[go: up one dir, main page]

FI973211L - Ihmisen leukosyyttielastaasin inhibiittoreina hyödylliset proliinijohdannaiset - Google Patents

Ihmisen leukosyyttielastaasin inhibiittoreina hyödylliset proliinijohdannaiset Download PDF

Info

Publication number
FI973211L
FI973211L FI973211A FI973211A FI973211L FI 973211 L FI973211 L FI 973211L FI 973211 A FI973211 A FI 973211A FI 973211 A FI973211 A FI 973211A FI 973211 L FI973211 L FI 973211L
Authority
FI
Finland
Prior art keywords
inhibitors
human leukocyte
derivatives useful
leukocyte elastase
proline derivatives
Prior art date
Application number
FI973211A
Other languages
English (en)
Swedish (sv)
Other versions
FI973211A0 (fi
FI973211A7 (fi
Inventor
Peter Robert Bernstein
Chris Allan Veale
Elwyn Peter Davies
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of FI973211A0 publication Critical patent/FI973211A0/fi
Publication of FI973211L publication Critical patent/FI973211L/fi
Publication of FI973211A7 publication Critical patent/FI973211A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
FI973211A 1995-02-03 1996-01-30 Ihmisen leukosyyttielastaasin inhibiittoreina hyödylliset proliinijohd annaiset FI973211A7 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9502152.3A GB9502152D0 (en) 1995-02-03 1995-02-03 Proline derivatives
PCT/GB1996/000193 WO1996023812A1 (en) 1995-02-03 1996-01-30 Proline derivatives useful as inhibitors of human leukocyte elastase

Publications (3)

Publication Number Publication Date
FI973211A0 FI973211A0 (fi) 1997-08-01
FI973211L true FI973211L (fi) 1997-08-01
FI973211A7 FI973211A7 (fi) 1997-08-01

Family

ID=10769064

Family Applications (1)

Application Number Title Priority Date Filing Date
FI973211A FI973211A7 (fi) 1995-02-03 1996-01-30 Ihmisen leukosyyttielastaasin inhibiittoreina hyödylliset proliinijohd annaiset

Country Status (23)

Country Link
US (4) US5686628A (fi)
EP (1) EP0808327A1 (fi)
JP (1) JPH10513173A (fi)
KR (1) KR19980701869A (fi)
CN (1) CN1172486A (fi)
AR (1) AR003922A1 (fi)
AU (1) AU704704B2 (fi)
BR (1) BR9607095A (fi)
CA (1) CA2209675A1 (fi)
CZ (1) CZ246697A3 (fi)
FI (1) FI973211A7 (fi)
GB (1) GB9502152D0 (fi)
HR (1) HRP960008A2 (fi)
HU (1) HUP9801991A3 (fi)
IL (1) IL117013A0 (fi)
NO (1) NO973539L (fi)
NZ (1) NZ300256A (fi)
PL (1) PL321680A1 (fi)
RU (1) RU2159249C2 (fi)
SK (1) SK105497A3 (fi)
TR (1) TR199700732T1 (fi)
WO (1) WO1996023812A1 (fi)
ZA (1) ZA96851B (fi)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0927049B1 (en) * 1996-09-16 2005-05-11 Amersham plc Labelled elastase inhibitors
AU734615B2 (en) * 1996-12-06 2001-06-21 Cortech, Inc. Serine protease inhibitors
US5773430A (en) * 1997-03-13 1998-06-30 Research Foundation Of State University Of New York Serine proteinase inhibitory activity by hydrophobic tetracycline
US6583139B1 (en) 1997-07-31 2003-06-24 Eugene D. Thorsett Compounds which inhibit leukocyte adhesion mediated by VLA-4
US7030114B1 (en) 1997-07-31 2006-04-18 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6492421B1 (en) 1997-07-31 2002-12-10 Athena Neurosciences, Inc. Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4
US6489300B1 (en) * 1997-07-31 2002-12-03 Eugene D. Thorsett Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4
US6559127B1 (en) 1997-07-31 2003-05-06 Athena Neurosciences, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6423688B1 (en) 1997-07-31 2002-07-23 Athena Neurosciences, Inc. Dipeptide and related compounds which inhibit leukocyte adhesion mediated by VLA-4
US6362341B1 (en) 1997-07-31 2002-03-26 Athena Neurosciences, Inc. Benzyl compounds which inhibit leukocyte adhesion mediated by VLA-4
US7232918B2 (en) * 2001-11-06 2007-06-19 Shell Oil Company Catalyst composition
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
AU2690100A (en) 1999-12-16 2001-06-25 Dainippon Pharmaceutical Co. Ltd. Processes for producing (aminomethyl)trifluorocarbinol derivatives
NZ540441A (en) * 2002-12-12 2007-10-26 Novartis Ag Process for peptide synthesis of peptides containing a 4-hydroxy-proline substructure
WO2006016720A1 (ja) * 2004-08-11 2006-02-16 Dainippon Sumitomo Pharma Co., Ltd. 医薬化合物
WO2006025216A1 (ja) * 2004-08-31 2006-03-09 Dainippon Sumitomo Pharma Co., Ltd. 医薬結晶化合物
US7533740B2 (en) * 2005-02-08 2009-05-19 Smith International Inc. Thermally stable polycrystalline diamond cutting elements and bits incorporating the same
EP3517531B1 (en) * 2016-09-23 2021-02-24 Kaken Pharmaceutical Co., Ltd. Method for producing (r)-5-(3,4-difluorophenyl)-5-[(3-methyl-2-oxopyridin-1(2h)-yl)methyl]imidazolidine-2,4-dione and intermediate for producing same
US20220354833A1 (en) 2019-09-17 2022-11-10 Mereo Biopharma 4 Limited Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
DK4106757T3 (da) 2020-04-16 2023-10-23 Mereo Biopharma 4 Ltd Fremgangsmåder der involverer neutrofil elastase-inhibitor alvelestat til behandling af luftvejssygdom medieret af alpha-1-antitrypsin-mangel
CN118265527A (zh) 2021-10-20 2024-06-28 美莱奥生物制药第四有限公司 用于治疗纤维化的中性粒细胞弹性蛋白酶抑制剂

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4277395A (en) * 1980-06-16 1981-07-07 Richardson-Merrell Inc. Novel enzyme inhibitors
DE3481913D1 (de) * 1983-04-27 1990-05-17 Ici America Inc Prolin-derivate.
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
US4643991A (en) * 1984-12-18 1987-02-17 The University Of Kentucky Research Foundation Peptide elastase inhibitors and methods
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
US5194588A (en) * 1985-01-22 1993-03-16 Ici Americas Inc. Aminoalcohol intermediates for peptide derivatives
US5055450A (en) * 1985-01-22 1991-10-08 Ici Americas Inc. Peptide derivatives
IL77748A (en) * 1985-02-04 1991-11-21 Merrell Dow Pharma Amino acid and peptide derivatives as peptidase inhibitors
CH672792A5 (fi) * 1985-02-19 1989-12-29 Sandoz Ag
IT1203971B (it) * 1987-04-24 1989-02-23 Roussel Maestretti Spa Derivati di 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro applicazione come medicamenti
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives

Also Published As

Publication number Publication date
FI973211A0 (fi) 1997-08-01
JPH10513173A (ja) 1998-12-15
SK105497A3 (en) 1997-12-10
US5686628A (en) 1997-11-11
CZ246697A3 (en) 1997-11-12
PL321680A1 (en) 1997-12-22
BR9607095A (pt) 1997-11-11
HUP9801991A2 (hu) 1999-02-01
ZA96851B (en) 1996-08-05
IL117013A0 (en) 1996-06-18
US6048889A (en) 2000-04-11
AR003922A1 (es) 1998-09-30
NZ300256A (en) 2000-01-28
EP0808327A1 (en) 1997-11-26
CN1172486A (zh) 1998-02-04
NO973539D0 (no) 1997-08-01
NO973539L (no) 1997-10-01
FI973211A7 (fi) 1997-08-01
GB9502152D0 (en) 1995-03-29
WO1996023812A1 (en) 1996-08-08
CA2209675A1 (en) 1996-08-08
HRP960008A2 (en) 1998-04-30
KR19980701869A (ko) 1998-06-25
RU2159249C2 (ru) 2000-11-20
US6054593A (en) 2000-04-25
HUP9801991A3 (en) 1999-06-28
MX9705231A (es) 1997-10-31
TR199700732T1 (xx) 1998-02-21
AU4494396A (en) 1996-08-21
US5808097A (en) 1998-09-15
AU704704B2 (en) 1999-04-29

Similar Documents

Publication Publication Date Title
FI973211A7 (fi) Ihmisen leukosyyttielastaasin inhibiittoreina hyödylliset proliinijohd annaiset
BR9507179A (pt) Derivados de 3-aril-4-hidróxi-delta3-dihidrotiofena
BR9611130A (pt) Derivados de 3-aril-5-halógeno-pirona
FI950309L (fi) Proliiniamidijohdannaisia
LV11895A (lv) 4-benzoilpirazola atvasinajumi un to pielietojums par herbicidiem
DE69608448D1 (de) Reduktion des biobewuchses
LV12102A (lv) Rotamazes funkciju inhibitori
ATE270679T1 (de) Assoziative verdickungsmittel
ITMI951020A0 (it) Derivati di diarildiammine
FI954649A0 (fi) Hyytymistekijä VII:n puhdistus
PT927183E (pt) Inibidores espirociclicos de metaloproteases
EE9800335A (et) Pürrolopürrolooni derivaadid kui neutrofiilelastaasi inhibiitorid
FI963132A7 (fi) Diastereomeerisesti puhtaat trifluorimetyyliketonipeptidijohdannaiset ihmisen leukosyyttielastaasin inhibiittoreina
EE200000138A (et) Pürrolopürrolooni derivaadid neutrofiili elastaasi inhibiitoritena
FI946202A7 (fi) Fluoria sisältäviä dipeptidejä inhibiittoreina ihmisen lenkosyyttielas taasi-inhibiittoreita vastaan
DE69708629D1 (de) Alkyloxyamin-substituierte fluorenonderivate und ihre verwendung als proteinkinase-c-inhibitoren
FI962235L (fi) Uudet bentseenisulfonyyli-imiinijohdannaiset IL-1:n toiminnan inhibiittoreina
EE200000137A (et) Pürrolopürrolooni derivaadid neutrofiili elastaasi inhibiitoritena
BR9607046A (pt) Derivados de 3-pirrolidiliden-2-ona-cefalosporinas
EE9900585A (et) 6-asauratsiili derivaadid IL-5 inhibiitoritena
IS4554A (is) Lyfjafræðileg notkun ákveðinna sýstín afleiða
DE69418656D1 (de) 2-acyloxycephemderivate als elastaseinhibitoren
BR9704770A (pt) Derivados de 1-carba-(detia)-cefalosporina
PT761766E (pt) Compostos assimetricos de trifenilenodioxazina
KR960031416U (ko) 투포원연사기의 스핀들