FI90664B - Förfarande för framställning av terapeutiskt användbara 3'-azido nukleosider - Google Patents

Förfarande för framställning av terapeutiskt användbara 3'-azido nukleosider Download PDF

Info

Publication number: FI90664B
Authority: FI; Finland
Prior art keywords: group; azido; compound; formula; mmol
Prior art date: 1985-09-17

Application number

FI863729A

Other languages

English (en)

Finnish (fi)

Other versions

FI863729A0 (sv

FI863729L (sv

FI90664C (sv

Inventor

Janet Litster Rideout

George Andrew Freeman

Sammy Ray Shaver

David Walter Barry

Sandra Nusinoff Lehrman

Clair Martha Heider St

Phillip Allen Furman

Thomas Paul Zimmerman

Gerald Wolberg

Miranda Paulo M De

Geoffrey White

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-09-17

Filing date

1986-09-15

Publication date

1993-11-30

1985-09-17 Priority claimed from US06/776,899 external-priority patent/US4724232A/en

1985-09-27 Priority claimed from GB858523878A external-priority patent/GB8523878D0/en

1986-02-12 Priority claimed from GB868603447A external-priority patent/GB8603447D0/en

1986-02-14 Priority claimed from GB868603719A external-priority patent/GB8603719D0/en

1986-04-04 Priority claimed from GB868608272A external-priority patent/GB8608272D0/en

1986-06-23 Priority claimed from GB868615322A external-priority patent/GB8615322D0/en

1986-09-15 Application filed by Wellcome Found filed Critical Wellcome Found

1986-09-15 Publication of FI863729A0 publication Critical patent/FI863729A0/sv

1987-03-18 Publication of FI863729L publication Critical patent/FI863729L/sv

1993-11-30 Publication of FI90664B publication Critical patent/FI90664B/sv

1994-03-10 Application granted granted Critical

1994-03-10 Publication of FI90664C publication Critical patent/FI90664C/sv

Links

238000004519 manufacturing process Methods 0.000 title 1
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-1 alkali metal azide Chemical class 0.000 claims description 27
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RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 15
239000003795 chemical substances by application Substances 0.000 claims description 15
229910052739 hydrogen Inorganic materials 0.000 claims description 15
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239000002243 precursor Substances 0.000 claims description 11
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 10
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FIAFUQMPZJWCLV-UHFFFAOYSA-N suramin Chemical compound OS(=O)(=O)C1=CC(S(O)(=O)=O)=C2C(NC(=O)C3=CC=C(C(=C3)NC(=O)C=3C=C(NC(=O)NC=4C=C(C=CC=4)C(=O)NC=4C(=CC=C(C=4)C(=O)NC=4C5=C(C=C(C=C5C(=CC=4)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)C)C=CC=3)C)=CC=C(S(O)(=O)=O)C2=C1 FIAFUQMPZJWCLV-UHFFFAOYSA-N 0.000 description 1
229960005314 suramin Drugs 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
230000009044 synergistic interaction Effects 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000007916 tablet composition Substances 0.000 description 1
238000003419 tautomerization reaction Methods 0.000 description 1
229960000814 tetanus toxoid Drugs 0.000 description 1
OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
206010043554 thrombocytopenia Diseases 0.000 description 1
208000014754 thrombocytosis disease Diseases 0.000 description 1
RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical group CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 1
LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
GRGCWBWNLSTIEN-UHFFFAOYSA-N trifluoromethanesulfonyl chloride Chemical compound FC(F)(F)S(Cl)(=O)=O GRGCWBWNLSTIEN-UHFFFAOYSA-N 0.000 description 1
JBWKIWSBJXDJDT-UHFFFAOYSA-N triphenylmethyl chloride Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(Cl)C1=CC=CC=C1 JBWKIWSBJXDJDT-UHFFFAOYSA-N 0.000 description 1
238000002211 ultraviolet spectrum Methods 0.000 description 1
208000007089 vaccinia Diseases 0.000 description 1
239000005723 virus inoculator Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1
238000005550 wet granulation Methods 0.000 description 1
ZXVNMYWKKDOREA-UHFFFAOYSA-N zomepirac Chemical compound C1=C(CC(O)=O)N(C)C(C(=O)C=2C=CC(Cl)=CC=2)=C1C ZXVNMYWKKDOREA-UHFFFAOYSA-N 0.000 description 1
229960003414 zomepirac Drugs 0.000 description 1

Classifications

- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

FI863729A 1985-09-17 1986-09-15 Förfarande för framställning av terapeutiskt användbara 3'-azido nukleosider FI90664C (sv)

Applications Claiming Priority (14)

Application Number	Priority Date	Filing Date	Title
US06/776,899 US4724232A (en)	1985-03-16	1985-09-17	Treatment of human viral infections
US77689985		1985-09-17
GB8523878		1985-09-27
GB858523878A GB8523878D0 (en)	1985-09-27	1985-09-27	Therapeutic compounds
GB868603447A GB8603447D0 (en)	1986-02-12	1986-02-12	Therapeutic compounds
GB8603447		1986-02-12
GB868603719A GB8603719D0 (en)	1986-02-14	1986-02-14	Antiviral compounds
GB8603719		1986-02-14
GB868608272A GB8608272D0 (en)	1986-04-04	1986-04-04	Antiviral combination
GB8608272		1986-04-04
US87779686A	1986-06-23	1986-06-23
GB8615322		1986-06-23
GB868615322A GB8615322D0 (en)	1986-06-23	1986-06-23	Antiviral combinations
US87779686		1986-06-23

Publications (4)

Publication Number	Publication Date
FI863729A0 FI863729A0 (sv)	1986-09-15
FI863729L FI863729L (sv)	1987-03-18
FI90664B true FI90664B (sv)	1993-11-30
FI90664C FI90664C (sv)	1994-03-10

Family

ID=27562739

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI863729A FI90664C (sv)	1985-09-17	1986-09-15	Förfarande för framställning av terapeutiskt användbara 3'-azido nukleosider

Country Status (5)

Country	Link
FI (1)	FI90664C (sv)
GR (1)	GR862345B (sv)
IL (1)	IL80035A0 (sv)
NZ (1)	NZ217587A (sv)
PT (1)	PT83375B (sv)

1986
- 1986-09-15 GR GR862345A patent/GR862345B/el unknown
- 1986-09-15 IL IL80035A patent/IL80035A0/xx not_active IP Right Cessation
- 1986-09-15 FI FI863729A patent/FI90664C/sv not_active IP Right Cessation
- 1986-09-15 NZ NZ217587A patent/NZ217587A/en unknown
- 1986-09-15 PT PT83375A patent/PT83375B/pt unknown

Also Published As

Publication number	Publication date
FI863729A0 (sv)	1986-09-15
FI863729L (sv)	1987-03-18
GR862345B (en)	1987-01-12
PT83375A (en)	1986-10-01
NZ217587A (en)	1990-04-26
PT83375B (pt)	1989-05-12
IL80035A0 (en)	1986-12-31
FI90664C (sv)	1994-03-10

Publication	Publication Date	Title
CA1302263C (en)	1992-06-02	Therapeutic nucleosides
FI111722B (sv)	2003-09-15	Förfarande för framställning av (-)-enantiomeren av cis-4-amino-1-(2-hydroximetyl-1,3-oxatiolan-5-yl)-(1H)-pyrimidin-2-on för att användas som ett antiviralt medel
CN1032258C (zh)	1996-07-10	新的核苷磷脂衍生物的制法
FI87783C (sv)	1993-02-25	Förfarande för framställning av terapeutiskt användbara 2',3'-dideoxin ukleosider
EP0199451B1 (en)	1996-03-06	Therapeutic nucleosides
EP1274713B1 (en)	2004-03-10	Anti-viral pyrimidine nucleoside analogues
SK95193A3 (en)	1994-01-12	Antiviral nucleoside combination
IE63655B1 (en)	1995-05-31	Antiviral compounds
AU774720B2 (en)	2004-07-08	Nucleosides with anti-hepatitis B virus activity
JPH02180894A (ja)	1990-07-13	抗ウイルス剤
FI91763B (sv)	1994-04-29	Förfarande för framställning av en terapeutiskt användbar 2',3'-dideoxi-3'-fluorpyrimidin- eller -purinnukleosid
EP0356166B1 (en)	1994-04-20	Therapeutic nucleosides
US5064946A (en)	1991-11-12	Therapeutic nucleosides
JP2523527B2 (ja)	1996-08-14	３′−アジド−ヌクレオシド類、それらの製造法、およびそれらからなる抗ビ−ルス剤
FI90664B (sv)	1993-11-30	Förfarande för framställning av terapeutiskt användbara 3'-azido nukleosider
PL153459B1 (en)	1991-04-30	A method of 3-azidenucleosides production
HU199865B (en)	1990-03-28	Process for production of healing nucleosides and medical compositions containing them
AP90A (en)	1990-07-14	Therapeutic nucleosides.
EP0788507A1 (en)	1997-08-13	L-pyranosyl nucleosides
AU1469100A (en)	2000-05-22	Beta-l-2'-deoxy-nucleosides for the treatment of hiv infection
US5198539A (en)	1993-03-30	5'-esters of 2',3'-dideoxy-3'-fluoro-5-ethynyluridine
KR920003804B1 (ko)	1992-05-15	3'-아지도뉴클레오시드의 제조방법
WO1988009796A1 (en)	1988-12-15	Nucleoside analogues
CZ18093A3 (en)	1993-06-16	Novel derivatives of phospholipid nucleosides, process of their preparation as well as their use as antiviral medicaments
AU2003261475A1 (en)	2003-12-04	Beta-L-2'-deoxy-nucleosides for the treatment of HIV infection

Legal Events

Date	Code	Title	Description
1993-11-01	BB	Publication of examined application
1995-04-18	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: THE WELLCOME FOUNDATION LIMITED