FR19C1046I1 - (+)-2-[1-(3-éthoxy-4-méthoxyphényl)-2-méthylsulfonyléthyl]-4-acétylaminoisoindoline-1,3-dione: ses procédés d'utilisation et compositions correspondantes - Google Patents
(+)-2-[1-(3-éthoxy-4-méthoxyphényl)-2-méthylsulfonyléthyl]-4-acétylaminoisoindoline-1,3-dione: ses procédés d'utilisation et compositions correspondantesInfo
- Publication number
- FR19C1046I1 FR19C1046I1 FR19C1046C FR19C1046I1 FR 19C1046 I1 FR19C1046 I1 FR 19C1046I1 FR 19C1046 C FR19C1046 C FR 19C1046C FR 19C1046 I1 FR19C1046 I1 FR 19C1046I1
- Authority
- FR
- France
- Prior art keywords
- acetylaminoisoindoline
- methylsulfonylethyl
- dione
- methoxyphenyl
- ethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- IMOZEMNVLZVGJZ-UHFFFAOYSA-N n-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide Chemical compound C1=C(OC)C(OCC)=CC(C(CS(C)(=O)=O)N2C(C3=C(NC(C)=O)C=CC=C3C2=O)=O)=C1 IMOZEMNVLZVGJZ-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36651502P | 2002-03-20 | 2002-03-20 | |
| US43845003P | 2003-01-07 | 2003-01-07 | |
| EP03721414A EP1485087B1 (fr) | 2002-03-20 | 2003-03-20 | (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione pour le traitement du psoriasis par administration orale |
| PCT/US2003/008738 WO2003080049A1 (fr) | 2002-03-20 | 2003-03-20 | (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: leurs procedes d'utilisation et leurs compositions |
| EP09003138.6A EP2074995B1 (fr) | 2002-03-20 | 2003-03-20 | (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: leurs procedes d'utilisation et leurs compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR19C1046I1 true FR19C1046I1 (fr) | 2019-08-09 |
| FR19C1046I2 FR19C1046I2 (fr) | 2022-07-08 |
Family
ID=28457137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR19C1046C Active FR19C1046I2 (fr) | 2002-03-20 | 2019-07-12 | (+)-2-[1-(3-éthoxy-4-méthoxyphényl)-2-méthylsulfonyléthyl]-4-acétylaminoisoindoline-1,3-dione: ses procédés d'utilisation et compositions correspondantes |
Country Status (23)
| Country | Link |
|---|---|
| US (14) | US6962940B2 (fr) |
| EP (9) | EP2311453B1 (fr) |
| JP (4) | JP2005525386A (fr) |
| KR (6) | KR101104991B1 (fr) |
| CN (2) | CN100427085C (fr) |
| AT (1) | ATE440599T1 (fr) |
| AU (1) | AU2003224729C1 (fr) |
| BE (1) | BE2019C008I2 (fr) |
| CA (2) | CA2479666C (fr) |
| CY (6) | CY1109380T1 (fr) |
| DE (1) | DE60328974D1 (fr) |
| DK (6) | DK2295055T3 (fr) |
| ES (8) | ES2595375T3 (fr) |
| FR (1) | FR19C1046I2 (fr) |
| HU (5) | HUE043539T2 (fr) |
| IL (3) | IL164147A0 (fr) |
| LU (1) | LUC00125I2 (fr) |
| MX (2) | MX366328B (fr) |
| NL (1) | NL300994I2 (fr) |
| NZ (1) | NZ535798A (fr) |
| PT (6) | PT2223687T (fr) |
| SI (5) | SI2295055T1 (fr) |
| WO (1) | WO2003080049A1 (fr) |
Families Citing this family (152)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK17799A3 (en) * | 1996-08-12 | 1999-11-08 | Celgene Corp | Cyano and carboxy derivatives of substituted styrenes, pharmaceutical composition containing same and their use |
| US8030343B2 (en) * | 2000-06-08 | 2011-10-04 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
| US7276529B2 (en) * | 2002-03-20 | 2007-10-02 | Celgene Corporation | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
| US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
| CA2379887C (fr) * | 2002-04-09 | 2004-01-20 | Bernard Charles Sherman | Comprimes stables contenant de la simvastatine |
| WO2003097040A1 (fr) * | 2002-05-17 | 2003-11-27 | Celgene Corporation | Methodes et compositions mettant en oeuvre des medicaments selectifs inhibiteurs des cytokines pour le traitement et la prise en charge des cancers et autres maladies |
| US20100129363A1 (en) * | 2002-05-17 | 2010-05-27 | Zeldis Jerome B | Methods and compositions using pde4 inhibitors for the treatment and management of cancers |
| AU2003228509B2 (en) * | 2002-10-15 | 2008-06-26 | Celgene Corporation | Selective cytokine inhibitory drugs for treating myelodysplastic syndrome |
| US20040087558A1 (en) * | 2002-10-24 | 2004-05-06 | Zeldis Jerome B. | Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain |
| US20050203142A1 (en) * | 2002-10-24 | 2005-09-15 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain |
| US7776907B2 (en) | 2002-10-31 | 2010-08-17 | Celgene Corporation | Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide |
| BR0316057A (pt) | 2002-11-06 | 2005-09-20 | Celgene Corp | Métodos de tratar, controlar ou prevenir um câncer especìfico e uma doença associada com angiogênese indesejada e de reduzir ou evitar um efeito adverso associado com a administração de um segundo ingrediente ativo e com a terapia de radiação, terapia hormonal, terapia biológica ou imunoterapia em um paciente sofrendo de um câncer especìfico, composição farmacêutica e kit |
| WO2004043336A2 (fr) * | 2002-11-06 | 2004-05-27 | Celgene Corporation | Methodes d'utilisation d'agents inhibiteurs selectifs de la cytokine et compositions comprenant ces agents pour le traitement et la gestion de maladies myeloproliferatives |
| WO2004045597A1 (fr) * | 2002-11-18 | 2004-06-03 | Celgene Corporation | Compositions comprenant un (+)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide et methodes d'utilisation de ces compositions |
| NZ540546A (en) * | 2002-11-18 | 2008-03-28 | Celgene Corp | Methods of using and compositions comprising (-)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide |
| US20040175382A1 (en) * | 2003-03-06 | 2004-09-09 | Schafer Peter H. | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system |
| EP1605935A4 (fr) * | 2003-03-06 | 2009-05-20 | Celgene Corp | Methodes d'utilisation et compositions comprenant des medicaments selectifs inhibitoires de cytokine pour le traitement et pour la gestion de troubles du systeme nerveux central |
| US20060205749A1 (en) * | 2003-03-13 | 2006-09-14 | Yuzuru Abe | Remedy and/or preventive for lung diseases |
| JP2007524656A (ja) * | 2003-10-23 | 2007-08-30 | セルジーン・コーポレーション | 疼痛を治療、改変および管理するための選択的サイトカイン阻害薬を含む組成物ならびにその使用方法 |
| US20050142104A1 (en) * | 2003-11-06 | 2005-06-30 | Zeldis Jerome B. | Methods of using and compositions comprising PDE4 modulators for the treatment and management of asbestos-related diseases and disorders |
| KR20060124610A (ko) * | 2003-11-06 | 2006-12-05 | 셀진 코포레이션 | 석면-관련된 질환 또는 장애를 치료 및 관리하기 위하여jnk 억제제를 사용하는 방법 및 이 물질을 포함하는조성물 |
| JPWO2005056009A1 (ja) * | 2003-12-12 | 2007-07-05 | 協和醗酵工業株式会社 | 肺疾患治療剤 |
| US20100173864A1 (en) | 2004-03-29 | 2010-07-08 | Cheng Jin Q | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
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- 2019-06-18 HU HUS1900032C patent/HUS1900032I1/hu unknown
- 2019-06-18 BE BE2019C008C patent/BE2019C008I2/nl unknown
- 2019-06-18 CY CY2019032C patent/CY2019032I2/el unknown
- 2019-06-18 NL NL300994C patent/NL300994I2/nl unknown
- 2019-07-12 FR FR19C1046C patent/FR19C1046I2/fr active Active
- 2019-08-14 CY CY20191100877T patent/CY1121888T1/el unknown
-
2020
- 2020-02-28 US US16/805,196 patent/US11040024B2/en not_active Expired - Fee Related
- 2020-08-26 US US17/003,238 patent/US11260046B2/en not_active Expired - Lifetime
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