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ES2089784T3 - Expresion de estafilocinasas sin peptido de señal. - Google Patents

Expresion de estafilocinasas sin peptido de señal.

Info

Publication number
ES2089784T3
ES2089784T3 ES93902129T ES93902129T ES2089784T3 ES 2089784 T3 ES2089784 T3 ES 2089784T3 ES 93902129 T ES93902129 T ES 93902129T ES 93902129 T ES93902129 T ES 93902129T ES 2089784 T3 ES2089784 T3 ES 2089784T3
Authority
ES
Spain
Prior art keywords
signal peptide
staphylocinases
expression
polypeptides
staphylokinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93902129T
Other languages
English (en)
Inventor
Detlev Behnke
Bernhard Schlott
Sybille Albrecht
Karl-Heinz Guhrs
Manfred Hartmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medac Gesellschaft fuer Klinische Spezialpraeparate mbH
Original Assignee
Medac Gesellschaft fuer Klinische Spezialpraeparate mbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4143279A external-priority patent/DE4143279A1/de
Priority claimed from DE4240801A external-priority patent/DE4240801A1/de
Application filed by Medac Gesellschaft fuer Klinische Spezialpraeparate mbH filed Critical Medac Gesellschaft fuer Klinische Spezialpraeparate mbH
Application granted granted Critical
Publication of ES2089784T3 publication Critical patent/ES2089784T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

LA INVENCION SE REFIERE A POLIPEPTIDOS ESTAFILOQUINASA RECOMBINADA CON ACCION PLASMINOGENA, ACTIVADORA ASI COMO SU ELABORACION Y UTILIZACION. LOS POLIPEPTIDOS SON OBTENIDOS MEDIANTE EXPRESIONES DE SECUENCIAS DNA, QUE ESTAN LIBRES DE REGIONES DE CODIFICACION DE PEPTIDOS DE SEÑAL.
ES93902129T 1991-12-30 1992-12-28 Expresion de estafilocinasas sin peptido de señal. Expired - Lifetime ES2089784T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4143279A DE4143279A1 (de) 1991-12-30 1991-12-30 Neue plasminogenaktivatoren, die sie kodierenden dna-sequenzen, zugehoerige expressionsplasmide und rekombinante escherichia coli-staemme, verfahren zur produktion dieser proteine und ihre verwendung
DE4220516 1992-06-22
DE4240801A DE4240801A1 (de) 1992-12-01 1992-12-01 Reife methioninfreie Staphylokinasen, die sie kodierenden DNA-Sequenzen, zugehörige Expressionsplasmide und rekombinante Escherichia coli-Stämme, Verfahren zur Herstellung dieser Proteine und ihre Verwendung

Publications (1)

Publication Number Publication Date
ES2089784T3 true ES2089784T3 (es) 1996-10-01

Family

ID=27203268

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93902129T Expired - Lifetime ES2089784T3 (es) 1991-12-30 1992-12-28 Expresion de estafilocinasas sin peptido de señal.

Country Status (14)

Country Link
US (2) US5801037A (es)
EP (1) EP0621899B1 (es)
JP (1) JP3310672B2 (es)
KR (1) KR100221150B1 (es)
AT (1) ATE139570T1 (es)
AU (1) AU669149B2 (es)
DE (1) DE59206628D1 (es)
DK (1) DK0621899T3 (es)
ES (1) ES2089784T3 (es)
FI (1) FI943146L (es)
GR (1) GR3020529T3 (es)
HK (1) HK1005886A1 (es)
HU (1) HU218043B (es)
WO (1) WO1993013209A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2089784T3 (es) * 1991-12-30 1996-10-01 Medac Klinische Spezialpraep Expresion de estafilocinasas sin peptido de señal.
CN1035192C (zh) * 1994-04-04 1997-06-18 上海医科大学 一种重组葡激酶的制备方法
JPH08289790A (ja) * 1995-01-06 1996-11-05 Leuven Res & Dev Vzw 新規なスタフィロキナーゼ誘導体
JP3399963B2 (ja) 1995-01-06 2003-04-28 リューベン・リサーチ・アンド・デベロップメント・ベー・ゼット・ウェー 新規スタフィロキナーゼ誘導体
ATE290598T1 (de) * 1995-01-06 2005-03-15 Leuven Res & Dev Vzw Neue staphylokinase derivate
EP0721982A1 (en) * 1995-01-06 1996-07-17 Leuven Research & Development V.Z.W. New staphylokinase derivatives
US5846943A (en) * 1996-11-08 1998-12-08 Synsorb Biotech, Inc. Solid support matricles containing a toxin binding oligosaccharide
CN1059926C (zh) * 1997-07-19 2000-12-27 张其玖 葡激酶基因及其高表达工程菌株
DE69925110T2 (de) * 1998-02-04 2006-02-02 Thromb-X N.V. Identifizierung, produktion und verwendung von staphylokinase-derivaten mit reduzierter immunogenizität und/oder "clearance"
US7781209B2 (en) * 2005-09-25 2010-08-24 Multispan, Inc. GPCR-expressing cell lines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5867181A (ja) * 1981-10-16 1983-04-21 Yakult Honsha Co Ltd スタフイロキナーゼ産生遺伝情報を担うｄｎａ断片組み換え体ｄｎａおよびそれを導入した大腸菌
EP0245444A1 (en) * 1985-11-01 1987-11-19 VAUGHAN, Thomas L. Hanger assembly
US5475089A (en) * 1990-12-17 1995-12-12 Kabushiki Kaisha Yakult Honsha Thrombolytic peptide, production thereof, and thrombolytic agent
EP0525252B1 (en) * 1991-06-28 1997-01-22 Leuven Research & Development V.Z.W. Use of staphylokinase for the preparation of a pharmaceutical composition for treating arterial thrombosis
ES2089784T3 (es) * 1991-12-30 1996-10-01 Medac Klinische Spezialpraep Expresion de estafilocinasas sin peptido de señal.

Also Published As

Publication number Publication date
FI943146A0 (fi) 1994-06-30
DK0621899T3 (da) 1996-10-28
KR940703920A (ko) 1994-12-12
US6010897A (en) 2000-01-04
WO1993013209A1 (de) 1993-07-08
FI943146A7 (fi) 1994-06-30
KR100221150B1 (ko) 1999-10-01
JPH07502652A (ja) 1995-03-23
GR3020529T3 (en) 1996-10-31
HU218043B (hu) 2000-05-28
DE59206628D1 (en) 1996-07-25
HU9401949D0 (en) 1994-11-28
HUT68067A (en) 1995-05-29
JP3310672B2 (ja) 2002-08-05
ATE139570T1 (de) 1996-07-15
EP0621899B1 (de) 1996-06-19
AU669149B2 (en) 1996-05-30
FI943146L (fi) 1994-06-30
AU3347293A (en) 1993-07-28
HK1005886A1 (en) 1999-01-29
US5801037A (en) 1998-09-01
EP0621899A1 (de) 1994-11-02

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