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CY1119204T1 - (+)-2-[1-(3-αιθοξυ-4-μεθοξυφαινυλο)-2-μεθυλοσουλφονυλαιθυλο]-4-ακετυλαμινοϊσονδολινο-1,3-διονη: μεθοδοι χρησης και συνθεσεις αυτης - Google Patents

(+)-2-[1-(3-αιθοξυ-4-μεθοξυφαινυλο)-2-μεθυλοσουλφονυλαιθυλο]-4-ακετυλαμινοϊσονδολινο-1,3-διονη: μεθοδοι χρησης και συνθεσεις αυτης

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Publication number
CY1119204T1
CY1119204T1 CY20171100748T CY171100748T CY1119204T1 CY 1119204 T1 CY1119204 T1 CY 1119204T1 CY 20171100748 T CY20171100748 T CY 20171100748T CY 171100748 T CY171100748 T CY 171100748T CY 1119204 T1 CY1119204 T1 CY 1119204T1
Authority
CY
Cyprus
Prior art keywords
methylsulfonylethyl
dione
methoxyphenyl
ethoxy
methods
Prior art date
Application number
CY20171100748T
Other languages
English (en)
Inventor
Peter H Schafer
George W Muller
Hon-Wah Man
Chuansheng Ge
Original Assignee
Celgene Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=28457137&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1119204(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celgene Corporation filed Critical Celgene Corporation
Publication of CY1119204T1 publication Critical patent/CY1119204T1/el

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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Abstract

Στερεομερικώς καθαρή (+)-2-[1 -(3-Αιθοξυ-4-μεθοξυφαινυλο)-2-μεθυλοσουλφονυλαιθυλο]-4-ακετυλαμινοϊσονδολινο-1,3-διόνη, ουσιαστικά απαλλαγμένη από το (-) ισομερές της, και προφάρμακα, μεταβολίτες, πολυμορφικές μορφές, άλατα, επιδιαλυτωμένα άλατα, ένυδρα άλατα, και ενώσεις εγκλεισμού αυτής συζητούνται. Επίσης συζητούνται μέθοδοι χρήσης και φαρμακευτικές συνθέσεις οι οποίες περιλαμβάνουν το (+) εναντιομερές της 2-[1-(3-Αιθοξυ-4-μεθοξυφαινυλο)-2-μεθυλοσουλφονυλαιθυλο]-4-ακετυλαμινοϊσονδολινο-1,3-διόνης. Οι μέθοδοι περιλαμβάνουν μεθόδους αντιμετώπισης και/ή πρόληψης διαταραχών οι οποίες βελτιώνονται με την μείωση των επιπέδων του TNF-άλφα ή την αναστολή της PDE4.
CY20171100748T 2002-03-20 2017-07-14 (+)-2-[1-(3-αιθοξυ-4-μεθοξυφαινυλο)-2-μεθυλοσουλφονυλαιθυλο]-4-ακετυλαμινοϊσονδολινο-1,3-διονη: μεθοδοι χρησης και συνθεσεις αυτης CY1119204T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36651502P 2002-03-20 2002-03-20
US43845003P 2003-01-07 2003-01-07
EP09003138.6A EP2074995B1 (en) 2002-03-20 2003-03-20 (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
EP03721414A EP1485087B1 (en) 2002-03-20 2003-03-20 (+)-2- [1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione for use in treating psoriasis by oral administration

Publications (1)

Publication Number Publication Date
CY1119204T1 true CY1119204T1 (el) 2018-02-14

Family

ID=28457137

Family Applications (6)

Application Number Title Priority Date Filing Date
CY20091100967T CY1109380T1 (el) 2002-03-20 2009-09-18 (+)-2-[1-(3-αιθοξυ-4-μεθοξυφαινυλο)-2-μεθυλοσουλφονυλαιθυλο]-4-ακετυλαμινοϊσονδολινο-1,3-διονη για χρηση στην αντιμετωπιση ψωριασης μεσω στοματικης χορηγησης
CY20171100748T CY1119204T1 (el) 2002-03-20 2017-07-14 (+)-2-[1-(3-αιθοξυ-4-μεθοξυφαινυλο)-2-μεθυλοσουλφονυλαιθυλο]-4-ακετυλαμινοϊσονδολινο-1,3-διονη: μεθοδοι χρησης και συνθεσεις αυτης
CY20171100884T CY1119340T1 (el) 2002-03-20 2017-08-21 (+)-2-[1-(3-αιθοξυ-4-μεθοξυφαινυλο)-2-μεθυλοσουλφονυλαιθυλο]-4-ακετυλαμινοϊσονδολινο-1,3-διονη: μεθοδοι χρησης και συνθεσεις αυτης
CY20191100372T CY1121720T1 (el) 2002-03-20 2019-04-03 (+)-2-[1-(3-αιθοξυ-4-μεθοξυφαινυλ)-2-μεθυλσουλφονυλαιθυλ]-4-ακετυλαμινoϊσoϊνδoλινo-1,3-διonη: μεθοδοι χρησης και συνθεσεις αυτης
CY2019032C CY2019032I2 (el) 2002-03-20 2019-06-18 (+)-2-[1-(3-αιθοξυ-4-μεθοξυφαινυλ)-2-μεθυλσουλφονυλαιθυλ]-4-ακετυλαμινoϊσoϊνδoλινo-1,3-διonη: μεθοδοι χρησης και συνθεσεις αυτης
CY20191100877T CY1121888T1 (el) 2002-03-20 2019-08-14 (+)-2-[1-(3-αιθοξυ-4-μεθοξυφαινυλ)-2-μεθυλοσουλφονυλαιθυλ]-4-ακετυλαμινοϊσοϊνδολινο-1,3-διονη: μεθοδοι χρησης και συνθεσεις αυτης

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20091100967T CY1109380T1 (el) 2002-03-20 2009-09-18 (+)-2-[1-(3-αιθοξυ-4-μεθοξυφαινυλο)-2-μεθυλοσουλφονυλαιθυλο]-4-ακετυλαμινοϊσονδολινο-1,3-διονη για χρηση στην αντιμετωπιση ψωριασης μεσω στοματικης χορηγησης

Family Applications After (4)

Application Number Title Priority Date Filing Date
CY20171100884T CY1119340T1 (el) 2002-03-20 2017-08-21 (+)-2-[1-(3-αιθοξυ-4-μεθοξυφαινυλο)-2-μεθυλοσουλφονυλαιθυλο]-4-ακετυλαμινοϊσονδολινο-1,3-διονη: μεθοδοι χρησης και συνθεσεις αυτης
CY20191100372T CY1121720T1 (el) 2002-03-20 2019-04-03 (+)-2-[1-(3-αιθοξυ-4-μεθοξυφαινυλ)-2-μεθυλσουλφονυλαιθυλ]-4-ακετυλαμινoϊσoϊνδoλινo-1,3-διonη: μεθοδοι χρησης και συνθεσεις αυτης
CY2019032C CY2019032I2 (el) 2002-03-20 2019-06-18 (+)-2-[1-(3-αιθοξυ-4-μεθοξυφαινυλ)-2-μεθυλσουλφονυλαιθυλ]-4-ακετυλαμινoϊσoϊνδoλινo-1,3-διonη: μεθοδοι χρησης και συνθεσεις αυτης
CY20191100877T CY1121888T1 (el) 2002-03-20 2019-08-14 (+)-2-[1-(3-αιθοξυ-4-μεθοξυφαινυλ)-2-μεθυλοσουλφονυλαιθυλ]-4-ακετυλαμινοϊσοϊνδολινο-1,3-διονη: μεθοδοι χρησης και συνθεσεις αυτης

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US (14) US6962940B2 (el)
EP (9) EP2420490B1 (el)
JP (4) JP2005525386A (el)
KR (6) KR100997001B1 (el)
CN (2) CN101683334A (el)
AT (1) ATE440599T1 (el)
AU (1) AU2003224729C1 (el)
BE (1) BE2019C008I2 (el)
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CY (6) CY1109380T1 (el)
DE (1) DE60328974D1 (el)
DK (6) DK2223688T3 (el)
ES (8) ES2637509T3 (el)
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HU (5) HUE034348T2 (el)
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MX (2) MXPA04009075A (el)
NL (1) NL300994I2 (el)
NZ (1) NZ535798A (el)
PT (6) PT2420490T (el)
SI (5) SI2295055T1 (el)
WO (1) WO2003080049A1 (el)

Families Citing this family (152)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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