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FR21C1051I1 - Nouveau sel hydrogenosulfate - Google Patents

Nouveau sel hydrogenosulfate

Info

Publication number
FR21C1051I1
FR21C1051I1 FR21C1051C FR21C1051C FR21C1051I1 FR 21C1051 I1 FR21C1051 I1 FR 21C1051I1 FR 21C1051 C FR21C1051 C FR 21C1051C FR 21C1051 C FR21C1051 C FR 21C1051C FR 21C1051 I1 FR21C1051 I1 FR 21C1051I1
Authority
FR
France
Prior art keywords
hydrogenosulfate
salt
new
new hydrogenosulfate
hydrogenosulfate salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR21C1051C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Array Biopharma Inc
Original Assignee
AstraZeneca AB
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38218759&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR21C1051(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AstraZeneca AB, Array Biopharma Inc filed Critical AstraZeneca AB
Publication of FR21C1051I1 publication Critical patent/FR21C1051I1/fr
Application granted granted Critical
Publication of FR21C1051I2 publication Critical patent/FR21C1051I2/fr
Active legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08Radicals containing only hydrogen and carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR21C1051C 2005-12-21 2021-11-05 Nouveau sel hydrogenosulfate Active FR21C1051I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75278105P 2005-12-21 2005-12-21
PCT/US2006/061895 WO2007076245A2 (fr) 2005-12-21 2006-12-12 Nouveau sel hydrogenosulfate

Publications (2)

Publication Number Publication Date
FR21C1051I1 true FR21C1051I1 (fr) 2021-12-24
FR21C1051I2 FR21C1051I2 (fr) 2023-02-17

Family

ID=38218759

Family Applications (1)

Application Number Title Priority Date Filing Date
FR21C1051C Active FR21C1051I2 (fr) 2005-12-21 2021-11-05 Nouveau sel hydrogenosulfate

Country Status (32)

Country Link
US (4) US20100016393A1 (fr)
EP (1) EP1968948B1 (fr)
JP (1) JP5127723B2 (fr)
KR (1) KR101361460B1 (fr)
CN (2) CN101360718B (fr)
AR (1) AR058696A1 (fr)
AU (1) AU2006330759B2 (fr)
BR (1) BRPI0620091B1 (fr)
CA (1) CA2634149C (fr)
CY (2) CY1114303T1 (fr)
DK (1) DK1968948T3 (fr)
EC (1) ECSP088597A (fr)
ES (1) ES2421746T3 (fr)
FI (1) FIC20210043I1 (fr)
FR (1) FR21C1051I2 (fr)
HR (1) HRP20130663T1 (fr)
HU (1) HUS2100046I1 (fr)
IL (1) IL192224A (fr)
LT (1) LTC1968948I2 (fr)
LU (1) LUC00234I2 (fr)
MX (1) MX2008008298A (fr)
MY (1) MY157733A (fr)
NL (1) NL301139I2 (fr)
NZ (1) NZ569792A (fr)
PL (1) PL1968948T3 (fr)
PT (1) PT1968948E (fr)
RS (1) RS52843B (fr)
SI (1) SI1968948T1 (fr)
TW (1) TWI405756B (fr)
UA (1) UA93531C2 (fr)
WO (1) WO2007076245A2 (fr)
ZA (1) ZA200805705B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2478374C (fr) 2002-03-13 2009-01-06 Eli M. Wallace Utilisation de derives de benzimidazole alkyles n3 en tant qu'inhibiteurs de mek
TWI405756B (zh) 2005-12-21 2013-08-21 Array Biopharma Inc 新穎硫酸氫鹽
US20100004247A1 (en) * 2007-12-12 2010-01-07 Astrazeneca Ab Combination comprising a mek inhibitor and an aurora kinase inhibitor 188
SA109300195B1 (ar) * 2008-03-28 2013-04-20 Astrazeneca Ab تركيبة صيدلانية جديدة مضادة للسرطان
WO2011095807A1 (fr) 2010-02-07 2011-08-11 Astrazeneca Ab Combinaisons d'inhibiteurs de mek et de hh
WO2012145503A1 (fr) * 2011-04-21 2012-10-26 Novartis Ag Combinaisons pharmaceutiques
MX350957B (es) 2011-11-23 2017-09-27 Medimmune Llc Moleculas de union especificas para her3 y usos de las mismas.
WO2013109142A1 (fr) 2012-01-16 2013-07-25 Stichting Het Nederlands Kanker Instituut Inhibition de la voie des mapk/erk et pdk combinée dans des cas de néoplasie
AR099630A1 (es) * 2012-10-19 2016-08-10 Novartis Ag Preparación de un inhibidor de mek y formulación que lo comprende
EP3342770B1 (fr) 2013-03-06 2022-03-30 AstraZeneca AB Inhibiteurs de quinazoline pour activer des formes mutantes du récepteur du facteur de croissance épidermique
EP3046557A1 (fr) 2013-09-20 2016-07-27 Stichting Het Nederlands Kanker Instituut Association de rock et de la voie mapk
WO2015041534A1 (fr) 2013-09-20 2015-03-26 Stichting Het Nederlands Kanker Instituut P90rsk en combinaison avec raf/erk/mek
US20170027940A1 (en) 2014-04-10 2017-02-02 Stichting Het Nederlands Kanker Instituut Method for treating cancer
WO2015178770A1 (fr) 2014-05-19 2015-11-26 Stichting Het Nederlands Kanker Instituut Compositions pour le traitement du cancer
CN105566327A (zh) * 2014-10-09 2016-05-11 江苏恒瑞医药股份有限公司 一种jak激酶抑制剂的硫酸氢盐的i型结晶及其制备方法
EP3355923B1 (fr) 2015-10-01 2022-02-23 Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis Inhibiteurs de l'histone désacétylase utilisables dans le traitement d'un mélanome résistant aux médicaments
BR112018003232A2 (pt) 2015-10-06 2018-09-25 Redhill Biopharma Ltd terapias de combinação para tratamento de câncer
WO2017099591A1 (fr) 2015-12-07 2017-06-15 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Traitement de cancers à mutation braf résistants aux inhibiteurs
WO2017204626A1 (fr) 2016-05-24 2017-11-30 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Polythérapie combinant map2k4/map3k1 et une inhibition de mek/erk
CN109438362B (zh) 2017-11-14 2020-07-21 深圳市塔吉瑞生物医药有限公司 一种取代的苯并咪唑化合物及包含该化合物的组合物
CA3117559C (fr) * 2018-10-31 2023-09-26 Les Laboratoires Servier Sel d'hydrogenosulfate d'un inhibiteur de bcl-2, forme cristalline connexe, methode de preparation et compositions pharmaceutiques les comprenant
US12175741B2 (en) * 2021-06-22 2024-12-24 Intrinsic Innovation Llc Systems and methods for a vision guided end effector
EP4536226A1 (fr) * 2022-06-06 2025-04-16 Alivus Life Sciences Limited Procédé de préparation de sélumétinib et de sels de celui-ci
US20240400519A1 (en) * 2023-06-01 2024-12-05 Chunghwa Chemical Synthesis & Biotech Co. Ltd. Crystal forms a, b, c, d, e, f and g of selumetinib sulfate and preparation methods thereof

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Publication number Priority date Publication date Assignee Title
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
US5863949A (en) 1995-03-08 1999-01-26 Pfizer Inc Arylsulfonylamino hydroxamic acid derivatives
CA2218503C (fr) 1995-04-20 2001-07-24 Pfizer Inc. Derives d'acide hydroxamique arylsufonyle en tant qu'inhibiteurs de mmp et de tnf
KR20000067904A (ko) 1996-07-18 2000-11-25 디. 제이. 우드, 스피겔 알렌 제이 매트릭스 메탈로프로테아제의 포스피네이트계 억제제
BR9711223A (pt) 1996-08-23 1999-08-17 Pfizer Derivados de cido arilsulfonilamino-hidrox mico
EP0950059B1 (fr) 1997-01-06 2004-08-04 Pfizer Inc. Derives de sulfone cyclique
IL131042A0 (en) 1997-02-03 2001-01-28 Pfizer Prod Inc Arylsulfonylamino hydroxamic acid derivatives
BR9807824A (pt) 1997-02-07 2000-03-08 Pfizer Derivados de n-hidróxi-beta-sulfonil-propionamida e seu uso como inibidores de metaloproteinases de matriz
KR20000070923A (ko) 1997-02-11 2000-11-25 디. 제이. 우드, 스피겔 알렌 제이 아릴설포닐 하이드록삼산 유도체
GB9725782D0 (en) 1997-12-05 1998-02-04 Pfizer Ltd Therapeutic agents
PA8469401A1 (es) 1998-04-10 2000-05-24 Pfizer Prod Inc Derivados biciclicos del acido hidroxamico
PA8469501A1 (es) 1998-04-10 2000-09-29 Pfizer Prod Inc Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
CA2478374C (fr) * 2002-03-13 2009-01-06 Eli M. Wallace Utilisation de derives de benzimidazole alkyles n3 en tant qu'inhibiteurs de mek
US7235537B2 (en) * 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
ATE380027T1 (de) 2003-09-09 2007-12-15 Fumapharm Ag Verwendung von fumarsäure-derivaten zur behandlung von herzinsuffizienz und asthma
TWI405756B (zh) 2005-12-21 2013-08-21 Array Biopharma Inc 新穎硫酸氫鹽
SA109300195B1 (ar) * 2008-03-28 2013-04-20 Astrazeneca Ab تركيبة صيدلانية جديدة مضادة للسرطان

Also Published As

Publication number Publication date
CA2634149C (fr) 2013-08-13
FR21C1051I2 (fr) 2023-02-17
LTPA2021530I1 (fr) 2021-12-27
US9156795B2 (en) 2015-10-13
CY2021030I2 (el) 2022-03-24
CN102329270A (zh) 2012-01-25
LTC1968948I2 (fr) 2023-07-10
CN101360718B (zh) 2012-01-11
HUS2100046I1 (hu) 2021-11-29
NL301139I2 (nl) 2022-02-22
NL301139I1 (fr) 2021-11-03
HK1124043A1 (en) 2009-07-03
BRPI0620091A2 (pt) 2011-11-01
AU2006330759A1 (en) 2007-07-05
FIC20210043I1 (fi) 2021-11-26
IL192224A (en) 2014-08-31
CY2021030I1 (el) 2022-03-24
JP2009521487A (ja) 2009-06-04
AR058696A1 (es) 2008-02-20
TW200800915A (en) 2008-01-01
UA93531C2 (en) 2011-02-25
US20160024018A1 (en) 2016-01-28
SI1968948T1 (sl) 2013-08-30
CN101360718A (zh) 2009-02-04
PT1968948E (pt) 2013-07-25
US20140221443A1 (en) 2014-08-07
ES2421746T3 (es) 2013-09-05
DK1968948T3 (da) 2013-08-26
LUC00234I2 (fr) 2025-02-03
BRPI0620091B1 (pt) 2024-04-30
EP1968948A2 (fr) 2008-09-17
ECSP088597A (es) 2008-08-29
KR101361460B1 (ko) 2014-02-10
MY157733A (en) 2016-07-15
WO2007076245A2 (fr) 2007-07-05
NZ569792A (en) 2011-01-28
MX2008008298A (es) 2008-09-24
US20120253049A1 (en) 2012-10-04
CA2634149A1 (fr) 2007-07-05
US20100016393A1 (en) 2010-01-21
US9562017B2 (en) 2017-02-07
IL192224A0 (en) 2009-02-11
TWI405756B (zh) 2013-08-21
AU2006330759B2 (en) 2012-12-06
PL1968948T3 (pl) 2013-10-31
JP5127723B2 (ja) 2013-01-23
EP1968948A4 (fr) 2010-12-15
RS52843B (sr) 2013-12-31
KR20080080200A (ko) 2008-09-02
ZA200805705B (en) 2012-09-26
WO2007076245A3 (fr) 2008-01-24
HRP20130663T1 (xx) 2013-08-31
CY1114303T1 (el) 2016-08-31
EP1968948B1 (fr) 2013-05-22

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