[go: up one dir, main page]

FI954556L - Cyclic compounds useful as platelet glycoprotein IIb/IIIa inhibitors - Google Patents

Cyclic compounds useful as platelet glycoprotein IIb/IIIa inhibitors Download PDF

Info

Publication number
FI954556L
FI954556L FI954556A FI954556A FI954556L FI 954556 L FI954556 L FI 954556L FI 954556 A FI954556 A FI 954556A FI 954556 A FI954556 A FI 954556A FI 954556 L FI954556 L FI 954556L
Authority
FI
Finland
Prior art keywords
compounds useful
cyclic compounds
glycoprotein iib
platelet glycoprotein
iiia inhibitors
Prior art date
Application number
FI954556A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI954556A0 (en
FI954556A7 (en
Inventor
William Frank Degrado
Sharon Anne Jackson
Shaker Ahmed Mousa
Anju Parthasarathy
Michael Sworin
Maria Rafalski
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of FI954556A0 publication Critical patent/FI954556A0/en
Publication of FI954556L publication Critical patent/FI954556L/en
Publication of FI954556A7 publication Critical patent/FI954556A7/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI954556A 1993-03-29 1994-03-28 Cyclic compounds useful as platelet glycoprotein IIb/IIIa inhibitors FI954556A7 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3844893A 1993-03-29 1993-03-29
PCT/US1994/003223 WO1994022910A1 (en) 1993-03-29 1994-03-28 CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa

Publications (3)

Publication Number Publication Date
FI954556A0 FI954556A0 (en) 1995-09-26
FI954556L true FI954556L (en) 1995-09-26
FI954556A7 FI954556A7 (en) 1995-09-26

Family

ID=21900014

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954556A FI954556A7 (en) 1993-03-29 1994-03-28 Cyclic compounds useful as platelet glycoprotein IIb/IIIa inhibitors

Country Status (10)

Country Link
EP (1) EP0691987A1 (en)
JP (1) JPH08508498A (en)
AU (1) AU6415894A (en)
CA (1) CA2159070A1 (en)
FI (1) FI954556A7 (en)
HU (1) HUT72896A (en)
NO (1) NO953832L (en)
NZ (1) NZ263456A (en)
PL (1) PL310896A1 (en)
WO (1) WO1994022910A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ263455A (en) * 1993-03-29 1997-10-24 Du Pont Merck Pharma Synthesis of platelet glycoprotein iib/iiia inhibitors
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
CA2272317C (en) * 1996-11-27 2001-01-30 Rhone-Poulenc Rorer Pharmaceuticals Inc. Pharmaceutical composition comprising a compound having anti-xa activity and a platelet aggregation antagonist compound
US6010911A (en) * 1997-04-30 2000-01-04 Medtronic, Inc. Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
GB0623607D0 (en) 2006-11-27 2007-01-03 Haemostatix Ltd Tissue adhesive
CA2677045C (en) 2007-01-31 2016-10-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
KR101623985B1 (en) 2007-03-28 2016-05-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Stitched polypeptides
US11673914B2 (en) 2009-11-10 2023-06-13 Allegro Pharmaceuticals, LLC Peptide therapies for reduction of macular thickening
AU2010319559A1 (en) 2009-11-10 2012-05-31 Allegro Pharmaceuticals, Inc. Compositions and methods for inhibiting cellular adhesion or directing diagnostic or therapeutic agents to RGD binding sites
KR102104762B1 (en) 2010-08-13 2020-04-24 에일러론 테라퓨틱스 인코포레이티드 Peptidomimetic macrocycles
ES2820855T3 (en) 2011-05-09 2021-04-22 Allegro Pharmaceuticals Llc Integrin receptor antagonists and their methods of use
CN108929375A (en) 2011-10-18 2018-12-04 爱勒让治疗公司 Peptidomimetic macrocyclic compound
KR102112373B1 (en) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 Peptidomimetic macrocycles
EP2819688A4 (en) 2012-02-15 2015-10-28 Aileron Therapeutics Inc TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES
KR20150082307A (en) 2012-11-01 2015-07-15 에일러론 테라퓨틱스 인코포레이티드 Disubstituted amino acids and methods of preparation and use thereof
SG10201902598VA (en) 2014-09-24 2019-04-29 Aileron Therapeutics Inc Peptidomimetic macrocycles and formulations thereof
CN106999541A (en) 2014-09-24 2017-08-01 艾瑞朗医疗公司 Peptidomimetic macrocycles and uses thereof
MX2017011834A (en) 2015-03-20 2018-04-11 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof.
JP2018528217A (en) 2015-09-10 2018-09-27 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Peptidomimetic macrocycles as modulators of MCL-1

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2636066B1 (en) * 1988-09-02 1991-10-25 Centre Nat Rech Scient CYCLOPEPTIDE DERIVATIVES FOR USE AS SELECTIVE INHIBITORS AGAINST ACTIVE SERINE PROTEASES
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
CA2027936C (en) * 1989-10-23 2001-07-24 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
IL103252A (en) * 1991-09-30 1997-03-18 Du Pont Merck Pharma CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
AU6415894A (en) 1994-10-24
EP0691987A1 (en) 1996-01-17
FI954556A0 (en) 1995-09-26
PL310896A1 (en) 1996-01-08
HUT72896A (en) 1996-06-28
CA2159070A1 (en) 1994-10-13
WO1994022910A1 (en) 1994-10-13
JPH08508498A (en) 1996-09-10
NO953832L (en) 1995-11-28
NZ263456A (en) 1996-11-26
FI954556A7 (en) 1995-09-26
HU9502832D0 (en) 1995-11-28
NO953832D0 (en) 1995-09-28

Similar Documents

Publication Publication Date Title
FI954556A7 (en) Cyclic compounds useful as platelet glycoprotein IIb/IIIa inhibitors
FI943478A7 (en) Glycoprotein IIb/IIIa antagonists
FI941457L (en) Cyclic compounds useful as inhibitors of platelet glycoprotein IIb/IIIa
FI935194A0 (en) Foerfarande Foer dubbelriktad oeverfoering i ett cellulaert mobilradiokommunikationssystem, i vilket foerfarande olika basstationer anvaends Foer downlink- och uplink-foerbindelse
FI940027L (en) Improvements to the contrast agents themselves or improvements related to them
NO900174D0 (en) CYCLIC AMINE COMPOUNDS.
FI935260A7 (en) TELEKOMMUNIKATIONSSYSTEM, I VILKET DEBITERINGSDATAN REGISTERRAS I HANDTELEFONEN
FI925619L (en) Transparent, biaxialt orienterat, termofixerat roerformigt lizmandshoelje i ett skikt
FI923550A7 (en) ANORDNING FOER BILDNING AV EN FIBERMATTA, SAERSKILT EN MINERALUDDFIBERMATTA, PAO ETT STOEDBAND
FI955910A0 (en) Holder for application stick, such as glue stick
DE69408806D1 (en) Packaging structure
FI943553A0 (en) Crucible, especially the crucible
DE69300566D1 (en) Packaging.
FI933980A0 (en) SKYDDSPLAGG FOER HYGIENKRAEVANDE OBJEKT, SAOSOM OPERATIONSSALAR
IT1277870B1 (en) MACHINE TO KNOT ELECOIDAL SPRINGS.
ITMI932056A1 (en) LOCK FOR CONTAINERS SUCH AS BAGS OR SIMILAR
TR199802213A3 (en) The tool used for tying the cross thread to the thread is the loom.
FI932251A7 (en) ANORDNING FOER STYRNING AV GENOMSTROEMNING AV ETT HYDRAULISKT TRYCKMEDIUM, SPECIEELLT FOER BRAENSLEINSPRUTNING AV EN KOLVFOERBRAENNINGSMOTOR
FI933581L (en) Jaernvaegsgodsvagn, saerskilt en flakvagn med ett maskinfundament adikat i underredets aendomraode
KR950006282U (en) packing
FIU920345U0 (en) Kapningsanordning Foer aemnesbana, saosom en pappersbana
ITBO910187A0 (en) BACKPACK FOR WRAPPING BOTTLES.
DE59207097D1 (en) Multilayered composition containing crystalline silicon carbide
KR950009109U (en) Compound tree
FI935130A0 (en) Raelsbund vagn med skjuttak, saerskilt Foer biltransport