FI894615A0 - The method produces pharmacologically valuable pteridine - Google Patents
The method produces pharmacologically valuable pteridineInfo
- Publication number
- FI894615A0 FI894615A0 FI894615A FI894615A FI894615A0 FI 894615 A0 FI894615 A0 FI 894615A0 FI 894615 A FI894615 A FI 894615A FI 894615 A FI894615 A FI 894615A FI 894615 A0 FI894615 A0 FI 894615A0
- Authority
- FI
- Finland
- Prior art keywords
- group
- pteridines
- pteridine
- substituted
- carbon atom
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- CPNGPNLZQNNVQM-UHFFFAOYSA-N pteridine Chemical compound N1=CN=CC2=NC=CN=C21 CPNGPNLZQNNVQM-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 150000003195 pteridines Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010070834 Sensitisation Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000000973 chemotherapeutic effect Effects 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 229930014626 natural product Natural products 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- -1 pyrrolidino, piperidino Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates to medicaments containing a pteridine of the formula <IMAGE> in which n is the number 0 or 1, R2 and R7 are each a pyrrolidino, piperidino or morpholino group which is optionally substituted by one or two methyl groups, R3 is a straight-chain or branched alkyl group in which one or two carbon atoms, excepting the carbon atom adjacent to the nitrogen atom, can be substituted by a hydroxyl group, R<4> is an alkyl or phenylalkyl group, in which one carbon atom, excepting the carbon atom adjacent to the nitrogen atom, can be substituted by a hydroxyl group, and R5 is a hydrogen atom or a methyl group, or the acid addition salts thereof and at least one chemotherapeutic from the natural product series, and to the use of the above pteridines for sensitisation of tumours during chemotherapy with the abovementioned chemotherapeutics, and to pteridines, process for the preparation thereof and medicaments containing these pteridines.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3833393A DE3833393A1 (en) | 1988-10-01 | 1988-10-01 | USE OF PTERIDINES TO PREVENT PRIMARY AND SECONDARY RESISTANCE IN CHEMOTHERAPY AND MEDICINES CONTAINING THESE COMPOUNDS |
| DE3833393 | 1988-10-01 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI894615A0 true FI894615A0 (en) | 1989-09-29 |
| FI894615A7 FI894615A7 (en) | 1990-04-02 |
| FI92699B FI92699B (en) | 1994-09-15 |
| FI92699C FI92699C (en) | 1994-12-27 |
Family
ID=6364156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI894615A FI92699C (en) | 1988-10-01 | 1989-09-29 | Process for the preparation of pharmacologically valuable pteridine |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0362645B1 (en) |
| JP (1) | JPH02256676A (en) |
| KR (1) | KR910006289A (en) |
| AT (1) | ATE106728T1 (en) |
| AU (1) | AU620645B2 (en) |
| DD (1) | DD299062A5 (en) |
| DE (2) | DE3833393A1 (en) |
| DK (1) | DK480489A (en) |
| ES (1) | ES2056174T3 (en) |
| FI (1) | FI92699C (en) |
| HU (1) | HU205761B (en) |
| IL (1) | IL91814A (en) |
| MX (1) | MX9203034A (en) |
| NO (1) | NO175979C (en) |
| NZ (1) | NZ230833A (en) |
| PT (1) | PT91836B (en) |
| SU (1) | SU1720491A3 (en) |
| UA (1) | UA8028A1 (en) |
| ZA (1) | ZA897414B (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7276506B2 (en) | 1998-12-28 | 2007-10-02 | 4 Aza Bioscience Nv | Immunosuppressive effects of pteridine derivatives |
| ATE277929T1 (en) * | 1998-12-28 | 2004-10-15 | 4 Aza Bioscience Nv | IMMUNOSUPRESSIVE EFFECTS OF PTERIDINE DERIVATIVES |
| DE10202468A1 (en) * | 2002-01-23 | 2004-09-30 | Faustus Forschungs Cie. Translational Cancer Research Gmbh | Pteridine derivatives, process for their preparation and their use |
| JP2007533617A (en) * | 2003-09-12 | 2007-11-22 | ４・アー・ゼット・アー・バイオサイエンス・ナムローゼ・フエンノートシャップ | Pteridine derivatives for the treatment of septic shock and TNF-α-related diseases |
| DK1673092T3 (en) * | 2003-10-17 | 2007-12-17 | 4 Aza Ip Nv | Heterocyclyl-substituted pteridine derivatives and their use in therapy |
| RU2447074C2 (en) * | 2005-05-12 | 2012-04-10 | Тиботек Фармасьютикалз Лтд. | Pteridines effective as hcv inhibitors and methods for producing pteridines |
| WO2008009078A2 (en) | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| US10144736B2 (en) | 2006-07-20 | 2018-12-04 | Gilead Sciences, Inc. | Substituted pteridines useful for the treatment and prevention of viral infections |
| HUE038059T2 (en) | 2015-03-04 | 2018-10-29 | Gilead Sciences Inc | Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds |
| KR20160003575A (en) | 2015-11-09 | 2016-01-11 | 정민시 | Power transmitting apparatus for generator |
| US10370342B2 (en) | 2016-09-02 | 2019-08-06 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| ES2826748T3 (en) | 2016-09-02 | 2021-05-19 | Gilead Sciences Inc | Derivatives of 4,6-diamino-pyrido [3,2-d] pyrimidine as modulators of Toll-like receptors |
| TWI751517B (en) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | Solid forms of a toll-like receptor modulator |
| TW202210480A (en) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | Solid forms of a toll-like receptor modulator |
| TWI879779B (en) | 2019-06-28 | 2025-04-11 | 美商基利科學股份有限公司 | Processes for preparing toll-like receptor modulator compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3574206A (en) * | 1965-04-15 | 1971-04-06 | Boehringer Sohn Ingelheim | 2,7-dimorpholino-4-amino-6-phenyl-pteridines |
| NL129630C (en) * | 1966-10-14 | |||
| DE1617336C2 (en) * | 1966-11-25 | 1982-07-01 | C.H. Boehringer Sohn, 6507 Ingelheim | Medicines for angina pectoris |
| DE1795515A1 (en) * | 1967-08-18 | 1972-03-30 | Thomae Gmbh Dr K | Process for the production of new pteridines |
| DE1795516A1 (en) * | 1967-12-15 | 1972-01-27 | Thomae Gmbh Dr K | 4-AEthanolisopropanolamino-2- (2'-methylmorpholino) -7-morpholino-6-phenyl-pteridine |
| DE1921308A1 (en) * | 1969-04-25 | 1971-01-07 | Boehringer Sohn Ingelheim | Pharmaceutical prepns. containing one or more of cpds. of general formula (I):- ArOCH2 - CHOH - CH2 - NHR (I) Ar= opt. mono-or polysubstd. iso-, hom |
| US4767761A (en) * | 1987-11-04 | 1988-08-30 | Dana-Farber Cancer Institute, Inc. | Ornithine derivatives and their use as methotrexate-resistant cell inhibitors |
-
1988
- 1988-10-01 DE DE3833393A patent/DE3833393A1/en not_active Withdrawn
-
1989
- 1989-09-23 EP EP89117610A patent/EP0362645B1/en not_active Expired - Lifetime
- 1989-09-23 DE DE58907824T patent/DE58907824D1/en not_active Expired - Fee Related
- 1989-09-23 ES ES89117610T patent/ES2056174T3/en not_active Expired - Lifetime
- 1989-09-23 AT AT89117610T patent/ATE106728T1/en not_active IP Right Cessation
- 1989-09-26 AU AU41749/89A patent/AU620645B2/en not_active Ceased
- 1989-09-28 PT PT91836A patent/PT91836B/en not_active IP Right Cessation
- 1989-09-28 IL IL9181489A patent/IL91814A/en not_active IP Right Cessation
- 1989-09-29 DD DD89333128A patent/DD299062A5/en not_active IP Right Cessation
- 1989-09-29 FI FI894615A patent/FI92699C/en not_active IP Right Cessation
- 1989-09-29 ZA ZA897414A patent/ZA897414B/en unknown
- 1989-09-29 HU HU895131A patent/HU205761B/en not_active IP Right Cessation
- 1989-09-29 NO NO893879A patent/NO175979C/en unknown
- 1989-09-29 NZ NZ230833A patent/NZ230833A/en unknown
- 1989-09-29 UA UA4742036A patent/UA8028A1/en unknown
- 1989-09-29 KR KR1019890014002A patent/KR910006289A/en not_active Ceased
- 1989-09-29 SU SU894742036A patent/SU1720491A3/en active
- 1989-09-29 JP JP1255126A patent/JPH02256676A/en active Pending
- 1989-09-29 DK DK480489A patent/DK480489A/en not_active Application Discontinuation
-
1992
- 1992-06-19 MX MX9203034A patent/MX9203034A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX9203034A (en) | 1992-07-01 |
| EP0362645A2 (en) | 1990-04-11 |
| NO893879D0 (en) | 1989-09-29 |
| EP0362645B1 (en) | 1994-06-08 |
| ZA897414B (en) | 1991-06-26 |
| NO175979C (en) | 1995-01-11 |
| NZ230833A (en) | 1991-05-28 |
| HUT52504A (en) | 1990-07-28 |
| AU620645B2 (en) | 1992-02-20 |
| DE3833393A1 (en) | 1990-04-05 |
| DE58907824D1 (en) | 1994-07-14 |
| DD299062A5 (en) | 1992-03-26 |
| JPH02256676A (en) | 1990-10-17 |
| ES2056174T3 (en) | 1994-10-01 |
| IL91814A0 (en) | 1990-06-10 |
| EP0362645A3 (en) | 1992-03-25 |
| ATE106728T1 (en) | 1994-06-15 |
| DK480489D0 (en) | 1989-09-29 |
| UA8028A1 (en) | 1995-12-26 |
| DK480489A (en) | 1990-04-02 |
| PT91836B (en) | 1995-07-18 |
| FI92699B (en) | 1994-09-15 |
| PT91836A (en) | 1990-04-30 |
| NO175979B (en) | 1994-10-03 |
| AU4174989A (en) | 1990-04-05 |
| NO893879L (en) | 1990-04-02 |
| SU1720491A3 (en) | 1992-03-15 |
| IL91814A (en) | 1994-02-27 |
| FI894615A7 (en) | 1990-04-02 |
| HU205761B (en) | 1992-06-29 |
| FI92699C (en) | 1994-12-27 |
| KR910006289A (en) | 1991-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: DR. KARL THOMAE GESELLSCHAFT MIT |