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FI943146A0 - Signaalipeptideistä vapaiden stafylokinaasien ilmentyminen - Google Patents

Signaalipeptideistä vapaiden stafylokinaasien ilmentyminen

Info

Publication number
FI943146A0
FI943146A0 FI943146A FI943146A FI943146A0 FI 943146 A0 FI943146 A0 FI 943146A0 FI 943146 A FI943146 A FI 943146A FI 943146 A FI943146 A FI 943146A FI 943146 A0 FI943146 A0 FI 943146A0
Authority
FI
Finland
Prior art keywords
pct
expression
free
staphylocinases
signal peptide
Prior art date
Application number
FI943146A
Other languages
English (en)
Swedish (sv)
Other versions
FI943146A7 (fi
FI943146L (fi
Inventor
Detlev Behnke
Bernhard Schlott
Sybille Albrecht
Karl-Heinz Guehrs
Manfred Hartmann
Original Assignee
Medac Klinische Spezialpraep
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4143279A external-priority patent/DE4143279A1/de
Priority claimed from DE4240801A external-priority patent/DE4240801A1/de
Application filed by Medac Klinische Spezialpraep filed Critical Medac Klinische Spezialpraep
Publication of FI943146A0 publication Critical patent/FI943146A0/fi
Publication of FI943146A7 publication Critical patent/FI943146A7/fi
Publication of FI943146L publication Critical patent/FI943146L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI943146A 1991-12-30 1992-12-28 Signaalipeptideistä vapaiden stafylokinaasien ilmentyminen FI943146L (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4143279A DE4143279A1 (de) 1991-12-30 1991-12-30 Neue plasminogenaktivatoren, die sie kodierenden dna-sequenzen, zugehoerige expressionsplasmide und rekombinante escherichia coli-staemme, verfahren zur produktion dieser proteine und ihre verwendung
DE4220516 1992-06-22
DE4240801A DE4240801A1 (de) 1992-12-01 1992-12-01 Reife methioninfreie Staphylokinasen, die sie kodierenden DNA-Sequenzen, zugehörige Expressionsplasmide und rekombinante Escherichia coli-Stämme, Verfahren zur Herstellung dieser Proteine und ihre Verwendung
PCT/EP1992/002989 WO1993013209A1 (de) 1991-12-30 1992-12-28 Expression signalpeptid-freier staphilokinasen

Publications (3)

Publication Number Publication Date
FI943146A0 true FI943146A0 (fi) 1994-06-30
FI943146A7 FI943146A7 (fi) 1994-06-30
FI943146L FI943146L (fi) 1994-06-30

Family

ID=27203268

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943146A FI943146L (fi) 1991-12-30 1992-12-28 Signaalipeptideistä vapaiden stafylokinaasien ilmentyminen

Country Status (14)

Country Link
US (2) US5801037A (fi)
EP (1) EP0621899B1 (fi)
JP (1) JP3310672B2 (fi)
KR (1) KR100221150B1 (fi)
AT (1) ATE139570T1 (fi)
AU (1) AU669149B2 (fi)
DE (1) DE59206628D1 (fi)
DK (1) DK0621899T3 (fi)
ES (1) ES2089784T3 (fi)
FI (1) FI943146L (fi)
GR (1) GR3020529T3 (fi)
HK (1) HK1005886A1 (fi)
HU (1) HU218043B (fi)
WO (1) WO1993013209A1 (fi)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU669149B2 (en) * 1991-12-30 1996-05-30 Thromb-X N.V. Expression signal-peptide-free staphylokinases
CN1035192C (zh) * 1994-04-04 1997-06-18 上海医科大学 一种重组葡激酶的制备方法
EP0721982A1 (en) * 1995-01-06 1996-07-17 Leuven Research & Development V.Z.W. New staphylokinase derivatives
ATE290598T1 (de) * 1995-01-06 2005-03-15 Leuven Res & Dev Vzw Neue staphylokinase derivate
JP3399963B2 (ja) 1995-01-06 2003-04-28 リューベン・リサーチ・アンド・デベロップメント・ベー・ゼット・ウェー 新規スタフィロキナーゼ誘導体
JPH08289790A (ja) * 1995-01-06 1996-11-05 Leuven Res & Dev Vzw 新規なスタフィロキナーゼ誘導体
US5846943A (en) * 1996-11-08 1998-12-08 Synsorb Biotech, Inc. Solid support matricles containing a toxin binding oligosaccharide
CN1059926C (zh) * 1997-07-19 2000-12-27 张其玖 葡激酶基因及其高表达工程菌株
JP2002505082A (ja) * 1998-02-04 2002-02-19 トロンブ−イックス・ナムローゼ・フェンノートシャップ 減少した免疫原性および／または減少したクリアランスを有するスタフィロキナーゼ誘導体の同定、製造および使用方法
US7781209B2 (en) * 2005-09-25 2010-08-24 Multispan, Inc. GPCR-expressing cell lines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5867181A (ja) * 1981-10-16 1983-04-21 Yakult Honsha Co Ltd スタフイロキナーゼ産生遺伝情報を担うｄｎａ断片組み換え体ｄｎａおよびそれを導入した大腸菌
WO1987002732A1 (en) * 1985-11-01 1987-05-07 Vaughan Thomas L Hanger assembly
ATE158613T1 (de) * 1990-12-17 1997-10-15 Yakult Honsha Kk Thrombolytisches peptid, seine produktion und thrombolisches agens
ES2096617T3 (es) * 1991-06-28 1997-03-16 Leuven Res & Dev Vzw Uso de estafiloquinasa para la preparacion de una composicion farmaceutica para tratar trombosis arterial.
AU669149B2 (en) * 1991-12-30 1996-05-30 Thromb-X N.V. Expression signal-peptide-free staphylokinases

Also Published As

Publication number Publication date
KR100221150B1 (ko) 1999-10-01
AU3347293A (en) 1993-07-28
HK1005886A1 (en) 1999-01-29
HU9401949D0 (en) 1994-11-28
US6010897A (en) 2000-01-04
ATE139570T1 (de) 1996-07-15
EP0621899B1 (de) 1996-06-19
AU669149B2 (en) 1996-05-30
KR940703920A (ko) 1994-12-12
GR3020529T3 (en) 1996-10-31
US5801037A (en) 1998-09-01
HUT68067A (en) 1995-05-29
DE59206628D1 (en) 1996-07-25
FI943146A7 (fi) 1994-06-30
JP3310672B2 (ja) 2002-08-05
HU218043B (hu) 2000-05-28
FI943146L (fi) 1994-06-30
EP0621899A1 (de) 1994-11-02
WO1993013209A1 (de) 1993-07-08
ES2089784T3 (es) 1996-10-01
DK0621899T3 (da) 1996-10-28
JPH07502652A (ja) 1995-03-23

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Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: THROMB-X N.V.

FD Application lapsed