FI894615A7 - Method for preparing pharmacologically valuable pteridine - Google Patents

Method for preparing pharmacologically valuable pteridine

Info

Publication number: FI894615A7
Authority: FI; Finland
Prior art keywords: pteridine; pharmacologically valuable; preparing pharmacologically; preparing; valuable
Prior art date: 1988-10-01

Application number

FI894615A

Other languages

Finnish (fi)

Swedish (sv)

Other versions

FI894615A0 (en

FI92699B (en

FI92699C (en

Inventor

Armin Heckel

Joerg Lebsanft

Uwe Bamberger

Avner Ramu

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-01

Filing date

1989-09-29

Publication date

1990-04-02

1989-09-29 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1989-09-29 Publication of FI894615A0 publication Critical patent/FI894615A0/en

1990-04-02 Publication of FI894615A7 publication Critical patent/FI894615A7/en

1994-09-15 Publication of FI92699B publication Critical patent/FI92699B/en

1994-12-27 Application granted granted Critical

1994-12-27 Publication of FI92699C publication Critical patent/FI92699C/en

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

FI894615A 1988-10-01 1989-09-29 Process for the preparation of pharmacologically valuable pteridine FI92699C (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3833393A DE3833393A1 (en)	1988-10-01	1988-10-01	USE OF PTERIDINES TO PREVENT PRIMARY AND SECONDARY RESISTANCE IN CHEMOTHERAPY AND MEDICINES CONTAINING THESE COMPOUNDS
DE3833393		1988-10-01

Publications (4)

Publication Number	Publication Date
FI894615A0 FI894615A0 (en)	1989-09-29
FI894615A7 true FI894615A7 (en)	1990-04-02
FI92699B FI92699B (en)	1994-09-15
FI92699C FI92699C (en)	1994-12-27

Family

ID=6364156

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI894615A FI92699C (en)	1988-10-01	1989-09-29	Process for the preparation of pharmacologically valuable pteridine

Country Status (19)

Country	Link
EP (1)	EP0362645B1 (en)
JP (1)	JPH02256676A (en)
KR (1)	KR910006289A (en)
AT (1)	ATE106728T1 (en)
AU (1)	AU620645B2 (en)
DD (1)	DD299062A5 (en)
DE (2)	DE3833393A1 (en)
DK (1)	DK480489A (en)
ES (1)	ES2056174T3 (en)
FI (1)	FI92699C (en)
HU (1)	HU205761B (en)
IL (1)	IL91814A (en)
MX (1)	MX9203034A (en)
NO (1)	NO175979C (en)
NZ (1)	NZ230833A (en)
PT (1)	PT91836B (en)
SU (1)	SU1720491A3 (en)
UA (1)	UA8028A1 (en)
ZA (1)	ZA897414B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7276506B2 (en)	1998-12-28	2007-10-02	4 Aza Bioscience Nv	Immunosuppressive effects of pteridine derivatives
WO2000039129A1 (en) *	1998-12-28	2000-07-06	K.U. Leuven Research & Development	Immunosuppressive effects of pteridine derivatives
DE10202468A1 (en) *	2002-01-23	2004-09-30	Faustus Forschungs Cie. Translational Cancer Research Gmbh	Pteridine derivatives, process for their preparation and their use
PT1663244E (en) *	2003-09-12	2007-11-15	4 Aza Ip Nv	Pteridine derivatives for the treatment of tnf-alpha-related diseases.
AU2004283479A1 (en) *	2003-10-17	2005-05-06	4 Aza Bioscience Nv	Heterocycle-substituted pteridine derivatives and their use in therapy
RU2447074C2 (en) *	2005-05-12	2012-04-10	Тиботек Фармасьютикалз Лтд.	Pteridines effective as hcv inhibitors and methods for producing pteridines
US9259426B2 (en)	2006-07-20	2016-02-16	Gilead Sciences, Inc.	4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
WO2008009079A2 (en)	2006-07-20	2008-01-24	Gilead Sciences, Inc.	Substituted pteridines useful for the treatment and prevention of viral infections
EP3722297A1 (en)	2015-03-04	2020-10-14	Gilead Sciences, Inc.	Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds
KR20160003575A (en)	2015-11-09	2016-01-11	정민시	Power transmitting apparatus for generator
US10640499B2 (en)	2016-09-02	2020-05-05	Gilead Sciences, Inc.	Toll like receptor modulator compounds
ES2906581T3 (en)	2016-09-02	2022-04-19	Gilead Sciences Inc	Toll-like receptor modulator compounds
TWI751516B (en)	2019-04-17	2022-01-01	美商基利科學股份有限公司	Solid forms of a toll-like receptor modulator
TWI751517B (en)	2019-04-17	2022-01-01	美商基利科學股份有限公司	Solid forms of a toll-like receptor modulator
TWI879779B (en)	2019-06-28	2025-04-11	美商基利科學股份有限公司	Processes for preparing toll-like receptor modulator compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3574206A (en) *	1965-04-15	1971-04-06	Boehringer Sohn Ingelheim	2,7-dimorpholino-4-amino-6-phenyl-pteridines
NL129630C (en) *	1966-10-14
DE1617336C2 (en) *	1966-11-25	1982-07-01	C.H. Boehringer Sohn, 6507 Ingelheim	Medicines for angina pectoris
DE1795515A1 (en) *	1967-08-18	1972-03-30	Thomae Gmbh Dr K	Process for the production of new pteridines
DE1795516A1 (en) *	1967-12-15	1972-01-27	Thomae Gmbh Dr K	4-AEthanolisopropanolamino-2- (2'-methylmorpholino) -7-morpholino-6-phenyl-pteridine
DE1921308A1 (en) *	1969-04-25	1971-01-07	Boehringer Sohn Ingelheim	Pharmaceutical prepns. containing one or more of cpds. of general formula (I):- ArOCH2 - CHOH - CH2 - NHR (I) Ar= opt. mono-or polysubstd. iso-, hom
US4767761A (en) *	1987-11-04	1988-08-30	Dana-Farber Cancer Institute, Inc.	Ornithine derivatives and their use as methotrexate-resistant cell inhibitors

1988
- 1988-10-01 DE DE3833393A patent/DE3833393A1/en not_active Withdrawn
1989
- 1989-09-23 AT AT89117610T patent/ATE106728T1/en not_active IP Right Cessation
- 1989-09-23 EP EP89117610A patent/EP0362645B1/en not_active Expired - Lifetime
- 1989-09-23 DE DE58907824T patent/DE58907824D1/en not_active Expired - Fee Related
- 1989-09-23 ES ES89117610T patent/ES2056174T3/en not_active Expired - Lifetime
- 1989-09-26 AU AU41749/89A patent/AU620645B2/en not_active Ceased
- 1989-09-28 IL IL9181489A patent/IL91814A/en not_active IP Right Cessation
- 1989-09-28 PT PT91836A patent/PT91836B/en not_active IP Right Cessation
- 1989-09-29 NO NO893879A patent/NO175979C/en unknown
- 1989-09-29 HU HU895131A patent/HU205761B/en not_active IP Right Cessation
- 1989-09-29 FI FI894615A patent/FI92699C/en not_active IP Right Cessation
- 1989-09-29 DD DD89333128A patent/DD299062A5/en not_active IP Right Cessation
- 1989-09-29 KR KR1019890014002A patent/KR910006289A/en not_active Ceased
- 1989-09-29 ZA ZA897414A patent/ZA897414B/en unknown
- 1989-09-29 JP JP1255126A patent/JPH02256676A/en active Pending
- 1989-09-29 SU SU894742036A patent/SU1720491A3/en active
- 1989-09-29 UA UA4742036A patent/UA8028A1/en unknown
- 1989-09-29 NZ NZ230833A patent/NZ230833A/en unknown
- 1989-09-29 DK DK480489A patent/DK480489A/en not_active Application Discontinuation
1992
- 1992-06-19 MX MX9203034A patent/MX9203034A/en unknown

Also Published As

Publication number	Publication date
NO175979C (en)	1995-01-11
DK480489D0 (en)	1989-09-29
SU1720491A3 (en)	1992-03-15
AU4174989A (en)	1990-04-05
NO893879L (en)	1990-04-02
FI894615A0 (en)	1989-09-29
DE3833393A1 (en)	1990-04-05
DK480489A (en)	1990-04-02
MX9203034A (en)	1992-07-01
EP0362645B1 (en)	1994-06-08
ZA897414B (en)	1991-06-26
IL91814A0 (en)	1990-06-10
NO893879D0 (en)	1989-09-29
FI92699B (en)	1994-09-15
DD299062A5 (en)	1992-03-26
AU620645B2 (en)	1992-02-20
KR910006289A (en)	1991-04-29
EP0362645A2 (en)	1990-04-11
ATE106728T1 (en)	1994-06-15
PT91836A (en)	1990-04-30
PT91836B (en)	1995-07-18
IL91814A (en)	1994-02-27
EP0362645A3 (en)	1992-03-25
HUT52504A (en)	1990-07-28
DE58907824D1 (en)	1994-07-14
NZ230833A (en)	1991-05-28
NO175979B (en)	1994-10-03
JPH02256676A (en)	1990-10-17
HU205761B (en)	1992-06-29
UA8028A1 (en)	1995-12-26
FI92699C (en)	1994-12-27
ES2056174T3 (en)	1994-10-01

Publication	Publication Date	Title
FI893158L (en)	1989-12-30	Method for preparing tetrahydrofolates
FI893226L (en)	1990-01-08	Method for preparing a pharmacologically valuable benzodiazepine
FI890282L (en)	1989-07-21	Method for preparing therapeutically useful 23,24-didehydro-25-hydroxycalciferol derivatives
FI863917L (en)	1987-04-08	Method for preparing pharmacologically useful quinazoline derivatives
FI894217L (en)	1990-03-08	Method for preparing 1-adamantane derivatives
FI881180L (en)	1988-09-14	Method for preparing therapeutically useful tetrahydronaphthalene derivatives
FI885409A7 (en)	1989-05-24	Method for preparing novel therapeutically useful pyridazineamine derivatives
FI890842A7 (en)	1989-08-25	Method for preparing therapeutically useful stilbene derivatives
FI892182A7 (en)	1989-11-07	Method for preparing therapeutically useful chroman derivatives
FI891711L (en)	1989-12-26	Method for preparing diorganodialkoxysilanes
FI895766A7 (en)	1990-06-03	Method for preparing novel lysosphingolipids
FI894615A7 (en)	1990-04-02	Method for preparing pharmacologically valuable pteridine
FI894693L (en)	1990-04-07	Method for preparing a pharmaceutically valuable imidazoline derivative
FI890283A7 (en)	1989-07-21	Method for preparing therapeutically useful 25-hydroxyvitamin D derivatives
FI892129A7 (en)	1989-11-05	Improved method for preparing ketimine
FI892948A7 (en)	1989-12-17	Method for preparing therapeutically useful chroman derivatives
FI892637A7 (en)	1989-12-07	Method for preparing a pharmacologically valuable cephem compound
FI881525A7 (en)	1988-10-02	Method for preparing novel therapeutically useful N-arylpiperazineacetamide derivatives
FI893003L (en)	1989-12-21	Method for preparing novel therapeutically useful neplanosin derivatives
FI891677L (en)	1989-10-12	Process for preparing 4-demethoxydaunomycinone
FI885560A7 (en)	1988-11-30	Method for preparing novel therapeutically useful bisphenylalkylpiperazine derivatives
FI874789L (en)	1988-05-05	Method for preparing pharmacologically active substituted 1H-imidazoles
FI891362A7 (en)	1989-09-30	Method for preparing new alkanophenones
FI895800A7 (en)	1990-06-09	Method for preparing novel a-cyano-b-oxopropionamides
FI896231A7 (en)	1989-12-22	Method for preparing L-alanine

Legal Events

Date	Code	Title	Description
1994-08-16	BB	Publication of examined application
1996-04-16	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: DR. KARL THOMAE GESELLSCHAFT MIT