FI970393L - (-)-(3R)-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)phenoxy)butyric acid as cell adhesion inhibitors - Google Patents

(-)-(3R)-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)phenoxy)butyric acid as cell adhesion inhibitors Download PDF

Info

Publication number: FI970393L
Authority: FI; Finland
Prior art keywords: piperazin; phenoxy; pyridyl; methyl; butyric acid
Prior art date: 1995-06-01

Application number

FI970393A

Other languages

Finnish (fi)

Swedish (sv)

Other versions

FI970393A0 (en

FI970393A7 (en

Inventor

Stuart Dennett Mills

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-01

Filing date

1996-05-28

Publication date

1997-01-30

1995-06-01 Priority claimed from US08/457,538 external-priority patent/US5652242A/en

1995-09-07 Priority claimed from GBGB9518188.9A external-priority patent/GB9518188D0/en

1996-05-28 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1997-01-30 Publication of FI970393L publication Critical patent/FI970393L/en

1997-01-30 Publication of FI970393A0 publication Critical patent/FI970393A0/en

1997-01-30 Publication of FI970393A7 publication Critical patent/FI970393A7/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

FI970393A 1995-06-01 1996-05-28 (-)-(3R)-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)phenoxy)butyric acid as cell adhesion inhibitors FI970393A7 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/457,538 US5652242A (en)	1993-03-29	1995-06-01	Heterocyclic derivatives
GBGB9518188.9A GB9518188D0 (en)	1995-09-07	1995-09-07	Optically active derivative
PCT/GB1996/001260 WO1996038416A1 (en)	1995-06-01	1996-05-28	(-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid as cellular adhesion inhibitor

Publications (3)

Publication Number	Publication Date
FI970393L true FI970393L (en)	1997-01-30
FI970393A0 FI970393A0 (en)	1997-01-30
FI970393A7 FI970393A7 (en)	1997-01-30

Family

ID=26307696

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI970393A FI970393A7 (en)	1995-06-01	1996-05-28	(-)-(3R)-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)phenoxy)butyric acid as cell adhesion inhibitors

Country Status (31)

Country	Link
EP (1)	EP0796247A1 (en)
JP (1)	JP2885941B2 (en)
KR (1)	KR100245957B1 (en)
AT (1)	AT406675B (en)
AU (1)	AU710105B2 (en)
BE (1)	BE1009520A5 (en)
BR (1)	BR9606409A (en)
CA (1)	CA2194397A1 (en)
CH (1)	CH691808A5 (en)
CZ (1)	CZ26997A3 (en)
DE (1)	DE19680509T1 (en)
DK (1)	DK10697A (en)
ES (1)	ES2137886B1 (en)
FI (1)	FI970393A7 (en)
GB (1)	GB2304340B (en)
GR (1)	GR1002702B (en)
HU (1)	HUP9700274A3 (en)
IE (1)	IE960405A1 (en)
IL (1)	IL118477A0 (en)
IT (1)	IT1290839B1 (en)
LU (1)	LU90008B1 (en)
MC (1)	MC2418A1 (en)
MX (1)	MX9700379A (en)
NL (1)	NL1003243C2 (en)
NO (1)	NO307460B1 (en)
NZ (1)	NZ308597A (en)
PL (1)	PL318440A1 (en)
SE (1)	SE510812C2 (en)
SK (1)	SK13097A3 (en)
TR (1)	TR199700020T1 (en)
WO (1)	WO1996038416A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0100158A3 (en) *	1982-07-28	1985-03-27	The Upjohn Company	(3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
GB8609630D0 (en) *	1986-04-19	1986-05-21	Pfizer Ltd	Anti-arrhythmia agents
EP0691959B1 (en) *	1993-03-29	1998-07-22	Zeneca Limited	Heterocyclic derivatives as platelet aggregation inhibitors
JP3088016B2 (en) *	1993-03-29	2000-09-18	ゼネカ・リミテッド	Heterocyclic compounds as platelet aggregation inhibitors

1996
- 1996-05-28 GR GR960100176A patent/GR1002702B/en not_active IP Right Cessation
- 1996-05-28 NZ NZ308597A patent/NZ308597A/en unknown
- 1996-05-28 BR BR9606409A patent/BR9606409A/en not_active Application Discontinuation
- 1996-05-28 JP JP8536281A patent/JP2885941B2/en not_active Expired - Fee Related
- 1996-05-28 AT AT0900596A patent/AT406675B/en active
- 1996-05-28 KR KR1019970700532A patent/KR100245957B1/en not_active Expired - Fee Related
- 1996-05-28 CZ CZ97269A patent/CZ26997A3/en unknown
- 1996-05-28 EP EP96919906A patent/EP0796247A1/en not_active Withdrawn
- 1996-05-28 DE DE19680509T patent/DE19680509T1/en not_active Withdrawn
- 1996-05-28 CH CH00224/97A patent/CH691808A5/en not_active IP Right Cessation
- 1996-05-28 FI FI970393A patent/FI970393A7/en unknown
- 1996-05-28 SK SK130-97A patent/SK13097A3/en unknown
- 1996-05-28 TR TR97/00020T patent/TR199700020T1/en unknown
- 1996-05-28 PL PL96318440A patent/PL318440A1/en unknown
- 1996-05-28 GB GB9627127A patent/GB2304340B/en not_active Expired - Fee Related
- 1996-05-28 WO PCT/GB1996/001260 patent/WO1996038416A1/en not_active Ceased
- 1996-05-28 ES ES009750006A patent/ES2137886B1/en not_active Expired - Fee Related
- 1996-05-28 MX MX9700379A patent/MX9700379A/en unknown
- 1996-05-28 AU AU58272/96A patent/AU710105B2/en not_active Ceased
- 1996-05-28 HU HU9700274A patent/HUP9700274A3/en unknown
- 1996-05-28 CA CA002194397A patent/CA2194397A1/en not_active Abandoned
- 1996-05-29 MC MC2347A patent/MC2418A1/en unknown
- 1996-05-30 IL IL11847796A patent/IL118477A0/en unknown
- 1996-05-31 NL NL1003243A patent/NL1003243C2/en not_active IP Right Cessation
- 1996-05-31 IT IT96MI001113A patent/IT1290839B1/en active IP Right Grant
- 1996-05-31 BE BE9600491A patent/BE1009520A5/en not_active IP Right Cessation
- 1996-05-31 IE IE960405A patent/IE960405A1/en not_active IP Right Cessation
1997
- 1997-01-22 LU LU90008A patent/LU90008B1/en active
- 1997-01-24 SE SE9700203A patent/SE510812C2/en not_active IP Right Cessation
- 1997-01-30 DK DK010697A patent/DK10697A/en not_active Application Discontinuation
- 1997-01-31 NO NO970437A patent/NO307460B1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPH09512836A (en)	1997-12-22
KR100245957B1 (en)	2000-04-01
LU90008B1 (en)	1997-04-16
ES2137886B1 (en)	2000-08-16
DK10697A (en)	1997-04-01
NO970437D0 (en)	1997-01-31
BR9606409A (en)	1997-09-30
MX9700379A (en)	1997-04-30
IE960405A1 (en)	1996-12-11
BE1009520A5 (en)	1997-04-01
AU5827296A (en)	1996-12-18
NL1003243C2 (en)	1996-12-04
GB2304340A (en)	1997-03-19
SE510812C2 (en)	1999-06-28
SK13097A3 (en)	1997-08-06
CH691808A5 (en)	2001-10-31
NO307460B1 (en)	2000-04-10
PL318440A1 (en)	1997-06-09
NZ308597A (en)	1998-11-25
CA2194397A1 (en)	1996-12-05
GB2304340B (en)	1998-07-29
IL118477A0 (en)	1996-09-12
HUP9700274A2 (en)	1999-06-28
CZ26997A3 (en)	1997-08-13
FI970393A0 (en)	1997-01-30
ITMI961113A0 (en)	1996-05-31
FI970393A7 (en)	1997-01-30
IT1290839B1 (en)	1998-12-14
WO1996038416A1 (en)	1996-12-05
ES2137886A1 (en)	1999-12-16
KR970704689A (en)	1997-09-06
NO970437L (en)	1997-02-20
ATA900596A (en)	1999-12-15
AU710105B2 (en)	1999-09-16
HU9700274D0 (en)	1997-04-28
MC2418A1 (en)	1997-05-23
TR199700020T1 (en)	1997-04-22
ITMI961113A1 (en)	1997-12-01
SE9700203D0 (en)	1997-01-24
GR1002702B (en)	1997-05-22
JP2885941B2 (en)	1999-04-26
AT406675B (en)	2000-07-25
EP0796247A1 (en)	1997-09-24
SE9700203L (en)	1997-01-24
DE19680509T1 (en)	1997-12-04
GB9627127D0 (en)	1997-02-19
HUP9700274A3 (en)	2000-02-28

Publication	Publication Date	Title
DE19680255T1 (en)	1997-06-05	Rotamase enzyme activity inhibitors
FI965019A7 (en)	1996-12-13	Enzyme inhibitors
NO974213L (en)	1997-12-04	Small molecular inhibitors of rotamase enzyme activity
DE69522690D1 (en)	2001-10-18	alpha-ketogultaric acid dehydrogenase gene
DE69637328D1 (en)	2008-01-03	Cell adhesion inhibitors
FI973087L (en)	1997-09-22	Cell adhesion inhibitors
DK199901518A (en)	1999-10-22	In the form of small molecules are inhibitors of rotamase enzyme activity
MX9705005A (en)	1998-07-31	MICROSOMIC TRIGLYCERIDE TRANSFER PROTEIN INHIBITORS AND METHOD.
NO990338L (en)	1999-03-25	cell adhesion inhibitor
EE9800125A (en)	1998-10-15	Inhibitors of rotamase enzymatic activity
ID27840A (en)	2001-04-26	HYDROCSAMIC PIPECOLATE ACID HYDROCAMATS AS MMP INHIBITORS
EE200000720A (en)	2002-04-15	Novel 3-aryl-2-hydroxypropanoic acid derivative (I)
ATE226590T1 (en)	2002-11-15	PHOSPHINIC ACID AMIDES AS MATRIX METALLOPROTEASE INHIBITORS
NO972307D0 (en)	1997-05-21	matrix metalloprotease inhibitors
NO981965L (en)	1998-06-30	thrombin inhibitors
EE9900180A (en)	1999-12-15	Substituted 4-Biphenyl-4-hydroxybutanoic Acid Derivatives as Metalloprotease Matrix Inhibitors
FI943850A7 (en)	1994-10-19	3-Alkyloxy-, aryloxy- or arylalkyloxybenzo(b)thiophene-2-carboxamides as cell adhesion inhibitors
FI970393L (en)	1997-01-30	(-)-(3R)-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)phenoxy)butyric acid as cell adhesion inhibitors
ATE227288T1 (en)	2002-11-15	ACETYLENEIC ORTHO-SULFONAMIDO AND PHOSPHIC ACID-AMIDO-BICYCLIC HETEROARYLHYDROXAMIC ACID AS TACE INHIBITORS
GB9610093D0 (en)	1996-07-17	(-)-(3R)-methyl-4-[4-[4-(4-pyridyl) piperazin-1-yl] phenoxy] butyric acid
ZA964509B (en)	1996-12-02	(-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy}butyric acid
NO965353D0 (en)	1996-12-13	3-Amino-2-oxo-1-piperidinedacetic acid derivatives as enzyme inhibitors
AU7504300A (en)	2001-02-19	Method of determining cell loss priority information