08-09 | 1966-09-14 | Prodotti Antibiotici Spa | Tetracycline derivatives |
| BE726063A (en) * | 1968-12-27 | 1969-05-29 |
-
1972
- 1972-07-11 GB GB3236772A patent/GB1377674A/en not_active Expired
- 1972-08-16 BE BE787620A patent/BE787620A/en unknown
- 1972-08-21 DE DE2241076A patent/DE2241076C3/en not_active Expired
- 1972-08-29 FR FR7230613A patent/FR2191880B1/fr not_active Expired
-
1973
- 1973-01-10 JP JP627273A patent/JPS531807B2/ja not_active Expired
- 1973-07-05 CH CH978273A patent/CH585190A5/xx not_active IP Right Cessation
- 1973-07-10 CA CA176,037A patent/CA994335A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2191880A1 (en) | 1974-02-08 |
| BE787620A (en) | 1972-12-18 |
| DE2241076A1 (en) | 1974-01-24 |
| FR2191880B1 (en) | 1976-04-16 |
| JPS4935522A (en) | 1974-04-02 |
| CH585190A5 (en) | 1977-02-28 |
| JPS531807B2 (en) | 1978-01-23 |
| DE2241076B2 (en) | 1979-05-17 |
| CA994335A (en) | 1976-08-03 |
| DE2241076C3 (en) | 1980-01-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1063749A (en) | New guanidine derivatives and processes for their production | |
| GB1269908A (en) | Amino acids having anti-viral effects | |
| GB1436978A (en) | Choline derivatives and pharmaceutical compositions containing the same | |
| FR2222097A1 (en) | ||
| GB1377674A (en) | Tetracycline complex | |
| IL37829A (en) | 2,4,6-triiodo-3-methylamino-benzoic acid derivatives | |
| GB1320032A (en) | Imidazole derivatives | |
| GB1386036A (en) | Erythromycin derivatives | |
| ES419016A1 (en) | 13-bromolysergic acid compounds | |
| ES427433A1 (en) | A procedure for preparing a selected chemical compound of the group consisting of nitroimidazool-ethyl O-thiocarbamate. (Machine-translation by Google Translate, not legally binding) | |
| GB1250045A (en) | A new water soluble derivative of erythromycin | |
| NL7410826A (en) | PROCESS FOR THE PREPARATION OF INDAZOLE-3-CARBONIC ACID HYDRAZIDES. | |
| GB1112909A (en) | Ergoline derivatives | |
| GB1299566A (en) | Bis-basic ethers of 2,6- and 2,7-dihydroxyanthraquinones | |
| GB1421580A (en) | Production of benzylamine derivatives | |
| ES427715A2 (en) | Complexes of a-6-deoxy-5-hydroxy tetracycline and their preparation | |
| GB1351921A (en) | Nitrofuryl triazolo-pyridazine-amides | |
| GB1286795A (en) | New azomethines and their production | |
| GB1369661A (en) | Hexafluoro-di-tolylamine derivatives | |
| GB1319402A (en) | 3-acyloxypropyl-2,-trimethylammoniumethyl phosphates | |
| GB1371757A (en) | Substituted aminoquinolizinium bromides their preparation and compositions thereof | |
| GB1372570A (en) | Synthetic penicillin and process for the preparation thereof | |
| ES378361A1 (en) | Nitroimidazolyl nitrones | |
| GB1397697A (en) | Phenoxyalicyclic carboxylic acid derivatives methods of making them and compositions containing them | |
| GB1333524A (en) | Penicilloic acid derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |